Motif ID: PLAG1

Z-value: 0.490


Transcription factors associated with PLAG1:

Gene SymbolEntrez IDGene Name
PLAG1 ENSG00000181690.3 PLAG1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PLAG1hg19_v2_chr8_-_57123815_57123867-0.341.0e-01Click!


Activity profile for motif PLAG1.

activity profile for motif PLAG1


Sorted Z-values histogram for motif PLAG1

Sorted Z-values for motif PLAG1



Network of associatons between targets according to the STRING database.



First level regulatory network of PLAG1

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_7654057 2.459 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr8_-_23261589 1.832 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2



chr12_-_58131931 1.743 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_-_2160180 1.573 ENST00000381406.4
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_+_90728145 1.326 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
 SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr19_+_41725088 1.256 ENST00000301178.4
 AXL
AXL receptor tyrosine kinase
chr11_-_1643368 1.083 ENST00000399682.1
 KRTAP5-4
keratin associated protein 5-4
chr1_-_24469602 0.973 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr14_-_75079026 0.962 ENST00000261978.4
 LTBP2
latent transforming growth factor beta binding protein 2
chr19_+_45844018 0.873 ENST00000585434.1
 KLC3
kinesin light chain 3
chr19_+_45843994 0.835 ENST00000391946.2
 KLC3
kinesin light chain 3
chr12_+_57522258 0.822 ENST00000553277.1
ENST00000243077.3
 LRP1

low density lipoprotein receptor-related protein 1

chr16_+_31483451 0.782 ENST00000565360.1
ENST00000361773.3
 TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr16_+_31483374 0.772 ENST00000394863.3
 TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_+_65343494 0.631 ENST00000309295.4
ENST00000533237.1
 EHBP1L1

EH domain binding protein 1-like 1

chr19_+_45844032 0.630 ENST00000589837.1
 KLC3
kinesin light chain 3
chr7_+_73703728 0.619 ENST00000361545.5
ENST00000223398.6
 CLIP2

CAP-GLY domain containing linker protein 2

chr15_-_70388943 0.527 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
 TLE3






transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)






chr15_+_74833518 0.523 ENST00000346246.5
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr9_+_34652164 0.506 ENST00000441545.2
ENST00000553620.1
 IL11RA

interleukin 11 receptor, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 2.3 GO:0008088 axo-dendritic transport(GO:0008088)
0.1 2.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 1.6 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.2 1.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 1.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.3 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.0 GO:0097435 fibril organization(GO:0097435)
0.0 1.0 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 0.7 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.2 0.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.5 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.4 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.1 0.4 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 0.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.3 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:0034436 glycoprotein transport(GO:0034436)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.6 GO:0033643 host cell part(GO:0033643)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 2.3 GO:0019894 kinesin binding(GO:0019894)
0.4 1.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.3 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.1 0.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.3 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins