Motif ID: PGR

Z-value: 0.767


Transcription factors associated with PGR:

Gene SymbolEntrez IDGene Name
PGR ENSG00000082175.10 PGR

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PGRhg19_v2_chr11_-_100999775_100999801,
hg19_v2_chr11_-_101000445_101000465		0.048.4e-01Click!


Activity profile for motif PGR.

activity profile for motif PGR


Sorted Z-values histogram for motif PGR

Sorted Z-values for motif PGR



Network of associatons between targets according to the STRING database.



First level regulatory network of PGR

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_27062860 1.884 ENST00000528583.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_-_71551652 1.738 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr15_-_49255632 1.651 ENST00000332408.4
 SHC4
SHC (Src homology 2 domain containing) family, member 4
chr7_-_5821225 1.425 ENST00000416985.1
 RNF216
ring finger protein 216
chr5_-_160279207 1.175 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr19_-_9003586 1.137 ENST00000380951.5
 MUC16
mucin 16, cell surface associated
chr11_+_111169565 1.074 ENST00000528846.1
 COLCA2
colorectal cancer associated 2
chr2_-_216300784 0.944 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr5_+_140261703 0.922 ENST00000409494.1
ENST00000289272.2
 PCDHA13

protocadherin alpha 13

chr6_-_46922659 0.916 ENST00000265417.7
 GPR116
G protein-coupled receptor 116
chr8_+_40010989 0.915 ENST00000315792.3
 C8orf4
chromosome 8 open reading frame 4
chr7_+_73442487 0.910 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
 ELN










elastin










chr5_-_121413974 0.876 ENST00000231004.4
 LOX
lysyl oxidase
chr19_-_40440533 0.847 ENST00000221347.6
 FCGBP
Fc fragment of IgG binding protein
chr7_+_73442422 0.808 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
 ELN



elastin



chr3_-_151102529 0.734 ENST00000302632.3
 P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_91505608 0.649 ENST00000266718.4
 LUM
lumican
chr7_+_73442457 0.626 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
 ELN


elastin


chr4_+_86525299 0.624 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr3_-_114343768 0.624 ENST00000393785.2
 ZBTB20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.2 1.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.4 1.6 GO:0018032 protein amidation(GO:0018032)
0.0 1.5 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.0 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.3 1.0 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.3 0.9 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.9 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.5 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.1 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.5 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.4 GO:0072229 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 GO:0071953 elastic fiber(GO:0071953)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.4 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.1 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 1.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 1.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 1.6 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.5 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.4 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.4 GO:0043559 insulin binding(GO:0043559)
0.0 0.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade