Motif ID: PGR

Z-value: 0.767


Transcription factors associated with PGR:

Gene SymbolEntrez IDGene Name
PGR ENSG00000082175.10 PGR

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PGRhg19_v2_chr11_-_100999775_100999801,
hg19_v2_chr11_-_101000445_101000465
0.048.4e-01Click!


Activity profile for motif PGR.

activity profile for motif PGR


Sorted Z-values histogram for motif PGR

Sorted Z-values for motif PGR



Network of associatons between targets according to the STRING database.



First level regulatory network of PGR

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_27062860 1.884 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_-_71551652 1.738 ENST00000546561.1
TSPAN8
tetraspanin 8
chr15_-_49255632 1.651 ENST00000332408.4
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr7_-_5821225 1.425 ENST00000416985.1
RNF216
ring finger protein 216
chr5_-_160279207 1.175 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr19_-_9003586 1.137 ENST00000380951.5
MUC16
mucin 16, cell surface associated
chr11_+_111169565 1.074 ENST00000528846.1
COLCA2
colorectal cancer associated 2
chr2_-_216300784 0.944 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1













fibronectin 1













chr5_+_140261703 0.922 ENST00000409494.1
ENST00000289272.2
PCDHA13

protocadherin alpha 13

chr6_-_46922659 0.916 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr8_+_40010989 0.915 ENST00000315792.3
C8orf4
chromosome 8 open reading frame 4
chr7_+_73442487 0.910 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
ELN










elastin










chr5_-_121413974 0.876 ENST00000231004.4
LOX
lysyl oxidase
chr19_-_40440533 0.847 ENST00000221347.6
FCGBP
Fc fragment of IgG binding protein
chr7_+_73442422 0.808 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN



elastin



chr3_-_151102529 0.734 ENST00000302632.3
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_91505608 0.649 ENST00000266718.4
LUM
lumican
chr7_+_73442457 0.626 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
ELN


elastin


chr4_+_86525299 0.624 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr3_-_114343768 0.624 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_78056412 0.586 ENST00000299642.4
ENST00000575655.1
CLEC3A

C-type lectin domain family 3, member A

chr11_+_6897856 0.584 ENST00000379829.2
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr1_-_145039835 0.574 ENST00000533259.1
PDE4DIP
phosphodiesterase 4D interacting protein
chrX_+_16964985 0.507 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr5_+_102201509 0.505 ENST00000348126.2
ENST00000379787.4
PAM

peptidylglycine alpha-amidating monooxygenase

chr19_+_13135731 0.495 ENST00000587260.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_+_102201430 0.492 ENST00000438793.3
ENST00000346918.2
PAM

peptidylglycine alpha-amidating monooxygenase

chr6_-_76782371 0.487 ENST00000369950.3
ENST00000369963.3
IMPG1

interphotoreceptor matrix proteoglycan 1

chr14_+_24674926 0.474 ENST00000339917.5
ENST00000556621.1
ENST00000287913.6
ENST00000428351.2
ENST00000555092.1
TSSK4




testis-specific serine kinase 4




chr6_-_32908792 0.471 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_+_73442102 0.461 ENST00000445912.1
ENST00000252034.7
ELN

elastin

chr1_-_156828810 0.450 ENST00000368195.3
INSRR
insulin receptor-related receptor
chr7_+_30960915 0.434 ENST00000441328.2
ENST00000409899.1
ENST00000409611.1
AQP1


aquaporin 1 (Colton blood group)


chr6_-_32908765 0.428 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_+_67584174 0.418 ENST00000320694.8
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_+_41119323 0.418 ENST00000599724.1
ENST00000597071.1
ENST00000243562.9
LTBP4


latent transforming growth factor beta binding protein 4


chr2_+_191334212 0.409 ENST00000444317.1
ENST00000535751.1
MFSD6

major facilitator superfamily domain containing 6

chr10_-_28571015 0.407 ENST00000375719.3
ENST00000375732.1
MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr3_-_58563094 0.393 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr20_+_23016057 0.390 ENST00000255008.3
SSTR4
somatostatin receptor 4
chr1_-_145039949 0.381 ENST00000313382.9
PDE4DIP
phosphodiesterase 4D interacting protein
chr20_+_52105495 0.365 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr10_-_49482907 0.358 ENST00000374201.3
ENST00000407470.4
FRMPD2

FERM and PDZ domain containing 2

chr6_-_154831779 0.355 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr12_+_56473628 0.349 ENST00000549282.1
ENST00000549061.1
ENST00000267101.3
ERBB3


v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3


chr12_-_88974236 0.339 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KITLG


KIT ligand


chr9_+_116225999 0.337 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr3_-_149051194 0.336 ENST00000470080.1
TM4SF18
transmembrane 4 L six family member 18
chr5_-_124081008 0.336 ENST00000306315.5
ZNF608
zinc finger protein 608
chr17_-_71088797 0.335 ENST00000580557.1
ENST00000579732.1
ENST00000578620.1
ENST00000542342.2
ENST00000255559.3
ENST00000579018.1
SLC39A11





solute carrier family 39, member 11





chr12_+_131438443 0.334 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr11_+_6502675 0.332 ENST00000254616.6
ENST00000530751.1
TIMM10B

translocase of inner mitochondrial membrane 10 homolog B (yeast)

chr3_-_114035026 0.331 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr15_-_45406385 0.326 ENST00000389039.6
DUOX2
dual oxidase 2
chr5_+_102201722 0.325 ENST00000274392.9
ENST00000455264.2
PAM

peptidylglycine alpha-amidating monooxygenase

chr4_-_154710210 0.318 ENST00000274063.4
SFRP2
secreted frizzled-related protein 2
chr5_+_102201687 0.317 ENST00000304400.7
PAM
peptidylglycine alpha-amidating monooxygenase
chr19_+_16771936 0.316 ENST00000187762.2
ENST00000599479.1
TMEM38A

transmembrane protein 38A

chr2_-_175711133 0.314 ENST00000409597.1
ENST00000413882.1
CHN1

chimerin 1

chr19_+_13135386 0.313 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX


nuclear factor I/X (CCAAT-binding transcription factor)


chr10_-_48416849 0.310 ENST00000249598.1
GDF2
growth differentiation factor 2
chr19_+_13135790 0.308 ENST00000358552.3
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chrX_+_130192216 0.306 ENST00000276211.5
ARHGAP36
Rho GTPase activating protein 36
chr12_-_81763127 0.305 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr2_+_38177575 0.304 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2



regulator of microtubule dynamics 2



chr12_-_81763184 0.301 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2


protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


chr19_-_42947121 0.300 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr2_-_158182410 0.292 ENST00000419116.2
ENST00000410096.1
ERMN

ermin, ERM-like protein

chr4_-_88450612 0.291 ENST00000418378.1
ENST00000282470.6
SPARCL1

SPARC-like 1 (hevin)

chr3_-_112218378 0.290 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr6_+_39760129 0.288 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_-_114343039 0.287 ENST00000481632.1
ZBTB20
zinc finger and BTB domain containing 20
chr11_-_73693875 0.280 ENST00000536983.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr3_+_149530836 0.275 ENST00000466478.1
ENST00000491086.1
ENST00000467977.1
RNF13


ring finger protein 13


chr22_-_31688431 0.268 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1



phosphoinositide-3-kinase interacting protein 1



chr22_-_31688381 0.265 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr6_+_27107053 0.264 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chr6_-_47010061 0.263 ENST00000371253.2
GPR110
G protein-coupled receptor 110
chr15_+_31658349 0.262 ENST00000558844.1
KLF13
Kruppel-like factor 13
chr8_-_22089845 0.261 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr6_-_132939317 0.261 ENST00000275191.2
TAAR2
trace amine associated receptor 2
chr16_-_3350614 0.260 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chrX_+_135570046 0.259 ENST00000370648.3
BRS3
bombesin-like receptor 3
chr11_+_123396528 0.255 ENST00000322282.7
ENST00000529750.1
GRAMD1B

GRAM domain containing 1B

chr19_-_51529849 0.252 ENST00000600362.1
ENST00000453757.3
ENST00000601671.1
KLK11


kallikrein-related peptidase 11


chr3_-_191000172 0.248 ENST00000427544.2
UTS2B
urotensin 2B
chr13_+_102104952 0.245 ENST00000376180.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr3_+_25469802 0.245 ENST00000330688.4
RARB
retinoic acid receptor, beta
chr5_-_94417339 0.243 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1


multiple C2 domains, transmembrane 1


chr17_-_26697304 0.241 ENST00000536498.1
VTN
vitronectin
chr17_+_73997796 0.241 ENST00000586261.1
CDK3
cyclin-dependent kinase 3
chr7_-_92855762 0.241 ENST00000453812.2
ENST00000394468.2
HEPACAM2

HEPACAM family member 2

chr7_-_150946015 0.237 ENST00000262188.8
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chrX_-_100641155 0.237 ENST00000372880.1
ENST00000308731.7
BTK

Bruton agammaglobulinemia tyrosine kinase

chr6_+_30951487 0.236 ENST00000486149.2
ENST00000376296.3
MUC21

mucin 21, cell surface associated

chr5_+_137419581 0.233 ENST00000506684.1
ENST00000504809.1
ENST00000398754.1
WNT8A


wingless-type MMTV integration site family, member 8A


chr16_+_202686 0.231 ENST00000252951.2
HBZ
hemoglobin, zeta
chr3_-_124839648 0.231 ENST00000430155.2
SLC12A8
solute carrier family 12, member 8
chr1_-_145039771 0.230 ENST00000493130.2
ENST00000532801.1
ENST00000478649.2
PDE4DIP


phosphodiesterase 4D interacting protein


chr9_-_140196703 0.223 ENST00000356628.2
NRARP
NOTCH-regulated ankyrin repeat protein
chr5_-_146435501 0.221 ENST00000336640.6
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr15_-_43877062 0.218 ENST00000381885.1
ENST00000396923.3
PPIP5K1

diphosphoinositol pentakisphosphate kinase 1

chr4_-_105416039 0.218 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr5_-_146435572 0.215 ENST00000394414.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr21_-_34185944 0.211 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr9_-_131940526 0.211 ENST00000372491.2
IER5L
immediate early response 5-like
chr7_+_105603683 0.211 ENST00000317716.9
CDHR3
cadherin-related family member 3
chr11_-_124806297 0.208 ENST00000298251.4
HEPACAM
hepatic and glial cell adhesion molecule
chr3_+_25469724 0.208 ENST00000437042.2
RARB
retinoic acid receptor, beta
chr6_-_89927151 0.205 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_-_26394114 0.202 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr1_-_167906277 0.200 ENST00000271373.4
MPC2
mitochondrial pyruvate carrier 2
chr15_+_31619013 0.198 ENST00000307145.3
KLF13
Kruppel-like factor 13
chrX_-_112084043 0.197 ENST00000304758.1
AMOT
angiomotin
chr5_-_38557561 0.196 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr19_+_10531150 0.196 ENST00000352831.6
PDE4A
phosphodiesterase 4A, cAMP-specific
chr14_-_67955426 0.195 ENST00000554480.1
TMEM229B
transmembrane protein 229B
chr9_-_34665983 0.193 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
RP11-195F19.5



HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015



chr6_+_30131318 0.192 ENST00000376688.1
TRIM15
tripartite motif containing 15
chr2_+_36923830 0.192 ENST00000379242.3
ENST00000389975.3
VIT

vitrin

chr10_-_104178857 0.189 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr5_-_146435694 0.189 ENST00000356826.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr1_-_166944561 0.188 ENST00000271417.3
ILDR2
immunoglobulin-like domain containing receptor 2
chr10_+_73156664 0.188 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
CDH23



cadherin-related 23



chr3_-_139195350 0.188 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr2_+_234602305 0.186 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr20_+_34129770 0.183 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
ERGIC3






ERGIC and golgi 3






chr1_-_85870177 0.183 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr20_+_138089 0.180 ENST00000382388.3
DEFB127
defensin, beta 127
chr12_+_58003935 0.178 ENST00000333972.7
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr5_+_139505520 0.177 ENST00000333305.3
IGIP
IgA-inducing protein
chr17_-_56621665 0.175 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr3_-_112218205 0.174 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr19_+_44488330 0.170 ENST00000591532.1
ENST00000407951.2
ENST00000270014.2
ENST00000590615.1
ENST00000586454.1
ZNF155




zinc finger protein 155




chr17_-_40540586 0.170 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr22_+_31644388 0.169 ENST00000333611.4
ENST00000340552.4
LIMK2

LIM domain kinase 2

chr4_+_146539415 0.165 ENST00000281317.5
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr7_+_138145145 0.158 ENST00000415680.2
TRIM24
tripartite motif containing 24
chr7_+_105603657 0.158 ENST00000542731.1
ENST00000343407.5
CDHR3

cadherin-related family member 3

chr20_+_23420322 0.156 ENST00000347397.1
CSTL1
cystatin-like 1
chr10_+_104178946 0.154 ENST00000432590.1
FBXL15
F-box and leucine-rich repeat protein 15
chr13_+_78315295 0.154 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr9_+_127615733 0.153 ENST00000373574.1
WDR38
WD repeat domain 38
chr20_+_30063067 0.152 ENST00000201979.2
REM1
RAS (RAD and GEM)-like GTP-binding 1
chr9_+_1051481 0.152 ENST00000358146.2
ENST00000259622.6
DMRT2

doublesex and mab-3 related transcription factor 2

chr7_+_22766766 0.151 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6






interleukin 6 (interferon, beta 2)






chr9_+_2159850 0.149 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr17_+_46970134 0.149 ENST00000503641.1
ENST00000514808.1
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chrX_+_70443050 0.148 ENST00000361726.6
GJB1
gap junction protein, beta 1, 32kDa
chr1_-_179112189 0.147 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr16_-_28506840 0.147 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chrX_+_69672136 0.146 ENST00000374355.3
DLG3
discs, large homolog 3 (Drosophila)
chr20_+_23420885 0.146 ENST00000246020.2
CSTL1
cystatin-like 1
chr5_-_76935513 0.145 ENST00000306422.3
OTP
orthopedia homeobox
chrX_+_54834159 0.145 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
MAGED2


melanoma antigen family D, 2


chr10_+_63808970 0.145 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr20_+_59654146 0.143 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr1_-_234667504 0.143 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1

RP5-855F14.1

chr8_+_10530155 0.142 ENST00000521818.1
C8orf74
chromosome 8 open reading frame 74
chr1_+_16370271 0.141 ENST00000375679.4
CLCNKB
chloride channel, voltage-sensitive Kb
chr3_+_147795932 0.141 ENST00000490465.1
RP11-639B1.1
RP11-639B1.1
chr2_-_27531313 0.140 ENST00000296099.2
UCN
urocortin
chr19_-_19144243 0.139 ENST00000594445.1
ENST00000452918.2
ENST00000600377.1
ENST00000337018.6
SUGP2



SURP and G patch domain containing 2



chr5_+_156607829 0.137 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chrX_+_54834004 0.136 ENST00000375068.1
MAGED2
melanoma antigen family D, 2
chr3_-_48057890 0.135 ENST00000434267.1
MAP4
microtubule-associated protein 4
chr12_-_70093190 0.135 ENST00000330891.5
BEST3
bestrophin 3
chr15_-_58306295 0.134 ENST00000559517.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr12_+_50146747 0.133 ENST00000547798.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr3_+_137906109 0.133 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8



armadillo repeat containing 8



chr16_-_66952779 0.132 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16


cadherin 16, KSP-cadherin


chr14_-_107219365 0.132 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr13_+_73632897 0.131 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr11_-_6502534 0.129 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
ARFIP2


ADP-ribosylation factor interacting protein 2


chr5_+_138629417 0.128 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3



matrin 3



chrX_-_133792480 0.128 ENST00000359237.4
PLAC1
placenta-specific 1
chr19_+_52264449 0.128 ENST00000599326.1
ENST00000598953.1
FPR2

formyl peptide receptor 2

chr17_-_7760457 0.127 ENST00000576384.1
LSMD1
LSM domain containing 1
chr18_+_6729698 0.126 ENST00000383472.4
ARHGAP28
Rho GTPase activating protein 28
chr15_+_65843130 0.125 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr2_+_219537015 0.124 ENST00000440309.1
ENST00000424080.1
STK36

serine/threonine kinase 36

chr16_-_3306587 0.124 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV



Mediterranean fever



chr6_-_159466042 0.122 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr16_-_66952742 0.122 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16


cadherin 16, KSP-cadherin


chr3_+_42695176 0.122 ENST00000232974.6
ENST00000457842.3
ZBTB47

zinc finger and BTB domain containing 47

chr12_-_6484715 0.122 ENST00000228916.2
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chrX_-_110513703 0.122 ENST00000324068.1
CAPN6
calpain 6
chr9_+_131683174 0.121 ENST00000372592.3
ENST00000428610.1
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr2_-_179315786 0.120 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA


protein kinase, interferon-inducible double stranded RNA dependent activator


chr11_-_6502580 0.119 ENST00000423813.2
ENST00000396777.3
ARFIP2

ADP-ribosylation factor interacting protein 2

chr4_-_87028478 0.119 ENST00000515400.1
ENST00000395157.3
MAPK10

mitogen-activated protein kinase 10

chr11_-_8832182 0.118 ENST00000527510.1
ENST00000528527.1
ENST00000528523.1
ENST00000313726.6
ST5



suppression of tumorigenicity 5



chr9_+_125281420 0.118 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr1_+_161736072 0.117 ENST00000367942.3
ATF6
activating transcription factor 6
chr3_+_29323043 0.115 ENST00000452462.1
ENST00000456853.1
RBMS3

RNA binding motif, single stranded interacting protein 3

chr17_-_4463856 0.115 ENST00000574584.1
ENST00000381550.3
ENST00000301395.3
GGT6


gamma-glutamyltransferase 6


chr9_-_73736511 0.115 ENST00000377110.3
ENST00000377111.2
TRPM3

transient receptor potential cation channel, subfamily M, member 3

chr1_-_32210275 0.115 ENST00000440175.2
BAI2
brain-specific angiogenesis inhibitor 2
chr17_+_59477233 0.115 ENST00000240328.3
TBX2
T-box 2
chr11_+_57105991 0.113 ENST00000263314.2
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0018032 protein amidation(GO:0018032)
0.3 1.0 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.3 0.9 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.4 GO:0072229 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.1 0.9 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.2 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.3 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.5 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.1 0.3 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.1 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.3 GO:1904956 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.1 GO:0010446 response to alkaline pH(GO:0010446)
0.1 0.4 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.1 0.2 GO:2000364 hepatic immune response(GO:0002384) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.0 0.2 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.2 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.4 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.5 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.2 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.1 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.5 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:1990641 cellular response to bile acid(GO:1903413) response to iron ion starvation(GO:1990641)
0.0 2.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.1 GO:0042414 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 1.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.4 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.1 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.3 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.0 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.0 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.0 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 GO:0071953 elastic fiber(GO:0071953)
0.1 0.4 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.4 1.6 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.4 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.2 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.4 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.5 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.0 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.3 GO:0016918 retinal binding(GO:0016918)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.0 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling