Motif ID: PBX3

Z-value: 0.881


Transcription factors associated with PBX3:

Gene SymbolEntrez IDGene Name
PBX3 ENSG00000167081.12 PBX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX3hg19_v2_chr9_+_128509663_128509733-0.673.1e-04Click!


Activity profile for motif PBX3.

activity profile for motif PBX3


Sorted Z-values histogram for motif PBX3

Sorted Z-values for motif PBX3



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_65769392 4.302 ENST00000555736.1
CTD-2509G16.5
CTD-2509G16.5
chr4_-_149363662 3.561 ENST00000355292.3
ENST00000358102.3
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr3_+_63638339 2.606 ENST00000343837.3
ENST00000469440.1
SNTN

sentan, cilia apical structure protein

chr11_+_111385497 2.063 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88


chromosome 11 open reading frame 88


chr6_-_46138676 1.851 ENST00000371383.2
ENST00000230565.3
ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chrX_-_8700171 1.837 ENST00000262648.3
KAL1
Kallmann syndrome 1 sequence
chr19_-_55972936 1.573 ENST00000425675.2
ENST00000589080.1
ENST00000085068.3
ISOC2


isochorismatase domain containing 2


chr16_+_30210552 1.529 ENST00000338971.5
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr1_+_85527987 1.506 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63


WD repeat domain 63


chr4_-_23891693 1.433 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_116937636 1.315 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr6_-_119670919 1.304 ENST00000368468.3
MAN1A1
mannosidase, alpha, class 1A, member 1
chr5_-_160279207 1.273 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr3_+_111393659 1.251 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr19_+_19976683 1.221 ENST00000592725.1
ZNF253
zinc finger protein 253
chr19_-_23578220 1.218 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
ZNF91



zinc finger protein 91



chr7_-_138386097 1.202 ENST00000421622.1
SVOPL
SVOP-like
chr19_+_50180317 1.187 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr19_-_12662314 1.176 ENST00000339282.7
ENST00000596193.1
ZNF564

zinc finger protein 564

chr19_+_50706866 1.166 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14




myosin, heavy chain 14, non-muscle




chr11_-_3400442 1.147 ENST00000429541.2
ENST00000532539.1
ZNF195

zinc finger protein 195

chr18_+_44526786 1.129 ENST00000245121.5
ENST00000356157.7
KATNAL2

katanin p60 subunit A-like 2

chr11_-_3400330 1.129 ENST00000427810.2
ENST00000005082.9
ENST00000534569.1
ENST00000438262.2
ENST00000528796.1
ENST00000528410.1
ENST00000529678.1
ENST00000354599.6
ENST00000526601.1
ENST00000525502.1
ENST00000533036.1
ENST00000399602.4
ZNF195











zinc finger protein 195











chr17_+_62075703 1.054 ENST00000577953.1
ENST00000582540.1
ENST00000579184.1
ENST00000425164.3
ENST00000412177.1
ENST00000539996.1
ENST00000583891.1
ENST00000580752.1
C17orf72







chromosome 17 open reading frame 72







chr11_-_105892937 1.054 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chrX_-_63450480 1.023 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr7_+_149571045 1.019 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATP6V0E2



ATPase, H+ transporting V0 subunit e2



chr9_-_3525968 1.014 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
RFX3


regulatory factor X, 3 (influences HLA class II expression)


chr10_+_114135004 1.006 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_-_59633951 0.990 ENST00000257264.3
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr16_+_89238149 0.987 ENST00000289746.2
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr17_+_26800756 0.983 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr22_-_37172111 0.975 ENST00000417951.2
ENST00000430701.1
ENST00000433985.2
IFT27


intraflagellar transport 27 homolog (Chlamydomonas)


chr17_+_26800648 0.945 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr19_-_12405606 0.944 ENST00000356109.5
ZNF44
zinc finger protein 44
chr22_-_37172191 0.929 ENST00000340630.5
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr17_+_61699766 0.924 ENST00000579585.1
ENST00000584573.1
ENST00000361733.3
ENST00000361357.3
MAP3K3



mitogen-activated protein kinase kinase kinase 3



chr19_-_12405689 0.923 ENST00000355684.5
ZNF44
zinc finger protein 44
chr2_+_63277927 0.911 ENST00000282549.2
OTX1
orthodenticle homeobox 1
chr12_-_91573132 0.884 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chr19_-_12251202 0.881 ENST00000334213.5
ZNF20
zinc finger protein 20
chr17_+_58755184 0.866 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3


breast carcinoma amplified sequence 3


chr19_+_22469210 0.820 ENST00000601693.1
ZNF729
zinc finger protein 729
chr2_-_220435963 0.802 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1




obscurin-like 1




chr2_-_45236540 0.789 ENST00000303077.6
SIX2
SIX homeobox 2
chr5_+_43602750 0.789 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT


nicotinamide nucleotide transhydrogenase


chrX_-_132549506 0.788 ENST00000370828.3
GPC4
glypican 4
chr9_-_124989804 0.771 ENST00000373755.2
ENST00000373754.2
LHX6

LIM homeobox 6

chr10_-_44144292 0.747 ENST00000374433.2
ZNF32
zinc finger protein 32
chr3_-_187454281 0.740 ENST00000232014.4
BCL6
B-cell CLL/lymphoma 6
chr5_+_43603229 0.736 ENST00000344920.4
ENST00000512996.2
NNT

nicotinamide nucleotide transhydrogenase

chr19_-_20844343 0.735 ENST00000595405.1
ZNF626
zinc finger protein 626
chr19_+_19976714 0.730 ENST00000589717.1
ENST00000355650.4
ZNF253

zinc finger protein 253

chrX_-_154250989 0.729 ENST00000360256.4
F8
coagulation factor VIII, procoagulant component
chr6_+_108487245 0.722 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr10_-_44144152 0.715 ENST00000395797.1
ZNF32
zinc finger protein 32
chr22_+_17082732 0.711 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr16_+_67927147 0.697 ENST00000291041.5
PSKH1
protein serine kinase H1
chr3_+_88108381 0.694 ENST00000473136.1
RP11-159G9.5
Uncharacterized protein
chr19_+_22469236 0.692 ENST00000357491.6
ZNF729
zinc finger protein 729
chr9_-_119449483 0.686 ENST00000288520.5
ENST00000358637.4
ENST00000341734.4
ASTN2


astrotactin 2


chr11_-_73720122 0.683 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr19_-_12551849 0.665 ENST00000301547.5
ENST00000595562.1
ZNF443
CTD-3105H18.16
zinc finger protein 443
Uncharacterized protein
chr14_-_61190754 0.655 ENST00000216513.4
SIX4
SIX homeobox 4
chr19_-_22605136 0.649 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98


zinc finger protein 98


chr17_+_17876127 0.646 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
LRRC48









leucine rich repeat containing 48









chr19_-_12595586 0.637 ENST00000397732.3
ZNF709
zinc finger protein 709
chr3_-_52486841 0.634 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr19_-_2740036 0.630 ENST00000269740.4
ENST00000586572.1
SLC39A3
AC006538.4
solute carrier family 39 (zinc transporter), member 3
Uncharacterized protein
chr8_+_57124245 0.625 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7









coiled-coil-helix-coiled-coil-helix domain containing 7









chr19_+_20959142 0.620 ENST00000344519.8
ZNF66
zinc finger protein 66
chr17_+_72270380 0.618 ENST00000582036.1
ENST00000307504.5
DNAI2

dynein, axonemal, intermediate chain 2

chr11_-_86383370 0.616 ENST00000526834.1
ENST00000359636.2
ME3

malic enzyme 3, NADP(+)-dependent, mitochondrial

chr8_+_105235572 0.615 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr9_-_33264676 0.600 ENST00000472232.3
ENST00000379704.2
BAG1

BCL2-associated athanogene

chr11_-_86383157 0.600 ENST00000393324.3
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr1_+_60280458 0.596 ENST00000455990.1
ENST00000371208.3
HOOK1

hook microtubule-tethering protein 1

chr17_+_26800296 0.591 ENST00000444914.3
ENST00000314669.5
SLC13A2

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

chr3_-_58652523 0.584 ENST00000489857.1
ENST00000358781.2
FAM3D

family with sequence similarity 3, member D

chr14_+_60975644 0.578 ENST00000327720.5
SIX6
SIX homeobox 6
chr12_-_42983478 0.572 ENST00000345127.3
ENST00000547113.1
PRICKLE1

prickle homolog 1 (Drosophila)

chrX_-_117119243 0.571 ENST00000539496.1
ENST00000469946.1
KLHL13

kelch-like family member 13

chr10_+_25463951 0.571 ENST00000376351.3
GPR158
G protein-coupled receptor 158
chr19_+_23299777 0.565 ENST00000597761.2
ZNF730
zinc finger protein 730
chr1_-_36235529 0.554 ENST00000318121.3
ENST00000373220.3
ENST00000520551.1
CLSPN


claspin


chr3_+_197518100 0.550 ENST00000438796.2
ENST00000414675.2
ENST00000441090.2
ENST00000334859.4
ENST00000425562.2
LRCH3




leucine-rich repeats and calponin homology (CH) domain containing 3




chr19_+_21324827 0.550 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431



zinc finger protein 431



chr14_+_23938891 0.547 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
NGDN


neuroguidin, EIF4E binding protein


chr1_+_161195781 0.540 ENST00000367988.3
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr19_-_12662240 0.539 ENST00000428311.1
ENST00000416136.1
ZNF709
ZNF564
ZNF709
zinc finger protein 564
chr2_-_239112347 0.539 ENST00000457149.1
ENST00000254654.3
ILKAP

integrin-linked kinase-associated serine/threonine phosphatase

chr2_-_220436248 0.536 ENST00000265318.4
OBSL1
obscurin-like 1
chr19_-_40931891 0.529 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chrX_-_7895479 0.520 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr5_-_96478466 0.519 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr16_+_23847267 0.518 ENST00000321728.7
PRKCB
protein kinase C, beta
chr3_+_30647994 0.516 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr7_+_55433131 0.514 ENST00000254770.2
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr19_+_11485333 0.513 ENST00000312423.2
SWSAP1
SWIM-type zinc finger 7 associated protein 1
chr3_+_125694347 0.513 ENST00000505382.1
ENST00000511082.1
ROPN1B

rhophilin associated tail protein 1B

chr7_-_16505440 0.508 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr17_+_46125707 0.507 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1



nuclear factor, erythroid 2-like 1



chrX_-_7895755 0.507 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4


patatin-like phospholipase domain containing 4


chr11_+_124055923 0.505 ENST00000318666.6
OR10D3
olfactory receptor, family 10, subfamily D, member 3 (non-functional)
chr9_+_119449576 0.502 ENST00000450136.1
ENST00000373983.2
ENST00000411410.1
TRIM32


tripartite motif containing 32


chr19_-_19843900 0.502 ENST00000344099.3
ZNF14
zinc finger protein 14
chr7_+_134331550 0.501 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
BPGM


2,3-bisphosphoglycerate mutase


chr14_+_77582905 0.500 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr2_+_74685527 0.490 ENST00000393972.3
ENST00000409737.1
ENST00000428943.1
WBP1


WW domain binding protein 1


chr9_-_128003606 0.488 ENST00000324460.6
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr3_+_158362299 0.487 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
GFM1


G elongation factor, mitochondrial 1


chr14_-_91526922 0.485 ENST00000418736.2
ENST00000261991.3
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr2_+_74685413 0.482 ENST00000233615.2
WBP1
WW domain binding protein 1
chr15_-_43785303 0.468 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
TP53BP1


tumor protein p53 binding protein 1


chr3_-_3221358 0.468 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN



cereblon



chr19_+_5720666 0.465 ENST00000381624.3
ENST00000381614.2
CATSPERD

catsper channel auxiliary subunit delta

chr19_+_49375649 0.458 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr3_+_184279566 0.457 ENST00000330394.2
EPHB3
EPH receptor B3
chr4_+_6202448 0.457 ENST00000508601.1
RP11-586D19.1
RP11-586D19.1
chr4_+_6271558 0.456 ENST00000503569.1
ENST00000226760.1
WFS1

Wolfram syndrome 1 (wolframin)

chr15_-_37391614 0.455 ENST00000219869.9
MEIS2
Meis homeobox 2
chr3_-_113415441 0.454 ENST00000491165.1
ENST00000316407.4
KIAA2018

KIAA2018

chr7_-_64023441 0.452 ENST00000309683.6
ZNF680
zinc finger protein 680
chr19_-_21512202 0.452 ENST00000356929.3
ZNF708
zinc finger protein 708
chr17_+_61627814 0.452 ENST00000310827.4
ENST00000431926.1
ENST00000415273.2
DCAF7


DDB1 and CUL4 associated factor 7


chr7_+_90338712 0.451 ENST00000265741.3
ENST00000406263.1
CDK14

cyclin-dependent kinase 14

chr3_-_15643090 0.451 ENST00000451445.2
ENST00000421993.1
HACL1

2-hydroxyacyl-CoA lyase 1

chr19_+_13906250 0.450 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr13_-_31736478 0.450 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr8_-_77912431 0.448 ENST00000357039.4
ENST00000522527.1
PEX2

peroxisomal biogenesis factor 2

chr17_-_42019836 0.445 ENST00000225992.3
PPY
pancreatic polypeptide
chr19_-_20748541 0.444 ENST00000427401.4
ENST00000594419.1
ZNF737

zinc finger protein 737

chr9_+_96026230 0.438 ENST00000448251.1
WNK2
WNK lysine deficient protein kinase 2
chr5_+_177631523 0.437 ENST00000506339.1
ENST00000355836.5
ENST00000514633.1
ENST00000515193.1
ENST00000506259.1
ENST00000504898.1
HNRNPAB





heterogeneous nuclear ribonucleoprotein A/B





chr3_+_169684553 0.437 ENST00000337002.4
ENST00000480708.1
SEC62

SEC62 homolog (S. cerevisiae)

chr21_+_44394620 0.436 ENST00000291547.5
PKNOX1
PBX/knotted 1 homeobox 1
chr3_-_15643060 0.432 ENST00000414979.1
ENST00000435217.2
ENST00000456194.2
ENST00000457447.2
HACL1



2-hydroxyacyl-CoA lyase 1



chr3_-_141747950 0.430 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr19_+_49496705 0.426 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr1_+_227751231 0.422 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
ZNF678


zinc finger protein 678


chr1_+_179050512 0.420 ENST00000367627.3
TOR3A
torsin family 3, member A
chr5_+_177631497 0.418 ENST00000358344.3
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr7_+_64254766 0.416 ENST00000307355.7
ENST00000359735.3
ZNF138

zinc finger protein 138

chr1_-_247335269 0.413 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124



zinc finger protein 124



chr10_+_114710425 0.413 ENST00000352065.5
ENST00000369395.1
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr7_-_27702455 0.408 ENST00000265395.2
HIBADH
3-hydroxyisobutyrate dehydrogenase
chr15_-_37392086 0.404 ENST00000561208.1
MEIS2
Meis homeobox 2
chr20_-_34330129 0.403 ENST00000397370.3
ENST00000528062.3
ENST00000407261.4
ENST00000374038.3
ENST00000361162.6
RBM39




RNA binding motif protein 39




chr11_-_4629388 0.402 ENST00000526337.1
ENST00000300747.5
TRIM68

tripartite motif containing 68

chr3_-_161090660 0.400 ENST00000359175.4
SPTSSB
serine palmitoyltransferase, small subunit B
chr7_+_21467642 0.400 ENST00000222584.3
ENST00000432066.2
SP4

Sp4 transcription factor

chr7_-_150652924 0.400 ENST00000330883.4
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr11_-_124981475 0.399 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218











transmembrane protein 218











chr4_+_331578 0.393 ENST00000512994.1
ZNF141
zinc finger protein 141
chr1_+_6845497 0.391 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr21_+_17961006 0.390 ENST00000602323.1
LINC00478
long intergenic non-protein coding RNA 478
chr11_-_73720276 0.390 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr1_+_6845384 0.388 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr19_+_58281014 0.385 ENST00000391702.3
ENST00000598885.1
ENST00000598183.1
ENST00000396154.2
ENST00000599802.1
ENST00000396150.4
ZNF586





zinc finger protein 586





chr5_+_151151504 0.385 ENST00000356245.3
ENST00000507878.2
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr22_+_42475692 0.384 ENST00000331479.3
SMDT1
single-pass membrane protein with aspartate-rich tail 1
chr3_-_112218378 0.383 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr19_+_12203069 0.382 ENST00000339302.4
ENST00000430298.2
ZNF788
ZNF788
Zinc finger protein 788
zinc finger family member 788
chr2_-_88927092 0.382 ENST00000303236.3
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr4_+_155702496 0.375 ENST00000510397.1
RBM46
RNA binding motif protein 46
chr3_+_15643245 0.374 ENST00000303498.5
ENST00000437172.1
BTD

biotinidase

chr9_-_88897426 0.373 ENST00000375991.4
ENST00000326094.4
ISCA1

iron-sulfur cluster assembly 1

chr17_-_44439084 0.372 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B





ADP-ribosylation factor-like 17B





chr19_+_41313017 0.369 ENST00000595621.1
ENST00000595051.1
EGLN2

egl-9 family hypoxia-inducible factor 2

chr15_+_41221536 0.369 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr9_-_123239632 0.367 ENST00000416449.1
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr19_+_22235310 0.366 ENST00000600162.1
ZNF257
zinc finger protein 257
chr17_-_73511584 0.364 ENST00000321617.3
CASKIN2
CASK interacting protein 2
chr19_-_23941680 0.364 ENST00000402377.3
ZNF681
zinc finger protein 681
chr17_+_59529743 0.363 ENST00000589003.1
ENST00000393853.4
TBX4

T-box 4

chr20_+_60813535 0.363 ENST00000358053.2
ENST00000313733.3
ENST00000439951.2
OSBPL2


oxysterol binding protein-like 2


chr19_+_21579908 0.358 ENST00000596302.1
ENST00000392288.2
ENST00000594390.1
ENST00000355504.4
ZNF493



zinc finger protein 493



chr6_-_39082922 0.356 ENST00000229903.4
SAYSD1
SAYSVFN motif domain containing 1
chr10_+_102790980 0.356 ENST00000393459.1
ENST00000224807.5
SFXN3

sideroflexin 3

chr7_+_64838712 0.354 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
ZNF92


zinc finger protein 92


chr16_-_29479154 0.353 ENST00000549950.1
RP11-345J4.3
Uncharacterized protein
chr5_+_78532003 0.352 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr13_+_20207782 0.350 ENST00000414242.2
ENST00000361479.5
MPHOSPH8

M-phase phosphoprotein 8

chr16_-_46782221 0.350 ENST00000394809.4
MYLK3
myosin light chain kinase 3
chr19_+_49497121 0.348 ENST00000413176.2
RUVBL2
RuvB-like AAA ATPase 2
chr6_+_43028182 0.348 ENST00000394058.1
KLC4
kinesin light chain 4
chr19_+_12273866 0.347 ENST00000425827.1
ENST00000439995.1
ENST00000343979.4
ENST00000398616.2
ENST00000418338.1
ZNF136




zinc finger protein 136




chr7_+_64254793 0.347 ENST00000494380.1
ENST00000440155.2
ENST00000440598.1
ENST00000437743.1
ZNF138



zinc finger protein 138



chr5_-_37249397 0.342 ENST00000425232.2
ENST00000274258.7
C5orf42

chromosome 5 open reading frame 42

chrX_+_11129388 0.337 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
HCCS


holocytochrome c synthase


chr8_-_90996459 0.336 ENST00000517337.1
ENST00000409330.1
NBN

nibrin

chr19_+_12075844 0.336 ENST00000592625.1
ENST00000586494.1
ENST00000343949.5
ENST00000545530.1
ENST00000358987.3
ZNF763




zinc finger protein 763




chr3_+_15643140 0.336 ENST00000449107.1
BTD
biotinidase
chr1_-_247267580 0.335 ENST00000366501.1
ENST00000366500.1
ENST00000476158.2
ENST00000448299.2
ENST00000358785.4
ENST00000343381.6
ZNF669





zinc finger protein 669





chr19_-_23941639 0.335 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
ZNF681


zinc finger protein 681


chr12_+_113623325 0.332 ENST00000549621.1
ENST00000548278.1
ENST00000552495.1
C12orf52


RBPJ interacting and tubulin associated 1


chr9_-_33264557 0.328 ENST00000473781.1
ENST00000488499.1
BAG1

BCL2-associated athanogene

chr3_-_186080012 0.327 ENST00000544847.1
ENST00000265022.3
DGKG

diacylglycerol kinase, gamma 90kDa

chr2_+_113670548 0.327 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37



interleukin 37



chr19_+_2841433 0.325 ENST00000334241.4
ENST00000585966.1
ENST00000591539.1
ZNF555


zinc finger protein 555



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.3 1.0 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.3 1.5 GO:0006740 NADPH regeneration(GO:0006740)
0.3 1.7 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.3 0.8 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.3 0.8 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 0.7 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.2 1.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 0.7 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.2 1.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.2 1.1 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 0.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 0.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 0.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 0.5 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.2 0.6 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.2 0.9 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 0.9 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.1 0.1 GO:0030225 macrophage differentiation(GO:0030225)
0.1 1.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.4 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.4 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1 0.5 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.3 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.3 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 0.5 GO:0030047 actin modification(GO:0030047)
0.1 0.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 1.0 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.2 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.5 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.4 GO:0072554 blood vessel lumenization(GO:0072554)
0.1 0.3 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 0.3 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 1.1 GO:0015074 DNA integration(GO:0015074)
0.1 0.7 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.1 0.3 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 1.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.6 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.1 0.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.3 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.2 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 0.3 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.4 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 1.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.3 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.3 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 1.9 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.1 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.5 GO:1901419 regulation of response to alcohol(GO:1901419)
0.1 0.5 GO:0006983 ER overload response(GO:0006983)
0.1 0.3 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.1 0.4 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 0.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.2 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.3 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 2.0 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 0.2 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.3 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.8 GO:0006768 biotin metabolic process(GO:0006768)
0.0 0.1 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) regulation of SA node cell action potential(GO:0098907)
0.0 0.1 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.5 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:2000617 positive regulation of histone H3-K9 acetylation(GO:2000617)
0.0 1.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0 2.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.0 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.4 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.7 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.2 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.1 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.1 GO:0044854 plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.5 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.2 GO:0048243 norepinephrine secretion(GO:0048243)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 2.2 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.4 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.0 0.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.0 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.3 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.1 GO:0060325 face development(GO:0060324) face morphogenesis(GO:0060325)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.1 GO:0032909 transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0001534 radial spoke(GO:0001534)
0.2 0.7 GO:0060187 cell pole(GO:0060187)
0.1 0.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:1990393 3M complex(GO:1990393)
0.1 0.5 GO:0097196 Shu complex(GO:0097196)
0.1 0.5 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.4 GO:0097513 myosin II filament(GO:0097513)
0.1 1.1 GO:0097255 R2TP complex(GO:0097255)
0.1 0.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.7 GO:0034709 methylosome(GO:0034709)
0.1 0.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 1.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.1 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.5 GO:0036128 CatSper complex(GO:0036128)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.4 GO:0097440 apical dendrite(GO:0097440)
0.1 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 1.5 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.6 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 0.7 GO:0005657 replication fork(GO:0005657)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.5 1.5 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.3 0.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 1.5 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.3 1.0 GO:0047708 biotinidase activity(GO:0047708)
0.2 1.7 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.2 0.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 1.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 1.2 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 1.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.4 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 1.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 2.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.3 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.5 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.6 GO:0016887 ATPase activity(GO:0016887)
0.1 0.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 1.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.2 GO:0008969 phosphohistidine phosphatase activity(GO:0008969)
0.1 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.2 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 0.6 GO:0031013 troponin I binding(GO:0031013)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 1.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 4.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 2.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.9 GO:0045502 dynein binding(GO:0045502)
0.0 0.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.2 GO:0016462 pyrophosphatase activity(GO:0016462)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 4.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.0 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 1.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 8.8 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.3 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.2 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.0 0.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER