Motif ID: PAX6

Z-value: 0.563


Transcription factors associated with PAX6:

Gene SymbolEntrez IDGene Name
PAX6 ENSG00000007372.16 PAX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX6hg19_v2_chr11_-_31839488_318395150.164.5e-01Click!


Activity profile for motif PAX6.

activity profile for motif PAX6


Sorted Z-values histogram for motif PAX6

Sorted Z-values for motif PAX6



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_2986107 1.016 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
FOXM1


forkhead box M1


chr11_-_28129656 1.015 ENST00000263181.6
KIF18A
kinesin family member 18A
chr11_-_58343319 1.014 ENST00000395074.2
LPXN
leupaxin
chr7_-_97501706 1.013 ENST00000455086.1
ENST00000453600.1
ASNS

asparagine synthetase (glutamine-hydrolyzing)

chr19_-_36019123 0.875 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN


suprabasin


chr7_-_97501733 0.837 ENST00000444334.1
ENST00000422745.1
ENST00000394308.3
ENST00000451771.1
ENST00000175506.4
ASNS




asparagine synthetase (glutamine-hydrolyzing)




chr11_-_87908600 0.797 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38


RAB38, member RAS oncogene family


chr12_-_47473425 0.768 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr7_-_76255444 0.744 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr1_+_163291732 0.707 ENST00000271452.3
NUF2
NUF2, NDC80 kinetochore complex component
chr18_-_21242774 0.658 ENST00000322980.9
ANKRD29
ankyrin repeat domain 29
chr6_-_131321863 0.622 ENST00000528282.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_+_47473369 0.618 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr12_-_47473707 0.569 ENST00000429635.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr13_+_96085847 0.549 ENST00000376873.3
CLDN10
claudin 10
chr18_+_61420169 0.545 ENST00000425392.1
ENST00000336429.2
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr18_+_61445007 0.543 ENST00000447428.1
ENST00000546027.1
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr12_-_85306594 0.537 ENST00000266682.5
SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr21_+_39628852 0.522 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_131291572 0.508 ENST00000529208.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr8_-_95487331 0.496 ENST00000336148.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr1_+_203651937 0.496 ENST00000341360.2
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_161056762 0.486 ENST00000428609.2
ENST00000409967.2
ITGB6

integrin, beta 6

chr18_-_21242833 0.478 ENST00000586087.1
ENST00000592179.1
ANKRD29

ankyrin repeat domain 29

chr2_-_163008903 0.473 ENST00000418842.2
ENST00000375497.3
GCG

glucagon

chr10_-_75226166 0.457 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr7_-_80551671 0.455 ENST00000419255.2
ENST00000544525.1
SEMA3C

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

chr3_-_119379719 0.439 ENST00000493094.1
POPDC2
popeye domain containing 2
chr12_-_10007448 0.416 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr2_-_161056802 0.405 ENST00000283249.2
ENST00000409872.1
ITGB6

integrin, beta 6

chr14_+_57671888 0.390 ENST00000391612.1
AL391152.1
AL391152.1
chr7_+_45067265 0.371 ENST00000474617.1
CCM2
cerebral cavernous malformation 2
chr2_-_85645545 0.356 ENST00000409275.1
CAPG
capping protein (actin filament), gelsolin-like
chr2_+_196521458 0.355 ENST00000409086.3
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr1_-_185597619 0.349 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1

GS1-204I12.1

chrX_-_65259914 0.339 ENST00000374737.4
ENST00000455586.2
VSIG4

V-set and immunoglobulin domain containing 4

chr11_+_844406 0.335 ENST00000397404.1
TSPAN4
tetraspanin 4
chr2_+_98986400 0.329 ENST00000272602.2
CNGA3
cyclic nucleotide gated channel alpha 3
chr10_+_35894338 0.321 ENST00000321660.1
GJD4
gap junction protein, delta 4, 40.1kDa
chr5_-_114938090 0.317 ENST00000427199.2
TICAM2
toll-like receptor adaptor molecule 2
chr1_+_73771844 0.316 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1



RP4-598G3.1



chr17_-_9694614 0.315 ENST00000330255.5
ENST00000571134.1
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr4_-_68749745 0.314 ENST00000283916.6
TMPRSS11D
transmembrane protease, serine 11D
chr2_+_196521845 0.308 ENST00000359634.5
ENST00000412905.1
SLC39A10

solute carrier family 39 (zinc transporter), member 10

chr8_-_95487272 0.308 ENST00000297592.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr19_-_50370509 0.304 ENST00000596014.1
PNKP
polynucleotide kinase 3'-phosphatase
chr11_+_86667117 0.303 ENST00000531827.1
RP11-736K20.6
RP11-736K20.6
chr8_-_79470728 0.297 ENST00000522807.1
ENST00000519242.1
ENST00000522302.1
RP11-594N15.2


RP11-594N15.2


chr13_-_24007815 0.297 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr8_+_66955648 0.294 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr12_+_56915776 0.290 ENST00000550726.1
ENST00000542360.1
RBMS2

RNA binding motif, single stranded interacting protein 2

chr11_-_117748138 0.290 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr1_+_84609944 0.289 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_132160448 0.288 ENST00000437751.1
AC073869.19
long intergenic non-protein coding RNA 1120
chr17_+_58499844 0.288 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr12_+_56915713 0.285 ENST00000262031.5
ENST00000552247.2
RBMS2

RNA binding motif, single stranded interacting protein 2

chr4_-_68749699 0.279 ENST00000545541.1
TMPRSS11D
transmembrane protease, serine 11D
chr8_+_59323823 0.275 ENST00000399598.2
UBXN2B
UBX domain protein 2B
chr4_-_174320687 0.269 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr22_+_26138108 0.261 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
MYO18B


myosin XVIIIB


chr13_+_25875662 0.260 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1


nucleoporin like 1


chr5_+_3596168 0.259 ENST00000302006.3
IRX1
iroquois homeobox 1
chr7_+_142919130 0.256 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr8_+_49984894 0.254 ENST00000522267.1
ENST00000399653.4
ENST00000303202.8
C8orf22


chromosome 8 open reading frame 22


chr21_-_40032581 0.251 ENST00000398919.2
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr12_+_69080734 0.247 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr1_+_207925391 0.246 ENST00000358170.2
ENST00000354848.1
ENST00000322918.5
ENST00000367042.1
ENST00000367041.1
ENST00000357714.1
ENST00000322875.4
ENST00000367047.1
ENST00000441839.2
ENST00000361067.1
ENST00000360212.2
ENST00000480003.1
CD46











CD46 molecule, complement regulatory protein











chr4_+_123747834 0.243 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr2_+_29320571 0.243 ENST00000401605.1
ENST00000401617.2
CLIP4

CAP-GLY domain containing linker protein family, member 4

chr21_+_39628655 0.241 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
KCNJ15



potassium inwardly-rectifying channel, subfamily J, member 15



chr6_+_25652501 0.240 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr2_+_220363579 0.239 ENST00000313597.5
ENST00000373917.3
ENST00000358215.3
ENST00000373908.1
ENST00000455657.1
ENST00000435316.1
ENST00000341142.3
GMPPA






GDP-mannose pyrophosphorylase A






chr11_+_116700600 0.239 ENST00000227667.3
APOC3
apolipoprotein C-III
chr10_-_118764862 0.238 ENST00000260777.10
KIAA1598
KIAA1598
chr11_+_116700614 0.238 ENST00000375345.1
APOC3
apolipoprotein C-III
chr6_-_137494775 0.237 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
IL22RA2


interleukin 22 receptor, alpha 2


chr2_-_85625857 0.237 ENST00000453973.1
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_41222998 0.236 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr3_-_196910721 0.232 ENST00000443183.1
DLG1
discs, large homolog 1 (Drosophila)
chr11_-_117747434 0.231 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6


FXYD domain containing ion transport regulator 6


chr11_-_117747607 0.230 ENST00000540359.1
ENST00000539526.1
FXYD6

FXYD domain containing ion transport regulator 6

chr12_-_85306562 0.220 ENST00000551612.1
ENST00000450363.3
ENST00000552192.1
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr5_+_147691979 0.218 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr10_-_118765081 0.217 ENST00000392903.2
ENST00000355371.4
KIAA1598

KIAA1598

chr1_+_147374915 0.212 ENST00000240986.4
GJA8
gap junction protein, alpha 8, 50kDa
chrX_-_53461288 0.204 ENST00000375298.4
ENST00000375304.5
HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

chr6_+_167704798 0.203 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr9_-_5185629 0.200 ENST00000381641.3
INSL6
insulin-like 6
chr12_+_113354341 0.198 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_11374904 0.196 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr8_-_13372253 0.190 ENST00000316609.5
DLC1
deleted in liver cancer 1
chr10_+_90354503 0.188 ENST00000531458.1
LIPJ
lipase, family member J
chr6_-_10412600 0.185 ENST00000379608.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_238877424 0.184 ENST00000434655.1
UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr6_-_42162654 0.182 ENST00000230361.3
GUCA1B
guanylate cyclase activator 1B (retina)
chr2_+_192110199 0.182 ENST00000304164.4
MYO1B
myosin IB
chr3_+_51663407 0.179 ENST00000432863.1
ENST00000296477.3
RAD54L2

RAD54-like 2 (S. cerevisiae)

chr8_+_67104323 0.178 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
LINC00967


long intergenic non-protein coding RNA 967


chr17_+_36283971 0.178 ENST00000327454.6
ENST00000378174.5
TBC1D3F

TBC1 domain family, member 3F

chr11_+_118175132 0.178 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chrX_-_53461305 0.173 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr7_-_87342564 0.173 ENST00000265724.3
ENST00000416177.1
ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

chr22_-_36220420 0.172 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_-_89458287 0.172 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr14_+_24099318 0.170 ENST00000432832.2
DHRS2
dehydrogenase/reductase (SDR family) member 2
chr2_+_192109911 0.167 ENST00000418908.1
ENST00000339514.4
ENST00000392318.3
MYO1B


myosin IB


chr12_-_69080590 0.164 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2

RP11-637A17.2

chr3_-_111852128 0.163 ENST00000308910.4
GCSAM
germinal center-associated, signaling and motility
chr14_+_88471468 0.162 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr4_+_70916119 0.162 ENST00000246896.3
ENST00000511674.1
HTN1

histatin 1

chr9_+_93589734 0.161 ENST00000375746.1
SYK
spleen tyrosine kinase
chrX_-_138914394 0.161 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATP11C



ATPase, class VI, type 11C



chr6_-_64029879 0.160 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN


lengsin, lens protein with glutamine synthetase domain


chr13_+_25875785 0.158 ENST00000381747.3
NUPL1
nucleoporin like 1
chr11_-_57298187 0.156 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10


translocase of inner mitochondrial membrane 10 homolog (yeast)


chr16_-_71264558 0.155 ENST00000448089.2
ENST00000393550.2
ENST00000448691.1
ENST00000393567.2
ENST00000321489.5
ENST00000539973.1
ENST00000288168.10
ENST00000545267.1
ENST00000541601.1
ENST00000538248.1
HYDIN









HYDIN, axonemal central pair apparatus protein









chr14_+_24867992 0.154 ENST00000382554.3
NYNRIN
NYN domain and retroviral integrase containing
chr8_+_22428457 0.153 ENST00000517962.1
SORBS3
sorbin and SH3 domain containing 3
chrX_-_64196376 0.153 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr3_-_195997410 0.152 ENST00000419333.1
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr10_-_104597286 0.152 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr6_+_42896865 0.151 ENST00000372836.4
ENST00000394142.3
CNPY3

canopy FGF signaling regulator 3

chr15_+_52155001 0.151 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr1_-_201368653 0.149 ENST00000367313.3
LAD1
ladinin 1
chr12_-_70093190 0.147 ENST00000330891.5
BEST3
bestrophin 3
chr5_-_135231516 0.146 ENST00000274520.1
IL9
interleukin 9
chrX_-_64196307 0.145 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr10_-_82049424 0.144 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr2_-_86116093 0.143 ENST00000377332.3
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chrX_-_64196351 0.143 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr1_-_23504176 0.143 ENST00000302291.4
LUZP1
leucine zipper protein 1
chr1_-_201368707 0.143 ENST00000391967.2
LAD1
ladinin 1
chr5_-_141338627 0.143 ENST00000231484.3
PCDH12
protocadherin 12
chrY_+_25130410 0.142 ENST00000331070.3
ENST00000382585.1
BPY2

basic charge, Y-linked, 2

chrY_-_27198251 0.142 ENST00000382287.1
BPY2C
basic charge, Y-linked, 2C
chrY_+_26764151 0.142 ENST00000382392.1
BPY2B
basic charge, Y-linked, 2B
chr11_+_60223312 0.141 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1




membrane-spanning 4-domains, subfamily A, member 1




chr9_-_128246769 0.140 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr12_+_10460417 0.137 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1


killer cell lectin-like receptor subfamily D, member 1


chr17_-_39023462 0.137 ENST00000251643.4
KRT12
keratin 12
chr14_+_29241910 0.135 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23


chromosome 14 open reading frame 23


chr11_-_18813353 0.135 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr7_+_65552756 0.135 ENST00000450043.1
AC068533.7
AC068533.7
chr12_+_83080659 0.134 ENST00000321196.3
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr1_-_110933663 0.134 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4


solute carrier family 16, member 4


chr12_+_18414446 0.133 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr19_-_41222775 0.131 ENST00000324464.3
ENST00000450541.1
ENST00000594720.1
ADCK4


aarF domain containing kinase 4


chr9_-_95166884 0.130 ENST00000375561.5
OGN
osteoglycin
chr18_+_18822185 0.128 ENST00000424526.1
ENST00000400483.4
ENST00000431264.1
GREB1L


growth regulation by estrogen in breast cancer-like


chr1_+_77333117 0.128 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr1_-_232598163 0.128 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_+_159409512 0.128 ENST00000423932.3
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr1_-_110933611 0.127 ENST00000472422.2
ENST00000437429.2
SLC16A4

solute carrier family 16, member 4

chr11_+_28129795 0.127 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15



methyltransferase like 15



chr2_+_168675182 0.127 ENST00000305861.1
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr17_-_3819751 0.127 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr7_-_150864635 0.126 ENST00000297537.4
GBX1
gastrulation brain homeobox 1
chr14_+_67291158 0.126 ENST00000555456.1
GPHN
gephyrin
chr16_-_47493041 0.125 ENST00000565940.2
ITFG1
integrin alpha FG-GAP repeat containing 1
chr10_+_18629628 0.125 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_-_98262240 0.115 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr4_+_123747979 0.115 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr16_+_84801852 0.113 ENST00000569925.1
ENST00000567526.1
USP10

ubiquitin specific peptidase 10

chr19_+_50936142 0.113 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr11_-_18813110 0.112 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr12_-_78753496 0.111 ENST00000548512.1
RP11-38F22.1
RP11-38F22.1
chr7_+_76109827 0.109 ENST00000446820.2
DTX2
deltex homolog 2 (Drosophila)
chr11_-_3078838 0.107 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr5_-_156593273 0.103 ENST00000302938.4
FAM71B
family with sequence similarity 71, member B
chr3_-_195310802 0.102 ENST00000421243.1
ENST00000453131.1
APOD

apolipoprotein D

chr4_+_115519577 0.100 ENST00000310836.6
UGT8
UDP glycosyltransferase 8
chr16_+_72088376 0.098 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP








HPR
haptoglobin








haptoglobin-related protein
chr16_-_18911366 0.097 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr1_+_207818460 0.097 ENST00000508064.2
CR1L
complement component (3b/4b) receptor 1-like
chr1_-_55089191 0.095 ENST00000302250.2
ENST00000371304.2
FAM151A

family with sequence similarity 151, member A

chr11_+_60223225 0.095 ENST00000524807.1
ENST00000345732.4
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_204183071 0.094 ENST00000308302.3
GOLT1A
golgi transport 1A
chr16_+_89228757 0.094 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr21_-_35014027 0.090 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1







crystallin, zeta (quinone reductase)-like 1







chr7_-_30726065 0.089 ENST00000341843.4
CRHR2
corticotropin releasing hormone receptor 2
chr19_-_22806764 0.088 ENST00000598042.1
AC011516.2
AC011516.2
chr20_-_44144249 0.087 ENST00000217428.6
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr18_+_18822216 0.086 ENST00000269218.6
GREB1L
growth regulation by estrogen in breast cancer-like
chrX_-_130423200 0.086 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chrX_-_130423386 0.086 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr5_+_119799927 0.084 ENST00000407149.2
ENST00000379551.2
PRR16

proline rich 16

chr4_+_71063641 0.080 ENST00000514097.1
ODAM
odontogenic, ameloblast asssociated
chr4_+_113970772 0.078 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2



ankyrin 2, neuronal



chr15_-_65282274 0.077 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr11_+_33563821 0.077 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L


KIAA1549-like


chr9_+_131549483 0.077 ENST00000372648.5
ENST00000539497.1
TBC1D13

TBC1 domain family, member 13

chr9_-_128412696 0.075 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr7_-_229557 0.075 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr16_-_87350970 0.073 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr5_+_94982558 0.073 ENST00000311364.4
ENST00000458310.1
RFESD

Rieske (Fe-S) domain containing

chr5_+_57787254 0.072 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT


GRB2-binding adaptor protein, transmembrane


chr14_+_61995722 0.071 ENST00000556347.1
RP11-47I22.4
RP11-47I22.4
chr1_+_203765437 0.070 ENST00000550078.1
ZBED6
zinc finger, BED-type containing 6
chr8_-_62602327 0.070 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH









aspartate beta-hydroxylase









chr9_+_42704004 0.068 ENST00000457288.1
CBWD7
COBW domain containing 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0070981 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.3 1.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 0.5 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.2 0.5 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 1.0 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.7 GO:0035803 egg coat formation(GO:0035803)
0.1 0.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.1 0.8 GO:0015820 leucine transport(GO:0015820) proline transmembrane transport(GO:0035524)
0.1 0.9 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 1.0 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 0.5 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 1.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.3 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.1 1.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.3 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 0.3 GO:0098502 DNA dephosphorylation(GO:0098502)
0.1 0.3 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.1 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.4 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0021503 neural fold bending(GO:0021503)
0.0 0.2 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.3 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 0.1 GO:0072579 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.3 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.3 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0098907 protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 0.1 GO:0039506 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.4 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
0.0 0.2 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:0009058 biosynthetic process(GO:0009058)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.5 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 0.8 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.7 GO:0031262 Ndc80 complex(GO:0031262)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.1 GO:0008091 spectrin(GO:0008091)
0.1 0.4 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 0.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.3 0.8 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.2 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.8 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2 0.5 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 0.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 1.1 GO:0042731 PH domain binding(GO:0042731)
0.1 0.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.1 0.7 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.4 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1