Motif ID: PAX5
Z-value: 0.952
Transcription factors associated with PAX5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PAX5 | ENSG00000196092.8 | PAX5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX5 | hg19_v2_chr9_-_37034028_37034157 | 0.18 | 4.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 631 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.2 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 2.1 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.3 | 1.2 | GO:2000768 | positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.1 | 1.2 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.0 | 1.2 | GO:0021895 | cerebral cortex neuron differentiation(GO:0021895) |
| 0.0 | 1.2 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 1.0 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.3 | 0.9 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.1 | 0.9 | GO:0040009 | regulation of growth rate(GO:0040009) |
| 0.0 | 0.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 0.8 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.0 | 0.8 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.8 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.8 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 0.7 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.1 | 0.7 | GO:0015747 | urate transport(GO:0015747) |
| 0.0 | 0.7 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 0.0 | 0.7 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.0 | 0.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 174 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 1.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 1.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 1.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.9 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.0 | 0.8 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 0.8 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.7 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 0.6 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.6 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 0.5 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 369 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.5 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.0 | 1.3 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 1.2 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 1.2 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 1.1 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 1.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 1.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 0.9 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
| 0.1 | 0.9 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.9 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.9 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.8 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.8 | GO:0042805 | actinin binding(GO:0042805) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 22 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.2 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.8 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.7 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.6 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.3 | 0.3 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.3 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.3 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.1 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.1 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.1 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.1 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 0.1 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.1 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 65 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 1.4 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.4 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 1.3 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 1.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.0 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.8 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.8 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.7 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.7 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.6 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.5 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
