Motif ID: PAX3

Z-value: 0.662


Transcription factors associated with PAX3:

Gene SymbolEntrez IDGene Name
PAX3 ENSG00000135903.14 PAX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX3hg19_v2_chr2_-_223163465_2231637300.291.6e-01Click!


Activity profile for motif PAX3.

activity profile for motif PAX3


Sorted Z-values histogram for motif PAX3

Sorted Z-values for motif PAX3



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_38420783 1.594 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
 TSPAN7


tetraspanin 7


chrX_+_38420623 1.451 ENST00000378482.2
 TSPAN7
tetraspanin 7
chr12_-_58131931 1.304 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr15_-_80263506 1.197 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr9_+_33795533 1.160 ENST00000379405.3
 PRSS3
protease, serine, 3
chr6_-_4135693 1.157 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
 ECI2


enoyl-CoA delta isomerase 2


chr15_+_45722727 1.149 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
 C15orf48


chromosome 15 open reading frame 48


chr13_+_96085847 1.017 ENST00000376873.3
 CLDN10
claudin 10
chr5_+_7654057 0.970 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr4_-_104119528 0.833 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE


centromere protein E, 312kDa


chr10_-_106098162 0.699 ENST00000337478.1
 ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr4_+_156680143 0.638 ENST00000505154.1
 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr3_+_160117087 0.591 ENST00000357388.3
 SMC4
structural maintenance of chromosomes 4
chr7_-_148580563 0.566 ENST00000476773.1
 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_-_38574169 0.539 ENST00000423485.1
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr19_-_48048518 0.498 ENST00000595558.1
ENST00000263351.5
 ZNF541

zinc finger protein 541

chr7_-_19813192 0.480 ENST00000422233.1
ENST00000433641.1
 TMEM196

transmembrane protein 196

chr4_+_156680153 0.477 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
 GUCY1B3




guanylate cyclase 1, soluble, beta 3




chr9_-_132515302 0.473 ENST00000340607.4
 PTGES
prostaglandin E synthase
chr19_-_2783363 0.408 ENST00000221566.2
 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 1.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 1.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 1.0 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 1.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.6 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.5 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.1 0.5 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.3 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.3 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.3 GO:0042420 dopamine catabolic process(GO:0042420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.9 GO:0000796 condensin complex(GO:0000796)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.0 0.6 GO:0045120 pronucleus(GO:0045120)
0.2 0.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.5 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 1.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 1.2 GO:0051400 BH domain binding(GO:0051400)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 0.5 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.2 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.2 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1