Motif ID: OTX2_CRX

Z-value: 0.637

Transcription factors associated with OTX2_CRX:

Gene SymbolEntrez IDGene Name
CRX ENSG00000105392.11 CRX
OTX2 ENSG00000165588.12 OTX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
OTX2hg19_v2_chr14_-_57277178_572772030.682.3e-04Click!
CRXhg19_v2_chr19_+_48325097_483252110.462.4e-02Click!


Activity profile for motif OTX2_CRX.

activity profile for motif OTX2_CRX


Sorted Z-values histogram for motif OTX2_CRX

Sorted Z-values for motif OTX2_CRX



Network of associatons between targets according to the STRING database.



First level regulatory network of OTX2_CRX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_38859996 7.290 ENST00000264651.2
 KRT24
keratin 24
chr8_+_54764346 2.705 ENST00000297313.3
ENST00000344277.6
 RGS20

regulator of G-protein signaling 20

chr19_-_51538118 1.937 ENST00000529888.1
 KLK12
kallikrein-related peptidase 12
chr19_-_51538148 1.929 ENST00000319590.4
ENST00000250351.4
 KLK12

kallikrein-related peptidase 12

chr15_-_74495188 1.762 ENST00000563965.1
ENST00000395105.4
 STRA6

stimulated by retinoic acid 6

chrX_+_69488174 1.318 ENST00000480877.2
ENST00000307959.8
 ARR3

arrestin 3, retinal (X-arrestin)

chr3_-_149095652 1.284 ENST00000305366.3
 TM4SF1
transmembrane 4 L six family member 1
chr9_+_75229616 1.224 ENST00000340019.3
 TMC1
transmembrane channel-like 1
chr5_-_149669192 1.190 ENST00000398376.3
 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr9_+_116298778 1.158 ENST00000462143.1
 RGS3
regulator of G-protein signaling 3
chr2_+_219472488 1.132 ENST00000450993.2
 PLCD4
phospholipase C, delta 4
chr8_-_91095099 1.130 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr16_+_58010339 1.100 ENST00000290871.5
ENST00000441824.2
 TEPP

testis, prostate and placenta expressed

chr6_+_130339710 1.075 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr1_+_180897269 1.070 ENST00000367587.1
 KIAA1614
KIAA1614
chr18_-_28681950 1.023 ENST00000251081.6
 DSC2
desmocollin 2
chrX_+_69488155 0.920 ENST00000374495.3
 ARR3
arrestin 3, retinal (X-arrestin)
chr11_-_62752162 0.909 ENST00000458333.2
ENST00000421062.2
 SLC22A6

solute carrier family 22 (organic anion transporter), member 6

chrX_+_69509927 0.897 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr18_-_64271316 0.775 ENST00000540086.1
ENST00000580157.1
 CDH19

cadherin 19, type 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0070268 cornification(GO:0070268)
0.1 1.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 1.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 1.8 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.5 1.5 GO:0097254 renal tubular secretion(GO:0097254)
0.0 1.5 GO:0043486 histone exchange(GO:0043486)
0.0 1.4 GO:0007340 acrosome reaction(GO:0007340)
0.1 1.3 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.2 1.2 GO:0060005 vestibular reflex(GO:0060005)
0.1 1.2 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) angiotensin-activated signaling pathway(GO:0038166)
0.0 1.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.1 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 0.7 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.7 GO:0071286 cellular response to magnesium ion(GO:0071286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0005882 intermediate filament(GO:0005882)
0.1 3.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.7 GO:0030057 desmosome(GO:0030057)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.1 1.5 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.2 0.7 GO:1990667 PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.4 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.1 0.2 GO:0035841 new growing cell tip(GO:0035841)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 2.2 GO:0002046 opsin binding(GO:0002046)
0.2 1.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 1.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 1.5 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.1 1.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.0 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 0.9 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.2 0.7 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.2 0.7 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.6 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 1.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 1.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_OPSINS Genes involved in Opsins
0.0 0.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion