Motif ID: OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.551

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4:

Gene SymbolEntrez IDGene Name
HOXC4 ENSG00000198353.6 HOXC4
HOXC4 ENSG00000273266.1 HOXC4
LHX1 ENSG00000132130.7 LHX1
LHX5 ENSG00000089116.3 LHX5
LMX1A ENSG00000162761.10 LMX1A
OTP ENSG00000171540.6 OTP
PHOX2B ENSG00000109132.5 PHOX2B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
OTPhg19_v2_chr5_-_76935513_769355130.424.3e-02Click!
HOXC4hg19_v2_chr12_+_54447637_544476610.311.5e-01Click!
LMX1Ahg19_v2_chr1_-_165325449_165325478,
hg19_v2_chr1_-_165325939_165325958		0.252.3e-01Click!
LHX1hg19_v2_chr17_+_35294075_352941020.232.9e-01Click!
PHOX2Bhg19_v2_chr4_-_41750922_417509870.164.5e-01Click!
LHX5hg19_v2_chr12_-_113909877_113909877-0.087.2e-01Click!


Activity profile for motif OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4.

activity profile for motif OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4


Sorted Z-values histogram for motif OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Sorted Z-values for motif OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4



Network of associatons between targets according to the STRING database.



First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_141747950 1.588 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr19_+_50016610 1.317 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016411 1.277 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
 FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr11_-_121986923 1.224 ENST00000560104.1
 BLID
BH3-like motif containing, cell death inducer
chr6_+_130339710 1.089 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr3_-_164796269 0.982 ENST00000264382.3
 SI
sucrase-isomaltase (alpha-glucosidase)
chr10_-_118928543 0.749 ENST00000419373.2
 RP11-501J20.2
RP11-501J20.2
chr17_+_1674982 0.724 ENST00000572048.1
ENST00000573763.1
 SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

chr1_+_117544366 0.705 ENST00000256652.4
ENST00000369470.1
 CD101

CD101 molecule

chr12_+_26348582 0.561 ENST00000535504.1
 SSPN
sarcospan
chr20_-_33735070 0.519 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chrX_+_43515467 0.513 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chrX_-_18690210 0.497 ENST00000379984.3
 RS1
retinoschisin 1
chr1_+_62439037 0.497 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr4_-_39033963 0.472 ENST00000381938.3
 TMEM156
transmembrane protein 156
chr12_+_26348246 0.454 ENST00000422622.2
 SSPN
sarcospan
chr4_-_120243545 0.422 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr1_-_190446759 0.417 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr6_+_114178512 0.403 ENST00000368635.4
 MARCKS
myristoylated alanine-rich protein kinase C substrate
chr9_-_99540328 0.397 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
 ZNF510


zinc finger protein 510



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.6 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 1.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.0 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.6 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.2 0.5 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.5 GO:2000852 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 0.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.5 GO:0009642 response to light intensity(GO:0009642)
0.1 0.4 GO:0050955 thermoception(GO:0050955)
0.1 0.4 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.3 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.3 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.7 GO:0043203 axon hillock(GO:0043203)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.6 GO:0019770 IgG receptor activity(GO:0019770)
0.3 1.0 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.7 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.2 GO:0004797 thymidine kinase activity(GO:0004797)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway