Motif ID: ONECUT1

Z-value: 0.572


Transcription factors associated with ONECUT1:

Gene SymbolEntrez IDGene Name
ONECUT1 ENSG00000169856.7 ONECUT1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ONECUT1hg19_v2_chr15_-_53082178_530822090.096.9e-01Click!


Activity profile for motif ONECUT1.

activity profile for motif ONECUT1


Sorted Z-values histogram for motif ONECUT1

Sorted Z-values for motif ONECUT1



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_112693865 1.772 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
 CD200R1


CD200 receptor 1


chr10_-_28270795 1.518 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr3_-_112693759 1.453 ENST00000440122.2
ENST00000490004.1
 CD200R1

CD200 receptor 1

chr11_+_60467047 1.417 ENST00000300226.2
 MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr7_-_69062391 1.356 ENST00000436600.2
 RP5-942I16.1
RP5-942I16.1
chr1_+_212738676 0.810 ENST00000366981.4
ENST00000366987.2
 ATF3

activating transcription factor 3

chr3_+_108308513 0.730 ENST00000361582.3
 DZIP3
DAZ interacting zinc finger protein 3
chr1_-_26633067 0.588 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
 UBXN11








UBX domain protein 11








chr1_-_197036364 0.584 ENST00000367412.1
 F13B
coagulation factor XIII, B polypeptide
chr14_+_62585332 0.564 ENST00000554895.1
 LINC00643
long intergenic non-protein coding RNA 643
chr6_+_127898312 0.538 ENST00000329722.7
 C6orf58
chromosome 6 open reading frame 58
chr8_-_27468842 0.532 ENST00000523500.1
 CLU
clusterin
chr10_+_97759848 0.516 ENST00000424464.1
ENST00000410012.2
ENST00000344386.3
 CC2D2B


coiled-coil and C2 domain containing 2B


chr11_+_102980126 0.504 ENST00000375735.2
 DYNC2H1
dynein, cytoplasmic 2, heavy chain 1
chr11_-_5531215 0.489 ENST00000311659.4
 UBQLN3
ubiquilin 3
chr7_+_141463897 0.471 ENST00000247879.2
 TAS2R3
taste receptor, type 2, member 3
chr3_-_170744498 0.458 ENST00000382808.4
ENST00000314251.3
 SLC2A2

solute carrier family 2 (facilitated glucose transporter), member 2

chr2_+_234959376 0.452 ENST00000425558.1
 SPP2
secreted phosphoprotein 2, 24kDa
chr12_-_95941987 0.433 ENST00000537435.2
 USP44
ubiquitin specific peptidase 44
chr2_+_71127699 0.429 ENST00000234392.2
 VAX2
ventral anterior homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.1 0.9 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.3 0.8 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 0.5 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.4 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.3 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.3 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.3 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.3 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.3 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 0.8 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.7 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.3 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.4 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions