Motif ID: NKX3-2

Z-value: 1.286


Transcription factors associated with NKX3-2:

Gene SymbolEntrez IDGene Name
NKX3-2 ENSG00000109705.7 NKX3-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v2_chr4_-_13546632_13546674-0.252.4e-01Click!


Activity profile for motif NKX3-2.

activity profile for motif NKX3-2


Sorted Z-values histogram for motif NKX3-2

Sorted Z-values for motif NKX3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_112970436 9.746 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr1_-_161337662 8.757 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr9_-_34397800 8.176 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr5_-_149792295 6.129 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr6_-_32557610 5.743 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr17_-_74137374 5.556 ENST00000322957.6
FOXJ1
forkhead box J1
chr7_-_99573677 5.503 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_34458771 5.475 ENST00000437363.1
ENST00000242317.4
DNAI1

dynein, axonemal, intermediate chain 1

chr13_+_43355683 5.307 ENST00000537894.1
FAM216B
family with sequence similarity 216, member B
chr13_+_43355732 5.281 ENST00000313851.1
FAM216B
family with sequence similarity 216, member B
chr11_-_111175739 4.386 ENST00000532918.1
COLCA1
colorectal cancer associated 1
chr6_+_32821924 3.754 ENST00000374859.2
ENST00000453265.2
PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr16_-_21289627 3.675 ENST00000396023.2
ENST00000415987.2
CRYM

crystallin, mu

chr1_-_183622442 3.646 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr5_+_156696362 3.574 ENST00000377576.3
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_98703643 3.530 ENST00000477737.1
VWA3B
von Willebrand factor A domain containing 3B
chr19_+_41497178 3.397 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr17_+_68071389 3.278 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr16_+_57406368 3.241 ENST00000006053.6
ENST00000563383.1
CX3CL1

chemokine (C-X3-C motif) ligand 1

chr11_-_26593649 3.205 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr9_-_75567962 3.094 ENST00000297785.3
ENST00000376939.1
ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr3_+_125694347 3.078 ENST00000505382.1
ENST00000511082.1
ROPN1B

rhophilin associated tail protein 1B

chr4_-_168155730 3.012 ENST00000502330.1
ENST00000357154.3
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr11_-_26593779 2.970 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr4_-_141348789 2.840 ENST00000414773.1
CLGN
calmegin
chr7_-_99573640 2.780 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr4_-_141348999 2.777 ENST00000325617.5
CLGN
calmegin
chr1_+_162351503 2.756 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr9_-_124976185 2.682 ENST00000464484.2
LHX6
LIM homeobox 6
chr9_-_124976154 2.641 ENST00000482062.1
LHX6
LIM homeobox 6
chr3_-_112693865 2.567 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1


CD200 receptor 1


chr5_+_156712372 2.459 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_-_113658892 2.415 ENST00000299732.2
ENST00000416617.2
IQCD

IQ motif containing D

chr19_-_6720686 2.351 ENST00000245907.6
C3
complement component 3
chr4_-_168155417 2.249 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr11_-_26593677 2.247 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr6_-_32731299 2.236 ENST00000435145.2
ENST00000437316.2
HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

chr15_-_40401062 2.180 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF



Bcl2 modifying factor



chr3_-_112693759 2.169 ENST00000440122.2
ENST00000490004.1
CD200R1

CD200 receptor 1

chr7_-_120498357 2.168 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12


tetraspanin 12


chr4_-_168155700 2.162 ENST00000357545.4
ENST00000512648.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr10_+_7745232 2.085 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_217262933 2.075 ENST00000359162.2
ESRRG
estrogen-related receptor gamma
chr5_-_54468974 2.047 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B




cell division cycle 20B




chr17_+_68071458 1.990 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_160279207 1.986 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr1_-_217262969 1.969 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chr12_+_56075330 1.940 ENST00000394252.3
METTL7B
methyltransferase like 7B
chr3_+_169629354 1.926 ENST00000428432.2
ENST00000335556.3
SAMD7

sterile alpha motif domain containing 7

chr17_+_58755184 1.821 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3


breast carcinoma amplified sequence 3


chr7_+_90338712 1.740 ENST00000265741.3
ENST00000406263.1
CDK14

cyclin-dependent kinase 14

chr6_+_159084188 1.715 ENST00000367081.3
SYTL3
synaptotagmin-like 3
chr10_-_46168156 1.684 ENST00000374371.2
ENST00000335258.7
ZFAND4

zinc finger, AN1-type domain 4

chr2_-_220435963 1.645 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1




obscurin-like 1




chr1_-_216978709 1.638 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr15_-_43513187 1.632 ENST00000540029.1
ENST00000441366.2
EPB42

erythrocyte membrane protein band 4.2

chr19_-_3028354 1.611 ENST00000586422.1
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr4_-_168155577 1.526 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3





sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3





chr11_-_106889157 1.489 ENST00000282249.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr12_-_10151773 1.481 ENST00000298527.6
ENST00000348658.4
CLEC1B

C-type lectin domain family 1, member B

chr5_-_176326333 1.399 ENST00000292432.5
HK3
hexokinase 3 (white cell)
chr11_+_66045634 1.343 ENST00000528852.1
ENST00000311445.6
CNIH2

cornichon family AMPA receptor auxiliary protein 2

chr1_+_211433275 1.339 ENST00000367005.4
RCOR3
REST corepressor 3
chr11_-_59633951 1.333 ENST00000257264.3
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr4_+_17579110 1.297 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr14_-_23770683 1.285 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E




protein phosphatase 1, regulatory subunit 3E




chr3_+_132316081 1.274 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr6_+_18155560 1.274 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
KDM1B


lysine (K)-specific demethylase 1B


chr16_-_3350614 1.274 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr2_-_25194963 1.265 ENST00000264711.2
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr19_+_17337473 1.262 ENST00000598068.1
OCEL1
occludin/ELL domain containing 1
chrX_+_48660287 1.243 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6



histone deacetylase 6



chr2_-_220436248 1.232 ENST00000265318.4
OBSL1
obscurin-like 1
chr1_-_217250231 1.231 ENST00000493748.1
ENST00000463665.1
ESRRG

estrogen-related receptor gamma

chr1_+_60280458 1.218 ENST00000455990.1
ENST00000371208.3
HOOK1

hook microtubule-tethering protein 1

chr3_-_112218378 1.203 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr6_-_27279949 1.203 ENST00000444565.1
ENST00000377451.2
POM121L2

POM121 transmembrane nucleoporin-like 2

chrX_+_95939711 1.189 ENST00000373049.4
ENST00000324765.8
DIAPH2

diaphanous-related formin 2

chr10_+_35415851 1.188 ENST00000374726.3
CREM
cAMP responsive element modulator
chr17_+_18380051 1.135 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C





lectin, galactoside-binding, soluble, 9C





chr2_-_188312971 1.131 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
CALCRL


calcitonin receptor-like


chr11_-_63381823 1.104 ENST00000323646.5
PLA2G16
phospholipase A2, group XVI
chr12_+_56473939 1.097 ENST00000450146.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr16_-_86532148 1.087 ENST00000594398.1
FENDRR
FOXF1 adjacent non-coding developmental regulatory RNA
chr7_-_50628745 1.087 ENST00000380984.4
ENST00000357936.5
ENST00000426377.1
DDC


dopa decarboxylase (aromatic L-amino acid decarboxylase)


chr7_+_90339169 1.080 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr11_+_36317830 1.071 ENST00000530639.1
PRR5L
proline rich 5 like
chr4_+_159727272 1.071 ENST00000379346.3
FNIP2
folliculin interacting protein 2
chr12_-_42983478 1.033 ENST00000345127.3
ENST00000547113.1
PRICKLE1

prickle homolog 1 (Drosophila)

chr11_+_118978045 1.029 ENST00000336702.3
C2CD2L
C2CD2-like
chr3_-_112218205 1.027 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr6_+_29910301 1.013 ENST00000376809.5
ENST00000376802.2
HLA-A

major histocompatibility complex, class I, A

chr1_-_48866517 1.009 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr14_+_21156915 1.004 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_160117301 1.004 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
IFT80



intraflagellar transport 80 homolog (Chlamydomonas)



chr8_+_67624653 0.983 ENST00000521198.2
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr2_-_208489707 0.979 ENST00000448007.2
ENST00000432416.1
ENST00000411432.1
METTL21A


methyltransferase like 21A


chr11_+_60970852 0.967 ENST00000325558.6
PGA3
pepsinogen 3, group I (pepsinogen A)
chr19_-_51412584 0.949 ENST00000431178.2
KLK4
kallikrein-related peptidase 4
chr20_+_53092123 0.939 ENST00000262593.5
DOK5
docking protein 5
chr21_-_43816052 0.907 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr16_+_3019552 0.899 ENST00000572687.1
PAQR4
progestin and adipoQ receptor family member IV
chr2_+_186603545 0.893 ENST00000424728.1
FSIP2
fibrous sheath interacting protein 2
chr8_+_144295067 0.891 ENST00000330824.2
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr6_+_29274403 0.889 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr1_-_156399184 0.886 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61



chromosome 1 open reading frame 61



chr6_-_116381918 0.867 ENST00000606080.1
FRK
fyn-related kinase
chr10_-_49459800 0.862 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr6_-_31697255 0.851 ENST00000436437.1
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr14_+_50779071 0.846 ENST00000426751.2
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr11_-_102401469 0.844 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr11_-_77531752 0.833 ENST00000440064.2
ENST00000528095.1
RSF1

remodeling and spacing factor 1

chr17_-_9929581 0.831 ENST00000437099.2
ENST00000396115.2
GAS7

growth arrest-specific 7

chr15_+_88120158 0.819 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr17_-_79623597 0.815 ENST00000574024.1
ENST00000331056.5
PDE6G

phosphodiesterase 6G, cGMP-specific, rod, gamma

chr10_+_16478942 0.811 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER


phosphotriesterase related


chr5_-_36152031 0.810 ENST00000296603.4
LMBRD2
LMBR1 domain containing 2
chr1_+_158259558 0.800 ENST00000368170.3
CD1C
CD1c molecule
chr11_-_22851367 0.798 ENST00000354193.4
SVIP
small VCP/p97-interacting protein
chr14_-_68066849 0.795 ENST00000558493.1
ENST00000561272.1
PIGH

phosphatidylinositol glycan anchor biosynthesis, class H

chr20_-_2821271 0.781 ENST00000448755.1
ENST00000360652.2
PCED1A

PC-esterase domain containing 1A

chr14_+_104604916 0.778 ENST00000423312.2
KIF26A
kinesin family member 26A
chr19_+_54609230 0.777 ENST00000420296.1
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr19_-_7764281 0.774 ENST00000360067.4
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr2_-_25016251 0.764 ENST00000328379.5
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
chrX_+_76709648 0.763 ENST00000439435.1
FGF16
fibroblast growth factor 16
chr20_+_53092232 0.763 ENST00000395939.1
DOK5
docking protein 5
chr18_-_6414884 0.747 ENST00000317931.7
ENST00000284898.6
ENST00000400104.3
L3MBTL4


l(3)mbt-like 4 (Drosophila)


chr10_-_27529486 0.744 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr14_-_68000442 0.744 ENST00000554278.1
TMEM229B
transmembrane protein 229B
chr3_+_48507210 0.737 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1



three prime repair exonuclease 1



chr12_-_122712038 0.721 ENST00000413918.1
ENST00000443649.3
DIABLO

diablo, IAP-binding mitochondrial protein

chr20_-_2821756 0.717 ENST00000356872.3
ENST00000439542.1
PCED1A

PC-esterase domain containing 1A

chr14_-_92506371 0.716 ENST00000267622.4
TRIP11
thyroid hormone receptor interactor 11
chr1_-_165324983 0.716 ENST00000367893.4
LMX1A
LIM homeobox transcription factor 1, alpha
chr1_+_22307592 0.713 ENST00000400277.2
CELA3B
chymotrypsin-like elastase family, member 3B
chr1_+_160097462 0.712 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_-_52443799 0.704 ENST00000470173.1
ENST00000296288.5
BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

chr20_+_2276639 0.690 ENST00000381458.5
TGM3
transglutaminase 3
chr1_-_202858227 0.689 ENST00000367262.3
RABIF
RAB interacting factor
chr12_+_6309517 0.686 ENST00000382519.4
ENST00000009180.4
CD9

CD9 molecule

chr5_+_64859066 0.686 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
PPWD1


peptidylprolyl isomerase domain and WD repeat containing 1


chr10_-_17171817 0.683 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr1_+_210001309 0.680 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr11_-_116662593 0.679 ENST00000227665.4
APOA5
apolipoprotein A-V
chr10_-_127505167 0.675 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr5_+_56111361 0.662 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr15_+_90895471 0.652 ENST00000354377.3
ENST00000379090.5
ZNF774

zinc finger protein 774

chrX_-_15332665 0.642 ENST00000537676.1
ENST00000344384.4
ASB11

ankyrin repeat and SOCS box containing 11

chr2_-_24270217 0.632 ENST00000295148.4
ENST00000406895.3
C2orf44

chromosome 2 open reading frame 44

chr3_+_52454971 0.620 ENST00000465863.1
PHF7
PHD finger protein 7
chr20_+_15177480 0.617 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr1_+_6845497 0.617 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr10_-_27529716 0.612 ENST00000375897.3
ENST00000396271.3
ACBD5

acyl-CoA binding domain containing 5

chr9_+_35161998 0.610 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
UNC13B


unc-13 homolog B (C. elegans)


chr15_+_89402148 0.610 ENST00000560601.1
ACAN
aggrecan
chr12_+_56473910 0.609 ENST00000411731.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr3_-_146262293 0.604 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chrX_+_100333709 0.602 ENST00000372930.4
TMEM35
transmembrane protein 35
chr7_-_56160666 0.601 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr10_+_35416223 0.599 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM





cAMP responsive element modulator





chr22_-_21356375 0.599 ENST00000215742.4
ENST00000399133.2
THAP7

THAP domain containing 7

chr20_+_55966444 0.596 ENST00000356208.5
ENST00000440234.2
RBM38

RNA binding motif protein 38

chr21_-_33984888 0.595 ENST00000382549.4
ENST00000540881.1
C21orf59

chromosome 21 open reading frame 59

chr15_-_37393406 0.588 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2


Meis homeobox 2


chr17_-_7145475 0.578 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP


GABA(A) receptor-associated protein


chr7_-_79082867 0.576 ENST00000419488.1
ENST00000354212.4
MAGI2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr6_-_30080876 0.573 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr3_-_52008016 0.568 ENST00000461108.1
ENST00000395008.2
ENST00000525795.1
ENST00000361143.5
ENST00000489595.2
ABHD14B



RP11-155D18.14
abhydrolase domain containing 14B



Poly(rC)-binding protein 4
chr21_-_33984865 0.565 ENST00000458138.1
C21orf59
chromosome 21 open reading frame 59
chr20_-_34330129 0.560 ENST00000397370.3
ENST00000528062.3
ENST00000407261.4
ENST00000374038.3
ENST00000361162.6
RBM39




RNA binding motif protein 39




chr5_+_68710906 0.557 ENST00000325631.5
ENST00000454295.2
MARVELD2

MARVEL domain containing 2

chr1_+_35734562 0.552 ENST00000314607.6
ENST00000373297.2
ZMYM4

zinc finger, MYM-type 4

chr1_-_91487013 0.552 ENST00000347275.5
ENST00000370440.1
ZNF644

zinc finger protein 644

chr20_-_61557821 0.550 ENST00000354665.4
ENST00000370368.1
ENST00000395343.1
ENST00000395340.1
DIDO1



death inducer-obliterator 1



chr16_-_20416053 0.550 ENST00000302451.4
PDILT
protein disulfide isomerase-like, testis expressed
chr5_+_68711209 0.537 ENST00000512803.1
MARVELD2
MARVEL domain containing 2
chr19_-_10444188 0.537 ENST00000293677.6
RAVER1
ribonucleoprotein, PTB-binding 1
chr11_-_77531858 0.534 ENST00000360355.2
RSF1
remodeling and spacing factor 1
chr17_-_60883993 0.534 ENST00000583803.1
ENST00000456609.2
MARCH10

membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase

chr9_+_5890802 0.524 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA


melan-A


chr11_+_77532155 0.523 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC




adipogenesis associated, Mth938 domain containing




chr3_+_23847432 0.514 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr9_+_134065506 0.505 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr1_+_152758690 0.501 ENST00000368771.1
ENST00000368770.3
LCE1E

late cornified envelope 1E

chr6_-_31697563 0.498 ENST00000375789.2
ENST00000416410.1
DDAH2

dimethylarginine dimethylaminohydrolase 2

chr15_-_43559055 0.482 ENST00000220420.5
ENST00000349114.4
TGM5

transglutaminase 5

chr4_-_11430221 0.479 ENST00000514690.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr7_-_56160625 0.478 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1



phosphorylase kinase, gamma 1 (muscle)



chr19_-_3061397 0.477 ENST00000586839.1
AES
amino-terminal enhancer of split
chr19_+_41313017 0.476 ENST00000595621.1
ENST00000595051.1
EGLN2

egl-9 family hypoxia-inducible factor 2

chr16_+_5121814 0.472 ENST00000262374.5
ENST00000586840.1
ALG1

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase

chr9_-_32526184 0.468 ENST00000545044.1
ENST00000379868.1
DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr17_-_19771216 0.463 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr21_-_33985127 0.460 ENST00000290155.3
C21orf59
chromosome 21 open reading frame 59
chr17_-_42295870 0.459 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
UBTF


upstream binding transcription factor, RNA polymerase I


chr6_-_47010061 0.457 ENST00000371253.2
GPR110
G protein-coupled receptor 110
chr2_+_232572361 0.455 ENST00000409321.1
PTMA
prothymosin, alpha
chr1_+_156756667 0.453 ENST00000526188.1
ENST00000454659.1
PRCC

papillary renal cell carcinoma (translocation-associated)

chr8_+_104033277 0.439 ENST00000518857.1
ENST00000395862.3
ATP6V1C1

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
1.2 6.1 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.1 5.7 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.1 3.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.8 2.4 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.8 3.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.6 6.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 1.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.4 5.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.4 8.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.1 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.3 1.2 GO:0090034 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.3 0.8 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.3 3.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 5.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 0.8 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.3 1.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3 1.3 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 0.7 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 0.7 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.2 1.7 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 2.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.4 GO:0030242 pexophagy(GO:0030242)
0.2 3.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 0.9 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 2.5 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.2 0.7 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 1.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 6.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.3 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219) negative regulation of phospholipid metabolic process(GO:1903726)
0.2 0.8 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 1.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 0.6 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 0.7 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 1.3 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 2.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 1.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.7 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.1 9.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.4 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 0.3 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 6.2 GO:0010107 potassium ion import(GO:0010107)
0.1 5.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.6 GO:2000302 regulation of synaptic vesicle priming(GO:0010807) positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1 0.3 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.1 1.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 1.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.8 GO:2000546 positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.3 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 1.7 GO:0006527 arginine catabolic process(GO:0006527)
0.1 1.0 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 2.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 7.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.4 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 0.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.4 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 2.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.1 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.4 GO:0071105 response to interleukin-11(GO:0071105)
0.1 0.7 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.1 0.5 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.1 0.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 2.8 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 0.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.3 GO:0044026 DNA hypermethylation(GO:0044026)
0.1 0.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0042048 olfactory behavior(GO:0042048)
0.1 0.3 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 1.0 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.5 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.1 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.5 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.7 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 1.2 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 1.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 5.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.0 GO:0044849 estrous cycle(GO:0044849)
0.0 1.4 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.3 GO:0008037 cell recognition(GO:0008037)
0.0 0.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.4 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.2 GO:0035900 response to isolation stress(GO:0035900)
0.0 0.9 GO:0097186 amelogenesis(GO:0097186)
0.0 0.8 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 2.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.7 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:2000861 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) positive regulation of estrogen secretion(GO:2000863) regulation of estradiol secretion(GO:2000864) positive regulation of estradiol secretion(GO:2000866)
0.0 1.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 3.5 GO:0031295 T cell costimulation(GO:0031295)
0.0 1.2 GO:0032259 methylation(GO:0032259)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0097327 response to antineoplastic agent(GO:0097327)
0.0 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.3 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.3 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 1.2 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.3 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.5 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.2 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.1 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 1.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 1.0 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.6 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0001505 regulation of neurotransmitter levels(GO:0001505)
0.0 0.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.1 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.4 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.6 2.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.5 5.5 GO:0036157 outer dynein arm(GO:0036157)
0.4 1.8 GO:0031213 RSF complex(GO:0031213)
0.4 3.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.9 GO:1990393 3M complex(GO:1990393)
0.4 7.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 1.0 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.3 1.0 GO:0097224 sperm connecting piece(GO:0097224)
0.2 1.2 GO:0070695 FHF complex(GO:0070695)
0.2 0.5 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 1.0 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.7 GO:0002081 inner acrosomal membrane(GO:0002079) outer acrosomal membrane(GO:0002081)
0.1 0.4 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.6 GO:0044305 calyx of Held(GO:0044305)
0.1 1.1 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 1.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 0.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 1.0 GO:0042611 MHC protein complex(GO:0042611)
0.1 1.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 9.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.1 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.8 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 5.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 2.5 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 3.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.2 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 7.8 GO:0043235 receptor complex(GO:0043235)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:0042289 MHC class II protein binding(GO:0042289)
1.0 6.9 GO:0050682 AF-2 domain binding(GO:0050682)
0.9 3.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 3.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.6 1.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.4 9.1 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.4 0.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.3 8.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.3 5.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.3 2.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 2.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 5.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.7 GO:0016403 dimethylargininase activity(GO:0016403)
0.2 2.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 0.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.2 1.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 1.3 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.2 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.0 GO:0031419 cobalamin binding(GO:0031419)
0.2 5.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 1.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 1.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 3.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 1.0 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 5.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.7 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.0 GO:0043559 insulin binding(GO:0043559)
0.1 0.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 0.7 GO:0035473 lipase binding(GO:0035473)
0.1 0.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 2.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.8 GO:0019863 IgE binding(GO:0019863)
0.1 2.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.1 1.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 3.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.0 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.2 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 2.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 3.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.5 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 2.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.9 GO:0005549 odorant binding(GO:0005549)
0.1 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226)
0.1 2.8 GO:0030332 cyclin binding(GO:0030332)
0.1 1.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 1.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 1.3 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 1.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 1.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.5 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.8 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 5.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 7.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 5.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 5.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.1 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 2.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 5.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.7 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.1 3.7 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 4.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 3.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 6.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.1 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.4 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 2.2 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME_OPSINS Genes involved in Opsins
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)