Motif ID: NKX2-5
Z-value: 0.464
Transcription factors associated with NKX2-5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NKX2-5 | ENSG00000183072.9 | NKX2-5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NKX2-5 | hg19_v2_chr5_-_172662303_172662360 | -0.07 | 7.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:1904588 | cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229) |
0.1 | 0.3 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
0.1 | 0.2 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
0.1 | 0.2 | GO:0051780 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
0.1 | 0.2 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
0.0 | 0.1 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
0.0 | 0.3 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
0.0 | 0.2 | GO:1904448 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
0.0 | 0.2 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) |
0.0 | 0.2 | GO:0030070 | insulin processing(GO:0030070) |
0.0 | 0.1 | GO:0048627 | myoblast development(GO:0048627) |
0.0 | 0.2 | GO:0000189 | MAPK import into nucleus(GO:0000189) regulation of Golgi inheritance(GO:0090170) |
0.0 | 0.1 | GO:0050960 | detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594) |
0.0 | 0.1 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
0.0 | 0.2 | GO:0075044 | autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071) |
0.0 | 0.1 | GO:0051012 | microtubule sliding(GO:0051012) |
0.0 | 0.2 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.0 | 0.1 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
0.0 | 0.1 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.0 | 0.1 | GO:1901529 | positive regulation of anion channel activity(GO:1901529) |
0.0 | 0.1 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
0.0 | 0.1 | GO:0035995 | detection of muscle stretch(GO:0035995) |
0.0 | 0.1 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.0 | 0.0 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) |
0.0 | 0.2 | GO:0006554 | lysine catabolic process(GO:0006554) |
0.0 | 0.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.0 | 0.3 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
0.0 | 0.2 | GO:0001778 | plasma membrane repair(GO:0001778) |
0.0 | 0.1 | GO:0014827 | intestine smooth muscle contraction(GO:0014827) |
0.0 | 0.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.0 | 0.1 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.2 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
0.0 | 0.1 | GO:0030849 | autosome(GO:0030849) |
0.0 | 0.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.0 | 0.2 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.0 | 0.1 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.2 | GO:0047150 | betaine-homocysteine S-methyltransferase activity(GO:0047150) |
0.1 | 0.2 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
0.1 | 0.2 | GO:0102007 | lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007) |
0.1 | 0.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
0.0 | 0.3 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
0.0 | 0.2 | GO:0032145 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
0.0 | 0.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
0.0 | 0.1 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
0.0 | 0.1 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
0.0 | 0.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.0 | 0.2 | GO:0048495 | Roundabout binding(GO:0048495) |
0.0 | 0.1 | GO:0097603 | temperature-gated ion channel activity(GO:0097603) |
0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.0 | 0.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.0 | 0.2 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 0.2 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.0 | 0.0 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
0.0 | 0.0 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
0.0 | 0.1 | GO:0035473 | lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230) |
0.0 | 0.2 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
0.0 | 0.1 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
0.0 | 0.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
0.0 | 0.3 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 0.3 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.3 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
0.0 | 0.2 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
0.0 | 0.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |