Motif ID: NKX2-5

Z-value: 0.464


Transcription factors associated with NKX2-5:

Gene SymbolEntrez IDGene Name
NKX2-5 ENSG00000183072.9 NKX2-5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.077.4e-01Click!


Activity profile for motif NKX2-5.

activity profile for motif NKX2-5


Sorted Z-values histogram for motif NKX2-5

Sorted Z-values for motif NKX2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_150254936 0.403 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
 C1orf51


chromosome 1 open reading frame 51


chr17_-_29641084 0.399 ENST00000544462.1
 EVI2B
ecotropic viral integration site 2B
chr4_+_81118647 0.376 ENST00000415738.2
 PRDM8
PR domain containing 8
chr11_+_76813886 0.357 ENST00000529803.1
 OMP
olfactory marker protein
chr9_+_118950325 0.335 ENST00000534838.1
 PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_-_111314230 0.313 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr17_-_8059638 0.302 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
 PER1


period circadian clock 1


chr10_-_7513904 0.296 ENST00000420395.1
 RP5-1031D4.2
RP5-1031D4.2
chr14_+_21467414 0.281 ENST00000554422.1
ENST00000298681.4
 SLC39A2

solute carrier family 39 (zinc transporter), member 2

chr7_-_122339162 0.271 ENST00000340112.2
 RNF133
ring finger protein 133
chr4_-_153700864 0.261 ENST00000304337.2
 TIGD4
tigger transposable element derived 4
chr14_+_78227105 0.242 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
 C14orf178



chromosome 14 open reading frame 178



chr17_-_29624343 0.237 ENST00000247271.4
 OMG
oligodendrocyte myelin glycoprotein
chr5_+_75699040 0.236 ENST00000274364.6
 IQGAP2
IQ motif containing GTPase activating protein 2
chr14_-_106830057 0.225 ENST00000390616.2
 IGHV4-34
immunoglobulin heavy variable 4-34
chr6_+_109169591 0.222 ENST00000368972.3
ENST00000392644.4
 ARMC2

armadillo repeat containing 2

chr7_-_37488834 0.217 ENST00000310758.4
 ELMO1
engulfment and cell motility 1
chr6_-_39290316 0.215 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
 KCNK16



potassium channel, subfamily K, member 16



chr14_-_106963409 0.211 ENST00000390621.2
 IGHV1-45
immunoglobulin heavy variable 1-45
chr17_-_29641104 0.197 ENST00000577894.1
ENST00000330927.4
 EVI2B

ecotropic viral integration site 2B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.3 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.3 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.2 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.2 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.2 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.2 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)
0.0 0.2 GO:0000189 MAPK import into nucleus(GO:0000189) regulation of Golgi inheritance(GO:0090170)
0.0 0.2 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0006554 lysine catabolic process(GO:0006554)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.1 GO:0048627 myoblast development(GO:0048627)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0030849 autosome(GO:0030849)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.2 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.2 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels