Motif ID: NKX2-4

Z-value: 0.744


Transcription factors associated with NKX2-4:

Gene SymbolEntrez IDGene Name
NKX2-4 ENSG00000125816.4 NKX2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-4hg19_v2_chr20_-_21378666_213786660.424.2e-02Click!


Activity profile for motif NKX2-4.

activity profile for motif NKX2-4


Sorted Z-values histogram for motif NKX2-4

Sorted Z-values for motif NKX2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_41620335 5.390 ENST00000331105.2
 CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr11_+_73675873 4.154 ENST00000537753.1
ENST00000542350.1
 DNAJB13

DnaJ (Hsp40) homolog, subfamily B, member 13

chr2_+_228736321 3.548 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr2_+_228736335 3.197 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr11_+_61976137 3.169 ENST00000244930.4
 SCGB2A1
secretoglobin, family 2A, member 1
chr5_+_140186647 3.088 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr12_-_71533055 2.914 ENST00000552128.1
 TSPAN8
tetraspanin 8
chr12_-_58329819 2.309 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr4_+_72204755 2.176 ENST00000512686.1
ENST00000340595.3
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr17_-_34329084 2.042 ENST00000536149.1
ENST00000354059.4
 CCL14
CCL15
chemokine (C-C motif) ligand 14
chemokine (C-C motif) ligand 15
chr19_-_40440533 1.631 ENST00000221347.6
 FCGBP
Fc fragment of IgG binding protein
chr5_-_160279207 1.597 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr12_+_109826524 1.550 ENST00000431443.2
 MYO1H
myosin IH
chr21_-_35884573 1.546 ENST00000399286.2
 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr13_-_36429763 1.500 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr12_-_58329888 1.447 ENST00000546580.1
 RP11-620J15.3
RP11-620J15.3
chr4_-_70518941 1.390 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
 UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr2_-_27712583 1.320 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
 IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr6_+_159071015 1.297 ENST00000360448.3
 SYTL3
synaptotagmin-like 3
chr5_-_13944652 1.278 ENST00000265104.4
 DNAH5
dynein, axonemal, heavy chain 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 5.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.8 4.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 3.2 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 2.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 2.1 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.3 1.8 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.5 GO:0045332 phospholipid translocation(GO:0045332)
0.5 1.4 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.1 1.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 1.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.3 GO:0061525 hindgut development(GO:0061525)
0.1 1.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 1.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 1.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.4 1.3 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 1.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.1 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 0.8 GO:0097513 myosin II filament(GO:0097513)
0.1 0.8 GO:0002177 manchette(GO:0002177)
0.1 0.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 0.5 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.2 0.5 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 3.4 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 2.1 GO:0003774 motor activity(GO:0003774)
0.0 2.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 1.8 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 0.7 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 ST_ADRENERGIC Adrenergic Pathway
0.0 1.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus