Motif ID: NHLH1
Z-value: 0.865

Transcription factors associated with NHLH1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NHLH1 | ENSG00000171786.5 | NHLH1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NHLH1 | hg19_v2_chr1_+_160336851_160336868 | 0.12 | 5.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 190 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 4.4 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.4 | 4.3 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
0.5 | 4.2 | GO:0071233 | cellular response to leucine(GO:0071233) |
0.1 | 3.4 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
0.0 | 3.1 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 2.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.2 | 2.6 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
0.2 | 2.4 | GO:0046541 | saliva secretion(GO:0046541) |
0.8 | 2.3 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
0.5 | 2.2 | GO:0048389 | intermediate mesoderm development(GO:0048389) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098) |
0.5 | 2.1 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
0.6 | 1.9 | GO:0035283 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
0.6 | 1.8 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
0.4 | 1.8 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
0.2 | 1.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.1 | 1.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.1 | 1.7 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.4 | 1.6 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
0.5 | 1.5 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
0.4 | 1.5 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 68 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 5.3 | GO:0005770 | late endosome(GO:0005770) |
0.7 | 4.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.1 | 2.4 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
0.0 | 2.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.2 | 2.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 1.8 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 1.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.1 | 1.6 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
0.0 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 1.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
0.0 | 1.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.1 | 1.4 | GO:0097386 | glial cell projection(GO:0097386) |
0.0 | 1.1 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 1.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.0 | 1.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 1.0 | GO:0097227 | sperm annulus(GO:0097227) |
0.0 | 1.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
0.0 | 1.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.0 | 0.9 | GO:0031932 | TORC2 complex(GO:0031932) |
0.1 | 0.8 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 124 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 4.0 | GO:0019003 | GDP binding(GO:0019003) |
0.0 | 3.2 | GO:0003924 | GTPase activity(GO:0003924) |
0.9 | 2.7 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
0.6 | 2.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
0.1 | 2.0 | GO:0015250 | water channel activity(GO:0015250) |
0.0 | 1.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.6 | 1.8 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
0.4 | 1.8 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
0.0 | 1.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 1.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 1.6 | GO:0070700 | co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700) |
0.1 | 1.6 | GO:0031957 | fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.3 | 1.4 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
0.1 | 1.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.1 | 1.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 1.1 | GO:0000049 | tRNA binding(GO:0000049) |
0.1 | 1.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 1.0 | GO:0048018 | receptor agonist activity(GO:0048018) |
0.0 | 1.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 1.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 23 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 7.0 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 4.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 2.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.1 | 2.3 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 2.0 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 1.9 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 1.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 1.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 1.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 1.1 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.0 | 0.9 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 0.8 | PID_VEGFR1_PATHWAY | VEGFR1 specific signals |
0.0 | 0.6 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
0.0 | 0.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 0.4 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
0.0 | 0.4 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.0 | 0.3 | PID_ALK2_PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 29 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.7 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.1 | 1.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.2 | 1.7 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 1.7 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.1 | 1.6 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 1.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.1 | 1.4 | REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT | Genes involved in Initial triggering of complement |
0.1 | 1.0 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 1.0 | REACTOME_MRNA_CAPPING | Genes involved in mRNA Capping |
0.0 | 0.8 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
0.0 | 0.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 0.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 0.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
0.1 | 0.6 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
0.0 | 0.6 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
0.0 | 0.6 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.0 | 0.6 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
0.0 | 0.5 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 0.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 0.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |