Motif ID: NHLH1

Z-value: 0.865


Transcription factors associated with NHLH1:

Gene SymbolEntrez IDGene Name
NHLH1 ENSG00000171786.5 NHLH1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH1hg19_v2_chr1_+_160336851_1603368680.125.6e-01Click!


Activity profile for motif NHLH1.

activity profile for motif NHLH1


Sorted Z-values histogram for motif NHLH1

Sorted Z-values for motif NHLH1



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_26625169 4.398 ENST00000319420.3
SHISA2
shisa family member 2
chr16_+_67465016 2.712 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr9_-_112970436 2.629 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr12_+_50355647 2.389 ENST00000293599.6
AQP5
aquaporin 5
chr2_-_7005785 2.271 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2


cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial


chr6_-_90121938 2.215 ENST00000369415.4
RRAGD
Ras-related GTP binding D
chr5_+_156693159 2.206 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_75858318 2.198 ENST00000307428.7
PARM1
prostate androgen-regulated mucin-like protein 1
chr11_+_61276214 2.175 ENST00000378075.2
LRRC10B
leucine rich repeat containing 10B
chr5_+_156693091 2.143 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2



cytoplasmic FMR1 interacting protein 2



chr7_-_131241361 2.126 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
PODXL



podocalyxin-like



chr13_+_35516390 2.076 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA


neurobeachin


chr6_-_90121789 2.019 ENST00000359203.3
RRAGD
Ras-related GTP binding D
chr4_+_75858290 1.948 ENST00000513238.1
PARM1
prostate androgen-regulated mucin-like protein 1
chr16_+_23847267 1.888 ENST00000321728.7
PRKCB
protein kinase C, beta
chr20_-_39317868 1.876 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr12_+_102091400 1.764 ENST00000229266.3
ENST00000549872.1
CHPT1

choline phosphotransferase 1

chr20_+_58179582 1.740 ENST00000371015.1
ENST00000395639.4
PHACTR3

phosphatase and actin regulator 3

chr2_+_85981008 1.712 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr14_-_65438865 1.631 ENST00000267512.5
RAB15
RAB15, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.4 4.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.5 4.2 GO:0071233 cellular response to leucine(GO:0071233)
0.1 3.4 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 3.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 2.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.6 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.2 2.4 GO:0046541 saliva secretion(GO:0046541)
0.8 2.3 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.5 2.2 GO:0048389 intermediate mesoderm development(GO:0048389) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098)
0.5 2.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 1.9 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.6 1.8 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.4 1.8 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.2 1.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 1.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 1.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.4 1.6 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.5 1.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.4 1.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0005770 late endosome(GO:0005770)
0.7 4.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 2.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 1.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.5 GO:0043202 lysosomal lumen(GO:0043202)
0.1 1.4 GO:0097386 glial cell projection(GO:0097386)
0.0 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.0 GO:0097227 sperm annulus(GO:0097227)
0.0 1.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0019003 GDP binding(GO:0019003)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.9 2.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.6 2.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 2.0 GO:0015250 water channel activity(GO:0015250)
0.0 1.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 1.8 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.4 1.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 1.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.6 GO:0070700 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.1 1.6 GO:0031957 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 1.4 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.1 GO:0000049 tRNA binding(GO:0000049)
0.1 1.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 4.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 2.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 1.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.0 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.0 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.0 0.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle