Motif ID: NFKB1
Z-value: 1.112

Transcription factors associated with NFKB1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NFKB1 | ENSG00000109320.7 | NFKB1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NFKB1 | hg19_v2_chr4_+_103423055_103423112 | 0.61 | 1.4e-03 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 139 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 9.6 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
0.1 | 8.7 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
0.1 | 7.5 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
1.5 | 7.4 | GO:0070842 | aggresome assembly(GO:0070842) |
0.4 | 6.0 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
0.0 | 5.6 | GO:0031295 | T cell costimulation(GO:0031295) |
1.4 | 5.4 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
0.5 | 5.4 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
0.5 | 4.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.3 | 4.6 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
1.3 | 3.8 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
1.1 | 3.4 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
0.8 | 3.2 | GO:0000255 | allantoin metabolic process(GO:0000255) |
0.1 | 3.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.2 | 2.9 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
0.1 | 2.9 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.1 | 2.8 | GO:0021670 | lateral ventricle development(GO:0021670) |
0.0 | 2.6 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
0.6 | 2.5 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
0.1 | 2.5 | GO:0006198 | cAMP catabolic process(GO:0006198) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 50 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 9.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
0.1 | 7.4 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 7.2 | GO:0005929 | cilium(GO:0005929) |
0.5 | 5.8 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.3 | 5.7 | GO:0042611 | MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613) |
0.5 | 5.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 4.6 | GO:0016363 | nuclear matrix(GO:0016363) |
0.1 | 3.8 | GO:0097542 | ciliary tip(GO:0097542) |
0.1 | 3.0 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.6 | 2.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
0.3 | 2.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.2 | 2.8 | GO:0060091 | kinocilium(GO:0060091) |
0.0 | 2.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
0.0 | 2.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
0.3 | 2.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
0.0 | 1.9 | GO:0060170 | ciliary membrane(GO:0060170) |
0.1 | 1.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.2 | 1.7 | GO:0043196 | varicosity(GO:0043196) |
0.2 | 1.7 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 94 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 13.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
1.9 | 9.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
0.3 | 7.0 | GO:0070628 | proteasome binding(GO:0070628) |
2.0 | 6.0 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
0.4 | 5.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
0.7 | 5.3 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
0.0 | 5.1 | GO:0004713 | protein tyrosine kinase activity(GO:0004713) |
0.3 | 4.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.1 | 4.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.6 | 3.9 | GO:0046979 | TAP2 binding(GO:0046979) |
0.1 | 3.7 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
0.0 | 3.6 | GO:0001047 | core promoter binding(GO:0001047) |
0.3 | 3.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
0.1 | 3.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.9 | 2.8 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
0.1 | 2.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.1 | 2.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
0.0 | 2.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.1 | 2.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.1 | 2.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 29 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 8.6 | PID_CD40_PATHWAY | CD40/CD40L signaling |
0.1 | 5.9 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.1 | 5.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 3.7 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
0.0 | 3.6 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
0.1 | 3.5 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
0.1 | 2.2 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.1 | 2.1 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 1.6 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.0 | 1.3 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
0.1 | 1.2 | PID_IL27_PATHWAY | IL27-mediated signaling events |
0.1 | 1.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
0.0 | 1.1 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 1.0 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 1.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.9 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 0.8 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
0.0 | 0.8 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 45 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 8.7 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
0.1 | 6.7 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
0.2 | 5.7 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.5 | 5.4 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.0 | 3.7 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.1 | 3.5 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
0.1 | 3.4 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
0.1 | 2.9 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
0.1 | 2.8 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 2.2 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.2 | 1.9 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
0.1 | 1.8 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 1.6 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 1.6 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.0 | 1.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 1.4 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
0.1 | 1.4 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
0.0 | 1.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.0 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 1.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |