Motif ID: NFKB1

Z-value: 1.112


Transcription factors associated with NFKB1:

Gene SymbolEntrez IDGene Name
NFKB1 ENSG00000109320.7 NFKB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v2_chr4_+_103423055_1034231120.611.4e-03Click!


Activity profile for motif NFKB1.

activity profile for motif NFKB1


Sorted Z-values histogram for motif NFKB1

Sorted Z-values for motif NFKB1



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_149792295 9.590 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr6_-_29527702 7.355 ENST00000377050.4
UBD
ubiquitin D
chr3_+_63638339 7.242 ENST00000343837.3
ENST00000469440.1
SNTN

sentan, cilia apical structure protein

chr16_+_67465016 6.010 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr16_-_66959429 5.426 ENST00000420652.1
ENST00000299759.6
RRAD

Ras-related associated with diabetes

chr5_-_54468974 5.304 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B




cell division cycle 20B




chr9_+_127615733 4.646 ENST00000373574.1
WDR38
WD repeat domain 38
chr6_+_32605195 3.453 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_45504688 3.408 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr6_+_135502466 3.380 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr17_+_40440481 3.233 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A



signal transducer and activator of transcription 5A



chr10_+_12391481 3.192 ENST00000378847.3
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr6_-_109762344 2.976 ENST00000521072.2
ENST00000424445.2
ENST00000440797.2
PPIL6


peptidylprolyl isomerase (cyclophilin)-like 6


chr6_+_32821924 2.761 ENST00000374859.2
ENST00000453265.2
PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr1_+_6845497 2.748 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr14_+_75536335 2.531 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C



zinc finger, C2HC-type containing 1C



chr19_+_10527449 2.512 ENST00000592685.1
ENST00000380702.2
PDE4A

phosphodiesterase 4A, cAMP-specific

chr14_+_75536280 2.415 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr6_+_32605134 2.243 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr1_+_6845578 2.039 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.6 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 8.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 7.5 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.5 7.4 GO:0070842 aggresome assembly(GO:0070842)
0.4 6.0 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 5.6 GO:0031295 T cell costimulation(GO:0031295)
1.4 5.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5 5.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.5 4.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.3 4.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.3 3.8 GO:1990108 protein linear deubiquitination(GO:1990108)
1.1 3.4 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.8 3.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 3.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 2.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 2.8 GO:0021670 lateral ventricle development(GO:0021670)
0.0 2.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.6 2.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 2.5 GO:0006198 cAMP catabolic process(GO:0006198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 7.4 GO:0016235 aggresome(GO:0016235)
0.0 7.2 GO:0005929 cilium(GO:0005929)
0.5 5.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 5.7 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
0.5 5.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 4.6 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.8 GO:0097542 ciliary tip(GO:0097542)
0.1 3.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.6 2.8 GO:0005879 axonemal microtubule(GO:0005879)
0.3 2.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 2.8 GO:0060091 kinocilium(GO:0060091)
0.0 2.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.3 2.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 1.9 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 1.7 GO:0043196 varicosity(GO:0043196)
0.2 1.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.9 9.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 7.0 GO:0070628 proteasome binding(GO:0070628)
2.0 6.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.4 5.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.7 5.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 5.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.3 4.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 4.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 3.9 GO:0046979 TAP2 binding(GO:0046979)
0.1 3.7 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 3.6 GO:0001047 core promoter binding(GO:0001047)
0.3 3.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 3.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.9 2.8 GO:0031862 prostanoid receptor binding(GO:0031862)
0.1 2.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 2.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 2.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 5.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 3.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 3.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 2.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.6 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.2 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 6.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 5.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 5.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 3.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 3.4 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 2.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 1.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 1.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.6 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.4 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane