Motif ID: NFIA

Z-value: 0.936


Transcription factors associated with NFIA:

Gene SymbolEntrez IDGene Name
NFIA ENSG00000162599.11 NFIA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIAhg19_v2_chr1_+_61869748_61869782-0.639.8e-04Click!


Activity profile for motif NFIA.

activity profile for motif NFIA


Sorted Z-values histogram for motif NFIA

Sorted Z-values for motif NFIA



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIA

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_41742697 4.594 ENST00000242208.4
INHBA
inhibin, beta A
chr2_-_31637560 4.207 ENST00000379416.3
XDH
xanthine dehydrogenase
chr13_-_20805109 2.828 ENST00000241124.6
GJB6
gap junction protein, beta 6, 30kDa
chr4_-_57547454 1.979 ENST00000556376.2
HOPX
HOP homeobox
chr4_-_57547870 1.974 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX



HOP homeobox



chr10_+_102106829 1.789 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_-_113542063 1.699 ENST00000263339.3
IL1A
interleukin 1, alpha
chrX_+_135251783 1.639 ENST00000394153.2
FHL1
four and a half LIM domains 1
chrX_+_135252050 1.567 ENST00000449474.1
ENST00000345434.3
FHL1

four and a half LIM domains 1

chr13_+_78109884 1.530 ENST00000377246.3
ENST00000349847.3
SCEL

sciellin

chr7_-_27135591 1.525 ENST00000343060.4
ENST00000355633.5
HOXA1

homeobox A1

chrX_+_135251835 1.499 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr13_+_78109804 1.466 ENST00000535157.1
SCEL
sciellin
chr5_+_135394840 1.462 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr19_+_41725088 1.439 ENST00000301178.4
AXL
AXL receptor tyrosine kinase
chr10_-_100995540 1.411 ENST00000370546.1
ENST00000404542.1
HPSE2

heparanase 2

chr21_-_44846999 1.363 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr15_+_67458357 1.314 ENST00000537194.2
SMAD3
SMAD family member 3
chr12_-_122238464 1.286 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr18_-_31802056 1.261 ENST00000538587.1
NOL4
nucleolar protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 4.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
1.5 4.6 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.1 4.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 4.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 2.9 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 2.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.6 2.5 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.3 2.4 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 2.4 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 2.4 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.3 2.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.7 2.1 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.4 2.0 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 1.9 GO:0002062 chondrocyte differentiation(GO:0002062)
0.6 1.8 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 1.8 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.0 1.8 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.3 1.7 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.0 1.7 GO:0060612 adipose tissue development(GO:0060612)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0001533 cornified envelope(GO:0001533)
1.5 4.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 3.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.8 GO:0005922 connexon complex(GO:0005922)
0.0 2.5 GO:0002102 podosome(GO:0002102)
0.0 2.4 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 2.2 GO:0035976 AP1 complex(GO:0035976)
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 2.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 2.0 GO:0033643 host cell part(GO:0033643)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0072686 mitotic spindle(GO:0072686)
0.3 1.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.0 GO:0031430 M band(GO:0031430)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.5 4.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.3 GO:0044325 ion channel binding(GO:0044325)
0.5 2.5 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.2 2.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 2.0 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 2.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 2.0 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.4 1.8 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.3 1.8 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 1.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.4 1.6 GO:0030305 heparanase activity(GO:0030305)
0.1 1.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 1.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 1.3 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.9 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 0.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 4.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 2.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 2.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 1.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE