Motif ID: NFE2L1

Z-value: 0.614


Transcription factors associated with NFE2L1:

Gene SymbolEntrez IDGene Name
NFE2L1 ENSG00000082641.11 NFE2L1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L1hg19_v2_chr17_+_46126135_46126152,
hg19_v2_chr17_+_46125707_46125746
0.481.6e-02Click!


Activity profile for motif NFE2L1.

activity profile for motif NFE2L1


Sorted Z-values histogram for motif NFE2L1

Sorted Z-values for motif NFE2L1



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_36019123 1.057 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN


suprabasin


chr2_-_113594279 1.050 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B


interleukin 1, beta


chr1_+_203651937 1.045 ENST00000341360.2
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr7_-_121944491 1.007 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr1_-_153113927 0.998 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr2_-_161056762 0.918 ENST00000428609.2
ENST00000409967.2
ITGB6

integrin, beta 6

chr11_-_125366089 0.907 ENST00000366139.3
ENST00000278919.3
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr12_-_91539918 0.776 ENST00000548218.1
DCN
decorin
chr19_+_35645618 0.768 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5






FXYD domain containing ion transport regulator 5






chr15_+_45406519 0.758 ENST00000323030.5
DUOXA2
dual oxidase maturation factor 2
chr2_-_161056802 0.747 ENST00000283249.2
ENST00000409872.1
ITGB6

integrin, beta 6

chr1_-_152131703 0.710 ENST00000316073.3
RPTN
repetin
chr6_+_74405501 0.605 ENST00000437994.2
ENST00000422508.2
CD109

CD109 molecule

chr16_+_8814563 0.583 ENST00000425191.2
ENST00000569156.1
ABAT

4-aminobutyrate aminotransferase

chr11_+_35201826 0.577 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr7_+_80275752 0.551 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr15_-_45406385 0.550 ENST00000389039.6
DUOX2
dual oxidase 2
chr4_+_74606223 0.530 ENST00000307407.3
ENST00000401931.1
IL8

interleukin 8

chr11_-_107729887 0.515 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr11_+_35198243 0.508 ENST00000528455.1
CD44
CD44 molecule (Indian blood group)
chr1_+_84630053 0.492 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr15_-_81616446 0.491 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr12_+_41086297 0.490 ENST00000551295.2
CNTN1
contactin 1
chr19_-_51538118 0.490 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr8_+_7738726 0.481 ENST00000314357.3
DEFB103A
defensin, beta 103A
chr11_-_82708519 0.480 ENST00000534301.1
RAB30
RAB30, member RAS oncogene family
chr19_-_51538148 0.466 ENST00000319590.4
ENST00000250351.4
KLK12

kallikrein-related peptidase 12

chr6_+_74405804 0.466 ENST00000287097.5
CD109
CD109 molecule
chr8_-_7287870 0.463 ENST00000318124.3
DEFB103B
defensin, beta 103B
chr1_+_192127578 0.459 ENST00000367460.3
RGS18
regulator of G-protein signaling 18
chr11_+_35211511 0.442 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr15_-_45406348 0.438 ENST00000603300.1
DUOX2
dual oxidase 2
chr3_-_47950745 0.437 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr9_-_128246769 0.434 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr7_-_41742697 0.419 ENST00000242208.4
INHBA
inhibin, beta A
chr17_+_42081914 0.417 ENST00000293404.3
ENST00000589767.1
NAGS

N-acetylglutamate synthase

chr11_+_35198118 0.407 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44



CD44 molecule (Indian blood group)



chr4_+_169013666 0.405 ENST00000359299.3
ANXA10
annexin A10
chr7_+_150811705 0.398 ENST00000335367.3
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_+_84630645 0.398 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_113735575 0.396 ENST00000376489.2
ENST00000259205.4
IL36G

interleukin 36, gamma

chr12_-_91572278 0.389 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
DCN



decorin



chr8_-_133123406 0.387 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr11_+_57308979 0.385 ENST00000457912.1
SMTNL1
smoothelin-like 1
chrX_+_135279179 0.384 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr12_+_22778291 0.379 ENST00000545979.1
ETNK1
ethanolamine kinase 1
chr12_-_54813229 0.378 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_-_64216748 0.377 ENST00000585162.1
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr8_+_10530133 0.372 ENST00000304519.5
C8orf74
chromosome 8 open reading frame 74
chr6_-_32145861 0.371 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr14_+_22977587 0.365 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr1_+_26605618 0.364 ENST00000270792.5
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr7_+_80275621 0.357 ENST00000426978.1
ENST00000432207.1
CD36

CD36 molecule (thrombospondin receptor)

chr12_-_52887034 0.352 ENST00000330722.6
KRT6A
keratin 6A
chrX_+_135278908 0.349 ENST00000539015.1
ENST00000370683.1
FHL1

four and a half LIM domains 1

chrX_+_99899180 0.341 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_123187890 0.339 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr8_+_104831472 0.326 ENST00000262231.10
ENST00000507740.1
RIMS2

regulating synaptic membrane exocytosis 2

chr17_+_40610862 0.326 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1








ATPase, H+ transporting, lysosomal V0 subunit a1








chr1_+_45265897 0.325 ENST00000372201.4
PLK3
polo-like kinase 3
chr6_-_29324054 0.324 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr11_+_35211429 0.324 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44


CD44 molecule (Indian blood group)


chr12_-_91576750 0.320 ENST00000228329.5
ENST00000303320.3
ENST00000052754.5
DCN


decorin


chr12_-_102874330 0.319 ENST00000307046.8
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_+_11200038 0.318 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR





low density lipoprotein receptor





chr12_-_95510743 0.317 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr11_+_117947724 0.312 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr2_+_228337079 0.310 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1


ArfGAP with FG repeats 1


chr4_+_144303093 0.309 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr19_+_15052301 0.300 ENST00000248072.3
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr10_+_5566916 0.299 ENST00000315238.1
CALML3
calmodulin-like 3
chr11_+_117063295 0.295 ENST00000525478.1
ENST00000532062.1
SIDT2

SID1 transmembrane family, member 2

chr12_-_102874102 0.294 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_-_123201337 0.291 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr9_+_139847347 0.288 ENST00000371632.3
LCN12
lipocalin 12
chr11_+_117947782 0.287 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4




transmembrane protease, serine 4




chr15_+_68582544 0.287 ENST00000566008.1
FEM1B
fem-1 homolog b (C. elegans)
chr12_+_21525818 0.278 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
IAPP


islet amyloid polypeptide


chr22_-_32651326 0.278 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr15_+_28624878 0.277 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr6_-_43595039 0.277 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr1_-_113258090 0.271 ENST00000309276.6
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr1_+_62439037 0.270 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr1_+_207038699 0.269 ENST00000367098.1
IL20
interleukin 20
chr2_-_29297127 0.267 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chr19_-_43383789 0.260 ENST00000595356.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr11_+_59522837 0.259 ENST00000437946.2
STX3
syntaxin 3
chr16_+_81348528 0.256 ENST00000568107.2
GAN
gigaxonin
chr12_-_91574142 0.256 ENST00000547937.1
DCN
decorin
chr21_-_33975547 0.256 ENST00000431599.1
C21orf59
chromosome 21 open reading frame 59
chr16_-_15180257 0.255 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr16_-_20364122 0.254 ENST00000396138.4
ENST00000577168.1
UMOD

uromodulin

chrX_+_70503037 0.250 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr18_+_34124507 0.246 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3
chr1_-_214638146 0.245 ENST00000543945.1
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr15_+_80215113 0.241 ENST00000560255.1
C15orf37
chromosome 15 open reading frame 37
chr1_+_28586006 0.240 ENST00000253063.3
SESN2
sestrin 2
chr1_+_64669294 0.240 ENST00000371077.5
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chrX_+_47078069 0.239 ENST00000357227.4
ENST00000519758.1
ENST00000520893.1
ENST00000517426.1
CDK16



cyclin-dependent kinase 16



chr10_+_81272287 0.236 ENST00000520547.2
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr3_+_52350335 0.236 ENST00000420323.2
DNAH1
dynein, axonemal, heavy chain 1
chr1_-_94312706 0.235 ENST00000370244.1
BCAR3
breast cancer anti-estrogen resistance 3
chr19_+_50706866 0.233 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14




myosin, heavy chain 14, non-muscle




chr1_+_46806452 0.232 ENST00000536062.1
NSUN4
NOP2/Sun domain family, member 4
chr19_+_11546153 0.230 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
PRKCSH


protein kinase C substrate 80K-H


chr2_-_89459813 0.227 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr14_+_79746249 0.227 ENST00000428277.2
NRXN3
neurexin 3
chr18_+_55888767 0.225 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr19_-_42192096 0.224 ENST00000602225.1
CEACAM7
carcinoembryonic antigen-related cell adhesion molecule 7
chr3_+_130650738 0.222 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_87808725 0.222 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr9_+_124103625 0.222 ENST00000594963.1
AL161784.1
Uncharacterized protein
chr2_+_87754887 0.221 ENST00000409054.1
ENST00000331944.6
ENST00000409139.1
LINC00152


long intergenic non-protein coding RNA 152


chr11_-_7847519 0.220 ENST00000328375.1
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr6_+_117586713 0.219 ENST00000352536.3
ENST00000326274.5
VGLL2

vestigial like 2 (Drosophila)

chr3_-_47934234 0.218 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr2_-_70781087 0.216 ENST00000394241.3
ENST00000295400.6
TGFA

transforming growth factor, alpha

chr17_+_26662597 0.214 ENST00000544907.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr17_+_73663470 0.213 ENST00000583536.1
SAP30BP
SAP30 binding protein
chr8_-_93029865 0.211 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_48814278 0.210 ENST00000455452.1
OTUD5
OTU domain containing 5
chr19_+_11546093 0.210 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H
chrX_-_49965663 0.210 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4


A kinase (PRKA) anchor protein 4


chr14_+_68189190 0.209 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr6_-_29395509 0.209 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr2_+_87755054 0.206 ENST00000423846.1
LINC00152
long intergenic non-protein coding RNA 152
chr16_-_20364030 0.205 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD






uromodulin






chr11_-_6817128 0.204 ENST00000332601.3
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr12_-_91573132 0.204 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chr2_+_201994208 0.203 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr14_+_22615942 0.203 ENST00000390457.2
TRAV27
T cell receptor alpha variable 27
chrX_-_48814810 0.202 ENST00000376488.3
ENST00000396743.3
ENST00000156084.4
OTUD5


OTU domain containing 5


chr1_+_207039154 0.200 ENST00000367096.3
ENST00000391930.2
IL20

interleukin 20

chr20_+_43992094 0.200 ENST00000453003.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chrX_+_107069063 0.200 ENST00000262843.6
MID2
midline 2
chr9_+_125281420 0.198 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr6_-_137494775 0.197 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
IL22RA2


interleukin 22 receptor, alpha 2


chr16_-_20681177 0.197 ENST00000524149.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr1_+_74701062 0.196 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr1_-_156265438 0.194 ENST00000362007.1
C1orf85
chromosome 1 open reading frame 85
chr12_-_10324716 0.193 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1



oxidized low density lipoprotein (lectin-like) receptor 1



chr4_+_3344141 0.192 ENST00000306648.7
RGS12
regulator of G-protein signaling 12
chr8_-_93029520 0.191 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_+_22853345 0.189 ENST00000522948.1
RHOBTB2
Rho-related BTB domain containing 2
chr14_+_67291158 0.189 ENST00000555456.1
GPHN
gephyrin
chr1_-_11865982 0.188 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_112630598 0.186 ENST00000302475.4
MCC
mutated in colorectal cancers
chr17_+_26662730 0.185 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr2_+_190306159 0.185 ENST00000314761.4
WDR75
WD repeat domain 75
chr1_-_6445809 0.184 ENST00000377855.2
ACOT7
acyl-CoA thioesterase 7
chr6_-_49604545 0.184 ENST00000371175.4
ENST00000229810.7
RHAG

Rh-associated glycoprotein

chr19_-_42192189 0.184 ENST00000401731.1
ENST00000338196.4
ENST00000006724.3
CEACAM7


carcinoembryonic antigen-related cell adhesion molecule 7


chr3_-_98241358 0.182 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1



claudin domain containing 1



chr2_+_242167319 0.182 ENST00000601871.1
AC104841.2
HCG1777198, isoform CRA_a; PRO2900; Uncharacterized protein
chr7_-_107443652 0.181 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
SLC26A3


solute carrier family 26 (anion exchanger), member 3


chr10_-_115904361 0.181 ENST00000428953.1
ENST00000543782.1
C10orf118

chromosome 10 open reading frame 118

chr2_-_89545079 0.181 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr2_+_87754989 0.181 ENST00000409898.2
ENST00000419680.2
ENST00000414584.1
ENST00000455131.1
LINC00152



long intergenic non-protein coding RNA 152



chr6_-_41130914 0.180 ENST00000373113.3
ENST00000338469.3
TREM2

triggering receptor expressed on myeloid cells 2

chr12_-_7596735 0.180 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1


CD163 molecule-like 1


chr6_+_132455118 0.179 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr11_+_126139005 0.178 ENST00000263578.5
ENST00000442061.2
ENST00000532125.1
FOXRED1


FAD-dependent oxidoreductase domain containing 1


chr2_+_234602305 0.178 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_-_119682812 0.178 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr16_+_3068393 0.177 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chrX_+_53123314 0.177 ENST00000605526.1
ENST00000604062.1
ENST00000604369.1
ENST00000366185.2
ENST00000604849.1
RP11-258C19.5




long intergenic non-protein coding RNA 1155




chr16_+_72090053 0.176 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
HP


haptoglobin


chr6_+_160183492 0.176 ENST00000541436.1
ACAT2
acetyl-CoA acetyltransferase 2
chr6_-_131321863 0.175 ENST00000528282.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr6_-_52109335 0.175 ENST00000336123.4
IL17F
interleukin 17F
chr6_+_63921399 0.174 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr2_+_201994042 0.173 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_-_31661000 0.173 ENST00000263693.1
ENST00000398657.2
ENST00000526106.1
NKAIN1


Na+/K+ transporting ATPase interacting 1


chr6_+_63921351 0.173 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr1_-_39395165 0.172 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr9_+_130213774 0.172 ENST00000373324.4
ENST00000323301.4
LRSAM1

leucine rich repeat and sterile alpha motif containing 1

chr22_+_38142235 0.172 ENST00000407319.2
ENST00000403663.2
ENST00000428075.1
TRIOBP


TRIO and F-actin binding protein


chr3_-_105588231 0.171 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr9_+_27524283 0.171 ENST00000276943.2
IFNK
interferon, kappa
chrX_+_47077632 0.171 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr2_-_65593784 0.170 ENST00000443619.2
SPRED2
sprouty-related, EVH1 domain containing 2
chr12_+_72080253 0.168 ENST00000549735.1
TMEM19
transmembrane protein 19
chr2_+_27301435 0.167 ENST00000380320.4
EMILIN1
elastin microfibril interfacer 1
chr16_+_2286726 0.166 ENST00000382437.4
ENST00000569184.1
DNASE1L2

deoxyribonuclease I-like 2

chr1_-_204135450 0.165 ENST00000272190.8
ENST00000367195.2
REN

renin

chr5_+_33440802 0.162 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS


threonyl-tRNA synthetase


chr3_+_124303539 0.159 ENST00000428018.2
KALRN
kalirin, RhoGEF kinase
chr14_+_22356029 0.158 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr2_+_234160340 0.158 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1


autophagy related 16-like 1 (S. cerevisiae)


chr12_+_100041527 0.157 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr8_+_21823726 0.157 ENST00000433566.4
XPO7
exportin 7
chr20_+_60174827 0.157 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr11_+_85339623 0.156 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B



transmembrane protein 126B



chr19_-_35992780 0.156 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN


dermokine


chr3_-_16306432 0.156 ENST00000383775.4
ENST00000488423.1
DPH3

diphthamide biosynthesis 3

chr20_-_43150601 0.154 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3


serine incorporator 3


chr2_+_114163945 0.154 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr6_+_31939608 0.154 ENST00000375331.2
ENST00000375333.2
STK19

serine/threonine kinase 19

chr22_+_32439019 0.152 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr2_-_220119280 0.152 ENST00000392088.2
TUBA4A
tubulin, alpha 4a

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.3 1.0 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.3 2.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.0 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.2 0.6 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.2 0.2 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.2 1.1 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.2 0.9 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.6 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.4 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.9 GO:0097338 response to clozapine(GO:0097338)
0.1 1.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.6 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.3 GO:0007113 endomitotic cell cycle(GO:0007113) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.8 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.1 0.5 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.4 GO:0001897 cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
0.1 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.1 0.9 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.3 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.1 0.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.3 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 0.2 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 0.2 GO:0072579 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.1 0.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.3 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.2 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.2 GO:0032499 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.1 0.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1 0.2 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.4 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.3 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.2 GO:0030047 actin modification(GO:0030047)
0.0 0.5 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.2 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.2 GO:0003335 corneocyte development(GO:0003335)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.4 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.3 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.1 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.2 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.1 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.1 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.3 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.1 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) transformation of host cell by virus(GO:0019087) uracil metabolic process(GO:0019860) intestinal epithelial cell maturation(GO:0060574)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.5 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.1 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 2.6 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0036159 inner dynein arm assembly(GO:0036159) cilium movement involved in cell motility(GO:0060294)
0.0 0.1 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of ribonucleoprotein complex localization(GO:2000197)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.0 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.7 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.4 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.0 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.4 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.0 GO:1901804 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.0 0.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0098502 DNA dephosphorylation(GO:0098502)
0.0 0.1 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.3 2.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.6 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 1.9 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.3 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.6 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 0.4 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.1 2.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0098590 plasma membrane region(GO:0098590)
0.0 0.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 1.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.0 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.2 0.5 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.2 0.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.6 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.1 1.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.2 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.2 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.4 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 1.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.5 GO:0032052 bile acid binding(GO:0032052)
0.0 0.5 GO:0019864 IgG binding(GO:0019864)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 2.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0008859 exoribonuclease II activity(GO:0008859)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.0 1.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.0 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.0 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation