Motif ID: NFAT5
Z-value: 0.753
Transcription factors associated with NFAT5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NFAT5 | ENSG00000102908.16 | NFAT5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NFAT5 | hg19_v2_chr16_+_69600058_69600111, hg19_v2_chr16_+_69599861_69599887 | 0.53 | 8.2e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 5.7 | GO:1901318 | negative regulation of sperm motility(GO:1901318) |
0.2 | 1.0 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
0.2 | 2.5 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
0.2 | 0.8 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
0.2 | 0.5 | GO:1901297 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
0.2 | 0.5 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
0.2 | 0.5 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
0.2 | 1.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
0.1 | 1.5 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.1 | 0.7 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.1 | 0.8 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
0.1 | 0.3 | GO:0000103 | sulfate assimilation(GO:0000103) |
0.1 | 0.3 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.1 | 3.8 | GO:0010107 | potassium ion import(GO:0010107) |
0.1 | 0.2 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
0.1 | 0.7 | GO:0070294 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
0.1 | 3.9 | GO:0006536 | glutamate metabolic process(GO:0006536) |
0.1 | 2.9 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.1 | 1.0 | GO:0002829 | negative regulation of type 2 immune response(GO:0002829) |
0.1 | 0.3 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
0.1 | 0.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.1 | 0.3 | GO:0018094 | protein polyglycylation(GO:0018094) |
0.1 | 0.9 | GO:0051601 | exocyst localization(GO:0051601) |
0.1 | 0.8 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.1 | 0.2 | GO:0070428 | B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) negative regulation of osteoclast proliferation(GO:0090291) |
0.0 | 1.3 | GO:0006590 | thyroid hormone generation(GO:0006590) |
0.0 | 0.3 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
0.0 | 0.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
0.0 | 0.2 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.0 | 0.2 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
0.0 | 0.1 | GO:0021592 | midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) |
0.0 | 0.2 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
0.0 | 0.2 | GO:0021564 | vagus nerve development(GO:0021564) |
0.0 | 0.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
0.0 | 0.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.0 | 0.3 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.4 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
0.0 | 0.3 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
0.0 | 0.1 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
0.0 | 0.1 | GO:2001171 | positive regulation of ATP biosynthetic process(GO:2001171) |
0.0 | 0.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
0.0 | 0.3 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.0 | 0.4 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.0 | 0.8 | GO:0048286 | lung alveolus development(GO:0048286) |
0.0 | 1.0 | GO:0045646 | regulation of erythrocyte differentiation(GO:0045646) |
0.0 | 0.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.0 | 0.2 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
0.0 | 0.1 | GO:0072396 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
0.0 | 0.1 | GO:0060215 | primitive hemopoiesis(GO:0060215) regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.0 | 0.5 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
0.0 | 1.3 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
0.0 | 0.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.0 | 0.1 | GO:1904685 | positive regulation of metalloendopeptidase activity(GO:1904685) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 5.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.1 | 0.5 | GO:0035339 | SPOTS complex(GO:0035339) |
0.1 | 0.5 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
0.1 | 0.8 | GO:0005579 | membrane attack complex(GO:0005579) |
0.1 | 4.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.1 | 0.2 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
0.0 | 0.1 | GO:0043159 | cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159) |
0.0 | 0.7 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
0.0 | 5.5 | GO:0036064 | ciliary basal body(GO:0036064) |
0.0 | 0.3 | GO:0005955 | calcineurin complex(GO:0005955) |
0.0 | 0.5 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.9 | GO:0000145 | exocyst(GO:0000145) |
0.0 | 0.3 | GO:0036157 | outer dynein arm(GO:0036157) |
0.0 | 0.5 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
0.0 | 3.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.9 | GO:0097546 | ciliary base(GO:0097546) |
0.0 | 0.1 | GO:0043293 | apoptosome(GO:0043293) |
0.0 | 0.3 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
0.0 | 0.2 | GO:0071438 | intercellular canaliculus(GO:0046581) invadopodium membrane(GO:0071438) |
0.0 | 1.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
0.0 | 0.1 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 0.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.0 | 0.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.9 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
0.5 | 1.5 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.5 | 2.9 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
0.2 | 0.7 | GO:0035034 | histone acetyltransferase regulator activity(GO:0035034) |
0.2 | 1.3 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
0.2 | 3.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 5.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 0.3 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
0.1 | 1.0 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
0.1 | 0.3 | GO:0097363 | protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363) |
0.1 | 1.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.1 | 0.2 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
0.1 | 0.4 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.1 | 2.5 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
0.1 | 0.3 | GO:0004925 | prolactin receptor activity(GO:0004925) |
0.1 | 0.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.1 | 0.5 | GO:0000150 | recombinase activity(GO:0000150) |
0.1 | 0.3 | GO:0070735 | protein-glycine ligase activity(GO:0070735) |
0.0 | 0.4 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
0.0 | 0.8 | GO:0003796 | lysozyme activity(GO:0003796) |
0.0 | 0.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
0.0 | 5.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 1.0 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
0.0 | 0.2 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
0.0 | 0.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.3 | GO:0030274 | LIM domain binding(GO:0030274) |
0.0 | 0.7 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
0.0 | 0.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.5 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
0.0 | 1.5 | GO:0004177 | aminopeptidase activity(GO:0004177) |
0.0 | 0.3 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
0.0 | 0.5 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.0 | 2.2 | GO:0032947 | protein complex scaffold(GO:0032947) |
0.0 | 0.3 | GO:0030957 | Tat protein binding(GO:0030957) |
0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
0.0 | 0.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.0 | 0.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.0 | 0.3 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
0.0 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.0 | 0.1 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
0.0 | 0.4 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 0.3 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.5 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
0.0 | 1.5 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.0 | 1.0 | PID_IL27_PATHWAY | IL27-mediated signaling events |
0.0 | 2.0 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 1.5 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.0 | 0.7 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
0.0 | 0.5 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.1 | 3.8 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.1 | 2.9 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.1 | 1.3 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 1.5 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
0.0 | 0.5 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.0 | 1.5 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
0.0 | 0.4 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
0.0 | 0.4 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.0 | 1.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.2 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 0.5 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.0 | 0.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 1.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.0 | 0.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |