Motif ID: NFAT5

Z-value: 0.753


Transcription factors associated with NFAT5:

Gene SymbolEntrez IDGene Name
NFAT5 ENSG00000102908.16 NFAT5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFAT5hg19_v2_chr16_+_69600058_69600111,
hg19_v2_chr16_+_69599861_69599887
0.538.2e-03Click!


Activity profile for motif NFAT5.

activity profile for motif NFAT5


Sorted Z-values histogram for motif NFAT5

Sorted Z-values for motif NFAT5



Network of associatons between targets according to the STRING database.



First level regulatory network of NFAT5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_24765248 2.874 ENST00000580774.1
ENST00000284224.8
CHST9

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

chr1_+_111888890 2.771 ENST00000369738.4
PIFO
primary cilia formation
chr1_+_111889212 2.693 ENST00000369737.4
PIFO
primary cilia formation
chr9_-_80263220 2.493 ENST00000341700.6
GNA14
guanine nucleotide binding protein (G protein), alpha 14
chr20_-_44176060 2.342 ENST00000354280.4
ENST00000504988.1
EPPIN
EPPIN-WFDC6
epididymal peptidase inhibitor
EPPIN-WFDC6 readthrough
chr20_-_44176391 2.119 ENST00000409554.1
EPPIN
epididymal peptidase inhibitor
chr17_+_68071458 1.931 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 1.916 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_+_45908974 1.860 ENST00000269025.4
LRRC46
leucine rich repeat containing 46
chr1_-_60539405 1.643 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 1.617 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr5_+_156712372 1.530 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr8_-_133772794 1.410 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71




transmembrane protein 71




chr1_+_54359854 1.344 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1





deiodinase, iodothyronine, type I





chr16_+_2079637 1.262 ENST00000561844.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr20_-_44176013 1.232 ENST00000555685.1
EPPIN
epididymal peptidase inhibitor
chr12_+_69742121 1.232 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ


lysozyme


chr12_+_119772502 1.196 ENST00000536742.1
ENST00000327554.2
CCDC60

coiled-coil domain containing 60

chr5_+_140186647 1.191 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4


protocadherin alpha 4


chr3_+_49027308 1.006 ENST00000383729.4
ENST00000343546.4
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr12_-_55375622 0.983 ENST00000316577.8
TESPA1
thymocyte expressed, positive selection associated 1
chr19_+_14142535 0.958 ENST00000263379.2
IL27RA
interleukin 27 receptor, alpha
chr14_+_91580777 0.953 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
C14orf159


chromosome 14 open reading frame 159


chr14_+_91580708 0.951 ENST00000518868.1
C14orf159
chromosome 14 open reading frame 159
chr4_-_83483395 0.951 ENST00000515780.2
TMEM150C
transmembrane protein 150C
chr16_+_2079501 0.949 ENST00000563587.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr14_+_91581011 0.937 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
C14orf159


chromosome 14 open reading frame 159


chr11_-_75062829 0.930 ENST00000393505.4
ARRB1
arrestin, beta 1
chr14_-_102706934 0.881 ENST00000523231.1
ENST00000524370.1
ENST00000517966.1
MOK


MOK protein kinase


chr14_+_100848311 0.869 ENST00000542471.2
WDR25
WD repeat domain 25
chr7_-_47579188 0.835 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3



tensin 3



chr5_-_41261540 0.819 ENST00000263413.3
C6
complement component 6
chr4_+_17579110 0.817 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr13_-_24463530 0.809 ENST00000382172.3
MIPEP
mitochondrial intermediate peptidase
chr5_+_140261703 0.808 ENST00000409494.1
ENST00000289272.2
PCDHA13

protocadherin alpha 13

chr1_-_57045228 0.790 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_95975672 0.758 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1

RP11-286B14.1

chr6_+_153552455 0.726 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr6_-_134495992 0.680 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1


serum/glucocorticoid regulated kinase 1


chr8_-_27469196 0.652 ENST00000546343.1
ENST00000560566.1
CLU

clusterin

chr19_+_859425 0.634 ENST00000327726.6
CFD
complement factor D (adipsin)
chr4_+_74718906 0.633 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr18_-_52989525 0.625 ENST00000457482.3
TCF4
transcription factor 4
chr15_+_45028753 0.599 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr11_-_75062730 0.572 ENST00000420843.2
ENST00000360025.3
ARRB1

arrestin, beta 1

chr2_+_56179262 0.557 ENST00000606639.1
RP11-481J13.1
RP11-481J13.1
chr14_+_91580732 0.557 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
C14orf159


chromosome 14 open reading frame 159


chr14_+_103589789 0.545 ENST00000558056.1
ENST00000560869.1
TNFAIP2

tumor necrosis factor, alpha-induced protein 2

chr9_-_13175823 0.542 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr9_+_139921916 0.541 ENST00000314330.2
C9orf139
chromosome 9 open reading frame 139
chr3_+_69812877 0.537 ENST00000457080.1
ENST00000328528.6
MITF

microphthalmia-associated transcription factor

chr16_+_30968615 0.535 ENST00000262519.8
SETD1A
SET domain containing 1A
chr2_-_20101385 0.535 ENST00000431392.1
TTC32
tetratricopeptide repeat domain 32
chr4_+_17578815 0.530 ENST00000226299.4
LAP3
leucine aminopeptidase 3
chr14_+_95078714 0.528 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3


chr11_+_103907308 0.507 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr14_+_91580357 0.484 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
C14orf159









chromosome 14 open reading frame 159









chr9_-_124989804 0.470 ENST00000373755.2
ENST00000373754.2
LHX6

LIM homeobox 6

chr17_-_38083843 0.461 ENST00000304046.2
ENST00000579695.1
ORMDL3

ORM1-like 3 (S. cerevisiae)

chr1_-_145470383 0.456 ENST00000369314.1
ENST00000369313.3
POLR3GL

polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like

chr12_-_323689 0.446 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr1_-_246670519 0.438 ENST00000388985.4
ENST00000490107.1
SMYD3

SET and MYND domain containing 3

chr3_-_42003479 0.435 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr15_+_45028520 0.429 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr15_+_45028719 0.423 ENST00000560442.1
ENST00000558329.1
ENST00000561043.1
TRIM69


tripartite motif containing 69


chr17_+_32646055 0.406 ENST00000394620.1
CCL8
chemokine (C-C motif) ligand 8
chr15_+_49170281 0.401 ENST00000560490.1
EID1
EP300 interacting inhibitor of differentiation 1
chr1_+_1115056 0.395 ENST00000379288.3
TTLL10
tubulin tyrosine ligase-like family, member 10
chr14_-_25479811 0.375 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr22_-_44208070 0.371 ENST00000396231.2
EFCAB6
EF-hand calcium binding domain 6
chr18_-_52989217 0.363 ENST00000570287.2
TCF4
transcription factor 4
chr2_+_198570081 0.351 ENST00000282276.6
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr10_+_89419370 0.349 ENST00000361175.4
ENST00000456849.1
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr3_+_8543533 0.340 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr17_-_202579 0.339 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL


rabphilin 3A-like (without C2 domains)


chrX_+_70752917 0.338 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_-_9834375 0.334 ENST00000343450.2
ENST00000301964.2
TADA3

transcriptional adaptor 3

chr10_+_111967345 0.304 ENST00000332674.5
ENST00000453116.1
MXI1

MAX interactor 1, dimerization protein

chr1_-_85870177 0.303 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr15_+_49170083 0.300 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr12_+_10365404 0.293 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1





GABA(A) receptor-associated protein like 1





chr20_+_33104199 0.288 ENST00000357156.2
ENST00000417166.2
ENST00000300469.9
ENST00000374846.3
DYNLRB1



dynein, light chain, roadblock-type 1



chr3_+_185000729 0.286 ENST00000448876.1
ENST00000446828.1
ENST00000447637.1
ENST00000424227.1
ENST00000454237.1
MAP3K13




mitogen-activated protein kinase kinase kinase 13




chr5_-_35230434 0.279 ENST00000504500.1
PRLR
prolactin receptor
chr15_+_43885252 0.274 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr4_+_26322185 0.274 ENST00000361572.6
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr2_-_68479614 0.270 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr19_+_15852203 0.267 ENST00000305892.1
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr7_-_92157760 0.265 ENST00000248633.4
PEX1
peroxisomal biogenesis factor 1
chr3_+_63805017 0.255 ENST00000295896.8
C3orf49
chromosome 3 open reading frame 49
chr3_+_120461484 0.252 ENST00000484715.1
ENST00000469772.1
ENST00000283875.5
ENST00000492959.1
GTF2E1



general transcription factor IIE, polypeptide 1, alpha 56kDa



chr7_-_92157747 0.250 ENST00000428214.1
ENST00000438045.1
PEX1

peroxisomal biogenesis factor 1

chr4_+_26322409 0.248 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
RBPJ



recombination signal binding protein for immunoglobulin kappa J region



chr15_+_43985084 0.234 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr10_-_118928543 0.234 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr7_+_65670186 0.228 ENST00000304842.5
ENST00000442120.1
TPST1

tyrosylprotein sulfotransferase 1

chr12_+_53848505 0.227 ENST00000552819.1
ENST00000455667.3
PCBP2

poly(rC) binding protein 2

chr12_+_120502441 0.222 ENST00000446727.2
CCDC64
coiled-coil domain containing 64
chr17_+_40950797 0.215 ENST00000588408.1
ENST00000585355.1
CNTD1

cyclin N-terminal domain containing 1

chr7_-_92855762 0.212 ENST00000453812.2
ENST00000394468.2
HEPACAM2

HEPACAM family member 2

chr15_+_43985725 0.202 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr3_-_49131013 0.198 ENST00000424300.1
QRICH1
glutamine-rich 1
chr11_+_65190245 0.194 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1


nuclear paraspeckle assembly transcript 1 (non-protein coding)


chr2_-_162931052 0.183 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr13_-_67804445 0.183 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
PCDH9


protocadherin 9


chr17_-_15466742 0.178 ENST00000584811.1
ENST00000419890.2
TVP23C

trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)

chr9_-_14314518 0.172 ENST00000397581.2
NFIB
nuclear factor I/B
chr17_-_15466850 0.169 ENST00000438826.3
ENST00000225576.3
ENST00000519970.1
ENST00000518321.1
ENST00000428082.2
ENST00000522212.2
TVP23C




TVP23C-CDRT4
trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)




TVP23C-CDRT4 readthrough
chr7_+_149570049 0.167 ENST00000421974.2
ENST00000456496.2
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr13_+_45694583 0.164 ENST00000340473.6
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr16_+_68573116 0.162 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
ZFP90




ZFP90 zinc finger protein




chr11_+_22696314 0.161 ENST00000532398.1
ENST00000433790.1
GAS2

growth arrest-specific 2

chr3_+_47866490 0.156 ENST00000457607.1
DHX30
DEAH (Asp-Glu-Ala-His) box helicase 30
chr6_+_138188551 0.152 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr16_-_51185172 0.151 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chr7_+_95401851 0.146 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr17_+_40950900 0.146 ENST00000588527.1
CNTD1
cyclin N-terminal domain containing 1
chr16_-_75498553 0.145 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A



RP11-77K12.1
transmembrane protein 170A



Uncharacterized protein
chr12_-_122018859 0.142 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B


lysine (K)-specific demethylase 2B


chrX_+_83116142 0.138 ENST00000329312.4
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr7_+_95401877 0.132 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1





dynein, cytoplasmic 1, intermediate chain 1





chr9_-_6015607 0.130 ENST00000259569.5
RANBP6
RAN binding protein 6
chr11_+_19798964 0.127 ENST00000527559.2
NAV2
neuron navigator 2
chr15_-_102285007 0.126 ENST00000560292.2
RP11-89K11.1
Uncharacterized protein
chr8_+_96037205 0.123 ENST00000396124.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chrX_-_45060135 0.121 ENST00000398000.2
ENST00000377934.4
CXorf36

chromosome X open reading frame 36

chr3_-_44552094 0.119 ENST00000436261.1
ZNF852
zinc finger protein 852
chr22_+_24551765 0.115 ENST00000337989.7
CABIN1
calcineurin binding protein 1
chr11_+_19799327 0.111 ENST00000540292.1
NAV2
neuron navigator 2
chr12_-_11214893 0.108 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chrX_+_12993202 0.107 ENST00000451311.2
ENST00000380636.1
TMSB4X

thymosin beta 4, X-linked

chr16_-_67514982 0.096 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1


ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1


chr1_+_36789335 0.094 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr6_+_109416684 0.090 ENST00000521522.1
ENST00000524064.1
ENST00000522608.1
ENST00000521503.1
ENST00000519407.1
ENST00000519095.1
ENST00000368968.2
ENST00000522490.1
ENST00000523209.1
ENST00000368970.2
ENST00000520883.1
ENST00000523787.1
CEP57L1











centrosomal protein 57kDa-like 1











chr6_+_89790459 0.088 ENST00000369472.1
PNRC1
proline-rich nuclear receptor coactivator 1
chr12_+_99038998 0.084 ENST00000359972.2
ENST00000357310.1
ENST00000339433.3
ENST00000333991.1
APAF1



apoptotic peptidase activating factor 1



chr1_+_18958008 0.080 ENST00000420770.2
ENST00000400661.3
PAX7

paired box 7

chr22_-_38380543 0.079 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr15_+_100348193 0.076 ENST00000558188.1
CTD-2054N24.2
Uncharacterized protein
chr1_+_34632484 0.075 ENST00000373374.3
C1orf94
chromosome 1 open reading frame 94
chr17_+_18684563 0.075 ENST00000476139.1
TVP23B
trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
chr5_-_137090028 0.073 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr2_+_47799601 0.069 ENST00000601243.1
AC138655.1
CDNA: FLJ23120 fis, clone LNG07989; HCG1987724; Uncharacterized protein
chr10_-_135122603 0.066 ENST00000368563.2
TUBGCP2
tubulin, gamma complex associated protein 2
chr20_-_23807358 0.064 ENST00000304725.2
CST2
cystatin SA
chr3_-_156878540 0.062 ENST00000461804.1
CCNL1
cyclin L1
chr8_-_99954788 0.057 ENST00000523601.1
STK3
serine/threonine kinase 3
chr5_-_35230771 0.055 ENST00000342362.5
PRLR
prolactin receptor
chr12_+_69139886 0.054 ENST00000398004.2
SLC35E3
solute carrier family 35, member E3
chr3_-_149293990 0.053 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr4_-_76861392 0.052 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr7_-_102119342 0.050 ENST00000393794.3
ENST00000292614.5
POLR2J

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

chr1_-_36945097 0.050 ENST00000331941.5
ENST00000418048.2
ENST00000338937.5
ENST00000440588.2
CSF3R



colony stimulating factor 3 receptor (granulocyte)



chr18_-_74839891 0.050 ENST00000581878.1
MBP
myelin basic protein
chrX_+_18725758 0.043 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr6_+_44094627 0.039 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr12_-_75603482 0.035 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr12_-_75603643 0.029 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr4_+_122685691 0.029 ENST00000424958.1
AC079341.1
Uncharacterized protein
chr3_+_77088989 0.028 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr11_+_56949221 0.026 ENST00000497933.1
LRRC55
leucine rich repeat containing 55
chr6_+_160327974 0.024 ENST00000252660.4
MAS1
MAS1 oncogene
chr14_+_97059070 0.022 ENST00000553378.1
ENST00000555496.1
RP11-433J8.1

RP11-433J8.1

chr7_-_19184929 0.020 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr13_-_50265570 0.018 ENST00000378270.5
ENST00000378284.2
ENST00000378272.5
ENST00000378268.1
ENST00000242827.6
ENST00000378282.5
EBPL





emopamil binding protein-like





chr19_-_46285736 0.011 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK


dystrophia myotonica-protein kinase


chr7_-_100888313 0.011 ENST00000442303.1
FIS1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr5_-_133747589 0.010 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr8_+_96037255 0.009 ENST00000286687.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chrX_+_48755183 0.004 ENST00000376563.1
ENST00000376566.4
PQBP1

polyglutamine binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.7 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.2 1.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.2 2.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2 0.8 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 0.5 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2 0.5 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 0.5 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.2 1.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 1.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.8 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 3.8 GO:0010107 potassium ion import(GO:0010107)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.7 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 3.9 GO:0006536 glutamate metabolic process(GO:0006536)
0.1 2.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 1.0 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.1 0.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.1 0.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.2 GO:0070428 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) negative regulation of osteoclast proliferation(GO:0090291)
0.0 1.3 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.4 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.2 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.3 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:2001171 positive regulation of ATP biosynthetic process(GO:2001171)
0.0 0.5 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.8 GO:0048286 lung alveolus development(GO:0048286)
0.0 1.0 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0 0.1 GO:0060215 primitive hemopoiesis(GO:0060215) regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 4.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0043159 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.0 0.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 5.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0071438 intercellular canaliculus(GO:0046581) invadopodium membrane(GO:0071438)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.5 1.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.5 2.9 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.2 0.7 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.2 1.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 3.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 5.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.3 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 1.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.3 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 2.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.5 GO:0000150 recombinase activity(GO:0000150)
0.1 0.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 5.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.4 GO:0008009 chemokine activity(GO:0008009)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.0 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 2.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.9 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation