Motif ID: MYF6

Z-value: 0.937


Transcription factors associated with MYF6:

Gene SymbolEntrez IDGene Name
MYF6 ENSG00000111046.3 MYF6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MYF6hg19_v2_chr12_+_81101277_811013210.377.9e-02Click!


Activity profile for motif MYF6.

activity profile for motif MYF6


Sorted Z-values histogram for motif MYF6

Sorted Z-values for motif MYF6



Network of associatons between targets according to the STRING database.



First level regulatory network of MYF6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39274606 2.660 ENST00000391413.2
 KRTAP4-11
keratin associated protein 4-11
chr17_-_39306054 2.102 ENST00000343246.4
 KRTAP4-5
keratin associated protein 4-5
chr19_-_51504411 1.967 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr17_-_39324424 1.933 ENST00000391356.2
 KRTAP4-3
keratin associated protein 4-3
chrX_-_38080077 1.742 ENST00000378533.3
ENST00000544439.1
ENST00000432886.2
ENST00000538295.1
 SRPX



sushi-repeat containing protein, X-linked



chr20_-_52790512 1.418 ENST00000216862.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr20_-_52790055 1.383 ENST00000395955.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr3_-_124774802 1.232 ENST00000311127.4
 HEG1
heart development protein with EGF-like domains 1
chr19_-_51504852 1.141 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr12_-_76425368 1.045 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr7_+_145813453 0.856 ENST00000361727.3
 CNTNAP2
contactin associated protein-like 2
chr2_-_216300784 0.828 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr13_-_36050819 0.822 ENST00000379919.4
 MAB21L1
mab-21-like 1 (C. elegans)
chr4_+_7194247 0.796 ENST00000507866.2
 SORCS2
sortilin-related VPS10 domain containing receptor 2
chr5_-_44388899 0.777 ENST00000264664.4
 FGF10
fibroblast growth factor 10
chr14_-_75422280 0.742 ENST00000238607.6
ENST00000553716.1
 PGF

placental growth factor

chr19_+_54371114 0.725 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
 MYADM



myeloid-associated differentiation marker



chr1_+_20915409 0.642 ENST00000375071.3
 CDA
cytidine deaminase
chr22_+_31489344 0.641 ENST00000404574.1
 SMTN
smoothelin
chr2_+_115199876 0.635 ENST00000436732.1
ENST00000410059.1
 DPP10

dipeptidyl-peptidase 10 (non-functional)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0031424 keratinization(GO:0031424)
0.4 3.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.9 2.8 GO:0042369 vitamin D catabolic process(GO:0042369)
0.2 1.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 1.4 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.4 1.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.3 1.0 GO:0045210 FasL biosynthetic process(GO:0045210)
0.1 1.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 0.9 GO:0060435 bronchiole development(GO:0060435)
0.3 0.9 GO:0071109 superior temporal gyrus development(GO:0071109)
0.3 0.9 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.3 0.8 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.8 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 0.7 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.1 0.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 0.7 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.7 GO:0006621 protein retention in ER lumen(GO:0006621)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 GO:0045095 keratin filament(GO:0045095)
0.0 3.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.9 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.5 GO:0043259 laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.1 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.5 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 2.8 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 1.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.3 0.9 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.3 0.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 0.8 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 0.8 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 0.7 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.1 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand