Motif ID: MXI1_MYC_MYCN

Z-value: 1.974

Transcription factors associated with MXI1_MYC_MYCN:

Gene SymbolEntrez IDGene Name
MXI1 ENSG00000119950.16 MXI1
MYC ENSG00000136997.10 MYC
MYCN ENSG00000134323.10 MYCN

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MXI1hg19_v2_chr10_+_111985713_111985774,
hg19_v2_chr10_+_111967345_111967442		-0.843.7e-07Click!
MYCNhg19_v2_chr2_+_16080659_160806860.183.9e-01Click!
MYChg19_v2_chr8_+_128748466_128748487,
hg19_v2_chr8_+_128748308_128748330		0.087.0e-01Click!


Activity profile for motif MXI1_MYC_MYCN.

activity profile for motif MXI1_MYC_MYCN


Sorted Z-values histogram for motif MXI1_MYC_MYCN

Sorted Z-values for motif MXI1_MYC_MYCN



Network of associatons between targets according to the STRING database.



First level regulatory network of MXI1_MYC_MYCN

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_11120057 5.635 ENST00000376957.2
 SRM
spermidine synthase
chr3_+_99536663 4.813 ENST00000421999.2
ENST00000463526.1
 CMSS1

cms1 ribosomal small subunit homolog (yeast)

chr2_-_10588630 4.103 ENST00000234111.4
 ODC1
ornithine decarboxylase 1
chr12_-_58146128 3.944 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
 CDK4


cyclin-dependent kinase 4


chr12_-_58146048 3.918 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
 CDK4




cyclin-dependent kinase 4




chr22_+_20105259 3.788 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
 RANBP1



RAN binding protein 1



chr19_+_50180317 3.639 ENST00000534465.1
 PRMT1
protein arginine methyltransferase 1
chr5_+_110427983 3.438 ENST00000513710.2
ENST00000505303.1
 WDR36

WD repeat domain 36

chr10_+_70715884 2.813 ENST00000354185.4
 DDX21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chrX_+_16804544 2.735 ENST00000380122.5
ENST00000398155.4
 TXLNG

taxilin gamma

chr22_+_20105012 2.600 ENST00000331821.3
ENST00000411892.1
 RANBP1

RAN binding protein 1

chr1_+_1167594 2.569 ENST00000379198.2
 B3GALT6
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr9_-_131709858 2.491 ENST00000372586.3
 DOLK
dolichol kinase
chr9_-_140196703 2.454 ENST00000356628.2
 NRARP
NOTCH-regulated ankyrin repeat protein
chr8_+_67341239 2.442 ENST00000320270.2
 RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr8_-_144691718 2.430 ENST00000377579.3
ENST00000433751.1
ENST00000220966.6
 PYCRL


pyrroline-5-carboxylate reductase-like


chr4_-_4291761 2.422 ENST00000513174.1
 LYAR
Ly1 antibody reactive
chr11_+_60609537 2.397 ENST00000227520.5
 CCDC86
coiled-coil domain containing 86
chr19_+_50180409 2.392 ENST00000391851.4
 PRMT1
protein arginine methyltransferase 1
chr4_-_57301748 2.391 ENST00000264220.2
 PPAT
phosphoribosyl pyrophosphate amidotransferase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 773 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0042254 ribosome biogenesis(GO:0042254)
0.3 9.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.5 8.9 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
1.1 8.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.3 7.9 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.9 7.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 7.1 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.4 7.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.2 6.7 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 6.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.6 6.5 GO:1902570 protein localization to nucleolus(GO:1902570)
1.5 6.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.9 6.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 5.7 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.4 5.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 5.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.3 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.4 5.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 5.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
1.2 4.8 GO:0046452 dihydrofolate metabolic process(GO:0046452)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 296 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 11.5 GO:0034709 methylosome(GO:0034709)
0.4 10.7 GO:0030686 90S preribosome(GO:0030686)
0.3 9.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 9.4 GO:0005635 nuclear envelope(GO:0005635)
1.4 8.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.6 7.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 7.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 7.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.2 6.9 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 6.8 GO:0016607 nuclear speck(GO:0016607)
0.0 6.7 GO:0016605 PML body(GO:0016605)
0.3 5.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 5.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 5.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.5 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.1 5.2 GO:0015030 Cajal body(GO:0015030)
0.4 4.7 GO:0097433 dense body(GO:0097433)
0.2 4.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 4.3 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 506 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 55.7 GO:0003723 RNA binding(GO:0003723)
0.3 13.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 9.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.2 8.6 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 8.1 GO:0051087 chaperone binding(GO:0051087)
0.3 6.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 6.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.3 6.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 5.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 5.8 GO:0000049 tRNA binding(GO:0000049)
1.9 5.6 GO:0004766 spermidine synthase activity(GO:0004766)
0.2 5.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 5.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.5 4.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 4.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 4.6 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 4.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 4.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 4.4 GO:0030515 snoRNA binding(GO:0030515)
0.1 4.4 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 13.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 8.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 8.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 5.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 4.9 PID_P73PATHWAY p73 transcription factor network
0.1 3.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 3.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.9 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.0 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 16.6 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.4 12.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 10.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 8.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 7.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 6.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 5.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 4.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 4.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 4.4 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.2 4.3 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 4.1 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 4.0 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.1 3.9 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 3.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 3.4 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease