Motif ID: MEIS1
Z-value: 0.557
Transcription factors associated with MEIS1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| MEIS1 | ENSG00000143995.15 | MEIS1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS1 | hg19_v2_chr2_+_66662690_66662711 | -0.46 | 2.4e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 266 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0070268 | cornification(GO:0070268) |
| 0.3 | 1.6 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.1 | 1.4 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 1.3 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 1.3 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.4 | 1.1 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.1 | 1.1 | GO:1904322 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.1 | 1.0 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 1.0 | GO:0043029 | T cell homeostasis(GO:0043029) |
| 0.0 | 1.0 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
| 0.2 | 0.9 | GO:0061743 | motor learning(GO:0061743) |
| 0.1 | 0.9 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 0.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.2 | 0.8 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.1 | 0.8 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.0 | 0.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.8 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 0.7 | GO:0033242 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 0.2 | 0.7 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 0.7 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 91 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 1.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 1.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.0 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 1.0 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.0 | 0.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.2 | 0.5 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 0.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.5 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.1 | 0.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 0.5 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.5 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 0.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 165 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.3 | 1.3 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.3 | 1.2 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 1.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 0.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.0 | 0.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 0.7 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 0.2 | 0.7 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.2 | 0.7 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 0.1 | 0.7 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.0 | 0.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.2 | 0.6 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 0.1 | 0.6 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 31 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.6 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.5 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.4 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.3 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.8 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.8 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.6 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.6 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.4 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.4 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.4 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 37 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.8 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.6 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 1.3 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.2 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.0 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.9 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.8 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.8 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.7 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 0.6 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.0 | 0.5 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.5 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
