Motif ID: MEF2C

Z-value: 0.698


Transcription factors associated with MEF2C:

Gene SymbolEntrez IDGene Name
MEF2C ENSG00000081189.9 MEF2C

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEF2Chg19_v2_chr5_-_88119580_88119605-0.291.7e-01Click!


Activity profile for motif MEF2C.

activity profile for motif MEF2C


Sorted Z-values histogram for motif MEF2C

Sorted Z-values for motif MEF2C



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2C

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_8543533 2.677 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr3_+_8543393 2.111 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1


LIM and cysteine-rich domains 1


chr3_+_8543561 1.973 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr15_-_70994612 1.511 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA


uveal autoantigen with coiled-coil domains and ankyrin repeats


chr7_+_143013198 1.162 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr4_-_143227088 1.139 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr14_-_94421923 0.965 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chrX_+_135279179 0.948 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr7_-_113559104 0.939 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr3_+_50316458 0.823 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chrX_+_135278908 0.805 ENST00000539015.1
ENST00000370683.1
FHL1

four and a half LIM domains 1

chr2_-_208031542 0.784 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_-_235405679 0.774 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr14_+_76776957 0.753 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr6_+_123038689 0.673 ENST00000354275.2
ENST00000368446.1
PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

chr14_+_24540731 0.671 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6




copine VI (neuronal)




chr3_+_99357319 0.643 ENST00000452013.1
ENST00000261037.3
ENST00000273342.4
COL8A1


collagen, type VIII, alpha 1


chr1_+_74701062 0.622 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr1_+_90098606 0.616 ENST00000370454.4
LRRC8C
leucine rich repeat containing 8 family, member C
chr2_-_208030647 0.613 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 1.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.6 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.6 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 1.5 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.1 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.3 0.8 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.8 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.7 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 0.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 0.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.5 GO:0046449 creatinine metabolic process(GO:0046449) cellular response to UV-A(GO:0071492)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.3 GO:0005861 troponin complex(GO:0005861)
0.1 1.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.0 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.1 0.6 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0016460 myosin II complex(GO:0016460)
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 0.4 GO:0030427 growth cone(GO:0030426) site of polarized growth(GO:0030427)
0.0 0.4 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 1.9 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 0.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.2 0.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.5 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.4 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)