Motif ID: MAF_NRL

Z-value: 0.966

Transcription factors associated with MAF_NRL:

Gene SymbolEntrez IDGene Name
MAF ENSG00000178573.6 MAF
NRL ENSG00000129535.8 NRL

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MAFhg19_v2_chr16_-_79633799_796338720.501.4e-02Click!
NRLhg19_v2_chr14_-_24551137_24551178,
hg19_v2_chr14_-_24551195_24551214		-0.433.8e-02Click!


Activity profile for motif MAF_NRL.

activity profile for motif MAF_NRL


Sorted Z-values histogram for motif MAF_NRL

Sorted Z-values for motif MAF_NRL



Network of associatons between targets according to the STRING database.



First level regulatory network of MAF_NRL

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152386732 3.580 ENST00000271835.3
 CRNN
cornulin
chr17_-_38859996 3.280 ENST00000264651.2
 KRT24
keratin 24
chr1_+_24645807 2.896 ENST00000361548.4
 GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_24645865 2.884 ENST00000342072.4
 GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_24646002 2.832 ENST00000356046.2
 GRHL3
grainyhead-like 3 (Drosophila)
chr17_-_39769005 2.285 ENST00000301653.4
ENST00000593067.1
 KRT16

keratin 16

chr19_-_51471362 1.958 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr4_-_57547454 1.868 ENST00000556376.2
 HOPX
HOP homeobox
chr2_+_113885138 1.650 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr11_-_2924720 1.633 ENST00000455942.2
 SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr2_-_190044480 1.508 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr20_+_33759854 1.320 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr11_-_2924970 1.263 ENST00000533594.1
 SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr22_+_31489344 1.254 ENST00000404574.1
 SMTN
smoothelin
chr4_-_57547870 1.240 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
 HOPX



HOP homeobox



chr19_-_51537982 1.194 ENST00000525263.1
 KLK12
kallikrein-related peptidase 12
chr1_+_152956549 1.184 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr3_+_188664988 1.178 ENST00000433971.1
 TPRG1
tumor protein p63 regulated 1
chr12_+_53662073 1.175 ENST00000553219.1
ENST00000257934.4
 ESPL1

extra spindle pole bodies homolog 1 (S. cerevisiae)

chr19_-_51456321 1.137 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0070268 cornification(GO:0070268)
0.5 8.6 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 4.0 GO:0009408 response to heat(GO:0009408)
0.0 3.3 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 3.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.4 2.3 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 2.3 GO:0051546 keratinocyte migration(GO:0051546)
0.0 2.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.5 1.9 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 1.9 GO:0016540 protein autoprocessing(GO:0016540)
0.6 1.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 1.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 1.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 1.4 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.1 1.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 1.3 GO:0050819 negative regulation of coagulation(GO:0050819)
0.2 1.1 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 1.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 1.0 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.8 GO:0005882 intermediate filament(GO:0005882)
0.0 2.6 GO:0072686 mitotic spindle(GO:0072686)
0.3 2.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 1.7 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.4 1.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.6 GO:0005859 muscle myosin complex(GO:0005859)
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.4 GO:0042627 chylomicron(GO:0042627)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.2 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0031904 endosome lumen(GO:0031904)
0.2 1.0 GO:0031262 Ndc80 complex(GO:0031262)
0.1 1.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 0.8 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.8 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 8.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 3.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 2.0 GO:0019841 retinol binding(GO:0019841)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.8 GO:0002162 dystroglycan binding(GO:0002162)
0.5 1.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.2 1.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.2 GO:0043495 protein anchor(GO:0043495)
0.3 1.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 1.0 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.0 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.7 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.6 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.0 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.1 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.9 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins