Motif ID: MAFK

Z-value: 1.103


Transcription factors associated with MAFK:

Gene SymbolEntrez IDGene Name
MAFK ENSG00000198517.5 MAFK

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MAFKhg19_v2_chr7_+_1570322_1570360-0.301.5e-01Click!


Activity profile for motif MAFK.

activity profile for motif MAFK


Sorted Z-values histogram for motif MAFK

Sorted Z-values for motif MAFK



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFK

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_70861647 8.929 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chr7_-_16921601 8.362 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr4_+_69962185 6.905 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_+_69962212 6.661 ENST00000508661.1
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_-_71533055 4.412 ENST00000552128.1
 TSPAN8
tetraspanin 8
chr11_+_61976137 4.043 ENST00000244930.4
 SCGB2A1
secretoglobin, family 2A, member 1
chr4_-_110723134 3.870 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr1_-_109655355 3.629 ENST00000369945.3
 C1orf194
chromosome 1 open reading frame 194
chr1_-_109655377 3.518 ENST00000369948.3
 C1orf194
chromosome 1 open reading frame 194
chr12_-_10282836 3.000 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A


C-type lectin domain family 7, member A


chr4_-_110723194 2.947 ENST00000394635.3
 CFI
complement factor I
chr1_-_207119738 2.944 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr1_-_161337662 2.943 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr10_-_13043697 2.846 ENST00000378825.3
 CCDC3
coiled-coil domain containing 3
chr16_+_82068830 2.774 ENST00000199936.4
 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_-_52668605 2.765 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chr11_+_27076764 2.719 ENST00000525090.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_62104897 2.383 ENST00000415229.2
ENST00000535727.1
ENST00000301776.5
 ASRGL1


asparaginase like 1


chr6_+_131958436 2.353 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
 ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr4_-_110723335 2.347 ENST00000394634.2
 CFI
complement factor I

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.6 8.9 GO:0046541 saliva secretion(GO:0046541)
0.1 7.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 7.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 5.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 4.4 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.4 4.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 3.8 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
1.1 3.4 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 3.2 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.6 2.9 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 2.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.2 2.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 2.6 GO:0044458 motile cilium assembly(GO:0044458)
0.8 2.4 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.3 2.4 GO:0006528 asparagine metabolic process(GO:0006528)
0.6 2.3 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.2 2.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.7 2.2 GO:0006711 estrogen catabolic process(GO:0006711)
0.1 2.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 3.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 2.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.9 GO:0036038 MKS complex(GO:0036038)
0.2 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.7 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.9 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.8 GO:0005863 striated muscle myosin thick filament(GO:0005863)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
3.0 8.9 GO:0046848 hydroxyapatite binding(GO:0046848)
0.3 7.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 6.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 6.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 5.6 GO:0005044 scavenger receptor activity(GO:0005044)
1.0 3.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.9 3.4 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 3.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 3.0 GO:0005178 integrin binding(GO:0005178)
0.7 2.9 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.4 2.9 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.8 2.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.4 2.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 2.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.7 GO:0070330 aromatase activity(GO:0070330)
0.3 1.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.6 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 1.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 3.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 18.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.3 8.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 6.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 4.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.9 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.3 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 1.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.6 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide