Motif ID: MAFB

Z-value: 1.608


Transcription factors associated with MAFB:

Gene SymbolEntrez IDGene Name
MAFB ENSG00000204103.2 MAFB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MAFBhg19_v2_chr20_-_39317868_39317884-0.828.7e-07Click!


Activity profile for motif MAFB.

activity profile for motif MAFB


Sorted Z-values histogram for motif MAFB

Sorted Z-values for motif MAFB



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_7942424 4.263 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr12_+_53491220 4.109 ENST00000548547.1
ENST00000301464.3
 IGFBP6

insulin-like growth factor binding protein 6

chr12_-_76425368 3.946 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_+_120967072 3.624 ENST00000392870.2
 GRK5
G protein-coupled receptor kinase 5
chr17_+_7942335 3.591 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
 ALOX15B


arachidonate 15-lipoxygenase, type B


chr4_-_57547454 3.559 ENST00000556376.2
 HOPX
HOP homeobox
chr4_-_57547870 3.527 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
 HOPX



HOP homeobox



chr2_+_238536207 3.161 ENST00000308482.9
 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr16_-_85784557 2.971 ENST00000602675.1
 C16orf74
chromosome 16 open reading frame 74
chr7_-_128045984 2.937 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
 IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr2_+_191745560 2.913 ENST00000338435.4
 GLS
glutaminase
chr22_-_37640456 2.777 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr1_+_20915409 2.774 ENST00000375071.3
 CDA
cytidine deaminase
chr4_-_57522470 2.745 ENST00000503639.3
 HOPX
HOP homeobox
chr3_-_50340996 2.713 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr12_-_58131931 2.682 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_+_16187085 2.673 ENST00000300933.4
 TPM4
tropomyosin 4
chr1_+_203651937 2.588 ENST00000341360.2
 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_113594279 2.584 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr16_-_79633799 2.530 ENST00000569649.1
 MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 714 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
1.1 7.9 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 7.2 GO:1901998 toxin transport(GO:1901998)
0.2 5.6 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 5.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
1.0 5.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.8 5.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 4.9 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 4.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 4.4 GO:0050832 defense response to fungus(GO:0050832)
1.4 4.3 GO:0045210 FasL biosynthetic process(GO:0045210)
0.4 4.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.3 4.0 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.0 4.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.8 3.9 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.3 3.8 GO:0019858 cytosine metabolic process(GO:0019858)
0.4 3.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 3.5 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.4 3.4 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2 3.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 284 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.0 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0 9.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 7.2 GO:0045095 keratin filament(GO:0045095)
0.3 5.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 5.6 GO:1990752 microtubule end(GO:1990752)
0.1 4.8 GO:0005811 lipid particle(GO:0005811)
0.0 4.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.4 4.5 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 4.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.3 3.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 3.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 3.4 GO:0034709 methylosome(GO:0034709)
0.0 3.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 421 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.1 GO:0045296 cadherin binding(GO:0045296)
0.1 10.1 GO:0008307 structural constituent of muscle(GO:0008307)
2.6 7.9 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 6.9 GO:0003743 translation initiation factor activity(GO:0003743)
1.0 5.1 GO:0004359 glutaminase activity(GO:0004359)
1.3 5.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 4.8 GO:0045499 chemorepellent activity(GO:0045499)
0.0 4.8 GO:0051015 actin filament binding(GO:0051015)
0.0 4.2 GO:0005126 cytokine receptor binding(GO:0005126)
0.2 4.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 4.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 4.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.3 3.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 3.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.2 3.7 GO:0008179 adenylate cyclase binding(GO:0008179)
1.2 3.6 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 3.6 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 3.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 3.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.9 3.5 GO:0008431 vitamin E binding(GO:0008431)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 10.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 6.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 5.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 5.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.2 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 7.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 7.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 6.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 5.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 5.2 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.1 4.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 4.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.2 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 4.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 3.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 3.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)