Motif ID: LHX6

Z-value: 0.732


Transcription factors associated with LHX6:

Gene SymbolEntrez IDGene Name
LHX6 ENSG00000106852.11 LHX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX6hg19_v2_chr9_-_124976185_124976212,
hg19_v2_chr9_-_124976154_124976177
-0.154.8e-01Click!


Activity profile for motif LHX6.

activity profile for motif LHX6


Sorted Z-values histogram for motif LHX6

Sorted Z-values for motif LHX6



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_35938674 2.951 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL



calcyphosine-like



chr12_+_7013897 2.767 ENST00000007969.8
ENST00000323702.5
LRRC23

leucine rich repeat containing 23

chr12_+_7014064 2.750 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr21_-_43916433 2.554 ENST00000291536.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr10_-_123274693 2.398 ENST00000429361.1
FGFR2
fibroblast growth factor receptor 2
chr17_-_1532106 2.238 ENST00000301335.5
ENST00000382147.4
SLC43A2

solute carrier family 43 (amino acid system L transporter), member 2

chr4_+_165675197 2.220 ENST00000515485.1
RP11-294O2.2
RP11-294O2.2
chr21_-_43916296 1.924 ENST00000398352.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr12_+_7014126 1.859 ENST00000415834.1
ENST00000436789.1
LRRC23

leucine rich repeat containing 23

chr16_-_55866997 1.759 ENST00000360526.3
ENST00000361503.4
CES1

carboxylesterase 1

chr4_+_165675269 1.639 ENST00000507311.1
RP11-294O2.2
RP11-294O2.2
chr1_-_36906474 1.615 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr11_-_33913708 1.223 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr13_+_37006421 1.163 ENST00000255465.4
CCNA1
cyclin A1
chr13_+_37006398 1.158 ENST00000418263.1
CCNA1
cyclin A1
chr18_+_44526786 1.011 ENST00000245121.5
ENST00000356157.7
KATNAL2

katanin p60 subunit A-like 2

chr13_+_37005967 1.001 ENST00000440264.1
ENST00000449823.1
CCNA1

cyclin A1

chr3_-_129147432 0.986 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12


EF-hand calcium binding domain 12


chr5_-_20575959 0.944 ENST00000507958.1
CDH18
cadherin 18, type 2
chr17_-_1531635 0.942 ENST00000571650.1
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr14_+_74034310 0.839 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr9_+_1050331 0.835 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2


doublesex and mab-3 related transcription factor 2


chr16_-_55867146 0.826 ENST00000422046.2
CES1
carboxylesterase 1
chr4_-_138453559 0.808 ENST00000511115.1
PCDH18
protocadherin 18
chr6_-_167040731 0.802 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_28261492 0.787 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr15_+_40697988 0.774 ENST00000487418.2
ENST00000479013.2
IVD

isovaleryl-CoA dehydrogenase

chr5_+_142149955 0.759 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr12_-_102133191 0.754 ENST00000392924.1
ENST00000266743.2
ENST00000392927.3
SYCP3


synaptonemal complex protein 3


chr22_-_39190116 0.728 ENST00000406622.1
ENST00000216068.4
ENST00000406199.3
SUN2
DNAL4

Sad1 and UNC84 domain containing 2
dynein, axonemal, light chain 4

chr1_+_28261621 0.712 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr6_+_29691198 0.695 ENST00000440587.2
ENST00000434407.2
HLA-F

major histocompatibility complex, class I, F

chr5_-_54830871 0.692 ENST00000307259.8
PPAP2A
phosphatidic acid phosphatase type 2A
chr6_+_29691056 0.682 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F


major histocompatibility complex, class I, F


chr18_+_5238055 0.661 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
LINC00667


long intergenic non-protein coding RNA 667


chr3_-_112693865 0.651 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1


CD200 receptor 1


chr13_-_86373536 0.645 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr5_-_54830784 0.635 ENST00000264775.5
PPAP2A
phosphatidic acid phosphatase type 2A
chr10_-_28571015 0.630 ENST00000375719.3
ENST00000375732.1
MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr3_-_121553830 0.588 ENST00000498104.1
ENST00000460108.1
ENST00000349820.6
ENST00000462442.1
ENST00000310864.6
IQCB1




IQ motif containing B1




chrX_+_77154935 0.566 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr17_+_57408994 0.554 ENST00000312655.4
YPEL2
yippee-like 2 (Drosophila)
chr3_-_112693759 0.552 ENST00000440122.2
ENST00000490004.1
CD200R1

CD200 receptor 1

chr3_+_108541545 0.535 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr6_+_39760129 0.528 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr17_-_73937116 0.506 ENST00000586717.1
ENST00000389570.4
ENST00000319129.5
FBF1


Fas (TNFRSF6) binding factor 1


chr1_-_48866517 0.505 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr16_+_31885079 0.495 ENST00000300870.10
ENST00000394846.3
ZNF267

zinc finger protein 267

chr11_+_100862811 0.491 ENST00000303130.2
TMEM133
transmembrane protein 133
chr20_+_19867150 0.487 ENST00000255006.6
RIN2
Ras and Rab interactor 2
chr6_+_26402465 0.485 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1





butyrophilin, subfamily 3, member A1





chr11_-_102651343 0.485 ENST00000279441.4
ENST00000539681.1
MMP10

matrix metallopeptidase 10 (stromelysin 2)

chr11_+_17298255 0.483 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2


nucleobindin 2


chr3_+_108541608 0.479 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr7_+_70597109 0.477 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr6_+_148663729 0.473 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr11_+_17298297 0.470 ENST00000529010.1
NUCB2
nucleobindin 2
chr11_-_76155700 0.469 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr19_-_40931891 0.468 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr6_-_49681235 0.468 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr3_-_105587879 0.450 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr1_+_145438469 0.449 ENST00000369317.4
TXNIP
thioredoxin interacting protein
chr9_+_71944241 0.438 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr4_-_1723040 0.432 ENST00000382936.3
ENST00000536901.1
ENST00000303277.2
TMEM129


transmembrane protein 129


chr3_-_42003479 0.415 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr7_+_120590803 0.409 ENST00000315870.5
ENST00000339121.5
ENST00000445699.1
ING3


inhibitor of growth family, member 3


chr2_-_242089677 0.405 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr2_+_220143989 0.400 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr3_+_179280668 0.397 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A



actin-like 6A



chr7_+_149571045 0.395 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATP6V0E2



ATPase, H+ transporting V0 subunit e2



chr6_+_52051171 0.392 ENST00000340057.1
IL17A
interleukin 17A
chr4_+_155702496 0.389 ENST00000510397.1
RBM46
RNA binding motif protein 46
chr6_+_30457244 0.388 ENST00000376630.4
HLA-E
major histocompatibility complex, class I, E
chr6_+_36164487 0.382 ENST00000357641.6
BRPF3
bromodomain and PHD finger containing, 3
chr14_+_100842735 0.377 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WDR25



WD repeat domain 25



chr17_-_62208169 0.375 ENST00000606895.1
ERN1
endoplasmic reticulum to nucleus signaling 1
chr10_-_46168156 0.374 ENST00000374371.2
ENST00000335258.7
ZFAND4

zinc finger, AN1-type domain 4

chr18_+_5238549 0.369 ENST00000580684.1
LINC00667
long intergenic non-protein coding RNA 667
chr1_+_44115814 0.369 ENST00000372396.3
KDM4A
lysine (K)-specific demethylase 4A
chr18_+_60190682 0.366 ENST00000588676.1
ZCCHC2
zinc finger, CCHC domain containing 2
chr5_+_142149932 0.364 ENST00000274498.4
ARHGAP26
Rho GTPase activating protein 26
chr1_-_190446759 0.364 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr11_-_133826852 0.362 ENST00000533871.2
ENST00000321016.8
IGSF9B

immunoglobulin superfamily, member 9B

chr18_+_60190226 0.358 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr11_+_77532233 0.354 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr1_-_13390765 0.353 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr19_-_54663473 0.351 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr2_+_201936458 0.347 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr17_+_73452695 0.344 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195



KIAA0195



chr6_-_32095968 0.343 ENST00000375203.3
ENST00000375201.4
ATF6B

activating transcription factor 6 beta

chr1_-_236228403 0.341 ENST00000366595.3
NID1
nidogen 1
chr11_+_77532155 0.332 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC




adipogenesis associated, Mth938 domain containing




chr11_-_76155618 0.332 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr1_-_236228417 0.330 ENST00000264187.6
NID1
nidogen 1
chr12_-_45270151 0.327 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr11_-_124981475 0.327 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218











transmembrane protein 218











chr6_-_139613269 0.323 ENST00000358430.3
TXLNB
taxilin beta
chr19_+_56459198 0.317 ENST00000291971.3
ENST00000590542.1
NLRP8

NLR family, pyrin domain containing 8

chr17_+_42148097 0.302 ENST00000269097.4
G6PC3
glucose 6 phosphatase, catalytic, 3
chr16_-_66584059 0.299 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2





thymidine kinase 2, mitochondrial





chr11_-_128894053 0.297 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr12_-_45270077 0.296 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2


NEL-like 2 (chicken)


chr18_-_21017817 0.294 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241





transmembrane protein 241





chr4_+_113558272 0.293 ENST00000509061.1
ENST00000508577.1
ENST00000513553.1
LARP7


La ribonucleoprotein domain family, member 7


chr11_-_236326 0.293 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3




sirtuin 3




chr4_-_66536196 0.290 ENST00000511294.1
EPHA5
EPH receptor A5
chr3_-_105588231 0.286 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr17_+_73452545 0.284 ENST00000314256.7
KIAA0195
KIAA0195
chr1_-_228613026 0.284 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr6_+_26402517 0.284 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr12_-_45269430 0.282 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr6_-_24358264 0.276 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr14_+_21249200 0.267 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr17_-_47841485 0.264 ENST00000506156.1
ENST00000240364.2
FAM117A

family with sequence similarity 117, member A

chr16_+_31724552 0.260 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
ZNF720




zinc finger protein 720




chr13_+_73632897 0.259 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr9_+_104161123 0.254 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
ZNF189


zinc finger protein 189


chr19_-_47137942 0.252 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr1_+_152943122 0.245 ENST00000328051.2
SPRR4
small proline-rich protein 4
chr11_-_102714534 0.241 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr7_-_86849883 0.236 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr11_+_59856130 0.236 ENST00000278888.3
MS4A2
membrane-spanning 4-domains, subfamily A, member 2
chr18_-_5238525 0.235 ENST00000581067.1
ENST00000581170.1
ENST00000579933.1
LINC00526
RP11-835E18.5

long intergenic non-protein coding RNA 526
RP11-835E18.5

chr1_-_1709845 0.233 ENST00000341426.5
ENST00000344463.4
NADK

NAD kinase

chr14_+_76127529 0.229 ENST00000556977.1
ENST00000557636.1
ENST00000286650.5
ENST00000298832.9
TTLL5



tubulin tyrosine ligase-like family, member 5



chr17_-_41466555 0.229 ENST00000586231.1
LINC00910
long intergenic non-protein coding RNA 910
chr19_-_41870026 0.228 ENST00000243578.3
B9D2
B9 protein domain 2
chr12_+_118573663 0.228 ENST00000261313.2
PEBP1
phosphatidylethanolamine binding protein 1
chr17_+_41323204 0.227 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1



neighbor of BRCA1 gene 1



chr12_-_56753858 0.226 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2


signal transducer and activator of transcription 2, 113kDa


chr17_-_44439084 0.223 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B





ADP-ribosylation factor-like 17B





chr22_+_41777927 0.221 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr19_-_10491234 0.221 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2


tyrosine kinase 2


chr12_-_82152420 0.221 ENST00000552948.1
ENST00000548586.1
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr2_-_152118352 0.219 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr6_-_33285505 0.218 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chrY_+_14813160 0.214 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr10_-_104001231 0.210 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr4_-_103748880 0.204 ENST00000453744.2
ENST00000349311.8
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr14_-_104181771 0.203 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
XRCC3








X-ray repair complementing defective repair in Chinese hamster cells 3








chr9_+_104296122 0.197 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr10_-_48416849 0.197 ENST00000249598.1
GDF2
growth differentiation factor 2
chrX_+_19362011 0.194 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1







pyruvate dehydrogenase (lipoamide) alpha 1







chr6_+_30585486 0.193 ENST00000259873.4
ENST00000506373.2
MRPS18B

mitochondrial ribosomal protein S18B

chr13_-_41593425 0.192 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_12833164 0.184 ENST00000356861.5
TNPO2
transportin 2
chr19_-_12833361 0.184 ENST00000592287.1
TNPO2
transportin 2
chr14_+_22293618 0.183 ENST00000390432.2
TRAV10
T cell receptor alpha variable 10
chr10_-_72142345 0.179 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
LRRC20



leucine rich repeat containing 20



chr19_+_7694623 0.179 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100


PET100 homolog (S. cerevisiae)


chr3_-_157221380 0.179 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr4_-_66536057 0.178 ENST00000273854.3
EPHA5
EPH receptor A5
chr6_-_85474219 0.172 ENST00000369663.5
TBX18
T-box 18
chr11_+_67798090 0.172 ENST00000313468.5
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr9_+_12775011 0.172 ENST00000319264.3
LURAP1L
leucine rich adaptor protein 1-like
chr1_-_1710229 0.171 ENST00000341991.3
NADK
NAD kinase
chr17_-_74733404 0.169 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2




serine/arginine-rich splicing factor 2




chr19_-_10491130 0.167 ENST00000530829.1
ENST00000529370.1
TYK2

tyrosine kinase 2

chr6_-_31125850 0.166 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
CCHCR1














coiled-coil alpha-helical rod protein 1














chr5_+_174151536 0.164 ENST00000239243.6
ENST00000507785.1
MSX2

msh homeobox 2

chr4_-_74486109 0.164 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_2113583 0.156 ENST00000397173.4
ENST00000280665.6
DCP1B

decapping mRNA 1B

chr9_-_127905736 0.154 ENST00000336505.6
ENST00000373549.4
SCAI

suppressor of cancer cell invasion

chr6_-_33385854 0.153 ENST00000488478.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chrX_-_6453159 0.149 ENST00000381089.3
ENST00000398729.1
VCX3A

variable charge, X-linked 3A

chr11_+_76156045 0.148 ENST00000533988.1
ENST00000524490.1
ENST00000334736.3
ENST00000343878.3
ENST00000533972.1
C11orf30




chromosome 11 open reading frame 30




chrX_+_77166172 0.147 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A


ATPase, Cu++ transporting, alpha polypeptide


chr15_-_77712477 0.145 ENST00000560626.2
PEAK1
pseudopodium-enriched atypical kinase 1
chr11_-_18548426 0.145 ENST00000357193.3
ENST00000536719.1
TSG101

tumor susceptibility 101

chr3_-_157221357 0.145 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr8_+_9413410 0.142 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS


tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase


chr19_-_51071302 0.142 ENST00000389201.3
ENST00000600381.1
LRRC4B

leucine rich repeat containing 4B

chr6_-_33385655 0.141 ENST00000440279.3
ENST00000607266.1
CUTA

cutA divalent cation tolerance homolog (E. coli)

chr6_-_33385870 0.137 ENST00000488034.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr6_-_33385823 0.133 ENST00000494751.1
ENST00000374496.3
CUTA

cutA divalent cation tolerance homolog (E. coli)

chr13_+_19756173 0.132 ENST00000382988.2
RP11-408E5.4
RP11-408E5.4
chr3_-_160823158 0.129 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
B3GALNT1


beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)


chr2_-_227050079 0.129 ENST00000423838.1
AC068138.1
AC068138.1
chr5_-_159846399 0.128 ENST00000297151.4
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr6_-_33385902 0.127 ENST00000374500.5
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr6_+_132455526 0.127 ENST00000443303.1
LINC01013
long intergenic non-protein coding RNA 1013
chr14_-_52535712 0.125 ENST00000216286.5
ENST00000541773.1
NID2

nidogen 2 (osteonidogen)

chr2_+_201936707 0.123 ENST00000433898.1
ENST00000454214.1
NDUFB3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

chr17_+_18086392 0.123 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr11_+_67798114 0.121 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NDUFS8



NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)



chr3_-_160823040 0.120 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
B3GALNT1






beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)






chr14_-_99947168 0.118 ENST00000331768.5
SETD3
SET domain containing 3
chr7_-_77427676 0.117 ENST00000257663.3
TMEM60
transmembrane protein 60
chr7_+_100210133 0.117 ENST00000393950.2
ENST00000424091.2
MOSPD3

motile sperm domain containing 3

chr7_+_150929550 0.112 ENST00000482173.1
ENST00000495645.1
ENST00000035307.2
CHPF2


chondroitin polymerizing factor 2


chr19_+_19303008 0.112 ENST00000353145.1
ENST00000421262.3
ENST00000303088.4
ENST00000456252.3
ENST00000593273.1
RFXANK




regulatory factor X-associated ankyrin-containing protein




chr17_+_80416482 0.109 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF





nuclear prelamin A recognition factor





chrX_+_49020882 0.108 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr17_-_44657017 0.108 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A





ADP-ribosylation factor-like 17A





chr12_-_9760482 0.107 ENST00000229402.3
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr20_+_18488137 0.106 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B



Sec23 homolog B (S. cerevisiae)



chr17_+_12569306 0.106 ENST00000425538.1
MYOCD
myocardin
chr1_+_15986364 0.105 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr20_+_35807512 0.104 ENST00000373622.5
RPN2
ribophorin II
chr11_+_5710919 0.103 ENST00000379965.3
ENST00000425490.1
TRIM22

tripartite motif containing 22


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.6 2.6 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.2 1.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.8 GO:0061055 myotome development(GO:0061055)
0.1 4.1 GO:0007141 male meiosis I(GO:0007141)
0.1 0.7 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.6 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 1.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.6 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.4 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.8 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 4.7 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.3 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.6 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.2 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 0.4 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.2 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.9 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 3.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 0.2 GO:0090427 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 0.1 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.1 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 1.2 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.4 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.0 0.4 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.8 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.5 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.4 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.4 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:0007507 heart development(GO:0007507)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.7 GO:0010038 response to metal ion(GO:0010038)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.3 4.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.5 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.8 GO:0000800 lateral element(GO:0000800)
0.0 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.2 2.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 1.4 GO:0046979 TAP2 binding(GO:0046979)
0.1 1.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.4 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.1 1.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.2 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.3 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 3.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 0.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.3 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.0 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 1.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins