Motif ID: LHX3

Z-value: 0.347


Transcription factors associated with LHX3:

Gene SymbolEntrez IDGene Name
LHX3 ENSG00000107187.11 LHX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139094988_139095012,
hg19_v2_chr9_-_139096955_139096979
-0.395.7e-02Click!


Activity profile for motif LHX3.

activity profile for motif LHX3


Sorted Z-values histogram for motif LHX3

Sorted Z-values for motif LHX3



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13835147 0.402 ENST00000493677.1
ENST00000355135.2
GPM6B

glycoprotein M6B

chr9_-_75567962 0.361 ENST00000297785.3
ENST00000376939.1
ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr12_-_10282836 0.357 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr19_+_11457232 0.298 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr12_-_10282681 0.276 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282742 0.273 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr17_+_68071458 0.264 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.254 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr19_+_49199209 0.247 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2


fucosyltransferase 2 (secretor status included)


chr19_+_50016411 0.219 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr3_-_141747950 0.216 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chrX_+_9431324 0.214 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X





transducin (beta)-like 1X-linked





chr19_+_50016610 0.213 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_-_39093672 0.192 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23


keratin 23 (histone deacetylase inducible)


chr11_+_27015628 0.187 ENST00000318627.2
FIBIN
fin bud initiation factor homolog (zebrafish)
chr11_-_63376013 0.178 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr19_-_49149553 0.172 ENST00000084798.4
CA11
carbonic anhydrase XI
chr2_+_26624775 0.171 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr18_+_72201664 0.161 ENST00000358821.3
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr18_-_53303123 0.157 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4


transcription factor 4


chr1_+_244214577 0.155 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr10_-_27529486 0.153 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr4_-_23891693 0.150 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_+_81771806 0.150 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2





latrophilin 2





chr15_+_64680003 0.148 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr18_+_72201829 0.142 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr9_+_125132803 0.141 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr16_-_28634874 0.135 ENST00000395609.1
ENST00000350842.4
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr17_+_1674982 0.131 ENST00000572048.1
ENST00000573763.1
SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

chr1_-_182641037 0.123 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr1_-_182640988 0.122 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr22_+_23487513 0.121 ENST00000263116.2
ENST00000341989.4
RAB36

RAB36, member RAS oncogene family

chrX_+_108779004 0.119 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_59989918 0.119 ENST00000547379.1
ENST00000549465.1
SLC16A7

solute carrier family 16 (monocarboxylate transporter), member 7

chr1_-_48866517 0.116 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr16_-_28937027 0.115 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr10_+_696000 0.114 ENST00000381489.5
PRR26
proline rich 26
chr14_-_101295407 0.113 ENST00000596284.1
AL117190.2
AL117190.2
chr14_-_21566731 0.113 ENST00000360947.3
ZNF219
zinc finger protein 219
chr19_-_11457162 0.113 ENST00000590482.1
TMEM205
transmembrane protein 205
chr5_+_140529630 0.112 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr6_+_130339710 0.107 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr4_-_41884582 0.105 ENST00000499082.2
LINC00682
long intergenic non-protein coding RNA 682
chr20_+_5987890 0.105 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chrX_+_105412290 0.104 ENST00000357175.2
ENST00000337685.2
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr8_+_105352050 0.104 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr3_+_157827841 0.099 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
RSRC1




arginine/serine-rich coiled-coil 1




chr5_+_67586465 0.098 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_52761262 0.097 ENST00000257901.3
KRT85
keratin 85
chr2_-_99279928 0.093 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_10372875 0.086 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr7_-_25268104 0.084 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr19_-_6279932 0.082 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr3_-_191000172 0.077 ENST00000427544.2
UTS2B
urotensin 2B
chr8_-_110986918 0.077 ENST00000297404.1
KCNV1
potassium channel, subfamily V, member 1
chr6_-_2634820 0.077 ENST00000296847.3
C6orf195
chromosome 6 open reading frame 195
chr4_+_186990298 0.077 ENST00000296795.3
ENST00000513189.1
TLR3

toll-like receptor 3

chr4_+_113568207 0.073 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr12_+_49740700 0.071 ENST00000549441.2
ENST00000395069.3
DNAJC22

DnaJ (Hsp40) homolog, subfamily C, member 22

chr1_+_115572415 0.070 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr1_-_57285038 0.069 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chr11_-_327537 0.065 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr11_-_67980744 0.060 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1


suppressor of variegation 4-20 homolog 1 (Drosophila)


chr3_-_47517302 0.060 ENST00000441517.2
ENST00000545718.1
SCAP

SREBF chaperone

chr9_-_116065551 0.060 ENST00000297894.5
RNF183
ring finger protein 183
chr14_-_21567009 0.060 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219



zinc finger protein 219



chr7_-_36764142 0.058 ENST00000258749.5
ENST00000535891.1
AOAH

acyloxyacyl hydrolase (neutrophil)

chr2_-_166930131 0.057 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A



sodium channel, voltage-gated, type I, alpha subunit



chr10_+_695888 0.056 ENST00000441152.2
PRR26
proline rich 26
chr4_+_41937131 0.055 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33



transmembrane protein 33



chr12_-_118628350 0.054 ENST00000537952.1
ENST00000537822.1
TAOK3

TAO kinase 3

chr15_-_75748115 0.054 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr3_-_141719195 0.052 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr18_+_28956740 0.050 ENST00000308128.4
ENST00000359747.4
DSG4

desmoglein 4

chr11_-_128894053 0.045 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr1_-_231005310 0.042 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr5_+_140557371 0.038 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr10_-_90611566 0.037 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr14_+_55493920 0.035 ENST00000395472.2
ENST00000555846.1
SOCS4

suppressor of cytokine signaling 4

chr7_+_134671234 0.034 ENST00000436302.2
ENST00000359383.3
ENST00000458078.1
ENST00000435976.2
ENST00000455283.2
AGBL3




ATP/GTP binding protein-like 3




chr15_-_20193370 0.033 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr9_-_128246769 0.031 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr11_+_5009424 0.031 ENST00000300762.1
MMP26
matrix metallopeptidase 26
chr12_-_86650077 0.030 ENST00000552808.2
ENST00000547225.1
MGAT4C

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

chr6_-_49712123 0.030 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr19_+_11457175 0.030 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159


coiled-coil domain containing 159


chr3_+_46919235 0.028 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr10_-_115904361 0.028 ENST00000428953.1
ENST00000543782.1
C10orf118

chromosome 10 open reading frame 118

chr14_+_55494323 0.027 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr5_+_147691979 0.027 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr15_+_65843130 0.027 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr3_+_69812877 0.027 ENST00000457080.1
ENST00000328528.6
MITF

microphthalmia-associated transcription factor

chrM_-_14670 0.026 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr12_-_53994805 0.026 ENST00000328463.7
ATF7
activating transcription factor 7
chr6_-_49712147 0.026 ENST00000433368.2
ENST00000354620.4
CRISP3

cysteine-rich secretory protein 3

chr7_-_122840015 0.026 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr6_-_66417107 0.024 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS



eyes shut homolog (Drosophila)



chr3_+_101443476 0.023 ENST00000327230.4
ENST00000494050.1
CEP97

centrosomal protein 97kDa

chr5_-_43557791 0.023 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1


poly(A) binding protein interacting protein 1


chr2_-_145278475 0.022 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_+_234826016 0.021 ENST00000324695.4
ENST00000433712.2
TRPM8

transient receptor potential cation channel, subfamily M, member 8

chr9_-_215744 0.021 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr6_+_114178512 0.021 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr19_-_43969796 0.020 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr19_+_48949030 0.019 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr15_+_75970672 0.019 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr12_-_11287243 0.019 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr4_+_3344141 0.018 ENST00000306648.7
RGS12
regulator of G-protein signaling 12
chr5_-_16916624 0.018 ENST00000513882.1
MYO10
myosin X
chr17_-_64225508 0.017 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_-_20053741 0.017 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chrX_+_84258832 0.016 ENST00000373173.2
APOOL
apolipoprotein O-like
chr8_-_49834299 0.016 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr19_+_9296279 0.015 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr6_-_9933500 0.015 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr6_+_83072923 0.014 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr3_+_148415571 0.014 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1




angiotensin II receptor, type 1




chr4_-_185275104 0.013 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr17_-_60142609 0.012 ENST00000397786.2
MED13
mediator complex subunit 13
chr5_-_78809950 0.012 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr13_+_53602894 0.012 ENST00000219022.2
OLFM4
olfactomedin 4
chr2_-_99871570 0.012 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2


lysozyme G-like 2


chr12_-_86650045 0.011 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr13_-_81801115 0.010 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr1_-_24126051 0.010 ENST00000445705.1
GALE
UDP-galactose-4-epimerase
chr20_-_29978383 0.009 ENST00000339144.3
ENST00000376321.3
DEFB119

defensin, beta 119

chr12_+_40787194 0.009 ENST00000425730.2
ENST00000454784.4
MUC19

mucin 19, oligomeric

chr12_+_64798095 0.008 ENST00000332707.5
XPOT
exportin, tRNA
chr4_+_95128748 0.008 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr7_+_30185406 0.008 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chrM_+_10053 0.008 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr8_+_119294456 0.007 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr1_-_24126023 0.007 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr5_+_59783941 0.005 ENST00000506884.1
ENST00000504876.2
PART1

prostate androgen-regulated transcript 1 (non-protein coding)

chr6_+_26104104 0.005 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr6_+_72926145 0.005 ENST00000425662.2
ENST00000453976.2
RIMS1

regulating synaptic membrane exocytosis 1

chr18_-_21852143 0.003 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr17_+_35851570 0.003 ENST00000394386.1
DUSP14
dual specificity phosphatase 14
chrX_+_24167746 0.002 ENST00000428571.1
ENST00000539115.1
ZFX

zinc finger protein, X-linked


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.9 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.1 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits