Motif ID: KLF3

Z-value: 0.889


Transcription factors associated with KLF3:

Gene SymbolEntrez IDGene Name
KLF3 ENSG00000109787.8 KLF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF3hg19_v2_chr4_+_38665810_386658270.164.6e-01Click!


Activity profile for motif KLF3.

activity profile for motif KLF3


Sorted Z-values histogram for motif KLF3

Sorted Z-values for motif KLF3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_7013897 1.950 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr2_+_172378757 1.557 ENST00000409484.1
ENST00000321348.4
ENST00000375252.3
 CYBRD1


cytochrome b reductase 1


chr1_+_38022572 1.530 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr16_+_618837 1.523 ENST00000409439.2
 PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr16_+_84209539 1.325 ENST00000569735.1
 DNAAF1
dynein, axonemal, assembly factor 1
chr22_-_50970506 1.317 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr1_-_42921915 1.314 ENST00000372565.3
ENST00000433602.2
 ZMYND12

zinc finger, MYND-type containing 12

chr1_-_162838551 1.311 ENST00000367910.1
ENST00000367912.2
ENST00000367911.2
 C1orf110


chromosome 1 open reading frame 110


chrX_+_152338301 1.306 ENST00000453825.2
 PNMA6A
paraneoplastic Ma antigen family member 6A
chr1_-_60539405 1.239 ENST00000450089.2
 C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 1.223 ENST00000371201.3
 C1orf87
chromosome 1 open reading frame 87
chr11_-_5248294 1.203 ENST00000335295.4
 HBB
hemoglobin, beta
chr3_-_50383096 1.071 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr19_+_917287 1.048 ENST00000592648.1
ENST00000234371.5
 KISS1R

KISS1 receptor

chr20_-_3762087 1.046 ENST00000379756.3
 SPEF1
sperm flagellar 1
chr21_-_35883613 1.015 ENST00000337385.3
 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_+_86085778 0.965 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
 CCDC81



coiled-coil domain containing 81



chr19_+_4639514 0.931 ENST00000327473.4
 TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr1_-_75139397 0.908 ENST00000326665.5
 C1orf173
chromosome 1 open reading frame 173
chr11_-_5462744 0.895 ENST00000380211.1
 OR51I1
olfactory receptor, family 51, subfamily I, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 2.1 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.1 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 1.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 1.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 1.3 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.1 1.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 1.3 GO:0010039 response to iron ion(GO:0010039)
0.3 1.2 GO:0030185 nitric oxide transport(GO:0030185)
0.1 1.1 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.1 GO:0045475 locomotor rhythm(GO:0045475)
0.3 1.0 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 1.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 1.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.9 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.9 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.1 0.9 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.8 GO:0035810 positive regulation of urine volume(GO:0035810)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 2.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.5 GO:0034451 centriolar satellite(GO:0034451)
0.3 1.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.1 0.6 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.6 GO:0036128 CatSper complex(GO:0036128)
0.0 0.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.4 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 1.8 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 1.8 GO:0031433 telethonin binding(GO:0031433)
0.1 1.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.4 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.4 GO:0030332 cyclin binding(GO:0030332)
0.4 1.3 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.2 1.2 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.0 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.9 GO:0070330 aromatase activity(GO:0070330)
0.1 0.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.7 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.0 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.8 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.0 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.9 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.7 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling