Motif ID: IRX3

Z-value: 0.850


Transcription factors associated with IRX3:

Gene SymbolEntrez IDGene Name
IRX3 ENSG00000177508.11 IRX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.048.4e-01Click!


Activity profile for motif IRX3.

activity profile for motif IRX3


Sorted Z-values histogram for motif IRX3

Sorted Z-values for motif IRX3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_69681710 2.233 ENST00000265403.7
ENST00000458688.2
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr2_-_89545079 1.348 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr12_-_91573132 1.126 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chr4_+_70861647 1.105 ENST00000246895.4
ENST00000381060.2
STATH

statherin

chr10_+_118187379 1.086 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_91574142 1.072 ENST00000547937.1
DCN
decorin
chr19_-_9092018 1.067 ENST00000397910.4
MUC16
mucin 16, cell surface associated
chr4_+_69962185 1.051 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_-_70080449 1.010 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr4_-_70725856 0.990 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr13_-_20080080 0.985 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr2_+_89975669 0.977 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr9_+_105757590 0.976 ENST00000374798.3
ENST00000487798.1
CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr10_+_118305435 0.962 ENST00000369221.2
PNLIP
pancreatic lipase
chr4_+_70146217 0.921 ENST00000335568.5
ENST00000511240.1
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr19_-_22379753 0.910 ENST00000397121.2
ZNF676
zinc finger protein 676
chr5_+_140235469 0.870 ENST00000506939.2
ENST00000307360.5
PCDHA10

protocadherin alpha 10

chr13_+_25254545 0.866 ENST00000218548.6
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr12_-_10282836 0.845 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chrX_-_15620192 0.832 ENST00000427411.1
ACE2
angiotensin I converting enzyme 2
chr10_+_95326416 0.828 ENST00000371481.4
ENST00000371483.4
ENST00000604414.1
FFAR4


free fatty acid receptor 4


chr12_-_10282681 0.759 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr13_+_25254693 0.750 ENST00000381946.3
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr16_+_19421803 0.749 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr6_-_52705641 0.734 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr12_-_10282742 0.711 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr12_+_21207503 0.700 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr1_-_31902614 0.694 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr4_+_69962212 0.678 ENST00000508661.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_-_91573316 0.663 ENST00000393155.1
DCN
decorin
chr5_+_147443534 0.643 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5



serine peptidase inhibitor, Kazal type 5



chr12_-_71182695 0.636 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr11_-_111782484 0.614 ENST00000533971.1
CRYAB
crystallin, alpha B
chr9_+_90112767 0.590 ENST00000408954.3
DAPK1
death-associated protein kinase 1
chr11_-_111782696 0.585 ENST00000227251.3
ENST00000526180.1
CRYAB

crystallin, alpha B

chr16_-_20709066 0.565 ENST00000520010.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr7_+_80267973 0.556 ENST00000394788.3
ENST00000447544.2
CD36

CD36 molecule (thrombospondin receptor)

chr7_-_99573640 0.552 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr3_-_127541194 0.547 ENST00000453507.2
MGLL
monoglyceride lipase
chr12_-_13248598 0.546 ENST00000337630.6
ENST00000545699.1
GSG1

germ cell associated 1

chr17_+_34639793 0.541 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2


chemokine (C-C motif) ligand 4-like 2


chr22_-_18923655 0.528 ENST00000438924.1
ENST00000457083.1
ENST00000420436.1
ENST00000334029.2
ENST00000357068.6
PRODH




proline dehydrogenase (oxidase) 1




chr11_+_27076764 0.514 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_27062502 0.514 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr22_+_23161491 0.511 ENST00000390316.2
IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr13_+_113030625 0.508 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr7_-_99573677 0.504 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr6_-_47009996 0.504 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr5_+_140220769 0.499 ENST00000531613.1
ENST00000378123.3
PCDHA8

protocadherin alpha 8

chr12_-_10605929 0.497 ENST00000347831.5
ENST00000359151.3
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr14_-_106453155 0.484 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr21_-_43528548 0.482 ENST00000329015.2
C21orf128
chromosome 21 open reading frame 128
chr19_+_50691437 0.479 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr17_-_9683238 0.468 ENST00000571771.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr12_-_127174806 0.466 ENST00000545853.1
ENST00000537478.1
RP11-407A16.3

RP11-407A16.3

chr8_+_84824920 0.462 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr2_-_16804320 0.461 ENST00000355549.2
FAM49A
family with sequence similarity 49, member A
chr18_+_9885961 0.457 ENST00000306084.6
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr11_+_57365150 0.445 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1




serpin peptidase inhibitor, clade G (C1 inhibitor), member 1




chr9_-_21975088 0.435 ENST00000304494.5
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr7_+_13141097 0.431 ENST00000411542.1
AC011288.2
AC011288.2
chr8_+_120885949 0.427 ENST00000523492.1
ENST00000286234.5
DEPTOR

DEP domain containing MTOR-interacting protein

chr9_-_37465396 0.422 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr11_-_63330842 0.420 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr4_-_170924888 0.418 ENST00000502832.1
ENST00000393704.3
MFAP3L

microfibrillar-associated protein 3-like

chr13_+_97928395 0.416 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr1_-_152086556 0.410 ENST00000368804.1
TCHH
trichohyalin
chr12_-_91546926 0.410 ENST00000550758.1
DCN
decorin
chr16_+_20775358 0.408 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr20_+_2276639 0.408 ENST00000381458.5
TGM3
transglutaminase 3
chr20_-_13971255 0.398 ENST00000284951.5
ENST00000378072.5
SEL1L2

sel-1 suppressor of lin-12-like 2 (C. elegans)

chr12_+_29542557 0.396 ENST00000550906.1
OVCH1-AS1
OVCH1 antisense RNA 1
chr12_+_69742121 0.396 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ


lysozyme


chr2_+_106679690 0.395 ENST00000409944.1
C2orf40
chromosome 2 open reading frame 40
chr3_-_185270383 0.390 ENST00000296252.4
LIPH
lipase, member H
chr10_+_82009466 0.390 ENST00000356374.4
AL359195.1
Uncharacterized protein; cDNA FLJ46261 fis, clone TESTI4025062
chr1_-_46598284 0.387 ENST00000423209.1
ENST00000262741.5
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr1_+_220863187 0.383 ENST00000294889.5
C1orf115
chromosome 1 open reading frame 115
chr1_-_46598371 0.376 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
PIK3R3




phosphoinositide-3-kinase, regulatory subunit 3 (gamma)




chr11_-_27384737 0.376 ENST00000317945.6
CCDC34
coiled-coil domain containing 34
chr10_-_96829246 0.371 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8


cytochrome P450, family 2, subfamily C, polypeptide 8


chr4_+_41361616 0.371 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr13_-_38172863 0.370 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN





periostin, osteoblast specific factor





chr17_-_29641084 0.364 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr22_+_51176624 0.362 ENST00000216139.5
ENST00000529621.1
ACR

acrosin

chr7_-_92777606 0.357 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L






sterile alpha motif domain containing 9-like






chr14_+_22636283 0.355 ENST00000557168.1
TRAV30
T cell receptor alpha variable 30
chr5_-_131879205 0.347 ENST00000231454.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr2_-_88125471 0.347 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr6_+_29407083 0.335 ENST00000444197.2
OR10C1
olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
chr21_-_33975547 0.328 ENST00000431599.1
C21orf59
chromosome 21 open reading frame 59
chr3_-_127441406 0.326 ENST00000487473.1
ENST00000484451.1
MGLL

monoglyceride lipase

chr8_+_9009296 0.323 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chr17_+_56232494 0.322 ENST00000268912.5
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr11_+_60048053 0.320 ENST00000337908.4
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr6_-_35765088 0.315 ENST00000259938.2
CLPS
colipase, pancreatic
chr9_+_130026756 0.312 ENST00000314904.5
ENST00000373387.4
GARNL3

GTPase activating Rap/RanGAP domain-like 3

chr19_-_40596828 0.310 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A



zinc finger protein 780A



chr22_-_36556821 0.308 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3


apolipoprotein L, 3


chr19_-_44388116 0.306 ENST00000587539.1
ZNF404
zinc finger protein 404
chr19_-_10491130 0.304 ENST00000530829.1
ENST00000529370.1
TYK2

tyrosine kinase 2

chr11_-_49230184 0.302 ENST00000340334.7
ENST00000256999.2
FOLH1

folate hydrolase (prostate-specific membrane antigen) 1

chr19_+_53761545 0.297 ENST00000341702.3
VN1R2
vomeronasal 1 receptor 2
chr12_-_91348949 0.297 ENST00000358859.2
CCER1
coiled-coil glutamate-rich protein 1
chrX_-_77150911 0.297 ENST00000373336.3
MAGT1
magnesium transporter 1
chr10_-_101841588 0.296 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr14_-_71001708 0.294 ENST00000256389.3
ADAM20
ADAM metallopeptidase domain 20
chr14_-_106926724 0.294 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr20_-_18477862 0.292 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr3_-_185270342 0.291 ENST00000424591.2
LIPH
lipase, member H
chr4_-_103998439 0.291 ENST00000503230.1
ENST00000503818.1
SLC9B2

solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

chr8_+_9009202 0.290 ENST00000518496.1
RP11-10A14.4
Uncharacterized protein
chr2_-_158300556 0.288 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr12_+_56114189 0.286 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr3_+_8543533 0.282 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr3_+_51895621 0.280 ENST00000333127.3
IQCF2
IQ motif containing F2
chr2_+_101591314 0.278 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr4_-_84035905 0.276 ENST00000311507.4
PLAC8
placenta-specific 8
chr2_-_228497888 0.276 ENST00000264387.4
ENST00000409066.1
C2orf83

chromosome 2 open reading frame 83

chr8_+_52730143 0.273 ENST00000415643.1
AC090186.1
Uncharacterized protein
chr13_-_46716969 0.270 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_175490540 0.261 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr7_-_112430427 0.261 ENST00000449743.1
ENST00000441474.1
ENST00000454074.1
ENST00000447395.1
TMEM168



transmembrane protein 168



chr1_+_145524891 0.260 ENST00000369304.3
ITGA10
integrin, alpha 10
chr1_+_158259558 0.259 ENST00000368170.3
CD1C
CD1c molecule
chr4_-_103997862 0.255 ENST00000394785.3
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr8_+_12803176 0.254 ENST00000524591.2
KIAA1456
KIAA1456
chr14_-_106963409 0.254 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr2_-_8464760 0.253 ENST00000430192.1
LINC00299
long intergenic non-protein coding RNA 299
chr8_+_7801144 0.253 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr11_-_26588634 0.251 ENST00000436318.2
ENST00000281268.8
MUC15

mucin 15, cell surface associated

chr12_+_8309630 0.249 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr3_-_151102529 0.248 ENST00000302632.3
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_+_15668240 0.247 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr10_+_96698406 0.245 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr13_+_76362974 0.244 ENST00000497947.2
LMO7
LIM domain 7
chr7_+_37960163 0.242 ENST00000199448.4
ENST00000559325.1
ENST00000423717.1
EPDR1


ependymin related 1


chr12_+_129028500 0.242 ENST00000315208.8
TMEM132C
transmembrane protein 132C
chr14_-_23624511 0.240 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr4_+_41540160 0.240 ENST00000503057.1
ENST00000511496.1
LIMCH1

LIM and calponin homology domains 1

chr2_+_119699864 0.236 ENST00000541757.1
ENST00000412481.1
MARCO

macrophage receptor with collagenous structure

chr14_-_51562745 0.235 ENST00000298355.3
TRIM9
tripartite motif containing 9
chr10_+_29577974 0.235 ENST00000375500.3
LYZL1
lysozyme-like 1
chr11_-_118213360 0.233 ENST00000529594.1
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr9_+_99690592 0.233 ENST00000354649.3
NUTM2G
NUT family member 2G
chr1_+_22778337 0.231 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
ZBTB40



zinc finger and BTB domain containing 40



chr19_-_54974894 0.230 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr14_+_100485712 0.229 ENST00000544450.2
EVL
Enah/Vasp-like
chr6_+_131958436 0.229 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr11_-_118213455 0.229 ENST00000300692.4
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr16_+_56995854 0.228 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr14_-_106471723 0.228 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr9_-_136203235 0.227 ENST00000372022.4
SURF6
surfeit 6
chr5_-_147211226 0.225 ENST00000296695.5
SPINK1
serine peptidase inhibitor, Kazal type 1
chr2_+_113829895 0.223 ENST00000393197.2
IL1F10
interleukin 1 family, member 10 (theta)
chr19_+_55281260 0.223 ENST00000336077.6
ENST00000291633.7
KIR2DL1

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1

chr16_-_72206034 0.220 ENST00000537465.1
ENST00000237353.10
PMFBP1

polyamine modulated factor 1 binding protein 1

chr15_-_51630772 0.219 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
CYP19A1







cytochrome P450, family 19, subfamily A, polypeptide 1







chr17_+_3379284 0.217 ENST00000263080.2
ASPA
aspartoacylase
chr1_+_160709076 0.217 ENST00000359331.4
ENST00000495334.1
SLAMF7

SLAM family member 7

chr12_+_10365404 0.216 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1





GABA(A) receptor-associated protein like 1





chr12_+_56114151 0.211 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5


retinol dehydrogenase 5 (11-cis/9-cis)


chrY_-_6742068 0.210 ENST00000215479.5
AMELY
amelogenin, Y-linked
chr5_-_146302078 0.210 ENST00000508545.2
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr17_-_34207295 0.209 ENST00000463941.1
ENST00000293272.3
CCL5

chemokine (C-C motif) ligand 5

chr2_+_234545148 0.209 ENST00000373445.1
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr3_-_46069223 0.209 ENST00000309285.3
XCR1
chemokine (C motif) receptor 1
chr5_+_55147205 0.208 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA



interleukin 31 receptor A



chr10_+_91092241 0.207 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_160709055 0.207 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7



SLAM family member 7



chrX_+_65382381 0.207 ENST00000519389.1
HEPH
hephaestin
chr5_-_177207634 0.206 ENST00000513554.1
ENST00000440605.3
FAM153A

family with sequence similarity 153, member A

chr12_+_55248289 0.205 ENST00000308796.6
MUCL1
mucin-like 1
chr14_+_22386325 0.204 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr1_+_26644441 0.204 ENST00000374213.2
CD52
CD52 molecule
chr1_-_227505289 0.204 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr17_-_61905005 0.203 ENST00000584574.1
ENST00000585145.1
ENST00000427159.2
FTSJ3


FtsJ homolog 3 (E. coli)


chr6_-_26247259 0.203 ENST00000244537.4
HIST1H4G
histone cluster 1, H4g
chr19_+_35849362 0.202 ENST00000327809.4
FFAR3
free fatty acid receptor 3
chr6_-_32920794 0.200 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chrX_-_138790348 0.198 ENST00000414978.1
ENST00000519895.1
MCF2

MCF.2 cell line derived transforming sequence

chr7_-_111202511 0.197 ENST00000452895.1
ENST00000452753.1
ENST00000331762.3
IMMP2L


IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)


chr2_-_233415220 0.197 ENST00000408957.3
TIGD1
tigger transposable element derived 1
chr3_-_187455680 0.197 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chr8_-_16043780 0.195 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr2_-_88427568 0.194 ENST00000393750.3
ENST00000295834.3
FABP1

fatty acid binding protein 1, liver

chr13_+_21714653 0.194 ENST00000382533.4
SAP18
Sin3A-associated protein, 18kDa
chr8_+_24151620 0.193 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr21_-_43816052 0.191 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr1_-_204165610 0.187 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr2_+_85921414 0.187 ENST00000263863.4
ENST00000524600.1
GNLY

granulysin

chr18_+_50278430 0.186 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC


deleted in colorectal carcinoma


chr12_-_129570545 0.185 ENST00000389441.4
TMEM132D
transmembrane protein 132D
chr11_+_114310164 0.185 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2


RNA exonuclease 2


chr12_-_21487829 0.185 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2




solute carrier organic anion transporter family, member 1A2




chr3_+_142838091 0.184 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chrX_+_52513455 0.183 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chr17_-_46657473 0.183 ENST00000332503.5
HOXB4
homeobox B4
chr4_-_103998060 0.182 ENST00000339611.4
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr1_+_202317815 0.181 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B


protein phosphatase 1, regulatory subunit 12B



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.2 3.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 0.6 GO:0018874 benzoate metabolic process(GO:0018874)
0.2 0.8 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.4 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.3 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:0002818 intracellular defense response(GO:0002818)
0.1 2.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.2 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.5 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.9 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.6 GO:0002784 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) negative regulation of defense response to bacterium(GO:1900425)
0.1 0.7 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.6 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 1.1 GO:0046541 saliva secretion(GO:0046541)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.6 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.2 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.1 0.2 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.4 GO:1990523 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.1 0.2 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 1.7 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 1.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)
0.1 0.2 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.2 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.1 0.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.1 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 1.0 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.6 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.1 GO:1990180 mitochondrial tRNA 3'-end processing(GO:1990180)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.4 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.0 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.4 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 4.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.2 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.0 1.1 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.2 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 0.4 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.3 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.4 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.0 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 1.5 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
0.0 0.2 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.0 GO:1990927 negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.8 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.0 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0051272 positive regulation of cell migration(GO:0030335) positive regulation of locomotion(GO:0040017) positive regulation of cellular component movement(GO:0051272) positive regulation of cell motility(GO:2000147)
0.0 0.1 GO:0097186 amelogenesis(GO:0097186)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.0 GO:1902161 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.0 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.6 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.0 GO:1903487 regulation of lactation(GO:1903487)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.3 1.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.2 3.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 0.4 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.1 0.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.3 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.2 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.1 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.0 GO:1990742 microvesicle(GO:1990742)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.4 1.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 1.0 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.2 0.7 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.1 6.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.0 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.6 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.3 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 3.1 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.5 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.3 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.4 GO:0004040 amidase activity(GO:0004040)
0.1 0.2 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.3 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.1 1.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.2 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.0 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.4 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.3 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.2 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.0 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.0 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 3.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.9 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.4 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.0 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway