Motif ID: IRF7

Z-value: 0.902


Transcription factors associated with IRF7:

Gene SymbolEntrez IDGene Name
IRF7 ENSG00000185507.15 IRF7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF7hg19_v2_chr11_-_615570_6157280.077.6e-01Click!


Activity profile for motif IRF7.

activity profile for motif IRF7


Sorted Z-values histogram for motif IRF7

Sorted Z-values for motif IRF7



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_39770803 3.571 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr1_-_207119738 2.365 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr16_-_21289627 2.210 ENST00000396023.2
ENST00000415987.2
CRYM

crystallin, mu

chr4_+_70861647 2.120 ENST00000246895.4
ENST00000381060.2
STATH

statherin

chr6_+_32821924 1.971 ENST00000374859.2
ENST00000453265.2
PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr6_-_29527702 1.827 ENST00000377050.4
UBD
ubiquitin D
chr10_+_51549498 1.769 ENST00000358559.2
ENST00000298239.6
MSMB

microseminoprotein, beta-

chr1_+_79115503 1.732 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44


interferon-induced protein 44


chr7_+_106685079 1.697 ENST00000265717.4
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr7_-_16921601 1.474 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
AGR3


anterior gradient 3


chr1_+_948803 1.430 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr5_+_96212185 1.430 ENST00000379904.4
ERAP2
endoplasmic reticulum aminopeptidase 2
chr5_+_96211643 1.413 ENST00000437043.3
ENST00000510373.1
ERAP2

endoplasmic reticulum aminopeptidase 2

chr12_-_91574142 1.401 ENST00000547937.1
DCN
decorin
chr12_-_10282836 1.339 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr11_+_27062272 1.268 ENST00000529202.1
ENST00000533566.1
BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

chr10_-_21435488 1.181 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113


chromosome 10 open reading frame 113


chr9_-_32526299 1.172 ENST00000379882.1
ENST00000379883.2
DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr4_-_100356844 1.162 ENST00000437033.2
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_+_6561190 1.131 ENST00000544021.1
ENST00000266556.7
TAPBPL

TAP binding protein-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.9 3.6 GO:0036269 swimming behavior(GO:0036269)
0.2 3.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 3.4 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.6 2.5 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.3 2.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 2.4 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.2 2.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 2.1 GO:0046541 saliva secretion(GO:0046541)
0.7 2.0 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 1.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.4 1.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 1.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.2 1.6 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 1.6 GO:0006536 glutamate metabolic process(GO:0006536)
0.3 1.5 GO:0071105 response to interleukin-11(GO:0071105)
0.1 1.3 GO:0045329 carnitine biosynthetic process(GO:0045329)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.6 3.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 3.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3 3.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 2.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.4 GO:0016235 aggresome(GO:0016235)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.9 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.8 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.8 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.1 0.7 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0070069 cytochrome complex(GO:0070069)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0050840 extracellular matrix binding(GO:0050840)
1.2 3.6 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 3.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 3.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 2.4 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.6 2.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 2.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.7 2.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.5 2.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 1.8 GO:0070628 proteasome binding(GO:0070628)
0.3 1.7 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.3 1.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 1.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.5 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.5 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.4 GO:0031386 protein tag(GO:0031386)
0.3 1.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.3 GO:0004000 adenosine deaminase activity(GO:0004000)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.6 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.5 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 0.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.3 3.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.7 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 2.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.9 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.5 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins