Motif ID: IRF3

Z-value: 1.278


Transcription factors associated with IRF3:

Gene SymbolEntrez IDGene Name
IRF3 ENSG00000126456.11 IRF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_50169132-0.145.1e-01Click!


Activity profile for motif IRF3.

activity profile for motif IRF3


Sorted Z-values histogram for motif IRF3

Sorted Z-values for motif IRF3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF3

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_142829162 7.363 ENST00000291009.3
 PIP
prolactin-induced protein
chr1_+_79115503 4.666 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr20_-_25038804 4.632 ENST00000323482.4
 ACSS1
acyl-CoA synthetase short-chain family member 1
chr12_+_6561190 4.367 ENST00000544021.1
ENST00000266556.7
 TAPBPL

TAP binding protein-like

chr6_+_32821924 3.996 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr8_+_39770803 3.782 ENST00000518237.1
 IDO1
indoleamine 2,3-dioxygenase 1
chr4_-_169239921 3.468 ENST00000514995.1
ENST00000393743.3
 DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr19_-_17516449 3.197 ENST00000252593.6
 BST2
bone marrow stromal cell antigen 2
chr17_-_40264692 3.008 ENST00000591220.1
ENST00000251642.3
 DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

chr10_+_91087651 2.958 ENST00000371818.4
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr7_-_122526499 2.803 ENST00000412584.2
 CADPS2
Ca++-dependent secretion activator 2
chr7_-_122526799 2.769 ENST00000334010.7
ENST00000313070.7
 CADPS2

Ca++-dependent secretion activator 2

chr1_+_948803 2.750 ENST00000379389.4
 ISG15
ISG15 ubiquitin-like modifier
chr21_+_42792442 2.724 ENST00000398600.2
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chrX_+_57313113 2.618 ENST00000374900.4
 FAAH2
fatty acid amide hydrolase 2
chr7_+_100728720 2.537 ENST00000306085.6
ENST00000412507.1
 TRIM56

tripartite motif containing 56

chr2_+_69240302 2.473 ENST00000303714.4
 ANTXR1
anthrax toxin receptor 1
chr10_+_91092241 2.425 ENST00000371811.4
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr9_+_74764340 2.321 ENST00000376986.1
ENST00000358399.3
 GDA

guanine deaminase

chr9_-_32526184 2.280 ENST00000545044.1
ENST00000379868.1
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.3 7.4 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.5 6.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
1.6 6.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.4 5.6 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.7 5.6 GO:1990504 dense core granule exocytosis(GO:1990504)
1.2 4.6 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.5 4.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.9 3.8 GO:0036269 swimming behavior(GO:0036269)
1.2 3.5 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.7 3.4 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 3.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 3.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.1 3.2 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
1.0 3.1 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.2 3.0 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.5 2.9 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 2.9 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 2.7 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 2.6 GO:0035456 response to interferon-beta(GO:0035456)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0016324 apical plasma membrane(GO:0016324)
0.6 5.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 4.5 GO:0032587 ruffle membrane(GO:0032587)
0.6 3.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 3.5 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 3.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.7 GO:0005771 multivesicular body(GO:0005771)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.4 2.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 2.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.8 GO:0044530 supraspliceosomal complex(GO:0044530)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 7.4 GO:0019864 IgG binding(GO:0019864)
0.2 5.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 4.6 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 4.5 GO:0003714 transcription corepressor activity(GO:0003714)
1.3 3.8 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 3.5 GO:0005518 collagen binding(GO:0005518)
0.1 3.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.0 2.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 2.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 2.7 GO:0031386 protein tag(GO:0031386)
0.0 2.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 2.5 GO:0019239 deaminase activity(GO:0019239)
0.3 2.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.9 GO:0005319 lipid transporter activity(GO:0005319)
0.2 1.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.7 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 4.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 7.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 5.6 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 4.8 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.3 4.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.8 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.2 3.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 2.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.0 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis