Motif ID: ID4_TCF4_SNAI2

Z-value: 2.358

Transcription factors associated with ID4_TCF4_SNAI2:

Gene SymbolEntrez IDGene Name
ID4 ENSG00000172201.6 ID4
SNAI2 ENSG00000019549.4 SNAI2
TCF4 ENSG00000196628.9 TCF4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ID4hg19_v2_chr6_+_19837592_198376210.941.3e-11Click!
TCF4hg19_v2_chr18_-_53303123_533031900.842.6e-07Click!
SNAI2hg19_v2_chr8_-_49834299_49834446,
hg19_v2_chr8_-_49833978_49833996
-0.793.6e-06Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of ID4_TCF4_SNAI2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_16085340 19.432 ENST00000508167.1
PROM1
prominin 1
chr4_-_16085314 19.430 ENST00000510224.1
PROM1
prominin 1
chr5_+_156693091 15.050 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2



cytoplasmic FMR1 interacting protein 2



chr5_+_156693159 14.691 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_-_73184588 13.323 ENST00000395145.2
CLDN3
claudin 3
chr1_-_75139397 10.869 ENST00000326665.5
C1orf173
chromosome 1 open reading frame 173
chr10_+_22634384 10.277 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
SPAG6






sperm associated antigen 6






chr3_+_63638339 9.948 ENST00000343837.3
ENST00000469440.1
SNTN

sentan, cilia apical structure protein

chr1_+_60280458 9.776 ENST00000455990.1
ENST00000371208.3
HOOK1

hook microtubule-tethering protein 1

chr22_-_50970506 9.731 ENST00000428989.2
ENST00000403326.1
ODF3B

outer dense fiber of sperm tails 3B

chr16_+_67465016 9.600 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr21_+_42688657 8.956 ENST00000357985.2
FAM3B
family with sequence similarity 3, member B
chr4_-_149363662 8.701 ENST00000355292.3
ENST00000358102.3
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr3_-_50383096 8.564 ENST00000442887.1
ENST00000360165.3
ZMYND10

zinc finger, MYND-type containing 10

chr9_-_75567962 8.364 ENST00000297785.3
ENST00000376939.1
ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr1_+_118148556 8.328 ENST00000369448.3
FAM46C
family with sequence similarity 46, member C
chr8_-_110656995 8.288 ENST00000276646.9
ENST00000533065.1
SYBU

syntabulin (syntaxin-interacting)

chr9_-_138391692 8.195 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr2_+_228735763 7.364 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr16_-_776431 7.304 ENST00000293889.6
CCDC78
coiled-coil domain containing 78

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 987 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.7 38.9 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.2 35.9 GO:0070286 axonemal dynein complex assembly(GO:0070286)
2.9 29.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.3 25.5 GO:0001895 retina homeostasis(GO:0001895)
3.4 16.8 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.5 16.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 15.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.4 14.8 GO:0003341 cilium movement(GO:0003341)
0.6 13.9 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 13.2 GO:0016266 O-glycan processing(GO:0016266)
0.4 12.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
2.9 11.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.7 11.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
1.7 10.4 GO:0001705 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.9 9.9 GO:0006824 cobalt ion transport(GO:0006824)
0.4 9.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 9.8 GO:0008333 endosome to lysosome transport(GO:0008333)
0.5 9.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 9.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
1.5 9.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 346 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 45.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
2.1 38.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 22.3 GO:0005796 Golgi lumen(GO:0005796)
0.8 17.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 15.6 GO:0070160 occluding junction(GO:0070160)
0.5 14.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 13.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 12.7 GO:0031526 brush border membrane(GO:0031526)
0.0 12.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 12.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 10.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 9.9 GO:0043202 lysosomal lumen(GO:0043202)
1.4 9.6 GO:0070695 FHF complex(GO:0070695)
0.2 8.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
2.7 8.2 GO:0001534 radial spoke(GO:0001534)
0.0 8.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 7.8 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.1 7.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 7.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 597 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 42.9 GO:0042805 actinin binding(GO:0042805)
0.0 20.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
4.4 17.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.7 16.8 GO:0070330 aromatase activity(GO:0070330)
0.8 14.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 13.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 13.0 GO:0042605 peptide antigen binding(GO:0042605)
2.2 11.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.7 9.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 9.0 GO:0070840 dynein complex binding(GO:0070840)
1.3 8.9 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 8.9 GO:0019003 GDP binding(GO:0019003)
1.1 8.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 8.6 GO:0017075 syntaxin-1 binding(GO:0017075)
2.8 8.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 8.3 GO:0048487 beta-tubulin binding(GO:0048487)
1.2 8.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 8.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
2.6 7.9 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.2 7.7 GO:0008009 chemokine activity(GO:0008009)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 11.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 9.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 5.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 5.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 5.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.4 4.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.3 4.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.3 4.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 4.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 3.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 3.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 3.0 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 3.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 2.4 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 19.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 19.2 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.0 17.0 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.3 13.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 11.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 11.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 11.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6 11.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
1.0 10.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 8.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 8.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 8.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.4 8.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 8.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 7.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 7.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.5 7.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 7.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 6.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 6.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins