Motif ID: ID4_TCF4_SNAI2
Z-value: 2.358



Transcription factors associated with ID4_TCF4_SNAI2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
ID4 | ENSG00000172201.6 | ID4 |
SNAI2 | ENSG00000019549.4 | SNAI2 |
TCF4 | ENSG00000196628.9 | TCF4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
ID4 | hg19_v2_chr6_+_19837592_19837621 | 0.94 | 1.3e-11 | Click! |
TCF4 | hg19_v2_chr18_-_53303123_53303190 | 0.84 | 2.6e-07 | Click! |
SNAI2 | hg19_v2_chr8_-_49834299_49834446, hg19_v2_chr8_-_49833978_49833996 | -0.79 | 3.6e-06 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 987 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
9.7 | 38.9 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
1.2 | 35.9 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
2.9 | 29.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
0.3 | 25.5 | GO:0001895 | retina homeostasis(GO:0001895) |
3.4 | 16.8 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
1.5 | 16.8 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
0.3 | 15.4 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
0.4 | 14.8 | GO:0003341 | cilium movement(GO:0003341) |
0.6 | 13.9 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.2 | 13.2 | GO:0016266 | O-glycan processing(GO:0016266) |
0.4 | 12.1 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
2.9 | 11.4 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
0.7 | 11.1 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
1.7 | 10.4 | GO:0001705 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
0.9 | 9.9 | GO:0006824 | cobalt ion transport(GO:0006824) |
0.4 | 9.9 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
0.2 | 9.8 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
0.5 | 9.6 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
0.2 | 9.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
1.5 | 9.1 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 346 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 45.7 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
2.1 | 38.3 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.2 | 22.3 | GO:0005796 | Golgi lumen(GO:0005796) |
0.8 | 17.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.1 | 15.6 | GO:0070160 | occluding junction(GO:0070160) |
0.5 | 14.3 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
0.1 | 13.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
0.2 | 12.7 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 12.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.3 | 12.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.2 | 10.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 9.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
1.4 | 9.6 | GO:0070695 | FHF complex(GO:0070695) |
0.2 | 8.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 8.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
2.7 | 8.2 | GO:0001534 | radial spoke(GO:0001534) |
0.0 | 8.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
0.1 | 7.8 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
0.1 | 7.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.2 | 7.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 597 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 42.9 | GO:0042805 | actinin binding(GO:0042805) |
0.0 | 20.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
4.4 | 17.7 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
0.7 | 16.8 | GO:0070330 | aromatase activity(GO:0070330) |
0.8 | 14.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.3 | 13.1 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
0.4 | 13.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
2.2 | 11.1 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
0.7 | 9.2 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.2 | 9.0 | GO:0070840 | dynein complex binding(GO:0070840) |
1.3 | 8.9 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
0.1 | 8.9 | GO:0019003 | GDP binding(GO:0019003) |
1.1 | 8.7 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
0.2 | 8.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
2.8 | 8.5 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
0.2 | 8.3 | GO:0048487 | beta-tubulin binding(GO:0048487) |
1.2 | 8.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
0.2 | 8.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
2.6 | 7.9 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
0.2 | 7.7 | GO:0008009 | chemokine activity(GO:0008009) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 62 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 28.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.1 | 11.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.1 | 9.9 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 7.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.3 | 5.8 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.1 | 5.2 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.1 | 5.2 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.4 | 4.7 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.3 | 4.7 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
0.3 | 4.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 4.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.1 | 3.9 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 3.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 3.7 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.1 | 3.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.1 | 3.4 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
0.0 | 3.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.3 | 3.0 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
0.1 | 3.0 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.2 | 2.4 | PID_BCR_5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 121 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 19.7 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.2 | 19.2 | REACTOME_SIGNALING_BY_NOTCH1 | Genes involved in Signaling by NOTCH1 |
0.0 | 17.0 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
0.3 | 13.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.4 | 11.8 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.3 | 11.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.5 | 11.5 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.6 | 11.2 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
1.0 | 10.5 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.1 | 8.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.1 | 8.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
0.3 | 8.4 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.4 | 8.0 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.1 | 8.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.2 | 7.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
0.1 | 7.7 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.5 | 7.6 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.2 | 7.2 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.2 | 6.7 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
0.4 | 6.4 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |