Motif ID: HSF1

Z-value: 0.661


Transcription factors associated with HSF1:

Gene SymbolEntrez IDGene Name
HSF1 ENSG00000185122.6 HSF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_145515299-0.529.8e-03Click!


Activity profile for motif HSF1.

activity profile for motif HSF1


Sorted Z-values histogram for motif HSF1

Sorted Z-values for motif HSF1



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_31870927 3.647 ENST00000253354.1
BPIFB1
BPI fold containing family B, member 1
chr6_-_33041378 3.521 ENST00000428995.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr19_-_55672037 3.070 ENST00000588076.1
DNAAF3
dynein, axonemal, assembly factor 3
chr20_+_18794370 2.456 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr6_-_32557610 2.222 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32498046 2.093 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr9_+_127615733 2.062 ENST00000373574.1
WDR38
WD repeat domain 38
chr7_-_99573677 1.985 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr2_+_132286754 1.937 ENST00000434330.1
CCDC74A
coiled-coil domain containing 74A
chr7_-_99573640 1.863 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr5_+_156696362 1.805 ENST00000377576.3
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_26624775 1.593 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr18_-_71815051 1.542 ENST00000582526.1
ENST00000419743.2
FBXO15

F-box protein 15

chr18_-_71814999 1.528 ENST00000269500.5
FBXO15
F-box protein 15
chr2_+_85981008 1.481 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr2_-_238499303 1.409 ENST00000409576.1
RAB17
RAB17, member RAS oncogene family
chr3_+_42947600 1.372 ENST00000328199.6
ENST00000541208.1
ZNF662

zinc finger protein 662

chr9_-_138391692 1.351 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr7_-_5821225 1.329 ENST00000416985.1
RNF216
ring finger protein 216
chr7_-_138347897 1.290 ENST00000288513.5
SVOPL
SVOP-like
chr1_-_151345159 1.287 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1




selenium binding protein 1




chr19_-_6720686 1.249 ENST00000245907.6
C3
complement component 3
chr6_+_32605195 1.231 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_-_60539405 1.213 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr2_+_106682103 1.194 ENST00000238044.3
C2orf40
chromosome 2 open reading frame 40
chr13_-_26625169 1.185 ENST00000319420.3
SHISA2
shisa family member 2
chr1_-_60539422 1.183 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr2_-_27851843 1.149 ENST00000324364.3
CCDC121
coiled-coil domain containing 121
chr5_+_131630117 1.122 ENST00000200652.3
SLC22A4
solute carrier family 22 (organic cation/zwitterion transporter), member 4
chr2_-_238499131 1.091 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr14_-_106926724 1.014 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr3_-_107941230 0.999 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr4_-_84030996 0.995 ENST00000411416.2
PLAC8
placenta-specific 8
chr12_+_111051832 0.991 ENST00000550703.2
ENST00000551590.1
TCTN1

tectonic family member 1

chr4_+_55524085 0.957 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr15_-_72490114 0.946 ENST00000309731.7
GRAMD2
GRAM domain containing 2
chr12_+_111051902 0.923 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1



tectonic family member 1



chr5_-_110062384 0.916 ENST00000429839.2
TMEM232
transmembrane protein 232
chr22_-_36556821 0.872 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3


apolipoprotein L, 3


chr10_+_114133773 0.871 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_46506358 0.866 ENST00000417439.1
ENST00000431944.1
LTF

lactotransferrin

chr3_+_160473996 0.850 ENST00000498165.1
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr7_+_100728720 0.826 ENST00000306085.6
ENST00000412507.1
TRIM56

tripartite motif containing 56

chr1_+_212782012 0.820 ENST00000341491.4
ENST00000366985.1
ATF3

activating transcription factor 3

chr5_-_101632153 0.817 ENST00000310954.6
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr6_+_32605134 0.815 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr5_-_110062349 0.803 ENST00000511883.2
ENST00000455884.2
TMEM232

transmembrane protein 232

chr1_+_47489240 0.787 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr21_-_43735446 0.785 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr7_+_107301065 0.744 ENST00000265715.3
SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr2_-_202316260 0.739 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr9_+_74764340 0.719 ENST00000376986.1
ENST00000358399.3
GDA

guanine deaminase

chr3_-_46506563 0.699 ENST00000231751.4
LTF
lactotransferrin
chr1_-_173638976 0.691 ENST00000333279.2
ANKRD45
ankyrin repeat domain 45
chr10_-_116444371 0.679 ENST00000533213.2
ENST00000369252.4
ABLIM1

actin binding LIM protein 1

chr6_-_46620522 0.679 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr12_+_93772326 0.676 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4



nudix (nucleoside diphosphate linked moiety X)-type motif 4



chr9_+_33025209 0.671 ENST00000330899.4
ENST00000544625.1
DNAJA1

DnaJ (Hsp40) homolog, subfamily A, member 1

chr7_-_6010263 0.649 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr1_-_114302086 0.638 ENST00000369604.1
ENST00000357783.2
PHTF1

putative homeodomain transcription factor 1

chr6_-_52705641 0.635 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr6_+_32811885 0.634 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1




PSMB9
TAP1 and PSMB8 antisense RNA 1




proteasome (prosome, macropain) subunit, beta type, 9
chr3_-_187454281 0.634 ENST00000232014.4
BCL6
B-cell CLL/lymphoma 6
chr7_+_6793740 0.634 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2



radial spoke head 10 homolog B2 (Chlamydomonas)



chr2_+_109403193 0.633 ENST00000412964.2
ENST00000295124.4
CCDC138

coiled-coil domain containing 138

chr4_+_106816644 0.632 ENST00000506666.1
ENST00000503451.1
NPNT

nephronectin

chr1_+_212738676 0.631 ENST00000366981.4
ENST00000366987.2
ATF3

activating transcription factor 3

chr9_-_88715044 0.627 ENST00000388711.3
ENST00000466178.1
GOLM1

golgi membrane protein 1

chr11_-_89956227 0.622 ENST00000457199.2
ENST00000530765.1
CHORDC1

cysteine and histidine-rich domain (CHORD) containing 1

chr6_+_32811861 0.607 ENST00000453426.1
TAPSAR1
TAP1 and PSMB8 antisense RNA 1
chr10_+_63422695 0.585 ENST00000330194.2
ENST00000389639.3
C10orf107

chromosome 10 open reading frame 107

chr12_+_119772502 0.574 ENST00000536742.1
ENST00000327554.2
CCDC60

coiled-coil domain containing 60

chr18_+_44526786 0.572 ENST00000245121.5
ENST00000356157.7
KATNAL2

katanin p60 subunit A-like 2

chr2_+_27274506 0.568 ENST00000451003.1
ENST00000323064.8
ENST00000360131.4
AGBL5


ATP/GTP binding protein-like 5


chr14_+_75988768 0.558 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr4_+_76932326 0.556 ENST00000513353.1
ENST00000341029.5
ART3

ADP-ribosyltransferase 3

chr22_+_35776828 0.549 ENST00000216117.8
HMOX1
heme oxygenase (decycling) 1
chr7_-_102715263 0.544 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr19_+_37342547 0.543 ENST00000331800.4
ENST00000586646.1
ZNF345

zinc finger protein 345

chr22_-_29196546 0.536 ENST00000403532.3
ENST00000216037.6
XBP1

X-box binding protein 1

chr2_+_102624977 0.530 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr16_-_18468926 0.528 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr20_-_44455976 0.528 ENST00000372555.3
TNNC2
troponin C type 2 (fast)
chr11_-_89956461 0.527 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr4_-_25865159 0.525 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr1_+_15256230 0.518 ENST00000376028.4
ENST00000400798.2
KAZN

kazrin, periplakin interacting protein

chr19_+_47813110 0.517 ENST00000355085.3
C5AR1
complement component 5a receptor 1
chrX_+_49020121 0.505 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGIX


MAGI family member, X-linked


chr21_+_42733870 0.504 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr19_-_4559814 0.504 ENST00000586582.1
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr3_+_119421849 0.503 ENST00000273390.5
ENST00000463700.1
MAATS1

MYCBP-associated, testis expressed 1

chr9_-_100395756 0.496 ENST00000341170.4
ENST00000354801.2
TSTD2

thiosulfate sulfurtransferase (rhodanese)-like domain containing 2

chr9_-_86432547 0.491 ENST00000376365.3
ENST00000376371.2
GKAP1

G kinase anchoring protein 1

chr11_+_123986069 0.488 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
VWA5A





von Willebrand factor A domain containing 5A





chr1_+_152635854 0.488 ENST00000368784.1
LCE2D
late cornified envelope 2D
chr2_+_85766280 0.487 ENST00000306434.3
MAT2A
methionine adenosyltransferase II, alpha
chr3_+_93698974 0.483 ENST00000535334.1
ENST00000478400.1
ENST00000303097.7
ENST00000394222.3
ENST00000471138.1
ENST00000539730.1
ARL13B





ADP-ribosylation factor-like 13B





chr19_-_7766991 0.481 ENST00000597921.1
ENST00000346664.5
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chrX_+_49020882 0.476 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr6_-_170599561 0.475 ENST00000366756.3
DLL1
delta-like 1 (Drosophila)
chr1_+_28261492 0.474 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr2_+_190722119 0.472 ENST00000452382.1
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr2_+_217524323 0.472 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_+_233527443 0.467 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr10_+_15001430 0.465 ENST00000407572.1
MEIG1
meiosis/spermiogenesis associated 1
chr9_+_74764278 0.464 ENST00000238018.4
ENST00000376989.3
GDA

guanine deaminase

chr19_-_50311896 0.463 ENST00000529634.2
FUZ
fuzzy planar cell polarity protein
chr12_-_76742183 0.460 ENST00000393262.3
BBS10
Bardet-Biedl syndrome 10
chrX_-_112084043 0.458 ENST00000304758.1
AMOT
angiomotin
chr1_+_28261621 0.457 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr6_-_52926539 0.453 ENST00000350082.5
ENST00000356971.3
ICK

intestinal cell (MAK-like) kinase

chr3_+_56591184 0.452 ENST00000422222.1
ENST00000394672.3
ENST00000326595.7
CCDC66


coiled-coil domain containing 66


chr6_+_29910301 0.451 ENST00000376809.5
ENST00000376802.2
HLA-A

major histocompatibility complex, class I, A

chrX_-_48776292 0.445 ENST00000376509.4
PIM2
pim-2 oncogene
chr8_-_101321584 0.443 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr9_-_34372830 0.440 ENST00000379142.3
KIAA1161
KIAA1161
chr11_-_105892937 0.436 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chr11_-_26593677 0.434 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr3_+_101443476 0.431 ENST00000327230.4
ENST00000494050.1
CEP97

centrosomal protein 97kDa

chr21_-_43346790 0.429 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr10_-_13544945 0.427 ENST00000378605.3
ENST00000341083.3
BEND7

BEN domain containing 7

chr2_+_241564655 0.426 ENST00000407714.1
GPR35
G protein-coupled receptor 35
chr15_-_42186248 0.424 ENST00000320955.6
SPTBN5
spectrin, beta, non-erythrocytic 5
chr11_-_86383650 0.420 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3



malic enzyme 3, NADP(+)-dependent, mitochondrial



chr17_+_72427477 0.408 ENST00000342648.5
ENST00000481232.1
GPRC5C

G protein-coupled receptor, family C, group 5, member C

chr19_+_42806250 0.408 ENST00000598490.1
ENST00000341747.3
PRR19

proline rich 19

chr11_+_10471836 0.396 ENST00000444303.2
AMPD3
adenosine monophosphate deaminase 3
chr2_-_96701722 0.393 ENST00000434632.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chrX_-_7895755 0.389 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4


patatin-like phospholipase domain containing 4


chr17_+_7590734 0.388 ENST00000457584.2
WRAP53
WD repeat containing, antisense to TP53
chr7_+_150065278 0.386 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1


replication initiator 1


chr12_-_55042140 0.386 ENST00000293371.6
ENST00000456047.2
DCD

dermcidin

chr3_-_39234074 0.384 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1


xin actin-binding repeat containing 1


chr12_+_6898638 0.372 ENST00000011653.4
CD4
CD4 molecule
chr15_-_82338460 0.367 ENST00000558133.1
ENST00000329713.4
MEX3B

mex-3 RNA binding family member B

chr10_-_62332357 0.363 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_7608511 0.358 ENST00000226091.2
EFNB3
ephrin-B3
chr1_+_15632231 0.352 ENST00000375997.4
ENST00000524761.1
ENST00000375995.3
ENST00000401090.2
FHAD1



forkhead-associated (FHA) phosphopeptide binding domain 1



chr17_+_72426891 0.348 ENST00000392627.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr4_-_104021009 0.347 ENST00000509245.1
ENST00000296424.4
BDH2

3-hydroxybutyrate dehydrogenase, type 2

chr11_-_107328527 0.343 ENST00000282251.5
ENST00000433523.1
CWF19L2

CWF19-like 2, cell cycle control (S. pombe)

chr5_+_178450753 0.343 ENST00000444149.2
ENST00000519896.1
ENST00000522442.1
ZNF879


zinc finger protein 879


chrX_-_73072534 0.342 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr9_-_139922726 0.341 ENST00000265662.5
ENST00000371605.3
ABCA2

ATP-binding cassette, sub-family A (ABC1), member 2

chrX_+_130192216 0.333 ENST00000276211.5
ARHGAP36
Rho GTPase activating protein 36
chr8_-_56685859 0.332 ENST00000523423.1
ENST00000523073.1
ENST00000519784.1
ENST00000434581.2
ENST00000519780.1
ENST00000521229.1
ENST00000522576.1
ENST00000523180.1
ENST00000522090.1
TMEM68








transmembrane protein 68








chr8_+_8559406 0.330 ENST00000519106.1
CLDN23
claudin 23
chr6_-_131949200 0.329 ENST00000539158.1
ENST00000368058.1
MED23

mediator complex subunit 23

chr1_+_231762526 0.328 ENST00000317586.4
ENST00000602873.1
ENST00000539444.1
ENST00000602281.1
ENST00000366633.3
ENST00000366636.4
ENST00000366637.3
ENST00000439617.2
ENST00000535983.1
ENST00000537876.1
DISC1









disrupted in schizophrenia 1









chr14_-_21493123 0.328 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
























NDRG family member 2
























chr17_+_76227391 0.327 ENST00000586400.1
ENST00000421688.1
ENST00000374946.3
TMEM235


transmembrane protein 235


chr8_-_38386175 0.322 ENST00000437935.2
ENST00000358138.1
C8orf86

chromosome 8 open reading frame 86

chr19_-_2740036 0.321 ENST00000269740.4
ENST00000586572.1
SLC39A3
AC006538.4
solute carrier family 39 (zinc transporter), member 3
Uncharacterized protein
chr1_+_202830876 0.321 ENST00000456105.2
RP11-480I12.7
RP11-480I12.7
chr12_+_93772402 0.315 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr7_+_5919458 0.315 ENST00000416608.1
OCM
oncomodulin
chr9_-_116102562 0.314 ENST00000374193.4
ENST00000465979.1
WDR31

WD repeat domain 31

chr17_+_73996987 0.312 ENST00000588812.1
ENST00000448471.1
CDK3

cyclin-dependent kinase 3

chr6_+_31795506 0.311 ENST00000375650.3
HSPA1B
heat shock 70kDa protein 1B
chr2_+_103089756 0.309 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr3_-_52931557 0.308 ENST00000355083.5
ENST00000504329.1
TMEM110
TMEM110-MUSTN1
transmembrane protein 110
TMEM110-MUSTN1 readthrough
chr6_+_31783291 0.307 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A


heat shock 70kDa protein 1A


chr2_-_201729284 0.306 ENST00000434813.2
CLK1
CDC-like kinase 1
chr6_-_32811771 0.306 ENST00000395339.3
ENST00000374882.3
PSMB8

proteasome (prosome, macropain) subunit, beta type, 8

chr6_-_39282329 0.305 ENST00000373231.4
KCNK17
potassium channel, subfamily K, member 17
chr9_-_88714421 0.305 ENST00000388712.3
GOLM1
golgi membrane protein 1
chr14_+_22694606 0.303 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr19_+_50338234 0.303 ENST00000593767.1
MED25
mediator complex subunit 25
chr11_+_60050026 0.302 ENST00000395016.3
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr6_-_32812420 0.296 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr21_+_45148735 0.295 ENST00000327574.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr17_+_53342311 0.294 ENST00000226067.5
HLF
hepatic leukemia factor
chrX_+_130192318 0.290 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr5_+_122110691 0.290 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2


sorting nexin 2


chr11_+_77184416 0.289 ENST00000598970.1
DKFZP434E1119
DKFZP434E1119
chr1_-_224517823 0.287 ENST00000469968.1
ENST00000436927.1
ENST00000469075.1
ENST00000488718.1
ENST00000482491.1
ENST00000340871.4
ENST00000492281.1
ENST00000361463.3
ENST00000391875.2
ENST00000461546.1
NVL









nuclear VCP-like









chr17_-_34313685 0.285 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
CCL14


chemokine (C-C motif) ligand 14


chr1_-_10856694 0.284 ENST00000377022.3
ENST00000344008.5
CASZ1

castor zinc finger 1

chr9_-_97356075 0.281 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr16_-_88770019 0.278 ENST00000541206.2
RNF166
ring finger protein 166
chr1_+_166958497 0.276 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr10_-_53459319 0.276 ENST00000331173.4
CSTF2T
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
chr2_-_218867711 0.276 ENST00000446903.1
TNS1
tensin 1
chr9_-_116102530 0.274 ENST00000374195.3
ENST00000341761.4
WDR31

WD repeat domain 31

chr3_-_125775629 0.274 ENST00000383598.2
SLC41A3
solute carrier family 41, member 3
chr16_-_52640834 0.273 ENST00000510238.3
CASC16
cancer susceptibility candidate 16 (non-protein coding)
chr12_+_1738363 0.272 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr19_+_3708376 0.270 ENST00000539908.2
TJP3
tight junction protein 3
chr19_-_47922750 0.269 ENST00000331559.5
MEIS3
Meis homeobox 3
chr3_-_150920979 0.267 ENST00000309180.5
ENST00000480322.1
GPR171

G protein-coupled receptor 171

chr19_+_3762645 0.266 ENST00000330133.4
MRPL54
mitochondrial ribosomal protein L54
chr12_+_109577202 0.265 ENST00000377848.3
ENST00000377854.5
ACACB

acetyl-CoA carboxylase beta

chr11_+_61520075 0.265 ENST00000278836.5
MYRF
myelin regulatory factor
chr2_-_97405775 0.265 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L




lectin, mannose-binding 2-like




chr17_+_4634705 0.257 ENST00000575284.1
ENST00000573708.1
ENST00000293777.5
MED11


mediator complex subunit 11


chr13_+_50571155 0.255 ENST00000420995.2
ENST00000378182.3
ENST00000356017.4
ENST00000457662.2
TRIM13



tripartite motif containing 13



chr17_+_71228740 0.253 ENST00000268942.8
ENST00000359042.2
C17orf80

chromosome 17 open reading frame 80

chr6_-_131949305 0.252 ENST00000368053.4
ENST00000354577.4
ENST00000403834.3
ENST00000540546.1
ENST00000368068.3
ENST00000368060.3
MED23





mediator complex subunit 23





chr21_+_35747773 0.249 ENST00000399292.3
ENST00000399299.1
ENST00000399295.2
SMIM11


small integral membrane protein 11


chr22_-_44894178 0.247 ENST00000341255.3
LDOC1L
leucine zipper, down-regulated in cancer 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.5 2.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.5 1.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.5 1.0 GO:0070662 mast cell proliferation(GO:0070662)
0.5 3.6 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.4 2.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.4 1.2 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.4 1.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.4 1.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.3 1.9 GO:0021523 somatic motor neuron differentiation(GO:0021523) protein localization to ciliary transition zone(GO:1904491)
0.2 0.7 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 1.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.2 0.9 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.2 1.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.5 GO:0035470 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
0.2 0.5 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.2 1.0 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 0.5 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633)
0.2 0.6 GO:2000721 pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.1 4.2 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.5 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.4 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 0.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.5 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1 0.5 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.2 GO:1901536 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.1 0.5 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 4.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.3 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.1 0.5 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 0.8 GO:0015705 iodide transport(GO:0015705)
0.1 0.3 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.4 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.1 0.2 GO:0042214 terpene metabolic process(GO:0042214)
0.1 0.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.2 GO:0051168 nuclear export(GO:0051168)
0.1 0.3 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.1 1.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.1 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 1.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 1.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 1.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.3 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.1 0.4 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.2 GO:0071529 cementum mineralization(GO:0071529)
0.1 1.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.2 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.2 GO:0097252 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.1 7.9 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.2 GO:0070839 divalent metal ion export(GO:0070839)
0.1 0.5 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.1 0.7 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.1 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.1 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.1 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.1 0.6 GO:0035608 protein deglutamylation(GO:0035608)
0.1 0.3 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.5 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.1 1.1 GO:1902603 carnitine transmembrane transport(GO:1902603)
0.1 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.1 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.3 GO:0035799 ureter maturation(GO:0035799)
0.0 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 1.0 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0003249 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250)
0.0 0.5 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 1.1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0060214 endocardium formation(GO:0060214)
0.0 0.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.3 GO:0035973 aggrephagy(GO:0035973)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.3 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.0 0.4 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.5 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.1 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 2.2 GO:0032608 interferon-beta production(GO:0032608)
0.0 0.3 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.4 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.6 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.5 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.0 GO:0003193 pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:1901142 insulin metabolic process(GO:1901142)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0071442 regulation of histone H3-K14 acetylation(GO:0071440) positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104) butyrate metabolic process(GO:0019605)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.5 GO:0003341 cilium movement(GO:0003341)
0.0 0.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 1.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.2 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.5 9.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.4 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)
0.2 0.5 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.6 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 1.9 GO:0036038 MKS complex(GO:0036038)
0.1 0.3 GO:0030849 autosome(GO:0030849)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.1 0.7 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.5 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.5 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 2.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.1 GO:0000779 condensed chromosome kinetochore(GO:0000777) condensed chromosome, centromeric region(GO:0000779)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.0 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.0 GO:0036398 TCR signalosome(GO:0036398)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 1.1 GO:0008513 secondary active organic cation transmembrane transporter activity(GO:0008513)
0.2 3.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 0.5 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.2 1.0 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 4.8 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 1.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.4 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 1.3 GO:0008430 selenium binding(GO:0008430)
0.1 0.3 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 0.5 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.5 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 0.3 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.1 0.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.2 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.2 GO:0090541 MIT domain binding(GO:0090541)
0.1 1.1 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0019863 IgE binding(GO:0019863)
0.0 1.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 1.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.6 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 1.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.1 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.4 GO:0034452 myosin heavy chain binding(GO:0032036) dynactin binding(GO:0034452)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.0 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.0 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.2 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 1.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.6 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling