Motif ID: HSF1
Z-value: 0.661
Transcription factors associated with HSF1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
HSF1 | ENSG00000185122.6 | HSF1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
HSF1 | hg19_v2_chr8_+_145515263_145515299 | -0.52 | 9.8e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0033214 | iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308) |
0.5 | 2.5 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
0.5 | 1.5 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
0.5 | 1.0 | GO:0070662 | mast cell proliferation(GO:0070662) |
0.5 | 3.6 | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) |
0.4 | 2.2 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
0.4 | 1.2 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
0.4 | 1.2 | GO:0032764 | negative regulation of mast cell cytokine production(GO:0032764) |
0.4 | 1.1 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
0.3 | 1.9 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) protein localization to ciliary transition zone(GO:1904491) |
0.2 | 0.7 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
0.2 | 1.2 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
0.2 | 0.9 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
0.2 | 1.8 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
0.2 | 0.5 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487) |
0.2 | 0.5 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
0.2 | 1.0 | GO:1901908 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
0.2 | 0.5 | GO:0045608 | negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633) |
0.2 | 0.6 | GO:2000721 | pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721) |
0.1 | 4.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.1 | 0.5 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
0.1 | 0.4 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
0.1 | 0.5 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
0.1 | 0.5 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
0.1 | 0.5 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
0.1 | 0.2 | GO:1901536 | regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) |
0.1 | 0.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
0.1 | 4.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.1 | 0.3 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
0.1 | 0.5 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
0.1 | 0.8 | GO:0015705 | iodide transport(GO:0015705) |
0.1 | 0.3 | GO:0034553 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
0.1 | 0.4 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.1 | 0.5 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
0.1 | 0.4 | GO:0071350 | interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350) |
0.1 | 0.2 | GO:0042214 | terpene metabolic process(GO:0042214) |
0.1 | 0.2 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
0.1 | 0.2 | GO:0051168 | nuclear export(GO:0051168) |
0.1 | 0.3 | GO:2001178 | mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178) |
0.1 | 1.0 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
0.1 | 0.1 | GO:1990418 | response to insulin-like growth factor stimulus(GO:1990418) |
0.1 | 0.2 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
0.1 | 0.4 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
0.1 | 1.2 | GO:0070314 | G1 to G0 transition(GO:0070314) |
0.1 | 1.2 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.1 | 1.6 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
0.1 | 0.3 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
0.1 | 0.4 | GO:0006196 | AMP catabolic process(GO:0006196) |
0.1 | 0.2 | GO:0071529 | cementum mineralization(GO:0071529) |
0.1 | 1.5 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.1 | 0.2 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
0.1 | 0.2 | GO:0097252 | negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252) |
0.1 | 7.9 | GO:0031295 | T cell costimulation(GO:0031295) |
0.1 | 0.2 | GO:0070839 | divalent metal ion export(GO:0070839) |
0.1 | 0.5 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
0.1 | 0.7 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
0.1 | 0.2 | GO:0007402 | ganglion mother cell fate determination(GO:0007402) |
0.1 | 0.1 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
0.1 | 0.1 | GO:1903721 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
0.1 | 0.6 | GO:0035608 | protein deglutamylation(GO:0035608) |
0.1 | 0.3 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
0.1 | 0.4 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
0.1 | 0.5 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
0.1 | 1.1 | GO:1902603 | carnitine transmembrane transport(GO:1902603) |
0.1 | 0.1 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
0.1 | 0.2 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
0.1 | 0.4 | GO:0072592 | oxygen metabolic process(GO:0072592) |
0.1 | 0.1 | GO:0040009 | regulation of growth rate(GO:0040009) |
0.0 | 0.3 | GO:0035799 | ureter maturation(GO:0035799) |
0.0 | 0.5 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
0.0 | 1.0 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
0.0 | 0.1 | GO:0003249 | left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) |
0.0 | 0.5 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
0.0 | 0.5 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
0.0 | 0.2 | GO:0043335 | protein unfolding(GO:0043335) |
0.0 | 0.1 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
0.0 | 0.2 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
0.0 | 0.2 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
0.0 | 1.1 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
0.0 | 0.2 | GO:0060214 | endocardium formation(GO:0060214) |
0.0 | 0.4 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.0 | 0.4 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
0.0 | 0.1 | GO:2000566 | positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566) |
0.0 | 0.3 | GO:0035973 | aggrephagy(GO:0035973) |
0.0 | 0.2 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
0.0 | 0.3 | GO:0045023 | G0 to G1 transition(GO:0045023) |
0.0 | 0.3 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
0.0 | 0.3 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
0.0 | 0.1 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
0.0 | 0.1 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
0.0 | 0.3 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
0.0 | 0.4 | GO:0042048 | olfactory behavior(GO:0042048) |
0.0 | 0.5 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
0.0 | 0.1 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
0.0 | 2.2 | GO:0032608 | interferon-beta production(GO:0032608) |
0.0 | 0.3 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860) |
0.0 | 0.1 | GO:0051664 | nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664) |
0.0 | 0.4 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.0 | 0.2 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
0.0 | 0.2 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.0 | 0.2 | GO:0021678 | third ventricle development(GO:0021678) |
0.0 | 0.1 | GO:0030070 | insulin processing(GO:0030070) |
0.0 | 0.6 | GO:0002320 | lymphoid progenitor cell differentiation(GO:0002320) |
0.0 | 0.2 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
0.0 | 0.2 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
0.0 | 0.9 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.0 | 0.3 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
0.0 | 0.1 | GO:0015798 | myo-inositol transport(GO:0015798) |
0.0 | 0.5 | GO:0046548 | retinal rod cell development(GO:0046548) |
0.0 | 0.2 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
0.0 | 0.1 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
0.0 | 0.4 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
0.0 | 0.3 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
0.0 | 0.1 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.0 | 0.2 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.0 | 1.7 | GO:0015914 | phospholipid transport(GO:0015914) |
0.0 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 0.2 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
0.0 | 0.0 | GO:0003193 | pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922) |
0.0 | 0.1 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
0.0 | 0.1 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.0 | 0.3 | GO:0070307 | lens fiber cell development(GO:0070307) |
0.0 | 0.1 | GO:1901142 | insulin metabolic process(GO:1901142) |
0.0 | 0.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.4 | GO:0034587 | piRNA metabolic process(GO:0034587) |
0.0 | 0.4 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.0 | 0.3 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
0.0 | 0.1 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.0 | 0.5 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
0.0 | 0.1 | GO:0071442 | regulation of histone H3-K14 acetylation(GO:0071440) positive regulation of histone H3-K14 acetylation(GO:0071442) |
0.0 | 0.2 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.0 | 0.1 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) butyrate metabolic process(GO:0019605) |
0.0 | 0.1 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
0.0 | 0.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.0 | 0.2 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.1 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
0.0 | 0.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.0 | 0.2 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
0.0 | 0.1 | GO:0048254 | snoRNA localization(GO:0048254) |
0.0 | 0.0 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
0.0 | 0.5 | GO:0003341 | cilium movement(GO:0003341) |
0.0 | 0.1 | GO:0048263 | determination of dorsal identity(GO:0048263) |
0.0 | 0.1 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
0.0 | 0.1 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.0 | 1.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
0.0 | 0.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 0.2 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
0.0 | 0.2 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
0.0 | 0.6 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
0.0 | 0.1 | GO:0052405 | negative regulation by host of symbiont molecular function(GO:0052405) |
0.0 | 0.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
0.0 | 0.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
0.0 | 0.0 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
0.0 | 0.1 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056) |
0.0 | 0.1 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
0.0 | 0.2 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
0.0 | 0.1 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
0.0 | 0.1 | GO:0045793 | positive regulation of cell size(GO:0045793) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
0.5 | 9.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.2 | 1.4 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
0.2 | 0.5 | GO:0001534 | radial spoke(GO:0001534) |
0.2 | 0.5 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
0.1 | 1.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.1 | 0.6 | GO:0034678 | integrin alpha8-beta1 complex(GO:0034678) |
0.1 | 1.9 | GO:0036038 | MKS complex(GO:0036038) |
0.1 | 0.3 | GO:0030849 | autosome(GO:0030849) |
0.1 | 1.0 | GO:0044292 | dendrite terminus(GO:0044292) |
0.1 | 0.7 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.1 | 0.5 | GO:0032389 | MutLalpha complex(GO:0032389) |
0.1 | 0.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.0 | 0.2 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
0.0 | 0.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
0.0 | 0.2 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
0.0 | 0.5 | GO:0042611 | MHC protein complex(GO:0042611) |
0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 0.3 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
0.0 | 0.1 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
0.0 | 0.2 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
0.0 | 0.2 | GO:0001940 | male pronucleus(GO:0001940) |
0.0 | 2.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 1.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 0.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.0 | 0.1 | GO:0032127 | dense core granule membrane(GO:0032127) |
0.0 | 0.4 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.4 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
0.0 | 0.3 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
0.0 | 0.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
0.0 | 0.2 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.0 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 0.1 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
0.0 | 0.1 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
0.0 | 0.1 | GO:0032444 | activin responsive factor complex(GO:0032444) |
0.0 | 0.2 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
0.0 | 0.1 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
0.0 | 0.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 0.6 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 0.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
0.0 | 0.1 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.0 | 0.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
0.0 | 0.2 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
0.0 | 0.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 2.0 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
0.0 | 0.1 | GO:0000779 | condensed chromosome kinetochore(GO:0000777) condensed chromosome, centromeric region(GO:0000779) |
0.0 | 1.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 1.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
0.0 | 0.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.0 | 0.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 0.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 0.1 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
0.0 | 0.1 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 0.1 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
0.0 | 0.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.0 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.0 | 0.0 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.0 | 1.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
0.0 | 0.1 | GO:0061574 | ASAP complex(GO:0061574) |
0.0 | 0.0 | GO:0036398 | TCR signalosome(GO:0036398) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 5.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
0.3 | 1.1 | GO:0008513 | secondary active organic cation transmembrane transporter activity(GO:0008513) |
0.2 | 3.8 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
0.2 | 0.5 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.2 | 0.5 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
0.2 | 1.0 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
0.2 | 4.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.1 | 0.7 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
0.1 | 1.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.1 | 0.4 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
0.1 | 1.3 | GO:0008430 | selenium binding(GO:0008430) |
0.1 | 0.3 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
0.1 | 0.5 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
0.1 | 0.5 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
0.1 | 0.3 | GO:0008478 | pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403) |
0.1 | 0.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.1 | 0.6 | GO:0043532 | angiostatin binding(GO:0043532) |
0.1 | 0.4 | GO:0042289 | MHC class II protein binding(GO:0042289) |
0.1 | 0.2 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
0.1 | 1.0 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.1 | 0.6 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.1 | 0.6 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
0.1 | 0.3 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
0.1 | 0.2 | GO:0051139 | metal ion:proton antiporter activity(GO:0051139) |
0.1 | 0.2 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
0.1 | 0.3 | GO:1990460 | leptin receptor binding(GO:1990460) |
0.1 | 0.2 | GO:0090541 | MIT domain binding(GO:0090541) |
0.1 | 1.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.1 | 1.0 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.0 | 0.4 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.0 | 0.4 | GO:0019863 | IgE binding(GO:0019863) |
0.0 | 1.9 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.0 | 0.1 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
0.0 | 0.1 | GO:0001032 | RNA polymerase III type 3 promoter DNA binding(GO:0001032) |
0.0 | 1.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.2 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
0.0 | 0.6 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.0 | 0.4 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
0.0 | 0.1 | GO:0005174 | CD40 receptor binding(GO:0005174) |
0.0 | 0.6 | GO:0030957 | Tat protein binding(GO:0030957) |
0.0 | 0.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.0 | 0.1 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
0.0 | 0.4 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.2 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
0.0 | 0.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 0.2 | GO:0004473 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
0.0 | 1.2 | GO:0019239 | deaminase activity(GO:0019239) |
0.0 | 0.3 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
0.0 | 0.7 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.0 | 0.1 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
0.0 | 2.2 | GO:0019003 | GDP binding(GO:0019003) |
0.0 | 0.2 | GO:0030911 | TPR domain binding(GO:0030911) |
0.0 | 0.4 | GO:0034452 | myosin heavy chain binding(GO:0032036) dynactin binding(GO:0034452) |
0.0 | 0.1 | GO:0035514 | DNA demethylase activity(GO:0035514) |
0.0 | 1.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
0.0 | 0.2 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.0 | 0.6 | GO:0070330 | aromatase activity(GO:0070330) |
0.0 | 1.5 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.2 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.0 | 0.5 | GO:0030983 | mismatched DNA binding(GO:0030983) |
0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.0 | 0.1 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
0.0 | 1.0 | GO:0015248 | sterol transporter activity(GO:0015248) |
0.0 | 0.1 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
0.0 | 0.1 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
0.0 | 0.2 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
0.0 | 0.2 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
0.0 | 0.2 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 0.1 | GO:0001602 | pancreatic polypeptide receptor activity(GO:0001602) |
0.0 | 0.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.2 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.0 | 0.1 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.1 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.0 | 0.7 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
0.0 | 0.3 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
0.0 | 0.1 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.0 | 0.0 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.1 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
0.0 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.0 | 0.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.0 | 0.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.1 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
0.0 | 0.2 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 0.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
0.0 | 0.0 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
0.0 | 0.0 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
0.0 | 0.1 | GO:0043199 | sulfate binding(GO:0043199) |
0.0 | 0.2 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
0.0 | 0.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
0.0 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
0.0 | 0.1 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
0.0 | 0.2 | GO:0035198 | miRNA binding(GO:0035198) |
0.0 | 0.5 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 0.9 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 0.2 | PID_IL27_PATHWAY | IL27-mediated signaling events |
0.0 | 1.6 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 1.7 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.0 | 1.7 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 0.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 0.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
0.0 | 0.3 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.6 | PID_IL1_PATHWAY | IL1-mediated signaling events |
0.0 | 0.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 10.3 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.1 | 1.2 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
0.1 | 0.7 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.1 | 1.2 | REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT | Genes involved in Initial triggering of complement |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.0 | 0.5 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.0 | 0.9 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.0 | 1.5 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.0 | 1.0 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 1.8 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.0 | 0.5 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 1.0 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 0.7 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
0.0 | 0.7 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.5 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
0.0 | 0.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 1.6 | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
0.0 | 0.3 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
0.0 | 0.8 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
0.0 | 0.3 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.0 | 0.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.0 | 0.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.4 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.0 | 0.3 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
0.0 | 0.5 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.0 | 0.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.0 | 0.5 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.0 | 0.3 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
0.0 | 0.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.3 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
0.0 | 0.6 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |