Motif ID: HOXC9

Z-value: 0.517


Transcription factors associated with HOXC9:

Gene SymbolEntrez IDGene Name
HOXC9 ENSG00000180806.4 HOXC9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXC9hg19_v2_chr12_+_54393880_54393962-0.405.0e-02Click!


Activity profile for motif HOXC9.

activity profile for motif HOXC9


Sorted Z-values histogram for motif HOXC9

Sorted Z-values for motif HOXC9



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_25055177 0.733 ENST00000538118.1
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr2_-_216878305 0.718 ENST00000263268.6
MREG
melanoregulin
chr11_+_125496400 0.658 ENST00000524737.1
CHEK1
checkpoint kinase 1
chr12_-_95945246 0.591 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr8_+_94241867 0.559 ENST00000598428.1
AC016885.1
Uncharacterized protein
chr1_-_197115818 0.559 ENST00000367409.4
ENST00000294732.7
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr11_+_125496619 0.495 ENST00000532669.1
ENST00000278916.3
CHEK1

checkpoint kinase 1

chr7_+_130126165 0.491 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST


mesoderm specific transcript


chr12_-_30887948 0.479 ENST00000433722.2
CAPRIN2
caprin family member 2
chr7_+_130126012 0.475 ENST00000341441.5
MEST
mesoderm specific transcript
chr21_-_31859755 0.450 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr3_-_108672609 0.447 ENST00000393963.3
ENST00000471108.1
GUCA1C

guanylate cyclase activator 1C

chr11_-_5323226 0.435 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr14_+_31046959 0.434 ENST00000547532.1
ENST00000555429.1
G2E3

G2/M-phase specific E3 ubiquitin protein ligase

chr18_-_19994830 0.434 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr18_+_34124507 0.428 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3
chr22_-_32767017 0.412 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr13_-_24007815 0.411 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_-_107729887 0.403 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr11_+_125496124 0.392 ENST00000533778.2
ENST00000534070.1
CHEK1

checkpoint kinase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.0 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.8 GO:0032402 melanosome transport(GO:0032402)
0.1 0.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 0.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.2 0.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.4 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 0.4 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.3 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.3 GO:0072709 cellular response to sorbitol(GO:0072709)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 1.0 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.8 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.1 0.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0000800 lateral element(GO:0000800)
0.1 0.2 GO:0030849 Y chromosome(GO:0000806) autosome(GO:0030849)
0.1 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.1 GO:0043235 receptor complex(GO:0043235)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 0.9 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.7 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 0.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.3 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins