Motif ID: HOXC6_HOXA7

Z-value: 0.525

Transcription factors associated with HOXC6_HOXA7:

Gene SymbolEntrez IDGene Name
HOXA7 ENSG00000122592.6 HOXA7
HOXC6 ENSG00000197757.7 HOXC6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA7hg19_v2_chr7_-_27196267_271963110.462.5e-02Click!
HOXC6hg19_v2_chr12_+_54422142_54422239-0.203.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC6_HOXA7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_26593779 1.206 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr11_-_26593677 1.153 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr11_-_26593649 0.972 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr13_+_36050881 0.916 ENST00000537702.1
NBEA
neurobeachin
chr2_+_228736335 0.700 ENST00000440997.1
ENST00000545118.1
DAW1

dynein assembly factor with WDR repeat domains 1

chr4_-_100356551 0.573 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr19_+_50016610 0.505 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_10282836 0.449 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr16_-_28634874 0.444 ENST00000395609.1
ENST00000350842.4
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr14_-_101295407 0.428 ENST00000596284.1
AL117190.2
AL117190.2
chr11_-_63376013 0.411 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr12_-_91573132 0.398 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chr2_+_26624775 0.393 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr10_-_118928543 0.391 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr20_+_15177480 0.380 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr4_-_120243545 0.368 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr12_-_10282681 0.367 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr12_+_131438443 0.366 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr12_-_10282742 0.357 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr17_+_4692230 0.353 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.7 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2 0.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.4 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.1 0.3 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.2 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 0.6 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.1 0.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.4 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate