Motif ID: HNF4A

Z-value: 0.528


Transcription factors associated with HNF4A:

Gene SymbolEntrez IDGene Name
HNF4A ENSG00000101076.12 HNF4A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF4Ahg19_v2_chr20_+_42984330_42984445-0.164.5e-01Click!


Activity profile for motif HNF4A.

activity profile for motif HNF4A


Sorted Z-values histogram for motif HNF4A

Sorted Z-values for motif HNF4A



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_7921090 1.415 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr10_-_61513146 1.393 ENST00000430431.1
LINC00948
long intergenic non-protein coding RNA 948
chr10_-_61513201 1.183 ENST00000414264.1
ENST00000594536.1
LINC00948

long intergenic non-protein coding RNA 948

chr19_+_41594377 0.987 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr12_+_56075330 0.929 ENST00000394252.3
METTL7B
methyltransferase like 7B
chr2_-_28113217 0.919 ENST00000444339.2
RBKS
ribokinase
chr11_+_60467047 0.839 ENST00000300226.2
MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr10_-_17171817 0.809 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_159313214 0.763 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148


coiled-coil domain containing 148


chr6_+_116937636 0.625 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr19_+_4639514 0.547 ENST00000327473.4
TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr10_+_96522361 0.539 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr16_-_16317321 0.526 ENST00000205557.7
ENST00000575728.1
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr1_-_177939348 0.479 ENST00000464631.2
SEC16B
SEC16 homolog B (S. cerevisiae)
chr5_-_16509101 0.439 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr17_+_7591639 0.415 ENST00000396463.2
WRAP53
WD repeat containing, antisense to TP53
chr10_+_96698406 0.408 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr17_+_7591747 0.404 ENST00000534050.1
WRAP53
WD repeat containing, antisense to TP53
chr14_+_23352374 0.393 ENST00000267396.4
ENST00000536884.1
REM2

RAS (RAD and GEM)-like GTP binding 2

chr2_+_241544834 0.387 ENST00000319838.5
ENST00000403859.1
ENST00000438013.2
GPR35


G protein-coupled receptor 35



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.9 GO:0019303 D-ribose catabolic process(GO:0019303)
0.2 0.9 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.1 0.9 GO:0009804 coumarin metabolic process(GO:0009804)
0.3 0.8 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.8 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0003032 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.1 0.4 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.4 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.4 GO:0015747 urate transport(GO:0015747)
0.0 0.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.3 GO:0060086 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.2 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.1 0.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 0.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.2 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.6 GO:0001534 radial spoke(GO:0001534)
0.1 0.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.5 1.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.8 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 0.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.2 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.2 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 1.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism