Motif ID: HMX1

Z-value: 0.599


Transcription factors associated with HMX1:

Gene SymbolEntrez IDGene Name
HMX1 ENSG00000215612.5 HMX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMX1hg19_v2_chr4_-_8873531_88735430.301.6e-01Click!


Activity profile for motif HMX1.

activity profile for motif HMX1


Sorted Z-values histogram for motif HMX1

Sorted Z-values for motif HMX1



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_21494654 1.576 ENST00000377142.4
 NKX2-2
NK2 homeobox 2
chr2_+_106682103 1.380 ENST00000238044.3
 C2orf40
chromosome 2 open reading frame 40
chr2_+_106682135 1.188 ENST00000437659.1
 C2orf40
chromosome 2 open reading frame 40
chr16_-_776431 1.042 ENST00000293889.6
 CCDC78
coiled-coil domain containing 78
chr1_-_46598371 0.909 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
 PIK3R3




phosphoinositide-3-kinase, regulatory subunit 3 (gamma)




chr1_-_46598284 0.874 ENST00000423209.1
ENST00000262741.5
 PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr20_+_44098346 0.849 ENST00000372676.3
 WFDC2
WAP four-disulfide core domain 2
chr13_+_25254545 0.807 ENST00000218548.6
 ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr18_-_45935663 0.766 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
 ZBTB7C







zinc finger and BTB domain containing 7C







chr5_+_156693159 0.765 ENST00000347377.6
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_+_156693091 0.741 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
 CYFIP2



cytoplasmic FMR1 interacting protein 2



chr13_+_35516390 0.693 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr19_-_14316980 0.674 ENST00000361434.3
ENST00000340736.6
 LPHN1

latrophilin 1

chr16_-_70712229 0.659 ENST00000562883.2
 MTSS1L
metastasis suppressor 1-like
chr3_+_69788576 0.657 ENST00000352241.4
ENST00000448226.2
 MITF

microphthalmia-associated transcription factor

chr3_-_107941209 0.640 ENST00000492106.1
 IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr22_-_29196030 0.604 ENST00000405219.3
 XBP1
X-box binding protein 1
chr2_-_27712583 0.572 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
 IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr13_+_25254693 0.570 ENST00000381946.3
 ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr22_-_29196546 0.536 ENST00000403532.3
ENST00000216037.6
 XBP1

X-box binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.5 1.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 1.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 1.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 1.2 GO:0044458 motile cilium assembly(GO:0044458)
0.4 1.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
0.1 1.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.8 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.8 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 0.6 GO:0061525 hindgut development(GO:0061525)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.2 0.5 GO:1902214 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
0.1 0.5 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.3 1.4 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.0 GO:0098536 deuterosome(GO:0098536)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.2 0.6 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.4 GO:1990393 3M complex(GO:1990393)
0.0 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.2 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 1.4 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.2 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.8 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.5 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.1 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling