Motif ID: HLF_TEF

Z-value: 0.657

Transcription factors associated with HLF_TEF:

Gene SymbolEntrez IDGene Name
HLF ENSG00000108924.9 HLF
TEF ENSG00000167074.10 TEF

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TEFhg19_v2_chr22_+_41777927_41777971,
hg19_v2_chr22_+_41763274_41763337		0.481.9e-02Click!
HLFhg19_v2_chr17_+_53344945_533449770.193.8e-01Click!


Activity profile for motif HLF_TEF.

activity profile for motif HLF_TEF


Sorted Z-values histogram for motif HLF_TEF

Sorted Z-values for motif HLF_TEF



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF_TEF

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_33759854 1.427 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr1_+_7844312 1.302 ENST00000377541.1
 PER3
period circadian clock 3
chr17_-_41623691 1.183 ENST00000545954.1
 ETV4
ets variant 4
chr14_+_78227105 1.160 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
 C14orf178



chromosome 14 open reading frame 178



chr2_-_113594279 1.119 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr17_-_41623075 1.112 ENST00000545089.1
 ETV4
ets variant 4
chr19_-_35992780 0.904 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
 DMKN


dermokine


chr17_-_41623259 0.878 ENST00000538265.1
ENST00000591713.1
 ETV4

ets variant 4

chr17_-_41623716 0.836 ENST00000319349.5
 ETV4
ets variant 4
chr12_-_71031185 0.818 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
 PTPRB


protein tyrosine phosphatase, receptor type, B


chr17_-_41623009 0.778 ENST00000393664.2
 ETV4
ets variant 4
chr1_-_244013384 0.761 ENST00000366539.1
 AKT3
v-akt murine thymoma viral oncogene homolog 3
chr2_-_31637560 0.738 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr5_-_140013275 0.719 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
 CD14


CD14 molecule


chr7_-_83824169 0.651 ENST00000265362.4
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_154797877 0.577 ENST00000462745.1
ENST00000493237.1
 MME

membrane metallo-endopeptidase

chr9_-_123639304 0.567 ENST00000436309.1
 PHF19
PHD finger protein 19
chr3_-_48130707 0.561 ENST00000360240.6
ENST00000383737.4
 MAP4

microtubule-associated protein 4

chr8_-_6735451 0.553 ENST00000297439.3
 DEFB1
defensin, beta 1
chr17_+_39975455 0.542 ENST00000455106.1
 FKBP10
FK506 binding protein 10, 65 kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 1.3 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 1.3 GO:0050819 negative regulation of coagulation(GO:0050819)
0.4 1.1 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 1.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 0.9 GO:0051012 microtubule sliding(GO:0051012)
0.2 0.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 0.7 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 0.7 GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 0.7 GO:0048880 sensory system development(GO:0048880)
0.0 0.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 0.6 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.6 GO:0046449 creatinine metabolic process(GO:0046449) cellular response to UV-A(GO:0071492)
0.1 0.6 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.6 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.2 0.5 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.5 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.1 0.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.0 GO:0070552 BRISC complex(GO:0070552)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:1990742 microvesicle(GO:1990742)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.4 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 1.1 GO:0004882 androgen receptor activity(GO:0004882)
0.1 1.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.0 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.7 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.7 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.5 GO:0008430 selenium binding(GO:0008430)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.4 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones