Motif ID: HIC1

Z-value: 0.789


Transcription factors associated with HIC1:

Gene SymbolEntrez IDGene Name
HIC1 ENSG00000177374.8 HIC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1hg19_v2_chr17_+_1959369_1959604,
hg19_v2_chr17_+_1958388_1958404
0.048.7e-01Click!


Activity profile for motif HIC1.

activity profile for motif HIC1


Sorted Z-values histogram for motif HIC1

Sorted Z-values for motif HIC1



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_2160611 1.122 ENST00000416167.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_26274917 0.705 ENST00000538142.1
SSPN
sarcospan
chr12_-_132905789 0.704 ENST00000328957.8
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr18_+_77623668 0.673 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr13_+_110959598 0.652 ENST00000360467.5
COL4A2
collagen, type IV, alpha 2
chr9_+_22446814 0.636 ENST00000325870.2
DMRTA1
DMRT-like family A1
chr11_+_120382417 0.633 ENST00000527524.2
ENST00000375081.2
GRIK4
AP002348.1
glutamate receptor, ionotropic, kainate 4
Uncharacterized protein
chr4_+_3768075 0.588 ENST00000509482.1
ENST00000330055.5
ADRA2C

adrenoceptor alpha 2C

chr6_+_159590423 0.559 ENST00000297267.9
ENST00000340366.6
FNDC1

fibronectin type III domain containing 1

chr10_+_116853201 0.559 ENST00000527407.1
ATRNL1
attractin-like 1
chrX_-_45710920 0.549 ENST00000456532.1
RP5-1158E12.3
RP5-1158E12.3
chr1_+_1551220 0.547 ENST00000378712.1
MIB2
mindbomb E3 ubiquitin protein ligase 2
chr13_+_28712614 0.527 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr7_+_70597109 0.515 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr3_+_52280173 0.514 ENST00000296487.4
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr11_+_119019722 0.512 ENST00000307417.3
ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4
chr5_+_6633456 0.511 ENST00000274192.5
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr1_-_62784935 0.508 ENST00000354381.3
KANK4
KN motif and ankyrin repeat domains 4
chr5_+_6633534 0.471 ENST00000537411.1
ENST00000538824.1
SRD5A1

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

chr4_-_109684120 0.470 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ETNPPL



ethanolamine-phosphate phospho-lyase




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 289 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 0.9 GO:0060992 response to fungicide(GO:0060992)
0.1 0.9 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.8 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 0.8 GO:0060179 male mating behavior(GO:0060179)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.7 GO:0032455 nerve growth factor processing(GO:0032455)
0.1 0.7 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.0 0.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 0.6 GO:0032811 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.1 0.6 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.6 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.6 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.6 GO:0016266 O-glycan processing(GO:0016266)
0.2 0.5 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.2 0.5 GO:0045062 extrathymic T cell selection(GO:0045062)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0034705 potassium channel complex(GO:0034705)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.0 GO:0070852 cell body fiber(GO:0070852)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.0 0.9 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.8 GO:0098845 postsynaptic endosome(GO:0098845)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.7 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0005874 microtubule(GO:0005874)
0.0 0.6 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 0.5 GO:0031251 PAN complex(GO:0031251)
0.0 0.5 GO:0043219 lateral loop(GO:0043219)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.4 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 1.0 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.2 1.0 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.9 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.7 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 0.7 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.2 0.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 0.6 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 0.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.5 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 0.5 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.5 GO:0097016 L27 domain binding(GO:0097016)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.1 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.0 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_GAB1_SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.6 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism