Motif ID: GUGCAAA

Z-value: 0.917


Mature miRNA associated with seed GUGCAAA:

NamemiRBase Accession
hsa-miR-19a-3p MIMAT0000073
hsa-miR-19b-3p MIMAT0000074



Activity profile for motif GUGCAAA.

activity profile for motif GUGCAAA


Sorted Z-values histogram for motif GUGCAAA

Sorted Z-values for motif GUGCAAA



Network of associatons between targets according to the STRING database.



First level regulatory network of GUGCAAA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_149365827 4.354 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr6_-_132272504 4.348 ENST00000367976.3
CTGF
connective tissue growth factor
chr4_+_75858290 4.122 ENST00000513238.1
PARM1
prostate androgen-regulated mucin-like protein 1
chr8_-_110660999 2.917 ENST00000424158.2
ENST00000533895.1
ENST00000446070.2
ENST00000528331.1
ENST00000526302.1
ENST00000433638.1
ENST00000408908.2
ENST00000524720.1
SYBU







syntabulin (syntaxin-interacting)







chr6_-_90121938 2.598 ENST00000369415.4
RRAGD
Ras-related GTP binding D
chr4_+_55524085 2.494 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr17_+_68165657 2.456 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_-_46598284 2.324 ENST00000423209.1
ENST00000262741.5
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr2_+_121103706 2.288 ENST00000295228.3
INHBB
inhibin, beta B
chr1_+_183605200 2.285 ENST00000304685.4
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr5_+_140254884 2.246 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr5_+_140248518 2.215 ENST00000398640.2
PCDHA11
protocadherin alpha 11
chr5_+_140227048 2.205 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr5_+_140213815 2.161 ENST00000525929.1
ENST00000378125.3
PCDHA7

protocadherin alpha 7

chr17_+_55333876 2.146 ENST00000284073.2
MSI2
musashi RNA-binding protein 2
chr5_+_140220769 2.091 ENST00000531613.1
ENST00000378123.3
PCDHA8

protocadherin alpha 8

chr10_+_115803650 2.078 ENST00000369295.2
ADRB1
adrenoceptor beta 1
chr3_+_113666748 2.071 ENST00000330212.3
ENST00000498275.1
ZDHHC23

zinc finger, DHHC-type containing 23

chr6_-_46138676 2.051 ENST00000371383.2
ENST00000230565.3
ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chr6_+_16129308 2.022 ENST00000356840.3
ENST00000349606.4
MYLIP

myosin regulatory light chain interacting protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4 4.3 GO:0034059 response to anoxia(GO:0034059)
0.1 3.5 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 3.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 3.2 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.3 2.6 GO:0071233 cellular response to leucine(GO:0071233)
0.8 2.5 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.8 2.5 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.5 2.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.7 2.1 GO:0003099 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.3 1.9 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.1 1.9 GO:0044320 cellular response to leptin stimulus(GO:0044320)
0.1 1.9 GO:0018345 protein palmitoylation(GO:0018345)
0.3 1.8 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.2 1.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 1.6 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 1.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.5 1.4 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.3 1.4 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.2 1.4 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 4.4 GO:0043235 receptor complex(GO:0043235)
0.2 2.9 GO:0097433 dense body(GO:0097433)
0.1 2.5 GO:0042629 mast cell granule(GO:0042629)
0.4 2.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 2.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 2.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.6 GO:0097542 ciliary tip(GO:0097542)
0.0 1.6 GO:0005844 polysome(GO:0005844)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.1 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.2 GO:0031985 Golgi cisterna(GO:0031985)
0.4 1.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 1.1 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 4.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 3.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 2.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 2.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 2.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 2.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.7 2.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.1 2.0 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.1 1.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.5 1.6 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.1 1.6 GO:0050811 GABA receptor binding(GO:0050811)
0.2 1.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.4 GO:0005112 Notch binding(GO:0005112)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 3.9 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 3.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 3.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.0 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.5 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 4.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.4 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 2.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 2.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 2.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.7 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 0.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling