Motif ID: GUAACAG

Z-value: 0.348


Mature miRNA associated with seed GUAACAG:

NamemiRBase Accession
hsa-miR-194-5p MIMAT0000460



Activity profile for motif GUAACAG.

activity profile for motif GUAACAG


Sorted Z-values histogram for motif GUAACAG

Sorted Z-values for motif GUAACAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAACAG

PNG image of the network

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Top targets:


Showing 1 to 20 of 159 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_115375107 0.991 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1





cell adhesion molecule 1





chr12_-_76425368 0.547 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_-_59995921 0.425 ENST00000453022.2
ENST00000545085.1
ENST00000265036.5
DEPDC1B


DEP domain containing 1B


chr2_-_208030647 0.421 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_-_94285511 0.401 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr21_-_16437255 0.401 ENST00000400199.1
ENST00000400202.1
NRIP1

nuclear receptor interacting protein 1

chr15_+_39873268 0.399 ENST00000397591.2
ENST00000260356.5
THBS1

thrombospondin 1

chr14_+_55034599 0.383 ENST00000392067.3
ENST00000357634.3
SAMD4A

sterile alpha motif domain containing 4A

chr14_+_85996471 0.377 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_-_139726181 0.367 ENST00000507104.1
ENST00000230990.6
HBEGF

heparin-binding EGF-like growth factor

chr2_+_210444142 0.328 ENST00000360351.4
ENST00000361559.4
MAP2

microtubule-associated protein 2

chr15_-_34628951 0.326 ENST00000397707.2
ENST00000560611.1
SLC12A6

solute carrier family 12 (potassium/chloride transporter), member 6

chr22_-_22221900 0.320 ENST00000215832.6
ENST00000398822.3
MAPK1

mitogen-activated protein kinase 1

chr17_-_33448468 0.310 ENST00000587405.1
ENST00000591723.1
ENST00000593039.1
RAD51D
RAD51L3-RFFL

RAD51 paralog D
Uncharacterized protein

chr10_-_75634260 0.310 ENST00000372765.1
ENST00000351293.3
CAMK2G

calcium/calmodulin-dependent protein kinase II gamma

chr22_+_40390930 0.302 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr7_-_98741642 0.302 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr14_-_35182994 0.291 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr8_+_42752053 0.252 ENST00000307602.4
HOOK3
hook microtubule-tethering protein 3
chr12_+_93965451 0.251 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.5 GO:0045210 FasL biosynthetic process(GO:0045210)
0.1 0.4 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 0.4 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.3 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.3 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.3 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.3 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.2 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 0.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion