Motif ID: GLIS2
Z-value: 0.659
Transcription factors associated with GLIS2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GLIS2 | ENSG00000126603.4 | GLIS2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLIS2 | hg19_v2_chr16_+_4382225_4382225, hg19_v2_chr16_+_4364762_4364762 | -0.30 | 1.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 136 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.3 | 3.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) positive regulation of axon regeneration(GO:0048680) action potential propagation(GO:0098870) |
| 0.8 | 2.4 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.5 | 2.0 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.6 | 1.7 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.5 | 1.5 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.4 | 1.4 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.4 | 1.4 | GO:0010752 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 0.0 | 1.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.3 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.1 | 1.2 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.1 | 1.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 1.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.4 | 1.1 | GO:1904298 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
| 0.0 | 1.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 1.1 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 1.1 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.3 | 1.0 | GO:2000646 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646) |
| 0.3 | 1.0 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.2 | 1.0 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 56 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 2.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 1.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.3 | 1.0 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.3 | 1.0 | GO:0048787 | presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.0 | 1.0 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 0.8 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 0.7 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 0.7 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.0 | 0.7 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.6 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 97 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.6 | 3.1 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.3 | 3.0 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 2.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 1.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.5 | 1.5 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.4 | 1.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.5 | 1.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.4 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.4 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 1.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 1.1 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.2 | 1.1 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.1 | 1.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 1.0 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 1.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 0.9 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.0 | 0.9 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in C2:CP category:
Showing 1 to 17 of 17 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.9 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 1.4 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.8 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.8 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.7 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.3 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.2 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.7 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.6 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 1.1 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.1 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.0 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.9 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.7 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.6 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.5 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.4 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.3 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.3 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
