Motif ID: GLIS2

Z-value: 0.659


Transcription factors associated with GLIS2:

Gene SymbolEntrez IDGene Name
GLIS2 ENSG00000126603.4 GLIS2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GLIS2hg19_v2_chr16_+_4382225_4382225,
hg19_v2_chr16_+_4364762_4364762
-0.301.6e-01Click!


Activity profile for motif GLIS2.

activity profile for motif GLIS2


Sorted Z-values histogram for motif GLIS2

Sorted Z-values for motif GLIS2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLIS2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_2903514 2.369 ENST00000380698.4
SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
chr19_+_35645817 1.791 ENST00000423817.3
FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_35645618 1.738 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5






FXYD domain containing ion transport regulator 5






chr2_+_24272576 1.686 ENST00000380986.4
ENST00000452109.1
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr1_-_186649543 1.515 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_24272543 1.459 ENST00000380991.4
FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr11_+_844067 1.217 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
TSPAN4


tetraspanin 4


chr1_-_28520447 1.139 ENST00000539896.1
PTAFR
platelet-activating factor receptor
chr1_-_153348067 1.062 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr7_-_73133959 1.029 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A



syntaxin 1A (brain)



chr19_+_45409011 0.952 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE


apolipoprotein E


chr22_+_31489344 0.908 ENST00000404574.1
SMTN
smoothelin
chr2_+_37571717 0.907 ENST00000338415.3
ENST00000404976.1
QPCT

glutaminyl-peptide cyclotransferase

chr19_+_54372639 0.860 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr19_+_17858509 0.809 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCHO1


FCH domain only 1


chr8_+_27183033 0.796 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr20_+_44637526 0.787 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_-_58131931 0.768 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr6_-_39290316 0.761 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16



potassium channel, subfamily K, member 16



chr11_-_64646086 0.738 ENST00000320631.3
EHD1
EH-domain containing 1
chr5_-_176836577 0.723 ENST00000253496.3
F12
coagulation factor XII (Hageman factor)
chr1_-_40157345 0.720 ENST00000372844.3
HPCAL4
hippocalcin like 4
chrX_-_153602991 0.714 ENST00000369850.3
ENST00000422373.1
FLNA

filamin A, alpha

chr19_+_45349432 0.704 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr19_+_45418067 0.703 ENST00000589078.1
ENST00000586638.1
APOC1

apolipoprotein C-I

chr22_+_23264766 0.702 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr19_+_2249308 0.694 ENST00000592877.1
ENST00000221496.4
AMH

anti-Mullerian hormone

chr12_+_57853918 0.685 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1



GLI family zinc finger 1



chr19_+_11200038 0.684 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR





low density lipoprotein receptor





chr2_-_27718052 0.677 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr17_+_41476327 0.635 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr2_+_37571845 0.631 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr17_-_76921459 0.628 ENST00000262768.7
TIMP2
TIMP metallopeptidase inhibitor 2
chr7_+_2671663 0.626 ENST00000407643.1
TTYH3
tweety family member 3
chr12_+_119616447 0.625 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr8_+_27182862 0.624 ENST00000521164.1
ENST00000346049.5
PTK2B

protein tyrosine kinase 2 beta

chr19_+_17858547 0.623 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCHO1







FCH domain only 1







chr16_+_70680439 0.588 ENST00000288098.2
IL34
interleukin 34
chr6_-_39290744 0.587 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr19_-_55652290 0.585 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr1_-_24127256 0.583 ENST00000418277.1
GALE
UDP-galactose-4-epimerase
chr13_-_20767037 0.578 ENST00000382848.4
GJB2
gap junction protein, beta 2, 26kDa
chr22_-_30685596 0.574 ENST00000404953.3
ENST00000407689.3
GATSL3

GATS protein-like 3

chr19_+_54369608 0.565 ENST00000336967.3
MYADM
myeloid-associated differentiation marker
chr19_+_48828582 0.560 ENST00000270221.6
ENST00000596315.1
EMP3

epithelial membrane protein 3

chr19_+_48824711 0.541 ENST00000599704.1
EMP3
epithelial membrane protein 3
chr19_-_41859814 0.530 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr7_+_77167343 0.523 ENST00000433369.2
ENST00000415482.2
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr1_-_156675535 0.520 ENST00000368221.1
CRABP2
cellular retinoic acid binding protein 2
chr1_-_19229248 0.519 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_42931567 0.511 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr8_+_38243951 0.510 ENST00000297720.5
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr1_-_6550625 0.501 ENST00000377725.1
ENST00000340850.5
PLEKHG5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

chr19_+_45417504 0.497 ENST00000588750.1
ENST00000588802.1
APOC1

apolipoprotein C-I

chr2_+_114737472 0.475 ENST00000420161.1
AC110769.3
AC110769.3
chr21_-_31869451 0.471 ENST00000334058.2
KRTAP19-4
keratin associated protein 19-4
chr22_-_28197486 0.466 ENST00000302326.4
MN1
meningioma (disrupted in balanced translocation) 1
chr10_-_33623564 0.457 ENST00000374875.1
ENST00000374822.4
NRP1

neuropilin 1

chr16_+_3070313 0.453 ENST00000326577.4
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr21_+_34775698 0.453 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr13_+_110959598 0.448 ENST00000360467.5
COL4A2
collagen, type IV, alpha 2
chr19_-_46405861 0.445 ENST00000322217.5
MYPOP
Myb-related transcription factor, partner of profilin
chr9_+_139847347 0.440 ENST00000371632.3
LCN12
lipocalin 12
chr3_-_48130314 0.434 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4


microtubule-associated protein 4


chr16_+_3070356 0.433 ENST00000341627.5
ENST00000575124.1
ENST00000575836.1
TNFRSF12A


tumor necrosis factor receptor superfamily, member 12A


chr1_-_156675368 0.429 ENST00000368222.3
CRABP2
cellular retinoic acid binding protein 2
chr16_+_57279248 0.422 ENST00000562023.1
ENST00000563234.1
ARL2BP

ADP-ribosylation factor-like 2 binding protein

chr16_-_29910365 0.420 ENST00000346932.5
ENST00000350527.3
ENST00000537485.1
ENST00000568380.1
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr5_-_1524015 0.416 ENST00000283415.3
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr10_-_75634219 0.411 ENST00000305762.7
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr19_+_45417921 0.409 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1


apolipoprotein C-I


chr9_-_34637806 0.401 ENST00000477726.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr22_-_46931191 0.400 ENST00000454637.1
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1
chr11_-_2160180 0.400 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_77167376 0.399 ENST00000435495.2
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr19_+_45417812 0.396 ENST00000592535.1
APOC1
apolipoprotein C-I
chr2_+_102508955 0.396 ENST00000414004.2
FLJ20373
FLJ20373
chr14_+_94640633 0.395 ENST00000304338.3
PPP4R4
protein phosphatase 4, regulatory subunit 4
chr12_-_51785182 0.395 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
GALNT6



UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)



chr3_+_111578131 0.390 ENST00000498699.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr7_+_116166331 0.372 ENST00000393468.1
ENST00000393467.1
CAV1

caveolin 1, caveolae protein, 22kDa

chr1_-_228604328 0.371 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17




tripartite motif containing 17




chr2_-_89310012 0.368 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr22_-_39640756 0.367 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr6_-_43484718 0.367 ENST00000372422.2
YIPF3
Yip1 domain family, member 3
chr17_+_7210898 0.358 ENST00000572815.1
EIF5A
eukaryotic translation initiation factor 5A
chr16_+_27078219 0.354 ENST00000418886.1
C16orf82
chromosome 16 open reading frame 82
chr7_-_98741714 0.353 ENST00000361125.1
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr21_+_34775181 0.352 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr22_-_21482046 0.350 ENST00000419447.1
POM121L7
POM121 transmembrane nucleoporin-like 7
chr12_-_57941004 0.348 ENST00000550750.1
ENST00000548249.1
DCTN2

dynactin 2 (p50)

chr20_-_23969416 0.348 ENST00000335694.4
GGTLC1
gamma-glutamyltransferase light chain 1
chr13_-_24007815 0.341 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr12_-_57940904 0.340 ENST00000550954.1
ENST00000434715.3
ENST00000546670.1
ENST00000543672.1
DCTN2



dynactin 2 (p50)



chr16_+_69458537 0.337 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B


cytochrome b5 type B (outer mitochondrial membrane)


chr1_+_148928291 0.336 ENST00000420597.1
ENST00000452399.1
ENST00000294715.2
ENST00000539543.1
RP11-14N7.2



RP11-14N7.2



chr11_+_86748998 0.336 ENST00000525018.1
ENST00000355734.4
TMEM135

transmembrane protein 135

chr10_+_106014468 0.336 ENST00000369710.4
ENST00000369713.5
ENST00000445155.1
GSTO1


glutathione S-transferase omega 1


chr5_+_169010638 0.334 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
SPDL1




spindle apparatus coiled-coil protein 1




chr13_+_47127322 0.333 ENST00000389798.3
LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr22_-_50700140 0.333 ENST00000215659.8
MAPK12
mitogen-activated protein kinase 12
chr14_-_54955721 0.332 ENST00000554908.1
GMFB
glia maturation factor, beta
chr17_+_28886584 0.331 ENST00000584297.1
ENST00000579181.1
TBC1D29

TBC1 domain family, member 29

chr1_-_24126892 0.328 ENST00000374497.3
ENST00000425913.1
GALE

UDP-galactose-4-epimerase

chr16_-_28518153 0.327 ENST00000356897.1
IL27
interleukin 27
chr11_-_627143 0.325 ENST00000176195.3
SCT
secretin
chr19_-_45661995 0.325 ENST00000438936.2
NKPD1
NTPase, KAP family P-loop domain containing 1
chr11_-_64546202 0.319 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
SF1




splicing factor 1




chr16_-_32688053 0.319 ENST00000398682.4
TP53TG3
TP53 target 3
chr3_-_48470838 0.319 ENST00000358459.4
ENST00000358536.4
PLXNB1

plexin B1

chr18_-_59274139 0.318 ENST00000586949.1
RP11-879F14.2
RP11-879F14.2
chr22_-_21482352 0.317 ENST00000329949.3
POM121L7
POM121 transmembrane nucleoporin-like 7
chr22_+_18834324 0.316 ENST00000342005.4
AC008132.13
Uncharacterized protein
chr4_+_37828255 0.315 ENST00000381967.4
ENST00000544359.1
ENST00000537241.1
PGM2


phosphoglucomutase 2


chr20_+_35974532 0.313 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr16_+_640201 0.313 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr19_+_45147098 0.306 ENST00000425690.3
ENST00000344956.4
ENST00000403059.4
PVR


poliovirus receptor


chr11_-_64510409 0.304 ENST00000394429.1
ENST00000394428.1
RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

chr14_+_24540731 0.303 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6




copine VI (neuronal)




chr21_-_45671014 0.303 ENST00000436357.1
DNMT3L
DNA (cytosine-5-)-methyltransferase 3-like
chr16_+_765092 0.298 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr8_+_38243967 0.298 ENST00000524874.1
ENST00000379957.4
ENST00000523983.2
LETM2


leucine zipper-EF-hand containing transmembrane protein 2


chr20_-_30310797 0.292 ENST00000422920.1
BCL2L1
BCL2-like 1
chr19_+_7733929 0.290 ENST00000221515.2
RETN
resistin
chr15_-_79383102 0.286 ENST00000558480.2
ENST00000419573.3
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr4_-_48082192 0.285 ENST00000507351.1
TXK
TXK tyrosine kinase
chr21_+_34775772 0.284 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr11_+_63753883 0.284 ENST00000538426.1
ENST00000543004.1
OTUB1

OTU domain, ubiquitin aldehyde binding 1

chr19_-_2050852 0.282 ENST00000541165.1
ENST00000591601.1
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr7_-_752577 0.281 ENST00000544935.1
ENST00000430040.1
ENST00000456696.2
ENST00000406797.1
PRKAR1B



protein kinase, cAMP-dependent, regulatory, type I, beta



chr19_-_4517613 0.278 ENST00000301286.3
PLIN4
perilipin 4
chr19_+_14640372 0.277 ENST00000215567.5
ENST00000598298.1
ENST00000596073.1
ENST00000600083.1
ENST00000436007.2
TECR




trans-2,3-enoyl-CoA reductase




chr6_+_144164455 0.276 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr22_+_21400229 0.275 ENST00000342608.4
ENST00000543388.1
ENST00000442047.1
AC002472.13


Leucine-rich repeat-containing protein LOC400891


chr3_-_43663519 0.273 ENST00000427171.1
ENST00000292246.3
ANO10

anoctamin 10

chr16_+_32264040 0.268 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr12_+_58166370 0.267 ENST00000300209.8
METTL21B
methyltransferase like 21B
chr1_-_201123546 0.267 ENST00000435310.1
ENST00000485839.2
ENST00000367330.1
TMEM9


transmembrane protein 9


chr12_+_57522258 0.267 ENST00000553277.1
ENST00000243077.3
LRP1

low density lipoprotein receptor-related protein 1

chr1_+_160051319 0.265 ENST00000368088.3
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr6_-_163148780 0.265 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2



parkin RBR E3 ubiquitin protein ligase



chr5_-_141060389 0.261 ENST00000504448.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_+_45582453 0.260 ENST00000587566.1
ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
MARK4
GEMIN7



MAP/microtubule affinity-regulating kinase 4
gem (nuclear organelle) associated protein 7



chr12_-_53242770 0.259 ENST00000304620.4
ENST00000547110.1
KRT78

keratin 78

chr6_-_71012773 0.256 ENST00000370496.3
ENST00000357250.6
COL9A1

collagen, type IX, alpha 1

chr20_-_30433396 0.254 ENST00000375978.3
FOXS1
forkhead box S1
chr15_+_42694573 0.251 ENST00000397200.4
ENST00000569827.1
CAPN3

calpain 3, (p94)

chr1_-_201123586 0.250 ENST00000414605.2
ENST00000367334.5
ENST00000367332.1
TMEM9


transmembrane protein 9


chr1_-_115300579 0.250 ENST00000358528.4
ENST00000525132.1
CSDE1

cold shock domain containing E1, RNA-binding

chr17_-_5138099 0.250 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SCIMP



SLP adaptor and CSK interacting membrane protein



chr1_+_87595497 0.250 ENST00000471417.1
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr9_-_35112376 0.249 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chrX_+_53078273 0.249 ENST00000332582.4
GPR173
G protein-coupled receptor 173
chr1_-_32110467 0.246 ENST00000440872.2
ENST00000373703.4
PEF1

penta-EF-hand domain containing 1

chr2_+_220492373 0.244 ENST00000317151.3
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr1_+_202431859 0.241 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr11_-_71955210 0.239 ENST00000298231.5
PHOX2A
paired-like homeobox 2a
chr1_+_1950763 0.238 ENST00000378585.4
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chrX_+_51927919 0.238 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr5_+_140566 0.236 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr17_-_7307358 0.236 ENST00000535512.1
ENST00000576017.1
ENST00000302422.3
TMEM256-PLSCR3
TMEM256

TMEM256-PLSCR3 readthrough (NMD candidate)
transmembrane protein 256

chr7_-_92107229 0.233 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr21_-_45681765 0.233 ENST00000431166.1
DNMT3L
DNA (cytosine-5-)-methyltransferase 3-like
chr19_+_11909329 0.232 ENST00000323169.5
ENST00000450087.1
ZNF491

zinc finger protein 491

chr1_-_209824643 0.231 ENST00000391911.1
ENST00000415782.1
LAMB3

laminin, beta 3

chr9_+_139839711 0.229 ENST00000224181.3
C8G
complement component 8, gamma polypeptide
chr1_-_31661000 0.229 ENST00000263693.1
ENST00000398657.2
ENST00000526106.1
NKAIN1


Na+/K+ transporting ATPase interacting 1


chr9_+_103189536 0.228 ENST00000374885.1
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr13_-_22033392 0.226 ENST00000320220.9
ENST00000415724.1
ENST00000422251.1
ENST00000382466.3
ENST00000542645.1
ENST00000400590.3
ZDHHC20





zinc finger, DHHC-type containing 20





chr11_-_72353451 0.225 ENST00000376450.3
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr19_-_38397228 0.224 ENST00000447313.2
WDR87
WD repeat domain 87
chr20_+_52824367 0.222 ENST00000371419.2
PFDN4
prefoldin subunit 4
chr19_+_11039391 0.221 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr1_+_35544968 0.220 ENST00000359858.4
ENST00000373330.1
ZMYM1

zinc finger, MYM-type 1

chr14_+_100150622 0.217 ENST00000261835.3
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr2_-_113999260 0.217 ENST00000468980.2
PAX8
paired box 8
chr19_+_45973120 0.217 ENST00000592811.1
ENST00000586615.1
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr19_+_41103063 0.215 ENST00000308370.7
LTBP4
latent transforming growth factor beta binding protein 4
chr1_-_43638168 0.214 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr19_-_38397285 0.213 ENST00000303868.5
WDR87
WD repeat domain 87
chr22_-_38794490 0.213 ENST00000400206.2
CSNK1E
casein kinase 1, epsilon
chr2_-_85829496 0.213 ENST00000409668.1
TMEM150A
transmembrane protein 150A
chr15_+_91478493 0.212 ENST00000418476.2
UNC45A
unc-45 homolog A (C. elegans)
chr1_-_115300592 0.209 ENST00000261443.5
ENST00000534699.1
ENST00000339438.6
ENST00000529046.1
ENST00000525970.1
ENST00000369530.1
ENST00000530886.1
CSDE1






cold shock domain containing E1, RNA-binding






chr14_-_36988882 0.208 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr1_-_1149506 0.206 ENST00000379236.3
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr11_+_66624527 0.202 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr3_+_38206975 0.201 ENST00000446845.1
ENST00000311806.3
OXSR1

oxidative stress responsive 1

chr9_+_139839686 0.200 ENST00000371634.2
C8G
complement component 8, gamma polypeptide
chr2_-_230933709 0.199 ENST00000436869.1
ENST00000295190.4
SLC16A14

solute carrier family 16, member 14

chr10_+_98064085 0.199 ENST00000419175.1
ENST00000371174.2
DNTT

DNA nucleotidylexotransferase

chr6_-_32908765 0.195 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr16_+_84224780 0.195 ENST00000315906.5
ADAD2
adenosine deaminase domain containing 2
chr1_+_65613217 0.195 ENST00000545314.1
AK4
adenylate kinase 4
chr16_+_33204980 0.193 ENST00000561509.1
TP53TG3C
TP53 target 3C
chr9_-_34710066 0.187 ENST00000378792.1
ENST00000259607.2
CCL21

chemokine (C-C motif) ligand 21

chr19_+_17186577 0.183 ENST00000595618.1
ENST00000594824.1
MYO9B

myosin IXB

chr22_-_18257178 0.180 ENST00000342111.5
BID
BH3 interacting domain death agonist
chr14_-_107211459 0.178 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr19_-_16008880 0.177 ENST00000011989.7
ENST00000221700.6
CYP4F2

cytochrome P450, family 4, subfamily F, polypeptide 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.8 2.4 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.6 1.7 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.5 1.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.5 2.0 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.4 1.1 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.4 1.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.4 1.4 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.0 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.3 0.3 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.3 3.1 GO:0019227 neuronal action potential propagation(GO:0019227) positive regulation of axon regeneration(GO:0048680) action potential propagation(GO:0098870)
0.3 1.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.2 0.7 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 1.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 0.5 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.7 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.6 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
0.1 0.7 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.1 0.4 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1 0.4 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.6 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.4 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 0.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.4 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.3 GO:0060455 negative regulation of gastric acid secretion(GO:0060455) positive regulation of pancreatic juice secretion(GO:0090187)
0.1 0.3 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.3 GO:0086098 angiotensin-activated signaling pathway involved in heart process(GO:0086098)
0.1 0.5 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 0.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 1.2 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 1.3 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1 0.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.2 GO:0021558 trochlear nerve development(GO:0021558)
0.1 0.5 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 1.2 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.2 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.2 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.2 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.5 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.5 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.2 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.2 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.3 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.3 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.5 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.2 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.3 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 1.1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:0002086 diaphragm contraction(GO:0002086)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.1 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 1.1 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.0 0.7 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:1903903 protein localization to plasma membrane raft(GO:0044860) regulation of establishment of T cell polarity(GO:1903903)
0.0 0.2 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.2 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:1901897 regulation of skeletal muscle adaptation(GO:0014733) regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.2 GO:2000172 endoplasmic reticulum tubular network assembly(GO:0071787) regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.0 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 0.1 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.0 0.5 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.1 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.4 GO:0032094 response to food(GO:0032094)
0.0 0.3 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.0 0.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 0.7 GO:0031523 Myb complex(GO:0031523)
0.2 0.7 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.6 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.8 GO:0042627 chylomicron(GO:0042627)
0.1 0.5 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.2 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.1 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 3.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.3 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.6 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0034448 EGO complex(GO:0034448)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 3.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.5 GO:0001726 ruffle(GO:0001726)
0.0 0.1 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.5 1.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.5 1.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 1.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 3.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 0.9 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.2 1.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.2 1.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.2 0.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.5 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.2 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 1.4 GO:0019841 retinol binding(GO:0019841)
0.1 0.2 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.3 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 1.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 3.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.6 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.4 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.0 0.4 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0070290 phospholipase D activity(GO:0004630) N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.0 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.8 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.0 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.1 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.7 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.1 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.2 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization