Motif ID: GGCAGUG

Z-value: 0.851


Mature miRNA associated with seed GGCAGUG:

NamemiRBase Accession
hsa-miR-34a-5p MIMAT0000255
hsa-miR-34c-5p MIMAT0000686
hsa-miR-449a MIMAT0001541
hsa-miR-449b-5p MIMAT0003327



Activity profile for motif GGCAGUG.

activity profile for motif GGCAGUG


Sorted Z-values histogram for motif GGCAGUG

Sorted Z-values for motif GGCAGUG



Network of associatons between targets according to the STRING database.



First level regulatory network of GGCAGUG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_100770328 2.731 ENST00000223095.4
ENST00000445463.2
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr19_+_54371114 1.571 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
MYADM



myeloid-associated differentiation marker



chr2_+_48541776 1.399 ENST00000413569.1
ENST00000340553.3
FOXN2

forkhead box N2

chr12_-_95044309 1.335 ENST00000261226.4
TMCC3
transmembrane and coiled-coil domain family 3
chr19_-_50143452 1.306 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr17_-_41174424 1.097 ENST00000355653.3
VAT1
vesicle amine transport 1
chr19_+_41725088 1.071 ENST00000301178.4
AXL
AXL receptor tyrosine kinase
chr19_-_2783363 1.038 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr7_+_145813453 1.024 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr19_-_49015050 0.876 ENST00000600059.1
LMTK3
lemur tyrosine kinase 3
chr4_+_75480629 0.852 ENST00000380846.3
AREGB
amphiregulin B
chr12_+_107712173 0.844 ENST00000280758.5
ENST00000420571.2
BTBD11

BTB (POZ) domain containing 11

chr9_-_123639600 0.818 ENST00000373896.3
PHF19
PHD finger protein 19
chr4_+_99182593 0.803 ENST00000508213.1
ENST00000408927.3
ENST00000514122.1
ENST00000453712.2
ENST00000511212.1
ENST00000408900.3
ENST00000339360.5
RAP1GDS1






RAP1, GTP-GDP dissociation stimulator 1






chr16_-_4588822 0.778 ENST00000564828.1
CDIP1
cell death-inducing p53 target 1
chr17_+_61086917 0.778 ENST00000424789.2
ENST00000389520.4
TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr1_+_84543734 0.770 ENST00000370689.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_1800179 0.756 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr9_+_131102925 0.733 ENST00000372870.1
ENST00000300456.4
SLC27A4

solute carrier family 27 (fatty acid transporter), member 4

chr11_-_119599794 0.733 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.7 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.4 1.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.2 1.2 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 1.1 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.3 1.0 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 1.0 GO:0007028 cytoplasm organization(GO:0007028)
0.3 0.9 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.9 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.8 GO:0097338 response to clozapine(GO:0097338)
0.1 0.8 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.2 0.7 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.2 0.7 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 0.6 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.6 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.6 GO:0090170 regulation of Golgi inheritance(GO:0090170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.2 GO:0033643 host cell part(GO:0033643)
0.0 1.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.0 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.8 GO:0016600 flotillin complex(GO:0016600)
0.0 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.2 0.6 GO:1990032 parallel fiber(GO:1990032)
0.2 0.6 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 1.0 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.7 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.7 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 0.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 0.6 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.1 0.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins