Motif ID: GFI1
Z-value: 1.158
Transcription factors associated with GFI1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GFI1 | ENSG00000162676.7 | GFI1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg19_v2_chr1_-_92951607_92951661, hg19_v2_chr1_-_92952433_92952489, hg19_v2_chr1_-_92949505_92949543 | 0.31 | 1.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 174 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.0 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.0 | 5.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.8 | 5.3 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 0.1 | 5.0 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 4.8 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 1.1 | 4.5 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.0 | 4.5 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 1.5 | 4.4 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.1 | 3.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 3.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 3.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 2.9 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.1 | 2.9 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.2 | 2.7 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 2.7 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.1 | 2.4 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.0 | 2.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 2.3 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 2.3 | GO:0007286 | spermatid development(GO:0007286) |
| 0.4 | 2.2 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 61 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 1.0 | 4.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 4.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 4.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 4.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 3.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.6 | 2.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.3 | 2.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 2.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 2.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 2.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 2.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.3 | 2.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 2.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 2.0 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 1.9 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 1.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.5 | GO:0071439 | clathrin complex(GO:0071439) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 126 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 9.0 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.0 | 6.0 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
| 1.3 | 5.3 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 1.6 | 4.8 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.0 | 4.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 4.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 4.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 3.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 2.9 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.3 | 2.7 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.1 | 2.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 2.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.4 | 2.2 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.1 | 2.1 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.1 | 2.1 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 2.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 2.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 2.0 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.3 | 1.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.5 | 1.8 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
Gene overrepresentation in C2:CP category:
Showing 1 to 19 of 19 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.8 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 2.3 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.8 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.3 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.2 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.2 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.9 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.9 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.7 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.7 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.5 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.4 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 4.0 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 4.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 2.9 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 2.9 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.2 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.9 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.2 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.2 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.0 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.0 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.9 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.8 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 0.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.7 | REACTOME_GAP_JUNCTION_TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
