Motif ID: GATA3

Z-value: 1.367


Transcription factors associated with GATA3:

Gene SymbolEntrez IDGene Name
GATA3 ENSG00000107485.11 GATA3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA3hg19_v2_chr10_+_8096631_80966600.281.9e-01Click!


Activity profile for motif GATA3.

activity profile for motif GATA3


Sorted Z-values histogram for motif GATA3

Sorted Z-values for motif GATA3



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51466681 6.517 ENST00000456750.2
KLK6
kallikrein-related peptidase 6
chr19_-_51471381 3.334 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr5_+_7654057 2.762 ENST00000537121.1
ADCY2
adenylate cyclase 2 (brain)
chr19_-_51471362 2.699 ENST00000376853.4
ENST00000424910.2
KLK6

kallikrein-related peptidase 6

chr19_-_51487071 2.248 ENST00000391807.1
ENST00000593904.1
KLK7

kallikrein-related peptidase 7

chr19_-_51487282 2.063 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
KLK7


kallikrein-related peptidase 7


chr1_-_153113927 1.975 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr19_-_51456321 1.847 ENST00000391809.2
KLK5
kallikrein-related peptidase 5
chr19_-_51456344 1.760 ENST00000336334.3
ENST00000593428.1
KLK5

kallikrein-related peptidase 5

chr19_-_51456198 1.724 ENST00000594846.1
KLK5
kallikrein-related peptidase 5
chr16_-_55867146 1.721 ENST00000422046.2
CES1
carboxylesterase 1
chr5_-_39274617 1.721 ENST00000510188.1
FYB
FYN binding protein
chr1_+_150480576 1.708 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr2_-_208030647 1.661 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_+_96211643 1.585 ENST00000437043.3
ENST00000510373.1
ERAP2

endoplasmic reticulum aminopeptidase 2

chr20_+_33759854 1.572 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr1_-_153066998 1.540 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr1_-_24469602 1.480 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr2_-_113594279 1.429 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B


interleukin 1, beta


chr5_-_39270725 1.422 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB


FYN binding protein



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,037 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.0 GO:0016540 protein autoprocessing(GO:0016540)
0.1 12.3 GO:0031424 keratinization(GO:0031424)
0.2 10.0 GO:0018149 peptide cross-linking(GO:0018149)
1.6 9.7 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 9.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 8.0 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 4.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 3.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 3.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 3.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 3.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 2.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.3 2.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 2.5 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 2.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.5 2.3 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 2.3 GO:2000404 regulation of T cell migration(GO:2000404)
0.0 2.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.7 2.1 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.3 2.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.6 GO:0005615 extracellular space(GO:0005615)
0.2 14.3 GO:0001533 cornified envelope(GO:0001533)
1.5 10.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 8.1 GO:0005901 caveola(GO:0005901)
0.1 7.8 GO:0045095 keratin filament(GO:0045095)
0.0 7.5 GO:0030027 lamellipodium(GO:0030027)
0.1 7.3 GO:0005882 intermediate filament(GO:0005882)
0.0 4.8 GO:0005884 actin filament(GO:0005884)
0.0 4.8 GO:0005925 focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0 4.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 4.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 3.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 3.4 GO:0030478 actin cap(GO:0030478)
0.0 3.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 3.1 GO:0005861 troponin complex(GO:0005861)
0.2 3.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 593 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 6.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 6.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 5.9 GO:0051015 actin filament binding(GO:0051015)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 4.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 4.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 4.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 3.9 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.1 GO:0031014 troponin T binding(GO:0031014)
0.2 3.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 3.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 2.9 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.7 GO:0019864 IgG binding(GO:0019864)
0.3 2.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 13.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 11.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 8.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 7.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 6.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 4.2 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 3.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 2.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 2.0 PID_BCR_5PATHWAY BCR signaling pathway
0.1 1.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 7.6 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 6.9 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 4.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 4.3 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 4.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.2 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 2.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.4 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 2.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.3 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins