Motif ID: GATA3
Z-value: 1.367

Transcription factors associated with GATA3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
GATA3 | ENSG00000107485.11 | GATA3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
GATA3 | hg19_v2_chr10_+_8096631_8096660 | 0.28 | 1.9e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,037 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 13.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
0.1 | 12.3 | GO:0031424 | keratinization(GO:0031424) |
0.2 | 10.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
1.6 | 9.7 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
0.1 | 9.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
0.0 | 8.0 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
0.3 | 4.2 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
0.1 | 3.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.1 | 3.5 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
0.2 | 3.2 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
0.2 | 3.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.0 | 2.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.3 | 2.6 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.2 | 2.5 | GO:1904322 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
0.1 | 2.4 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
0.5 | 2.3 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
0.1 | 2.3 | GO:2000404 | regulation of T cell migration(GO:2000404) |
0.0 | 2.2 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
0.7 | 2.1 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
0.3 | 2.1 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 307 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 23.6 | GO:0005615 | extracellular space(GO:0005615) |
0.2 | 14.3 | GO:0001533 | cornified envelope(GO:0001533) |
1.5 | 10.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
0.1 | 8.1 | GO:0005901 | caveola(GO:0005901) |
0.1 | 7.8 | GO:0045095 | keratin filament(GO:0045095) |
0.0 | 7.5 | GO:0030027 | lamellipodium(GO:0030027) |
0.1 | 7.3 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 4.8 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 4.8 | GO:0005925 | focal adhesion(GO:0005925) cell-substrate junction(GO:0030055) |
0.0 | 4.6 | GO:0015629 | actin cytoskeleton(GO:0015629) |
0.0 | 4.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
0.0 | 3.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.1 | 3.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.1 | 3.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.2 | 3.4 | GO:0030478 | actin cap(GO:0030478) |
0.0 | 3.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 3.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.2 | 3.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
0.1 | 3.1 | GO:0005861 | troponin complex(GO:0005861) |
0.2 | 3.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 593 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 31.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.1 | 7.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 6.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
0.0 | 6.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 5.9 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 4.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.2 | 4.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.1 | 4.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.3 | 4.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.0 | 4.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.5 | 3.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.0 | 3.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 3.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.2 | 3.1 | GO:0031014 | troponin T binding(GO:0031014) |
0.2 | 3.1 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
0.2 | 3.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.1 | 2.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.1 | 2.9 | GO:0003785 | actin monomer binding(GO:0003785) |
0.2 | 2.7 | GO:0019864 | IgG binding(GO:0019864) |
0.3 | 2.5 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 86 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 18.2 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 13.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 11.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 8.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.2 | 7.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.1 | 6.2 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.1 | 4.2 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
0.1 | 3.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.1 | 3.2 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.1 | 3.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 3.1 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.1 | 2.6 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
0.1 | 2.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.1 | 2.2 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
0.1 | 2.2 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.1 | 2.2 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 2.0 | PID_IL1_PATHWAY | IL1-mediated signaling events |
0.0 | 2.0 | PID_BCR_5PATHWAY | BCR signaling pathway |
0.1 | 1.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 1.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 143 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 11.3 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.1 | 7.6 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
0.0 | 6.9 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
0.1 | 4.6 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.0 | 4.3 | REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
0.1 | 4.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 3.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 3.2 | REACTOME_KINESINS | Genes involved in Kinesins |
0.2 | 3.0 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
0.0 | 2.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.1 | 2.8 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.1 | 2.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.1 | 2.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.1 | 2.6 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.1 | 2.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.1 | 2.4 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
0.1 | 2.4 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.1 | 2.4 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.1 | 2.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.1 | 2.3 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |