Motif ID: FOXO4

Z-value: 0.825


Transcription factors associated with FOXO4:

Gene SymbolEntrez IDGene Name
FOXO4 ENSG00000184481.12 FOXO4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXO4hg19_v2_chrX_+_70316005_70316047-0.511.2e-02Click!


Activity profile for motif FOXO4.

activity profile for motif FOXO4


Sorted Z-values histogram for motif FOXO4

Sorted Z-values for motif FOXO4



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_27109392 3.177 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr13_-_39564993 2.056 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr20_-_21494654 1.774 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr2_+_42104692 1.177 ENST00000398796.2
ENST00000442214.1
AC104654.1

AC104654.1

chr5_-_110062384 1.174 ENST00000429839.2
TMEM232
transmembrane protein 232
chr5_-_110062349 1.153 ENST00000511883.2
ENST00000455884.2
TMEM232

transmembrane protein 232

chr12_-_68696652 1.116 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr12_-_111358372 1.106 ENST00000548438.1
ENST00000228841.8
MYL2

myosin, light chain 2, regulatory, cardiac, slow

chr6_-_152489484 1.101 ENST00000354674.4
ENST00000539504.1
SYNE1

spectrin repeat containing, nuclear envelope 1

chr17_+_17876127 1.023 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
LRRC48









leucine rich repeat containing 48









chr22_+_45809560 1.021 ENST00000342894.3
ENST00000538017.1
RIBC2

RIB43A domain with coiled-coils 2

chr2_+_58655461 0.943 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1


long intergenic non-protein coding RNA 1122


chr13_+_24144509 0.907 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_63989004 0.902 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr8_-_72459885 0.889 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr11_-_114466471 0.876 ENST00000424261.2
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr6_-_31651817 0.836 ENST00000375863.3
ENST00000375860.2
LY6G5C

lymphocyte antigen 6 complex, locus G5C

chr8_-_133772794 0.801 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71




transmembrane protein 71




chr4_-_70518941 0.758 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr7_-_25702669 0.758 ENST00000446840.1
AC003090.1
AC003090.1
chr13_+_24144796 0.756 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_57530051 0.727 ENST00000311202.6
ENST00000351747.2
ENST00000495027.1
ENST00000389536.4
DNAH12



dynein, axonemal, heavy chain 12



chr17_-_30185946 0.713 ENST00000579741.1
COPRS
coordinator of PRMT5, differentiation stimulator
chr6_+_72596604 0.696 ENST00000348717.5
ENST00000517960.1
ENST00000518273.1
ENST00000522291.1
ENST00000521978.1
ENST00000520567.1
ENST00000264839.7
RIMS1






regulating synaptic membrane exocytosis 1






chr9_+_27109133 0.692 ENST00000519097.1
ENST00000380036.4
TEK

TEK tyrosine kinase, endothelial

chr11_-_62477041 0.689 ENST00000433053.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_-_86542455 0.685 ENST00000595886.1
ENST00000597578.1
ENST00000593604.1
FENDRR


FOXF1 adjacent non-coding developmental regulatory RNA


chr2_+_233527443 0.676 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr19_+_859654 0.637 ENST00000592860.1
CFD
complement factor D (adipsin)
chr11_-_62476965 0.603 ENST00000405837.1
ENST00000531524.1
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr14_-_64108125 0.590 ENST00000267522.3
WDR89
WD repeat domain 89
chr3_+_132316081 0.584 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr6_-_87804815 0.574 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr7_+_7811992 0.570 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr12_-_10251576 0.569 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr14_+_102276192 0.544 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr12_-_10251603 0.530 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr5_-_137674000 0.530 ENST00000510119.1
ENST00000513970.1
CDC25C

cell division cycle 25C

chr14_-_61124977 0.524 ENST00000554986.1
SIX1
SIX homeobox 1
chr3_+_159570722 0.522 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr3_+_148447887 0.504 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1


angiotensin II receptor, type 1


chr10_-_13570533 0.498 ENST00000396900.2
ENST00000396898.2
BEND7

BEN domain containing 7

chr1_+_153940346 0.498 ENST00000405694.3
ENST00000449724.1
ENST00000368607.3
ENST00000271889.4
CREB3L4



cAMP responsive element binding protein 3-like 4



chr17_-_46806540 0.495 ENST00000290295.7
HOXB13
homeobox B13
chr1_+_153940713 0.494 ENST00000368601.1
ENST00000368603.1
ENST00000368600.3
CREB3L4


cAMP responsive element binding protein 3-like 4


chr17_-_30185971 0.493 ENST00000378634.2
COPRS
coordinator of PRMT5, differentiation stimulator
chr10_-_82049424 0.485 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr5_+_64920543 0.484 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr12_+_54378923 0.470 ENST00000303460.4
HOXC10
homeobox C10
chr11_-_85397167 0.461 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr7_-_6098770 0.460 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1


eukaryotic translation initiation factor 2-alpha kinase 1


chr9_-_86432547 0.458 ENST00000376365.3
ENST00000376371.2
GKAP1

G kinase anchoring protein 1

chr1_+_174844645 0.441 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr9_-_39288092 0.427 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3



contactin associated protein-like 3



chr1_-_157811588 0.421 ENST00000368174.4
CD5L
CD5 molecule-like
chr3_-_3151664 0.420 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
IL5RA



interleukin 5 receptor, alpha



chr10_-_61900762 0.415 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_-_13175823 0.413 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr9_-_15472730 0.406 ENST00000481862.1
PSIP1
PC4 and SFRS1 interacting protein 1
chr1_-_54405773 0.405 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr3_+_98072698 0.400 ENST00000354924.2
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr11_-_77531752 0.383 ENST00000440064.2
ENST00000528095.1
RSF1

remodeling and spacing factor 1

chr7_+_120628731 0.380 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr11_+_127140956 0.376 ENST00000608214.1
RP11-480C22.1
RP11-480C22.1
chr14_-_103987679 0.369 ENST00000553610.1
CKB
creatine kinase, brain
chr7_-_105332084 0.366 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr2_-_148779106 0.357 ENST00000416719.1
ENST00000264169.2
ORC4

origin recognition complex, subunit 4

chr5_-_10308125 0.356 ENST00000296658.3
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chrX_-_114252193 0.355 ENST00000243213.1
IL13RA2
interleukin 13 receptor, alpha 2
chr7_+_134832808 0.349 ENST00000275767.3
TMEM140
transmembrane protein 140
chr10_-_62332357 0.348 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_-_58662139 0.346 ENST00000598312.1
ZNF329
zinc finger protein 329
chr12_-_57472522 0.346 ENST00000379391.3
ENST00000300128.4
TMEM194A

transmembrane protein 194A

chr19_+_13906250 0.340 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr1_-_207095324 0.337 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chrX_+_9431324 0.331 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X





transducin (beta)-like 1X-linked





chr1_+_236686717 0.323 ENST00000341872.6
ENST00000450372.2
LGALS8

lectin, galactoside-binding, soluble, 8

chr5_-_133706695 0.322 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3





cyclin-dependent kinase-like 3





chr9_-_136933615 0.318 ENST00000371834.2
BRD3
bromodomain containing 3
chr17_+_67410832 0.317 ENST00000590474.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr8_+_31497271 0.315 ENST00000520407.1
NRG1
neuregulin 1
chr3_-_150920979 0.312 ENST00000309180.5
ENST00000480322.1
GPR171

G protein-coupled receptor 171

chr15_+_49462434 0.309 ENST00000558145.1
ENST00000543495.1
ENST00000544523.1
ENST00000560138.1
GALK2



galactokinase 2



chr16_+_84801852 0.309 ENST00000569925.1
ENST00000567526.1
USP10

ubiquitin specific peptidase 10

chr1_+_160765919 0.306 ENST00000341032.4
ENST00000368041.2
ENST00000368040.1
LY9


lymphocyte antigen 9


chr18_+_32073253 0.306 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA


dystrobrevin, alpha


chr4_-_155511887 0.305 ENST00000302053.3
ENST00000403106.3
FGA

fibrinogen alpha chain

chr2_-_101767715 0.303 ENST00000376840.4
ENST00000409318.1
TBC1D8

TBC1 domain family, member 8 (with GRAM domain)

chr18_+_77160282 0.298 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1




nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1




chr1_-_57431679 0.289 ENST00000371237.4
ENST00000535057.1
ENST00000543257.1
C8B


complement component 8, beta polypeptide


chr3_+_160394940 0.287 ENST00000320767.2
ARL14
ADP-ribosylation factor-like 14
chr1_+_160765884 0.286 ENST00000392203.4
LY9
lymphocyte antigen 9
chr2_+_177025619 0.284 ENST00000410016.1
HOXD3
homeobox D3
chr1_+_160765860 0.281 ENST00000368037.5
LY9
lymphocyte antigen 9
chr1_-_207095212 0.281 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr10_-_118032979 0.279 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr5_+_79703823 0.277 ENST00000338008.5
ENST00000510158.1
ENST00000505560.1
ZFYVE16


zinc finger, FYVE domain containing 16


chr18_+_72922710 0.274 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr6_-_29013017 0.272 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr14_+_102276132 0.268 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr17_+_33474826 0.263 ENST00000268876.5
ENST00000433649.1
ENST00000378449.1
UNC45B


unc-45 homolog B (C. elegans)


chr17_+_33474860 0.262 ENST00000394570.2
UNC45B
unc-45 homolog B (C. elegans)
chr11_-_5173599 0.261 ENST00000328942.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr3_-_52868931 0.258 ENST00000486659.1
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr12_-_100486668 0.256 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L




UHRF1 binding protein 1-like




chr3_-_71294304 0.256 ENST00000498215.1
FOXP1
forkhead box P1
chr11_-_114466477 0.251 ENST00000375478.3
NXPE4
neurexophilin and PC-esterase domain family, member 4
chrX_-_101726732 0.249 ENST00000457521.2
ENST00000412230.2
ENST00000453326.2
NXF2B

TCP11X2
nuclear RNA export factor 2B

t-complex 11 family, X-linked 2
chr2_+_109204743 0.248 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr4_+_184365744 0.248 ENST00000504169.1
ENST00000302350.4
CDKN2AIP

CDKN2A interacting protein

chrX_+_101470280 0.245 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
NXF2

TCP11X1
nuclear RNA export factor 2

t-complex 11 family, X-linked 1
chr3_-_71179988 0.245 ENST00000491238.1
FOXP1
forkhead box P1
chr2_-_71454185 0.245 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr7_-_37026108 0.242 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr2_+_191513959 0.240 ENST00000337386.5
ENST00000357215.5
NAB1

NGFI-A binding protein 1 (EGR1 binding protein 1)

chr1_+_10490127 0.238 ENST00000602787.1
ENST00000602296.1
ENST00000400900.2
APITD1

APITD1-CORT
apoptosis-inducing, TAF9-like domain 1

APITD1-CORT readthrough
chr3_-_71632894 0.238 ENST00000493089.1
FOXP1
forkhead box P1
chr5_+_137203465 0.236 ENST00000239926.4
MYOT
myotilin
chr3_-_52869205 0.233 ENST00000446157.2
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr4_-_186696425 0.232 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2


sorbin and SH3 domain containing 2


chr1_+_47533160 0.230 ENST00000334194.3
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr11_-_123612319 0.230 ENST00000526252.1
ENST00000530393.1
ENST00000533463.1
ENST00000336139.4
ENST00000529691.1
ENST00000528306.1
ZNF202





zinc finger protein 202





chr7_+_151038850 0.230 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1


negative regulator of ubiquitin-like proteins 1


chr3_-_101232019 0.229 ENST00000394095.2
ENST00000394091.1
ENST00000394094.2
ENST00000358203.3
ENST00000348610.3
ENST00000314261.7
SENP7





SUMO1/sentrin specific peptidase 7





chr17_-_67138015 0.228 ENST00000284425.2
ENST00000590645.1
ABCA6

ATP-binding cassette, sub-family A (ABC1), member 6

chr8_-_42698433 0.227 ENST00000345117.2
ENST00000254250.3
THAP1

THAP domain containing, apoptosis associated protein 1

chr6_+_126277842 0.225 ENST00000229633.5
HINT3
histidine triad nucleotide binding protein 3
chr10_-_90751038 0.219 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
ACTA2


actin, alpha 2, smooth muscle, aorta


chr1_-_150669500 0.217 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr13_-_38443860 0.217 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr20_+_44035200 0.216 ENST00000372717.1
ENST00000360981.4
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr11_-_107328527 0.215 ENST00000282251.5
ENST00000433523.1
CWF19L2

CWF19-like 2, cell cycle control (S. pombe)

chr16_+_69958887 0.214 ENST00000568684.1
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr2_+_109204909 0.213 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_+_44035847 0.210 ENST00000372712.2
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_77531858 0.209 ENST00000360355.2
RSF1
remodeling and spacing factor 1
chr11_+_112130988 0.208 ENST00000595053.1
AP002884.2
LOC100132686 protein; Uncharacterized protein
chr3_+_101504200 0.208 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr1_+_154193325 0.205 ENST00000428931.1
ENST00000441890.1
ENST00000271877.7
ENST00000412596.1
ENST00000368504.1
ENST00000437652.1
UBAP2L





ubiquitin associated protein 2-like





chr17_-_49021974 0.204 ENST00000501718.2
RP11-700H6.1
RP11-700H6.1
chr16_-_18887627 0.200 ENST00000563235.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr13_+_32838801 0.199 ENST00000542859.1
FRY
furry homolog (Drosophila)
chr4_+_78804393 0.198 ENST00000502384.1
MRPL1
mitochondrial ribosomal protein L1
chr13_+_103459704 0.196 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr7_-_141673573 0.194 ENST00000547270.1
TAS2R38
taste receptor, type 2, member 38
chr1_+_28879588 0.194 ENST00000373830.3
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr5_+_140529630 0.190 ENST00000543635.1
PCDHB6
protocadherin beta 6
chrX_+_100743031 0.189 ENST00000423738.3
ARMCX4
armadillo repeat containing, X-linked 4
chr4_-_186697044 0.188 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr10_-_1246300 0.188 ENST00000381310.3
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr1_+_97188188 0.187 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr12_-_71031185 0.187 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB


protein tyrosine phosphatase, receptor type, B


chr9_-_95186739 0.185 ENST00000375550.4
OMD
osteomodulin
chr19_+_15160130 0.185 ENST00000427043.3
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr2_+_182850551 0.178 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr11_-_94227029 0.177 ENST00000323977.3
ENST00000536754.1
ENST00000323929.3
MRE11A


MRE11 meiotic recombination 11 homolog A (S. cerevisiae)


chr5_-_125930929 0.175 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr11_-_89224299 0.175 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4


NADPH oxidase 4


chr10_-_73848086 0.174 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr6_+_97010424 0.173 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5


four and a half LIM domains 5


chr14_-_102605983 0.172 ENST00000334701.7
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr9_+_108006880 0.171 ENST00000374723.1
ENST00000374720.3
ENST00000374724.1
SLC44A1


solute carrier family 44 (choline transporter), member 1


chr5_+_98104978 0.171 ENST00000308234.7
RGMB
repulsive guidance molecule family member b
chr8_-_87755878 0.168 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr14_+_94577074 0.164 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27








interferon, alpha-inducible protein 27








chr8_+_74903580 0.161 ENST00000284818.2
ENST00000518893.1
LY96

lymphocyte antigen 96

chr2_+_65283506 0.160 ENST00000377990.2
CEP68
centrosomal protein 68kDa
chr17_-_40897043 0.155 ENST00000428826.2
ENST00000592492.1
ENST00000585893.1
ENST00000593214.1
ENST00000590078.1
ENST00000586382.1
ENST00000415827.2
ENST00000592743.1
ENST00000586089.1
ENST00000435174.1
EZH1









enhancer of zeste homolog 1 (Drosophila)









chr1_-_13673511 0.154 ENST00000344998.3
ENST00000334600.6
PRAMEF14

PRAME family member 14

chr16_+_28943260 0.153 ENST00000538922.1
ENST00000324662.3
ENST00000567541.1
CD19


CD19 molecule


chr3_-_28390581 0.150 ENST00000479665.1
AZI2
5-azacytidine induced 2
chrX_-_148676974 0.147 ENST00000524178.1
HSFX2
heat shock transcription factor family, X linked 2
chr15_-_40600026 0.146 ENST00000456256.2
ENST00000557821.1
PLCB2

phospholipase C, beta 2

chr3_-_28390415 0.145 ENST00000414162.1
ENST00000420543.2
AZI2

5-azacytidine induced 2

chr18_-_53303123 0.144 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4


transcription factor 4


chr13_-_36944307 0.144 ENST00000355182.4
SPG20
spastic paraplegia 20 (Troyer syndrome)
chrX_+_148855726 0.144 ENST00000370416.4
HSFX1
heat shock transcription factor family, X linked 1
chr8_+_19171128 0.143 ENST00000265807.3
SH2D4A
SH2 domain containing 4A
chr12_-_10251539 0.143 ENST00000420265.2
CLEC1A
C-type lectin domain family 1, member A
chr14_+_105267250 0.139 ENST00000342537.7
ZBTB42
zinc finger and BTB domain containing 42
chr3_+_124223586 0.137 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr3_-_28390120 0.133 ENST00000334100.6
AZI2
5-azacytidine induced 2
chr14_+_102606181 0.133 ENST00000335263.5
ENST00000322340.5
ENST00000424963.2
ENST00000342702.3
ENST00000556807.1
ENST00000499851.2
ENST00000558567.1
ENST00000299135.6
ENST00000454394.2
ENST00000556511.2
WDR20









WD repeat domain 20









chr5_-_122758994 0.132 ENST00000306467.5
ENST00000515110.1
CEP120

centrosomal protein 120kDa

chr5_+_135468516 0.128 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5



SMAD family member 5



chr20_+_17680587 0.128 ENST00000427254.1
ENST00000377805.3
BANF2

barrier to autointegration factor 2

chr13_-_36920420 0.126 ENST00000438666.2
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr1_+_151739131 0.126 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr4_+_74347400 0.124 ENST00000226355.3
AFM
afamin
chr6_-_32122106 0.124 ENST00000428778.1
PRRT1
proline-rich transmembrane protein 1
chr16_-_28608424 0.124 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_+_169490606 0.123 ENST00000349841.5
MYNN
myoneurin
chr14_+_24439148 0.123 ENST00000543805.1
ENST00000534993.1
DHRS4L2

dehydrogenase/reductase (SDR family) member 4 like 2

chr13_-_99910673 0.123 ENST00000397473.2
ENST00000397470.2
GPR18

G protein-coupled receptor 18

chr19_-_40791302 0.121 ENST00000392038.2
ENST00000578123.1
AKT2

v-akt murine thymoma viral oncogene homolog 2

chr10_-_49482907 0.120 ENST00000374201.3
ENST00000407470.4
FRMPD2

FERM and PDZ domain containing 2

chr7_-_115670804 0.119 ENST00000320239.7
TFEC
transcription factor EC
chr10_-_118032697 0.119 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr4_+_76871883 0.118 ENST00000599764.1
AC110615.1
Uncharacterized protein
chr8_+_50824233 0.118 ENST00000522124.1
SNTG1
syntrophin, gamma 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.5 3.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 0.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 0.5 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.5 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.5 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.1 0.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.3 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 1.1 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.4 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.3 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.3 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 0.2 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.9 GO:0032740 positive regulation of interleukin-17 production(GO:0032740)
0.0 0.4 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.0 0.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 0.7 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.8 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.2 GO:0042426 choline catabolic process(GO:0042426)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.4 GO:0006805 xenobiotic metabolic process(GO:0006805) response to xenobiotic stimulus(GO:0009410) cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.0 GO:1903487 regulation of lactation(GO:1903487)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.5 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.5 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031213 RSF complex(GO:0031213)
0.1 4.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.3 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 0.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.3 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0004917 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.6 GO:0019956 chemokine binding(GO:0019956)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 3.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere