Motif ID: EZH2
Z-value: 1.316

Transcription factors associated with EZH2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
EZH2 | ENSG00000106462.6 | EZH2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
EZH2 | hg19_v2_chr7_-_148581251_148581347 | -0.50 | 1.2e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 355 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 5.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
0.5 | 2.8 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
0.1 | 2.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
0.0 | 2.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.1 | 2.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
0.0 | 2.5 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.1 | 2.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.0 | 2.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.7 | 2.2 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
0.0 | 2.1 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
0.6 | 1.7 | GO:0009946 | proximal/distal axis specification(GO:0009946) |
0.2 | 1.7 | GO:0031642 | negative regulation of myelination(GO:0031642) |
0.2 | 1.6 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
0.1 | 1.6 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.0 | 1.6 | GO:0051602 | response to electrical stimulus(GO:0051602) |
0.5 | 1.5 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
0.5 | 1.4 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
0.2 | 1.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
0.1 | 1.4 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
0.4 | 1.3 | GO:0001172 | transcription, RNA-templated(GO:0001172) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 125 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 4.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.2 | 2.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.1 | 2.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 2.7 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 2.5 | GO:0001533 | cornified envelope(GO:0001533) |
0.8 | 2.4 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
0.3 | 2.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
0.1 | 2.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 1.9 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
0.1 | 1.8 | GO:0008091 | spectrin(GO:0008091) |
0.0 | 1.8 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
0.1 | 1.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.1 | 1.4 | GO:0033010 | paranodal junction(GO:0033010) |
0.1 | 1.3 | GO:0030056 | hemidesmosome(GO:0030056) |
0.1 | 1.3 | GO:0000974 | Prp19 complex(GO:0000974) |
0.1 | 1.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.0 | 1.3 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
0.0 | 1.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
0.0 | 1.2 | GO:0031904 | endosome lumen(GO:0031904) |
0.0 | 1.2 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 233 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 4.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.1 | 2.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 2.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 2.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.4 | 2.3 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
0.2 | 2.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.1 | 2.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.7 | 2.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.2 | 1.8 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 1.7 | GO:0015643 | toxic substance binding(GO:0015643) |
0.1 | 1.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.2 | 1.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 1.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.4 | 1.3 | GO:0003968 | RNA-directed RNA polymerase activity(GO:0003968) |
0.3 | 1.3 | GO:0050436 | microfibril binding(GO:0050436) |
0.2 | 1.3 | GO:0005502 | 11-cis retinal binding(GO:0005502) |
0.1 | 1.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.1 | 1.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
0.1 | 1.2 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 43 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 7.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.1 | 6.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 4.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.1 | 3.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 3.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 2.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 2.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
0.0 | 2.2 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
0.0 | 2.1 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
0.0 | 1.9 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.1 | 1.7 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 1.5 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
0.1 | 1.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 1.3 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.0 | 1.2 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.0 | 1.1 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
0.0 | 1.0 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 1.0 | PID_FOXO_PATHWAY | FoxO family signaling |
0.0 | 1.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 0.9 | PID_ENDOTHELIN_PATHWAY | Endothelins |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 80 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.1 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.1 | 3.2 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.0 | 3.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 2.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 2.7 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
0.2 | 2.6 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.0 | 2.1 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
0.1 | 2.0 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.1 | 2.0 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
0.1 | 1.7 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.0 | 1.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.1 | 1.3 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 1.3 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 1.3 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.1 | 1.2 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.0 | 1.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.0 | 1.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.1 | 1.1 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.1 | 1.1 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
0.1 | 1.1 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |