Motif ID: EZH2

Z-value: 1.316


Transcription factors associated with EZH2:

Gene SymbolEntrez IDGene Name
EZH2 ENSG00000106462.6 EZH2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EZH2hg19_v2_chr7_-_148581251_148581347-0.501.2e-02Click!


Activity profile for motif EZH2.

activity profile for motif EZH2


Sorted Z-values histogram for motif EZH2

Sorted Z-values for motif EZH2



Network of associatons between targets according to the STRING database.



First level regulatory network of EZH2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_41740181 2.187 ENST00000442711.1
INHBA
inhibin, beta A
chr1_-_205391178 2.164 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1



LEM domain containing 1



chr8_-_7274385 1.978 ENST00000318157.2
DEFB4B
defensin, beta 4B
chr1_-_145076186 1.816 ENST00000369348.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_51504852 1.748 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
KLK8



kallikrein-related peptidase 8



chr12_-_91576561 1.699 ENST00000547568.2
ENST00000552962.1
DCN

decorin

chr19_+_51152702 1.575 ENST00000425202.1
C19orf81
chromosome 19 open reading frame 81
chr1_+_152881014 1.508 ENST00000368764.3
ENST00000392667.2
IVL

involucrin

chr13_-_20805109 1.476 ENST00000241124.6
GJB6
gap junction protein, beta 6, 30kDa
chr5_+_92919043 1.436 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr7_+_145813453 1.376 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr3_-_195538728 1.345 ENST00000349607.4
ENST00000346145.4
MUC4

mucin 4, cell surface associated

chr11_-_66496430 1.338 ENST00000533211.1
SPTBN2
spectrin, beta, non-erythrocytic 2
chr12_-_91576429 1.323 ENST00000552145.1
ENST00000546745.1
DCN

decorin

chr1_+_47264711 1.309 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr7_-_121944491 1.309 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr2_+_45168875 1.298 ENST00000260653.3
SIX3
SIX homeobox 3
chr10_-_105845674 1.283 ENST00000353479.5
ENST00000369733.3
COL17A1

collagen, type XVII, alpha 1

chr15_-_89764929 1.277 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr17_+_34538310 1.160 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
CCL4L1











chemokine (C-C motif) ligand 4-like 1












Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 355 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5 2.8 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 2.6 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 2.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 2.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 2.4 GO:0002377 immunoglobulin production(GO:0002377)
0.7 2.2 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 2.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.6 1.7 GO:0009946 proximal/distal axis specification(GO:0009946)
0.2 1.7 GO:0031642 negative regulation of myelination(GO:0031642)
0.2 1.6 GO:0018879 biphenyl metabolic process(GO:0018879)
0.1 1.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 1.6 GO:0051602 response to electrical stimulus(GO:0051602)
0.5 1.5 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.5 1.4 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 1.4 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 1.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.4 1.3 GO:0001172 transcription, RNA-templated(GO:0001172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 2.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.5 GO:0001533 cornified envelope(GO:0001533)
0.8 2.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.3 2.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 2.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.9 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.1 1.8 GO:0008091 spectrin(GO:0008091)
0.0 1.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.4 GO:0033010 paranodal junction(GO:0033010)
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.3 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.2 GO:0031904 endosome lumen(GO:0031904)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 4.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 2.3 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.2 2.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.7 2.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 1.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.4 1.3 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.3 1.3 GO:0050436 microfibril binding(GO:0050436)
0.2 1.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 1.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 6.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 4.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.2 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 2.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.1 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_ENDOTHELIN_PATHWAY Endothelins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 3.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 2.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 2.1 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.0 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.1 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 1.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly