Motif ID: ESR1

Z-value: 1.105


Transcription factors associated with ESR1:

Gene SymbolEntrez IDGene Name
ESR1 ENSG00000091831.17 ESR1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESR1hg19_v2_chr6_+_152126790_1521268280.193.8e-01Click!


Activity profile for motif ESR1.

activity profile for motif ESR1


Sorted Z-values histogram for motif ESR1

Sorted Z-values for motif ESR1



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_46089718 4.992 ENST00000421127.2
ENST00000343901.2
ENST00000528266.1
 CCDC17


coiled-coil domain containing 17


chr7_-_99569468 4.201 ENST00000419575.1
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_-_46089639 4.065 ENST00000445048.2
 CCDC17
coiled-coil domain containing 17
chr15_+_81426588 3.949 ENST00000286732.4
 C15orf26
chromosome 15 open reading frame 26
chr16_-_67427389 3.804 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr16_-_28621353 3.594 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr2_+_120187465 3.341 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr1_+_47264711 3.238 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr16_-_21289627 3.149 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr14_-_107078851 3.021 ENST00000390628.2
 IGHV1-58
immunoglobulin heavy variable 1-58
chr1_+_245133656 3.003 ENST00000366521.3
 EFCAB2
EF-hand calcium binding domain 2
chr8_+_120885949 2.763 ENST00000523492.1
ENST00000286234.5
 DEPTOR

DEP domain containing MTOR-interacting protein

chr13_-_36705425 2.665 ENST00000255448.4
ENST00000360631.3
ENST00000379892.4
 DCLK1


doublecortin-like kinase 1


chr1_-_36915880 2.518 ENST00000445843.3
 OSCP1
organic solute carrier partner 1
chr3_-_52488048 2.505 ENST00000232975.3
 TNNC1
troponin C type 1 (slow)
chr11_-_111170526 2.495 ENST00000355430.4
 COLCA1
colorectal cancer associated 1
chr14_-_106642049 2.422 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr9_-_130637244 2.318 ENST00000373156.1
 AK1
adenylate kinase 1
chr1_+_217804661 2.281 ENST00000366933.4
 SPATA17
spermatogenesis associated 17
chr15_+_50474385 2.218 ENST00000267842.5
 SLC27A2
solute carrier family 27 (fatty acid transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 5.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.1 4.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 4.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 4.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 4.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 4.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 3.7 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.2 3.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 3.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 3.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.2 3.0 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2 2.7 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 2.6 GO:0072592 oxygen metabolic process(GO:0072592)
0.6 2.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.4 2.5 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.1 2.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 2.3 GO:0002377 immunoglobulin production(GO:0002377)
0.6 2.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.5 2.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 6.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 5.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 4.8 GO:0097427 microtubule bundle(GO:0097427)
0.1 4.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 4.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.2 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.9 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.4 2.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 2.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 2.0 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.3 2.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.6 1.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 1.7 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 1.6 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.3 6.1 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 4.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.1 4.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 4.0 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.3 3.3 GO:0031013 troponin I binding(GO:0031013)
0.3 3.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.8 3.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2 3.0 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.8 GO:0032947 protein complex scaffold(GO:0032947)
0.4 2.6 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 2.6 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.6 2.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.2 2.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 2.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.1 GO:0019003 GDP binding(GO:0019003)
0.1 2.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 1.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.6 1.8 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.8 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 1.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 5.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 5.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 3.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.2 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 2.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 1.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors