Motif ID: E4F1

Z-value: 0.353


Transcription factors associated with E4F1:

Gene SymbolEntrez IDGene Name
E4F1 ENSG00000167967.11 E4F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273558_2273637-0.184.1e-01Click!


Activity profile for motif E4F1.

activity profile for motif E4F1


Sorted Z-values histogram for motif E4F1

Sorted Z-values for motif E4F1



Network of associatons between targets according to the STRING database.



First level regulatory network of E4F1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216300784 1.168 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1













fibronectin 1













chr4_+_75310851 0.685 ENST00000395748.3
ENST00000264487.2
AREG

amphiregulin

chr4_+_75311019 0.662 ENST00000502307.1
AREG
amphiregulin
chr20_+_58179582 0.445 ENST00000371015.1
ENST00000395639.4
PHACTR3

phosphatase and actin regulator 3

chr17_+_41476327 0.403 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr19_+_1941117 0.391 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr1_-_8086343 0.386 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1


ERBB receptor feedback inhibitor 1


chr10_+_95256356 0.352 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr20_+_34203794 0.345 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr4_-_122744998 0.288 ENST00000274026.5
CCNA2
cyclin A2
chr20_-_44420507 0.254 ENST00000243938.4
WFDC3
WAP four-disulfide core domain 3
chr6_+_64282447 0.250 ENST00000370650.2
ENST00000578299.1
PTP4A1

protein tyrosine phosphatase type IVA, member 1

chr6_-_163148700 0.242 ENST00000366894.1
ENST00000338468.3
PARK2

parkin RBR E3 ubiquitin protein ligase

chr12_+_107168418 0.233 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B




RIC8 guanine nucleotide exchange factor B




chr12_+_107168342 0.226 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr20_+_44420570 0.222 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr3_+_150126101 0.222 ENST00000361875.3
ENST00000361136.2
TSC22D2

TSC22 domain family, member 2

chr20_-_5591626 0.220 ENST00000379019.4
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr20_+_44420617 0.210 ENST00000449078.1
ENST00000456939.1
DNTTIP1

deoxynucleotidyltransferase, terminal, interacting protein 1

chr9_+_131644398 0.210 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_-_32110467 0.207 ENST00000440872.2
ENST00000373703.4
PEF1

penta-EF-hand domain containing 1

chr9_-_131644202 0.203 ENST00000320665.6
ENST00000436267.2
CCBL1

cysteine conjugate-beta lyase, cytoplasmic

chr17_-_36831156 0.203 ENST00000325814.5
C17orf96
chromosome 17 open reading frame 96
chr8_-_29208183 0.199 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chr9_+_131644781 0.192 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr9_+_131644388 0.191 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr9_-_131644306 0.190 ENST00000302586.3
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr6_-_53213587 0.188 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5


ELOVL fatty acid elongase 5


chr3_+_38206975 0.180 ENST00000446845.1
ENST00000311806.3
OXSR1

oxidative stress responsive 1

chr11_+_66188475 0.179 ENST00000311034.2
NPAS4
neuronal PAS domain protein 4
chr6_+_30029008 0.169 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1



zinc ribbon domain containing 1



chr17_+_71161140 0.166 ENST00000357585.2
SSTR2
somatostatin receptor 2
chr19_+_45349432 0.165 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr6_+_64281906 0.164 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_220408430 0.160 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr17_+_25621102 0.159 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1







WD repeat and SOCS box containing 1







chr1_+_39456895 0.152 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1


akirin 1


chr11_-_67276100 0.149 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr8_-_98290087 0.144 ENST00000322128.3
TSPYL5
TSPY-like 5
chr17_+_7211656 0.141 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr6_-_163148780 0.141 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2



parkin RBR E3 ubiquitin protein ligase



chr6_+_47445467 0.140 ENST00000359314.5
CD2AP
CD2-associated protein
chr3_+_185304059 0.137 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr6_+_28048753 0.133 ENST00000377325.1
ZNF165
zinc finger protein 165
chr10_-_50970322 0.127 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr6_+_26204825 0.124 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr8_+_94929110 0.121 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr10_-_50970382 0.120 ENST00000419399.1
ENST00000432695.1
OGDHL

oxoglutarate dehydrogenase-like

chr14_+_94492674 0.119 ENST00000203664.5
ENST00000553723.1
OTUB2

OTU domain, ubiquitin aldehyde binding 2

chr18_+_23806437 0.118 ENST00000578121.1
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr9_+_125027127 0.117 ENST00000441707.1
ENST00000373723.5
ENST00000373729.1
MRRF


mitochondrial ribosome recycling factor


chr10_+_64893039 0.111 ENST00000277746.6
ENST00000435510.2
NRBF2

nuclear receptor binding factor 2

chr6_+_33176265 0.110 ENST00000374656.4
RING1
ring finger protein 1
chr22_+_18121356 0.109 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13




BCL2-like 13 (apoptosis facilitator)




chr6_+_110299501 0.106 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr4_-_186456652 0.100 ENST00000284767.5
ENST00000284770.5
PDLIM3

PDZ and LIM domain 3

chr19_+_54705025 0.100 ENST00000441429.1
RPS9
ribosomal protein S9
chr8_-_66754172 0.099 ENST00000401827.3
PDE7A
phosphodiesterase 7A
chr6_-_31774714 0.099 ENST00000375661.5
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_-_186456766 0.098 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr7_-_129592471 0.097 ENST00000473814.2
ENST00000490974.1
UBE2H

ubiquitin-conjugating enzyme E2H

chr9_+_125026882 0.095 ENST00000297908.3
ENST00000373730.3
ENST00000546115.1
ENST00000344641.3
MRRF



mitochondrial ribosome recycling factor



chr11_+_66059339 0.093 ENST00000327259.4
TMEM151A
transmembrane protein 151A
chr7_-_129592700 0.091 ENST00000472396.1
ENST00000355621.3
UBE2H

ubiquitin-conjugating enzyme E2H

chr20_-_62258394 0.091 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr8_-_95274536 0.091 ENST00000297596.2
ENST00000396194.2
GEM

GTP binding protein overexpressed in skeletal muscle

chr8_+_94929168 0.090 ENST00000518107.1
ENST00000396200.3
PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1

chr6_-_34664612 0.088 ENST00000374023.3
ENST00000374026.3
C6orf106

chromosome 6 open reading frame 106

chr1_-_47184745 0.085 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr8_+_94929077 0.083 ENST00000297598.4
ENST00000520614.1
PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1

chr11_-_33183006 0.082 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr22_+_39101728 0.080 ENST00000216044.5
ENST00000484657.1
GTPBP1

GTP binding protein 1

chr1_+_180199393 0.078 ENST00000263726.2
LHX4
LIM homeobox 4
chr3_+_101292939 0.078 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP


PEST proteolytic signal containing nuclear protein


chr17_+_35294075 0.075 ENST00000254457.5
LHX1
LIM homeobox 1
chr2_+_202899310 0.074 ENST00000286201.1
FZD7
frizzled family receptor 7
chr19_+_54704718 0.073 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
RPS9


ribosomal protein S9


chr11_-_8680383 0.073 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr6_+_44355257 0.071 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr4_-_76598544 0.070 ENST00000515457.1
ENST00000357854.3
G3BP2

GTPase activating protein (SH3 domain) binding protein 2

chr3_-_156877997 0.069 ENST00000295926.3
CCNL1
cyclin L1
chr11_+_4116005 0.068 ENST00000300738.5
RRM1
ribonucleotide reductase M1
chr7_-_140624499 0.066 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr5_-_138210977 0.065 ENST00000274711.6
ENST00000521094.2
LRRTM2

leucine rich repeat transmembrane neuronal 2

chr16_-_27561209 0.063 ENST00000356183.4
ENST00000561623.1
GTF3C1

general transcription factor IIIC, polypeptide 1, alpha 220kDa

chr17_-_7165662 0.063 ENST00000571881.2
ENST00000360325.7
CLDN7

claudin 7

chr22_+_18121562 0.063 ENST00000355028.3
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr19_-_10341948 0.062 ENST00000592342.1
ENST00000588952.1
ENST00000590320.1
DNMT1

S1PR2
DNA (cytosine-5-)-methyltransferase 1

sphingosine-1-phosphate receptor 2
chr11_+_4116054 0.061 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr15_-_53082178 0.060 ENST00000305901.5
ONECUT1
one cut homeobox 1
chr11_+_111411384 0.059 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
LAYN



layilin



chr19_+_54704610 0.057 ENST00000302907.4
RPS9
ribosomal protein S9
chrX_+_152224766 0.054 ENST00000370265.4
ENST00000447306.1
PNMA3

paraneoplastic Ma antigen 3

chr4_-_104119528 0.054 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE


centromere protein E, 312kDa


chr19_+_54704990 0.053 ENST00000391753.2
RPS9
ribosomal protein S9
chr15_-_41047421 0.053 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3


regulator of microtubule dynamics 3


chr4_+_1873100 0.052 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr12_-_110011288 0.051 ENST00000540016.1
ENST00000266839.5
MMAB

methylmalonic aciduria (cobalamin deficiency) cblB type

chr6_-_144416737 0.051 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr6_-_27440460 0.050 ENST00000377419.1
ZNF184
zinc finger protein 184
chr16_+_68057153 0.049 ENST00000358896.6
ENST00000568099.2
DUS2

dihydrouridine synthase 2

chr22_-_41252962 0.047 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr1_-_47184723 0.042 ENST00000371933.3
EFCAB14
EF-hand calcium binding domain 14
chr17_+_39845134 0.042 ENST00000591776.1
ENST00000469257.1
EIF1

eukaryotic translation initiation factor 1

chr17_-_80231300 0.042 ENST00000398519.5
ENST00000580446.1
CSNK1D

casein kinase 1, delta

chr1_+_212208919 0.040 ENST00000366991.4
ENST00000542077.1
DTL

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

chr16_+_68056844 0.040 ENST00000565263.1
DUS2
dihydrouridine synthase 2
chr1_-_16482554 0.039 ENST00000358432.5
EPHA2
EPH receptor A2
chr2_-_240964716 0.037 ENST00000404554.1
ENST00000407129.3
ENST00000307300.4
ENST00000443626.1
ENST00000252711.2
NDUFA10




NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa




chr16_+_68057179 0.037 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
DUS2



dihydrouridine synthase 2



chr3_+_185303962 0.036 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr14_-_50053081 0.034 ENST00000396020.3
ENST00000245458.6
RPS29

ribosomal protein S29

chrX_-_153236819 0.032 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr19_+_52693259 0.032 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A



protein phosphatase 2, regulatory subunit A, alpha



chr17_+_42385927 0.031 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A


RUN domain containing 3A


chr6_-_27440837 0.031 ENST00000211936.6
ZNF184
zinc finger protein 184
chr2_-_62115659 0.029 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr4_-_111558135 0.028 ENST00000394598.2
ENST00000394595.3
PITX2

paired-like homeodomain 2

chr2_-_62115725 0.024 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4


chaperonin containing TCP1, subunit 4 (delta)


chrX_-_153237258 0.024 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr17_-_80231557 0.021 ENST00000392334.2
ENST00000314028.6
CSNK1D

casein kinase 1, delta

chr12_+_111471828 0.021 ENST00000261726.6
CUX2
cut-like homeobox 2
chr5_+_68513557 0.020 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr17_+_7476136 0.019 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1









eukaryotic translation initiation factor 4A1









chr20_-_44600810 0.019 ENST00000322927.2
ENST00000426788.1
ZNF335

zinc finger protein 335

chr10_-_64576105 0.018 ENST00000242480.3
ENST00000411732.1
EGR2

early growth response 2

chrX_+_153672468 0.017 ENST00000393600.3
FAM50A
family with sequence similarity 50, member A
chr17_-_40540586 0.015 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr4_+_47487285 0.012 ENST00000273859.3
ENST00000504445.1
ATP10D

ATPase, class V, type 10D

chr11_-_6633799 0.012 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr17_-_40540484 0.011 ENST00000588969.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr3_-_101395936 0.009 ENST00000461821.1
ZBTB11
zinc finger and BTB domain containing 11
chr17_+_685513 0.006 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr5_-_95297678 0.005 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr1_+_2004901 0.005 ENST00000400921.2
PRKCZ
protein kinase C, zeta
chr3_-_185655795 0.005 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B


transformer 2 beta homolog (Drosophila)


chr4_-_76598326 0.004 ENST00000503660.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr10_-_119134918 0.004 ENST00000334464.5
PDZD8
PDZ domain containing 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.3 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 0.3 GO:0071314 cellular response to cocaine(GO:0071314)
0.1 0.2 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.1 0.1 GO:0060067 cervix development(GO:0060067)
0.1 0.6 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.4 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 0.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.0 GO:0048320 axial mesoderm formation(GO:0048320) negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.1 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition