Motif ID: E2F8

Z-value: 1.346


Transcription factors associated with E2F8:

Gene SymbolEntrez IDGene Name
E2F8 ENSG00000129173.8 E2F8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F8hg19_v2_chr11_-_19263145_192631760.873.0e-08Click!


Activity profile for motif E2F8.

activity profile for motif E2F8


Sorted Z-values histogram for motif E2F8

Sorted Z-values for motif E2F8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51845378 5.354 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr12_+_8975061 5.101 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr9_-_123639304 4.652 ENST00000436309.1
PHF19
PHD finger protein 19
chr20_+_42295745 4.613 ENST00000396863.4
ENST00000217026.4
MYBL2

v-myb avian myeloblastosis viral oncogene homolog-like 2

chr22_+_19467261 4.135 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45



cell division cycle 45



chr2_+_10262857 4.133 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr11_+_125495862 3.800 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1




checkpoint kinase 1




chr22_+_35796108 3.780 ENST00000382011.5
ENST00000416905.1
MCM5

minichromosome maintenance complex component 5

chr22_+_35796056 3.626 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr9_-_123639445 3.489 ENST00000312189.6
PHF19
PHD finger protein 19
chr22_+_38071615 3.237 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr11_+_125496124 3.177 ENST00000533778.2
ENST00000534070.1
CHEK1

checkpoint kinase 1

chr9_-_123639600 2.983 ENST00000373896.3
PHF19
PHD finger protein 19
chr2_-_136633940 2.818 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr14_-_55658252 2.728 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr7_+_26331541 2.420 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10


sorting nexin 10


chr12_-_57146095 2.420 ENST00000550770.1
ENST00000338193.6
PRIM1

primase, DNA, polypeptide 1 (49kDa)

chr14_-_55658323 2.367 ENST00000554067.1
ENST00000247191.2
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr17_+_39975455 2.288 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr16_+_11439286 2.248 ENST00000312499.5
ENST00000576027.1
RMI2

RecQ mediated genome instability 2

chr8_+_27632083 2.197 ENST00000519637.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr10_-_17659234 2.161 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr17_+_39975544 2.096 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr15_-_70390191 2.015 ENST00000559191.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr11_-_19263145 1.994 ENST00000532666.1
ENST00000527884.1
E2F8

E2F transcription factor 8

chr3_+_127317066 1.983 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr15_-_64673630 1.929 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101


KIAA0101


chr4_-_174254823 1.899 ENST00000438704.2
HMGB2
high mobility group box 2
chr11_-_19262486 1.885 ENST00000250024.4
E2F8
E2F transcription factor 8
chr10_+_106028923 1.859 ENST00000338595.2
GSTO2
glutathione S-transferase omega 2
chr7_-_56119238 1.859 ENST00000275605.3
ENST00000395471.3
PSPH

phosphoserine phosphatase

chr7_-_21985656 1.840 ENST00000406877.3
CDCA7L
cell division cycle associated 7-like
chr7_-_21985489 1.797 ENST00000356195.5
ENST00000447180.1
ENST00000373934.4
ENST00000457951.1
CDCA7L



cell division cycle associated 7-like



chr1_-_26232522 1.768 ENST00000399728.1
STMN1
stathmin 1
chr11_+_33061543 1.701 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1


t-complex 11, testis-specific-like 1


chr7_-_56118981 1.643 ENST00000419984.2
ENST00000413218.1
ENST00000424596.1
PSPH


phosphoserine phosphatase


chr1_-_17307173 1.626 ENST00000438542.1
ENST00000375535.3
MFAP2

microfibrillar-associated protein 2

chr9_+_79792410 1.478 ENST00000357409.5
VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr11_+_35201826 1.438 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr12_+_123011776 1.422 ENST00000450485.2
ENST00000333479.7
KNTC1

kinetochore associated 1

chr3_+_44803209 1.407 ENST00000326047.4
KIF15
kinesin family member 15
chr10_-_17659357 1.401 ENST00000326961.6
ENST00000361271.3
PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr7_-_56119156 1.399 ENST00000421312.1
ENST00000416592.1
PSPH

phosphoserine phosphatase

chr10_+_115312766 1.389 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr1_-_150693318 1.360 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1




HORMA domain containing 1




chr12_+_107168342 1.355 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr7_+_135242652 1.332 ENST00000285968.6
ENST00000440390.2
NUP205

nucleoporin 205kDa

chr14_-_67878917 1.317 ENST00000216446.4
PLEK2
pleckstrin 2
chr17_+_37894570 1.317 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr14_+_64854958 1.292 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1



methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase



chr11_+_47236489 1.267 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
DDB2



damage-specific DNA binding protein 2, 48kDa



chr12_+_107168418 1.257 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B




RIC8 guanine nucleotide exchange factor B




chr17_-_59940830 1.234 ENST00000259008.2
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr8_+_27631903 1.228 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr8_-_131455835 1.227 ENST00000518721.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr8_-_92053212 1.201 ENST00000285419.3
TMEM55A
transmembrane protein 55A
chr8_-_120868078 1.199 ENST00000313655.4
DSCC1
DNA replication and sister chromatid cohesion 1
chr6_+_110299501 1.188 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr21_+_39644305 1.156 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_70876926 1.143 ENST00000370938.3
ENST00000346806.2
CTH

cystathionase (cystathionine gamma-lyase)

chr11_+_126225789 1.139 ENST00000530591.1
ENST00000534083.1
ST3GAL4

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

chrX_-_54522558 1.139 ENST00000375135.3
FGD1
FYVE, RhoGEF and PH domain containing 1
chr4_-_21699380 1.129 ENST00000382148.3
KCNIP4
Kv channel interacting protein 4
chr14_-_100841670 1.121 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS





tryptophanyl-tRNA synthetase





chr14_-_24898731 1.119 ENST00000267406.6
CBLN3
cerebellin 3 precursor
chr12_-_8815215 1.109 ENST00000544889.1
ENST00000543369.1
MFAP5

microfibrillar associated protein 5

chr7_+_114562909 1.102 ENST00000423503.1
ENST00000427207.1
MDFIC

MyoD family inhibitor domain containing

chr18_+_21718924 1.100 ENST00000399496.3
CABYR
calcium binding tyrosine-(Y)-phosphorylation regulated
chr8_+_27632047 1.097 ENST00000397418.2
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr15_-_64673665 1.083 ENST00000300035.4
KIAA0101
KIAA0101
chr12_-_8815299 1.077 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr18_+_21719018 1.046 ENST00000585037.1
ENST00000415309.2
ENST00000399481.2
ENST00000577705.1
ENST00000327201.6
CABYR




calcium binding tyrosine-(Y)-phosphorylation regulated




chr12_+_56521840 1.044 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr7_+_114562616 1.032 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr6_-_32157947 1.012 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr15_+_44119159 0.992 ENST00000263795.6
ENST00000381246.2
ENST00000452115.1
WDR76


WD repeat domain 76


chr15_-_89456630 0.976 ENST00000268150.8
MFGE8
milk fat globule-EGF factor 8 protein
chr15_-_81616446 0.975 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr1_+_150245099 0.969 ENST00000369099.3
C1orf54
chromosome 1 open reading frame 54
chr8_+_48873453 0.959 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr19_+_50887585 0.957 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1



polymerase (DNA directed), delta 1, catalytic subunit



chr15_-_70390213 0.956 ENST00000557997.1
ENST00000317509.8
ENST00000442299.2
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr19_+_4402659 0.947 ENST00000301280.5
ENST00000585854.1
CHAF1A

chromatin assembly factor 1, subunit A (p150)

chr2_-_24346218 0.942 ENST00000436622.1
ENST00000313213.4
PFN4

profilin family, member 4

chr19_-_33360647 0.911 ENST00000590341.1
ENST00000587772.1
ENST00000023064.4
SLC7A9


solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9


chr1_+_70876891 0.908 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr8_+_48873479 0.907 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr3_-_123168551 0.897 ENST00000462833.1
ADCY5
adenylate cyclase 5
chr18_-_12656715 0.890 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1



spire-type actin nucleation factor 1



chr1_-_52499443 0.881 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr17_+_75401152 0.877 ENST00000585930.1
SEPT9
septin 9
chr9_-_138591341 0.849 ENST00000298466.5
ENST00000425225.1
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr1_-_6453399 0.848 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr2_-_215674374 0.829 ENST00000449967.2
ENST00000421162.1
ENST00000260947.4
BARD1


BRCA1 associated RING domain 1


chr22_+_29999647 0.820 ENST00000334961.7
ENST00000353887.4
NF2

neurofibromin 2 (merlin)

chr3_+_197677047 0.811 ENST00000448864.1
RPL35A
ribosomal protein L35a
chr11_+_126225529 0.804 ENST00000227495.6
ENST00000444328.2
ENST00000356132.4
ST3GAL4


ST3 beta-galactoside alpha-2,3-sialyltransferase 4


chr13_+_32889605 0.803 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2


breast cancer 2, early onset


chr1_+_156024552 0.792 ENST00000368304.5
ENST00000368302.3
LAMTOR2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

chr7_+_100136811 0.791 ENST00000300176.4
ENST00000262935.4
AGFG2

ArfGAP with FG repeats 2

chr6_+_70576457 0.777 ENST00000322773.4
COL19A1
collagen, type XIX, alpha 1
chr2_-_70780572 0.772 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr15_-_89456593 0.771 ENST00000558029.1
ENST00000539437.1
ENST00000542878.1
ENST00000268151.7
ENST00000566497.1
MFGE8




milk fat globule-EGF factor 8 protein




chrX_+_131157290 0.748 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr16_-_34740829 0.742 ENST00000562591.1
RP11-80F22.15
RP11-80F22.15
chr4_-_130014705 0.733 ENST00000503401.1
SCLT1
sodium channel and clathrin linker 1
chr13_-_88463487 0.716 ENST00000606221.1
RP11-471M2.3
RP11-471M2.3
chr9_-_37904084 0.700 ENST00000377716.2
ENST00000242275.6
SLC25A51

solute carrier family 25, member 51

chr1_+_150245177 0.693 ENST00000369098.3
C1orf54
chromosome 1 open reading frame 54
chrX_+_131157322 0.690 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4


Serine/threonine-protein kinase MST4


chr8_+_128748466 0.686 ENST00000524013.1
ENST00000520751.1
MYC

v-myc avian myelocytomatosis viral oncogene homolog

chr18_-_19994830 0.684 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr4_-_130014609 0.679 ENST00000511426.1
SCLT1
sodium channel and clathrin linker 1
chr1_+_33283043 0.671 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100PBP



S100P binding protein



chr1_+_156024525 0.671 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chrX_-_52736211 0.669 ENST00000336777.5
ENST00000337502.5
SSX2

synovial sarcoma, X breakpoint 2

chrX_+_51927919 0.661 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr11_-_441964 0.657 ENST00000332826.6
ANO9
anoctamin 9
chr14_+_105155925 0.630 ENST00000330634.7
ENST00000398337.4
ENST00000392634.4
INF2


inverted formin, FH2 and WH2 domain containing


chr2_-_130939115 0.618 ENST00000441135.1
ENST00000339679.7
ENST00000426662.2
ENST00000443958.2
ENST00000351288.6
ENST00000453750.1
ENST00000452225.2
SMPD4






sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)






chrX_+_55026763 0.618 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr12_-_16761007 0.612 ENST00000354662.1
ENST00000441439.2
LMO3

LIM domain only 3 (rhombotin-like 2)

chr19_-_17559376 0.611 ENST00000341130.5
TMEM221
transmembrane protein 221
chr12_+_57146233 0.611 ENST00000554643.1
ENST00000556650.1
ENST00000554150.1
ENST00000554155.1
HSD17B6



hydroxysteroid (17-beta) dehydrogenase 6



chr1_-_43638168 0.608 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr14_+_24899141 0.607 ENST00000556842.1
ENST00000553935.1
KHNYN

KH and NYN domain containing

chr12_+_56324933 0.604 ENST00000549629.1
ENST00000555218.1
DGKA

diacylglycerol kinase, alpha 80kDa

chr1_+_205473720 0.603 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
CDK18


cyclin-dependent kinase 18


chr12_+_3069037 0.601 ENST00000397122.2
TEAD4
TEA domain family member 4
chr1_-_159893507 0.600 ENST00000368096.1
TAGLN2
transgelin 2
chr3_-_57113314 0.599 ENST00000338458.4
ENST00000468727.1
ARHGEF3

Rho guanine nucleotide exchange factor (GEF) 3

chr19_+_10765003 0.595 ENST00000407004.3
ENST00000589998.1
ENST00000589600.1
ILF3


interleukin enhancer binding factor 3, 90kDa


chr19_-_49865639 0.594 ENST00000593945.1
ENST00000601519.1
ENST00000539846.1
ENST00000596757.1
ENST00000311227.2
TEAD2




TEA domain family member 2




chr19_+_11546153 0.590 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
PRKCSH


protein kinase C substrate 80K-H


chr11_+_65029233 0.589 ENST00000265465.3
POLA2
polymerase (DNA directed), alpha 2, accessory subunit
chrX_-_119077695 0.572 ENST00000371410.3
NKAP
NFKB activating protein
chr3_+_122296443 0.567 ENST00000464300.2
PARP15
poly (ADP-ribose) polymerase family, member 15
chr19_-_49864746 0.565 ENST00000598810.1
TEAD2
TEA domain family member 2
chr14_-_51135036 0.563 ENST00000324679.4
SAV1
salvador homolog 1 (Drosophila)
chr9_-_131486367 0.562 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12




zinc finger, DHHC-type containing 12




chr2_-_177502659 0.562 ENST00000295549.4
AC017048.3
long intergenic non-protein coding RNA 1116
chr13_-_19755975 0.562 ENST00000400113.3
TUBA3C
tubulin, alpha 3c
chr11_-_13484713 0.561 ENST00000526841.1
ENST00000529708.1
ENST00000278174.5
ENST00000528120.1
BTBD10



BTB (POZ) domain containing 10



chr19_+_11546440 0.561 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
PRKCSH





protein kinase C substrate 80K-H





chr8_+_128748308 0.559 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr22_+_40742497 0.556 ENST00000216194.7
ADSL
adenylosuccinate lyase
chrX_-_40594755 0.555 ENST00000324817.1
MED14
mediator complex subunit 14
chrX_+_135614293 0.554 ENST00000370634.3
VGLL1
vestigial like 1 (Drosophila)
chr20_+_60174827 0.547 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr1_-_111682662 0.546 ENST00000286692.4
DRAM2
DNA-damage regulated autophagy modulator 2
chrX_-_119695279 0.542 ENST00000336592.6
CUL4B
cullin 4B
chr20_+_31595406 0.536 ENST00000170150.3
BPIFB2
BPI fold containing family B, member 2
chr22_+_20105259 0.528 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1



RAN binding protein 1



chr19_+_10764937 0.526 ENST00000449870.1
ENST00000318511.3
ENST00000420083.1
ILF3


interleukin enhancer binding factor 3, 90kDa


chr17_+_16120512 0.523 ENST00000581006.1
ENST00000584797.1
ENST00000498772.2
ENST00000225609.5
ENST00000395844.4
ENST00000477745.1
PIGL





phosphatidylinositol glycan anchor biosynthesis, class L





chr17_-_29151794 0.519 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr17_-_39928106 0.516 ENST00000540235.1
JUP
junction plakoglobin
chr5_+_34757309 0.515 ENST00000397449.1
RAI14
retinoic acid induced 14
chr22_+_40742512 0.515 ENST00000454266.2
ENST00000342312.6
ADSL

adenylosuccinate lyase

chr8_-_81083731 0.509 ENST00000379096.5
TPD52
tumor protein D52
chr2_-_152589670 0.498 ENST00000604864.1
ENST00000603639.1
NEB

nebulin

chr4_-_57844989 0.490 ENST00000264230.4
NOA1
nitric oxide associated 1
chr10_-_131762105 0.486 ENST00000368648.3
ENST00000355311.5
EBF3

early B-cell factor 3

chr15_+_66797627 0.483 ENST00000565627.1
ENST00000564179.1
ZWILCH

zwilch kinetochore protein

chr1_-_32827682 0.483 ENST00000432622.1
FAM229A
family with sequence similarity 229, member A
chr9_-_74675521 0.472 ENST00000377024.3
C9orf57
chromosome 9 open reading frame 57
chr4_+_25314388 0.469 ENST00000302874.4
ZCCHC4
zinc finger, CCHC domain containing 4
chr15_-_34635314 0.467 ENST00000557912.1
ENST00000328848.4
NOP10

NOP10 ribonucleoprotein

chr4_+_15341442 0.466 ENST00000397700.2
ENST00000295297.4
C1QTNF7

C1q and tumor necrosis factor related protein 7

chr17_-_15165854 0.465 ENST00000395936.1
ENST00000395938.2
PMP22

peripheral myelin protein 22

chr19_-_46146946 0.463 ENST00000536630.1
EML2
echinoderm microtubule associated protein like 2
chr1_+_92632542 0.462 ENST00000409154.4
ENST00000370378.4
KIAA1107

KIAA1107

chr9_-_136039314 0.460 ENST00000372040.3
GBGT1
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
chr19_-_47291843 0.451 ENST00000542575.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_73127353 0.450 ENST00000580423.1
ENST00000578337.1
ENST00000582160.1
NT5C


5', 3'-nucleotidase, cytosolic


chr6_-_41747595 0.446 ENST00000373018.3
FRS3
fibroblast growth factor receptor substrate 3
chr2_-_208994548 0.445 ENST00000282141.3
CRYGC
crystallin, gamma C
chr4_+_153701081 0.443 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ARFIP1




ADP-ribosylation factor interacting protein 1




chr12_-_71003568 0.441 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB




protein tyrosine phosphatase, receptor type, B




chr22_-_29457832 0.434 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr3_+_14058794 0.426 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
TPRXL


tetra-peptide repeat homeobox-like


chr5_+_109025067 0.421 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr4_-_130014729 0.418 ENST00000281142.5
ENST00000434680.1
SCLT1

sodium channel and clathrin linker 1

chr4_-_174255400 0.416 ENST00000506267.1
HMGB2
high mobility group box 2
chr10_+_70847852 0.415 ENST00000242465.3
SRGN
serglycin
chr17_+_56769924 0.415 ENST00000461271.1
ENST00000583539.1
ENST00000337432.4
ENST00000421782.2
RAD51C



RAD51 paralog C



chr13_+_21277482 0.412 ENST00000304920.3
IL17D
interleukin 17D
chr17_+_66243715 0.412 ENST00000359904.3
AMZ2
archaelysin family metallopeptidase 2
chr6_+_26251835 0.405 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr12_+_56324756 0.403 ENST00000331886.5
ENST00000555090.1
DGKA

diacylglycerol kinase, alpha 80kDa

chr22_+_29999545 0.401 ENST00000413209.2
ENST00000347330.5
ENST00000338641.4
ENST00000403435.1
ENST00000361452.4
ENST00000403999.3
NF2





neurofibromin 2 (merlin)





chrX_+_150866779 0.400 ENST00000370353.3
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr3_+_133293278 0.397 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3





CDV3 homolog (mouse)





chr22_+_20105012 0.395 ENST00000331821.3
ENST00000411892.1
RANBP1

RAN binding protein 1

chr4_+_128702969 0.394 ENST00000508776.1
ENST00000439123.2
HSPA4L

heat shock 70kDa protein 4-like

chr11_+_73882144 0.390 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr2_+_130939235 0.385 ENST00000425361.1
ENST00000457492.1
MZT2B

mitotic spindle organizing protein 2B

chr2_+_132233664 0.385 ENST00000321253.6
TUBA3D
tubulin, alpha 3d
chr8_+_118532937 0.381 ENST00000297347.3
MED30
mediator complex subunit 30
chr3_-_185542761 0.381 ENST00000457616.2
ENST00000346192.3
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
1.4 4.1 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.3 3.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.2 7.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.0 5.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.9 11.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.8 5.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.7 6.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 3.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.6 1.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.5 2.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.5 1.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.4 1.2 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.4 2.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 4.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3 1.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.2 1.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.7 GO:0010360 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.2 1.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.2 0.8 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 2.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.2 1.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 1.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.2 1.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.9 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.2 1.0 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 4.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 0.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 7.1 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.9 GO:0015811 L-cystine transport(GO:0015811)
0.1 0.4 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.9 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 1.7 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.6 GO:0006710 androgen catabolic process(GO:0006710)
0.1 1.2 GO:0014010 Schwann cell proliferation(GO:0014010)
0.1 1.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.5 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 3.6 GO:0000732 strand displacement(GO:0000732)
0.1 0.3 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 1.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.8 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.5 GO:0002159 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.1 0.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412) regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.9 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 0.4 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.6 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.3 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 0.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 1.3 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.2 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 2.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 2.1 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 1.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.6 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.3 GO:0030903 notochord development(GO:0030903)
0.1 1.9 GO:0097503 sialylation(GO:0097503)
0.1 0.2 GO:0018194 N-terminal protein amino acid methylation(GO:0006480) N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573)
0.1 0.2 GO:0002290 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.1 1.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 3.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.2 GO:0046452 glycine biosynthetic process(GO:0006545) dihydrofolate metabolic process(GO:0046452)
0.1 1.0 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 1.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.6 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 4.3 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.5 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 2.0 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.3 GO:1903301 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.9 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 1.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.6 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.0 1.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 1.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.9 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.7 GO:0015695 organic cation transport(GO:0015695)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.4 GO:0009219 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.5 GO:0032060 bleb assembly(GO:0032060)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.4 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.1 GO:0051036 regulation of endosome size(GO:0051036) receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.6 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.7 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.4 GO:0006954 inflammatory response(GO:0006954)
0.0 1.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 2.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 1.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.4 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 4.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.1 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 1.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.8 GO:0030574 collagen catabolic process(GO:0030574)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0031523 Myb complex(GO:0031523)
1.4 4.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.9 14.1 GO:0042555 MCM complex(GO:0042555)
0.8 4.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 3.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 1.9 GO:1990423 RZZ complex(GO:1990423)
0.5 0.9 GO:0033186 CAF-1 complex(GO:0033186)
0.5 1.4 GO:0005873 plus-end kinesin complex(GO:0005873)
0.3 1.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 10.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 5.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 1.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 4.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 1.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 0.8 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.2 1.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 2.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.5 GO:0071986 Ragulator complex(GO:0071986)
0.2 3.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.8 GO:0071439 clathrin complex(GO:0071439)
0.1 0.4 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.3 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.6 GO:0070847 core mediator complex(GO:0070847)
0.1 0.5 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 1.5 GO:0031045 dense core granule(GO:0031045)
0.1 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.3 GO:1990246 uniplex complex(GO:1990246)
0.1 0.5 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 6.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 1.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.4 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 1.0 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.9 GO:0031105 septin complex(GO:0031105)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 11.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 4.1 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0043218 compact myelin(GO:0043218)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.8 4.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 4.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.8 3.2 GO:0030395 lactose binding(GO:0030395)
0.7 12.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.6 2.4 GO:0003896 DNA primase activity(GO:0003896)
0.6 4.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.5 2.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.4 1.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.4 1.9 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.3 1.9 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 1.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.6 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.2 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 0.8 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.2 0.9 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.2 1.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 1.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 4.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 2.1 GO:0030957 Tat protein binding(GO:0030957)
0.1 10.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.7 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 5.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.1 1.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.4 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.1 0.5 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 2.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.3 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.2 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 1.0 GO:0032052 bile acid binding(GO:0032052)
0.1 0.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.2 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.2 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.1 0.6 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.4 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.2 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 5.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.0 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.4 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 3.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 10.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 2.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 18.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.0 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.2 4.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 4.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 4.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 3.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.3 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade
0.0 0.3 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation