Motif ID: E2F8

Z-value: 1.346


Transcription factors associated with E2F8:

Gene SymbolEntrez IDGene Name
E2F8 ENSG00000129173.8 E2F8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F8hg19_v2_chr11_-_19263145_192631760.873.0e-08Click!


Activity profile for motif E2F8.

activity profile for motif E2F8


Sorted Z-values histogram for motif E2F8

Sorted Z-values for motif E2F8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51845378 5.354 ENST00000335624.4
 VSIG10L
V-set and immunoglobulin domain containing 10 like
chr12_+_8975061 5.101 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr9_-_123639304 4.652 ENST00000436309.1
 PHF19
PHD finger protein 19
chr20_+_42295745 4.613 ENST00000396863.4
ENST00000217026.4
 MYBL2

v-myb avian myeloblastosis viral oncogene homolog-like 2

chr22_+_19467261 4.135 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
 CDC45



cell division cycle 45



chr2_+_10262857 4.133 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr11_+_125495862 3.800 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
 CHEK1




checkpoint kinase 1




chr22_+_35796108 3.780 ENST00000382011.5
ENST00000416905.1
 MCM5

minichromosome maintenance complex component 5

chr22_+_35796056 3.626 ENST00000216122.4
 MCM5
minichromosome maintenance complex component 5
chr9_-_123639445 3.489 ENST00000312189.6
 PHF19
PHD finger protein 19
chr22_+_38071615 3.237 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr11_+_125496124 3.177 ENST00000533778.2
ENST00000534070.1
 CHEK1

checkpoint kinase 1

chr9_-_123639600 2.983 ENST00000373896.3
 PHF19
PHD finger protein 19
chr2_-_136633940 2.818 ENST00000264156.2
 MCM6
minichromosome maintenance complex component 6
chr14_-_55658252 2.728 ENST00000395425.2
 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr7_+_26331541 2.420 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
 SNX10


sorting nexin 10


chr12_-_57146095 2.420 ENST00000550770.1
ENST00000338193.6
 PRIM1

primase, DNA, polypeptide 1 (49kDa)

chr14_-_55658323 2.367 ENST00000554067.1
ENST00000247191.2
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr17_+_39975455 2.288 ENST00000455106.1
 FKBP10
FK506 binding protein 10, 65 kDa
chr16_+_11439286 2.248 ENST00000312499.5
ENST00000576027.1
 RMI2

RecQ mediated genome instability 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 7.1 GO:0006270 DNA replication initiation(GO:0006270)
1.2 7.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 6.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.0 5.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.8 5.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.4 4.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.5 4.4 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.0 4.3 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 4.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
1.4 4.1 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 4.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.3 3.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 3.6 GO:0000732 strand displacement(GO:0000732)
0.6 3.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 3.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 2.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.4 2.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 2.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.5 2.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 14.1 GO:0042555 MCM complex(GO:0042555)
0.0 11.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 10.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 6.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 5.1 GO:0031616 spindle pole centrosome(GO:0031616)
1.5 4.6 GO:0031523 Myb complex(GO:0031523)
0.3 4.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.4 4.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.8 4.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 4.1 GO:0001650 fibrillar center(GO:0001650)
0.2 3.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.5 3.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 2.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 2.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.5 1.9 GO:1990423 RZZ complex(GO:1990423)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.8 GO:0071439 clathrin complex(GO:0071439)
0.2 1.5 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.5 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 10.9 GO:0035064 methylated histone binding(GO:0035064)
1.2 7.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 5.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.8 4.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.6 4.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 4.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 4.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.8 3.2 GO:0030395 lactose binding(GO:0030395)
0.0 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 2.4 GO:0003896 DNA primase activity(GO:0003896)
0.1 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 2.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.2 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.1 GO:0030957 Tat protein binding(GO:0030957)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 PID_E2F_PATHWAY E2F transcription factor network
0.5 7.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 3.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 18.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 4.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 4.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 4.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 4.0 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 3.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 1.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids