Motif ID: E2F2_E2F5

Z-value: 2.283

Transcription factors associated with E2F2_E2F5:

Gene SymbolEntrez IDGene Name
E2F2 ENSG00000007968.6 E2F2
E2F5 ENSG00000133740.6 E2F5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F2hg19_v2_chr1_-_23857698_238577330.752.5e-05Click!
E2F5hg19_v2_chr8_+_86121448_86121494-0.377.6e-02Click!


Activity profile for motif E2F2_E2F5.

activity profile for motif E2F2_E2F5


Sorted Z-values histogram for motif E2F2_E2F5

Sorted Z-values for motif E2F2_E2F5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F2_E2F5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_10262857 10.886 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr10_+_62538089 9.182 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1


cyclin-dependent kinase 1


chr20_+_25388293 8.956 ENST00000262460.4
ENST00000429262.2
 GINS1

GINS complex subunit 1 (Psf1 homolog)

chr2_-_136633940 8.894 ENST00000264156.2
 MCM6
minichromosome maintenance complex component 6
chr2_+_174219548 8.604 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
 CDCA7




cell division cycle associated 7




chr15_-_64673630 8.370 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
 KIAA0101


KIAA0101


chr10_+_62538248 8.119 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr9_-_99180597 7.684 ENST00000375256.4
 ZNF367
zinc finger protein 367
chr8_-_124408652 7.678 ENST00000287394.5
 ATAD2
ATPase family, AAA domain containing 2
chr1_+_212208919 7.496 ENST00000366991.4
ENST00000542077.1
 DTL

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

chr11_+_125495862 6.992 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
 CHEK1




checkpoint kinase 1




chr22_+_35796108 6.931 ENST00000382011.5
ENST00000416905.1
 MCM5

minichromosome maintenance complex component 5

chr3_+_127317066 6.824 ENST00000265056.7
 MCM2
minichromosome maintenance complex component 2
chr22_+_35796056 6.726 ENST00000216122.4
 MCM5
minichromosome maintenance complex component 5
chr4_+_154265784 6.595 ENST00000240488.3
 MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr15_-_64673665 6.122 ENST00000300035.4
 KIAA0101
KIAA0101
chr14_-_50154921 6.079 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
 POLE2



polymerase (DNA directed), epsilon 2, accessory subunit



chr1_-_26232522 5.892 ENST00000399728.1
 STMN1
stathmin 1
chr6_+_24775641 5.824 ENST00000378054.2
ENST00000476555.1
 GMNN

geminin, DNA replication inhibitor

chr11_-_118966167 5.640 ENST00000530167.1
 H2AFX
H2A histone family, member X

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 28.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 28.6 GO:0006270 DNA replication initiation(GO:0006270)
2.9 17.3 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
1.0 15.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
2.6 13.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.5 11.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
3.9 11.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 11.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.8 10.9 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
3.4 10.2 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.8 7.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 7.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
1.4 7.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.2 7.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.3 6.7 GO:0060356 leucine import(GO:0060356)
0.6 6.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.2 6.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 5.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 5.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 5.2 GO:0071480 cellular response to gamma radiation(GO:0071480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 42.4 GO:0042555 MCM complex(GO:0042555)
3.5 17.3 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 13.3 GO:0005667 transcription factor complex(GO:0005667)
2.4 11.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.9 11.7 GO:0000811 GINS complex(GO:0000811)
0.6 10.2 GO:0045120 pronucleus(GO:0045120)
0.0 9.7 GO:0005874 microtubule(GO:0005874)
0.3 9.2 GO:0005721 pericentric heterochromatin(GO:0005721)
1.1 9.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.9 8.5 GO:0031298 replication fork protection complex(GO:0031298)
0.9 7.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.7 7.1 GO:0000796 condensin complex(GO:0000796)
1.1 6.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 6.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 6.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 6.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 6.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 5.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 5.8 GO:0000800 lateral element(GO:0000800)
1.8 5.3 GO:0005873 plus-end kinesin complex(GO:0005873)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 24.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 18.2 GO:0001047 core promoter binding(GO:0001047)
0.5 18.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.8 17.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 13.5 GO:0015631 tubulin binding(GO:0015631)
2.4 11.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 11.7 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.3 11.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 10.5 GO:0035064 methylated histone binding(GO:0035064)
1.1 9.7 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 9.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 8.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 7.4 GO:0003684 damaged DNA binding(GO:0003684)
1.2 7.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 7.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 6.9 GO:0004386 helicase activity(GO:0004386)
0.4 6.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 6.6 GO:0042393 histone binding(GO:0042393)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.3 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.4 PID_E2F_PATHWAY E2F transcription factor network
2.0 27.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.7 12.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 10.3 PID_BARD1_PATHWAY BARD1 signaling events
0.2 9.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 8.3 PID_ATR_PATHWAY ATR signaling pathway
0.1 6.6 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 6.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 5.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 5.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 54.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.6 44.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 14.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 11.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.5 11.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.6 10.6 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.6 7.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 7.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 5.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 5.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.3 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.7 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.1 1.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 1.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex